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The map label for this gene is lpxD [H]

Identifier: 158334524

GI number: 158334524

Start: 1326233

End: 1327318

Strand: Reverse

Name: lpxD [H]

Synonym: AM1_1350

Alternate gene names: 158334524

Gene position: 1327318-1326233 (Counterclockwise)

Preceding gene: 158334525

Following gene: 158334523

Centisome position: 20.41

GC content: 51.57

Gene sequence:

>1086_bases
GTGACCTCAATGATGAAGTTGAGTGAGCTGATGGAGCGGCTTGCTGTCACGCCTGTCGCCATGAGCTGTCCCCTAACGGA
TCCCACCCTAGAAGGATGTGCAGCGCTGGATCGGGCTTACCCTGGAACCCTTAGTTTTGTAGAAGGCTCACAACGGGGTC
ACCTGATGCAAAACACTCAAGCGAGTGCCTTGATATTGCCTCCTGATGTTGAATTACAAGCTCTGGCGACGTCTAGGAGG
ATTGCTTGGTTTGCGATAGAACATCCACGATATTGGTTTGCCCGAGCCCTGAACTGCTTTTATCAACCGTGGCGATTACC
GCCGGTCTGCCATGCTACTGCTGTCATTGACACGACGGCTGAAGTAGGAGAAGGCGTTGGGGTTGGAGCTCATGTGGTGA
TCCATGCAGATGTCCATTTAGGAAATGAAGTACAAATTTTTCCCAATGTAGTGATTTATCCAGGGGTGGTAGTGGGGGAT
CGCACTGTTCTCCATGCCAACTGTGTGATTCATGAACGCACGATTATTGGGGCTGATTGTGTCATTCATAGTGGGGCGGT
GATTGGAGCGGAGGGGTTTGGGTTTGTCCCTGTTGTAGATCAAGCACATCGTTGGTATCCAATGCCCCAATCGGGGCAGA
CGATCCTCGAGGATCAGGTCGTGGTGGGCTGCAATACAACCATTGATCGGCCAGCTGTTGGTGAGACTCGTATAGGCGCG
GGGACGAAGATCGATAATCTCGTCCAGATTGGCCATGGTAGTCAGATTGGAGCGGATAGCCTAATTTGTGCTCAGGTGGG
TTTGGCGGGGGCAACAAAATTAGAGCAGCAGGTGATTTTGGCGGGACAAGTGGGTATTTCAGGGCAAGTCACTTTGGGAG
CGCGAACGACGGTTGCTGCTCAAAGTGGCGTTCACCAATCTTTGAACCCAGATTCTAAGGTAGCGGGCTATCCAGCCATT
AATCATCGACTGTGGCTGCGGGCTATGGCGATGGTTAAACGGTTACCCGAACTGGTCCAGCGAGTAAAGGCCCTAGAACA
GAAAATTGCTGAACTGTTAGGGTCTGATGAGTCTGAAATTAGCTGA

Upstream 100 bases:

>100_bases
TGTCCGCTATCAGCTTGTTCGAGAACAAGATCAGTGGAAGATCAAGCAAATGCAGGTACTGAACTAACCATTACAAGTTT
GCTCGGATAGTAGTAGAGGG

Downstream 100 bases:

>100_bases
GATGTTAGGGACCTACGGTTAATTCTGGGGGGAAGGCTGCCTGCAAGGTAGAATAAGAGGGCAAAATGCATAGGACTTCG
TCCTTGAGGCTGTATGCCAG

Product: UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 361; Mature: 360

Protein sequence:

>361_residues
MTSMMKLSELMERLAVTPVAMSCPLTDPTLEGCAALDRAYPGTLSFVEGSQRGHLMQNTQASALILPPDVELQALATSRR
IAWFAIEHPRYWFARALNCFYQPWRLPPVCHATAVIDTTAEVGEGVGVGAHVVIHADVHLGNEVQIFPNVVIYPGVVVGD
RTVLHANCVIHERTIIGADCVIHSGAVIGAEGFGFVPVVDQAHRWYPMPQSGQTILEDQVVVGCNTTIDRPAVGETRIGA
GTKIDNLVQIGHGSQIGADSLICAQVGLAGATKLEQQVILAGQVGISGQVTLGARTTVAAQSGVHQSLNPDSKVAGYPAI
NHRLWLRAMAMVKRLPELVQRVKALEQKIAELLGSDESEIS

Sequences:

>Translated_361_residues
MTSMMKLSELMERLAVTPVAMSCPLTDPTLEGCAALDRAYPGTLSFVEGSQRGHLMQNTQASALILPPDVELQALATSRR
IAWFAIEHPRYWFARALNCFYQPWRLPPVCHATAVIDTTAEVGEGVGVGAHVVIHADVHLGNEVQIFPNVVIYPGVVVGD
RTVLHANCVIHERTIIGADCVIHSGAVIGAEGFGFVPVVDQAHRWYPMPQSGQTILEDQVVVGCNTTIDRPAVGETRIGA
GTKIDNLVQIGHGSQIGADSLICAQVGLAGATKLEQQVILAGQVGISGQVTLGARTTVAAQSGVHQSLNPDSKVAGYPAI
NHRLWLRAMAMVKRLPELVQRVKALEQKIAELLGSDESEIS
>Mature_360_residues
TSMMKLSELMERLAVTPVAMSCPLTDPTLEGCAALDRAYPGTLSFVEGSQRGHLMQNTQASALILPPDVELQALATSRRI
AWFAIEHPRYWFARALNCFYQPWRLPPVCHATAVIDTTAEVGEGVGVGAHVVIHADVHLGNEVQIFPNVVIYPGVVVGDR
TVLHANCVIHERTIIGADCVIHSGAVIGAEGFGFVPVVDQAHRWYPMPQSGQTILEDQVVVGCNTTIDRPAVGETRIGAG
TKIDNLVQIGHGSQIGADSLICAQVGLAGATKLEQQVILAGQVGISGQVTLGARTTVAAQSGVHQSLNPDSKVAGYPAIN
HRLWLRAMAMVKRLPELVQRVKALEQKIAELLGSDESEIS

Specific function: Lipid A biosynthesis; third step. [C]

COG id: COG1044

COG function: function code M; UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase

Gene ontology:
GO:0008610: UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase
GO:0009245: UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase
GO:0016740: UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase
GO:0016746: UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase
GO:0016747: UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transferase hexapeptide repeat family. LpxD subfamily [H]

Homologues:

Organism=Escherichia coli, GI1786376, Length=330, Percent_Identity=31.2121212121212, Blast_Score=147, Evalue=8e-37,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001451
- InterPro:   IPR011004
- InterPro:   IPR007691
- InterPro:   IPR020573 [H]

Pfam domain/function: PF00132 Hexapep; PF04613 LpxD [H]

EC number: 2.3.1.-

Molecular weight: Translated: 38618; Mature: 38487

Theoretical pI: Translated: 6.31; Mature: 6.31

Prosite motif: PS00101 HEXAPEP_TRANSFERASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTSMMKLSELMERLAVTPVAMSCPLTDPTLEGCAALDRAYPGTLSFVEGSQRGHLMQNTQ
CCHHHHHHHHHHHHCCCCEEEECCCCCCHHHHHHHHHHCCCCCEEEECCCCCCCEEECCC
ASALILPPDVELQALATSRRIAWFAIEHPRYWFARALNCFYQPWRLPPVCHATAVIDTTA
CCEEEECCCCCEEEECCCCEEEEEEEECCHHHHHHHHHHHCCCCCCCCHHHHHEEEECHH
EVGEGVGVGAHVVIHADVHLGNEVQIFPNVVIYPGVVVGDRTVLHANCVIHERTIIGADC
HHCCCCCCCEEEEEEEEEECCCEEEECCCEEEECCEEECCCEEEEEEEEEEECEEEECCC
VIHSGAVIGAEGFGFVPVVDQAHRWYPMPQSGQTILEDQVVVGCNTTIDRPAVGETRIGA
EEECCEEECCCCCCCEEECCCCHHCCCCCCCCCEEECCCEEEECCCCCCCCCCCCCCCCC
GTKIDNLVQIGHGSQIGADSLICAQVGLAGATKLEQQVILAGQVGISGQVTLGARTTVAA
CCCHHHEEEECCCCCCCCCHHHHHHHCCCCCHHHHHEEEEEECCCCCCEEEECCCEEEHH
QSGVHQSLNPDSKVAGYPAINHRLWLRAMAMVKRLPELVQRVKALEQKIAELLGSDESEI
HCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHCC
S
C
>Mature Secondary Structure 
TSMMKLSELMERLAVTPVAMSCPLTDPTLEGCAALDRAYPGTLSFVEGSQRGHLMQNTQ
CHHHHHHHHHHHHCCCCEEEECCCCCCHHHHHHHHHHCCCCCEEEECCCCCCCEEECCC
ASALILPPDVELQALATSRRIAWFAIEHPRYWFARALNCFYQPWRLPPVCHATAVIDTTA
CCEEEECCCCCEEEECCCCEEEEEEEECCHHHHHHHHHHHCCCCCCCCHHHHHEEEECHH
EVGEGVGVGAHVVIHADVHLGNEVQIFPNVVIYPGVVVGDRTVLHANCVIHERTIIGADC
HHCCCCCCCEEEEEEEEEECCCEEEECCCEEEECCEEECCCEEEEEEEEEEECEEEECCC
VIHSGAVIGAEGFGFVPVVDQAHRWYPMPQSGQTILEDQVVVGCNTTIDRPAVGETRIGA
EEECCEEECCCCCCCEEECCCCHHCCCCCCCCCEEECCCEEEECCCCCCCCCCCCCCCCC
GTKIDNLVQIGHGSQIGADSLICAQVGLAGATKLEQQVILAGQVGISGQVTLGARTTVAA
CCCHHHEEEECCCCCCCCCHHHHHHHCCCCCHHHHHEEEEEECCCCCCEEEECCCEEEHH
QSGVHQSLNPDSKVAGYPAINHRLWLRAMAMVKRLPELVQRVKALEQKIAELLGSDESEI
HCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHCC
S
C

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Acyltransferases; Transferring groups other than amino-acyl groups [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA