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The map label for this gene is yiaY [H]

Identifier: 158334511

GI number: 158334511

Start: 1317047

End: 1318282

Strand: Direct

Name: yiaY [H]

Synonym: AM1_1335

Alternate gene names: 158334511

Gene position: 1317047-1318282 (Clockwise)

Preceding gene: 158334508

Following gene: 158334512

Centisome position: 20.25

GC content: 49.19

Gene sequence:

>1236_bases
ATGTTGAAACGACTCACCAACCTTTCACTCAAAATGTTCACTGTGCTATTTCCTTCAGAGAAGCCGCTCCTATTCACTGG
TGCCAATTCGACCATCCAGCTAGCATCCCTAGCCCAGGCATCTGGGAGCAAACGCCCCTTGCTTGTGACTGAGAAATTTT
TACTGCAACTGGGACTTCTCGATGAGGTGCTTGAGTACTTCAAGAATGAAGGCTGCGAAGTCACCATCTTCGATGGCATT
ATTCCGAATCCCACCTATGAGGTGATAGAAGAGGGCATACGAGCCTGCCAAAAGAACGACTGTGACAGTGTCTTTGCTGT
AGGAGGTGGTTCTACCATTGACGCAGCCAAAGTGATTGCCGCTTGCTACTCCAACGAAGTCGGTGTTGAACAAGTCGTGG
GCTTACTAAAAGTCAAGAAGCCAACTCTGCCCTTCTACACGGTTCCAACAACGTCTGGTACTGGCTCAGAAGTGACCAAT
TCAGCCGTCATCTCCGAGACTACAACTCACCAGAAGAAGTTTGTTGTTGATCCAAAGCTGATTCCATCTGCTGCTGCCCT
CGACGCGAACATGCTGAAGTCGTTGCCACCACATATTACGGCAGCAACCGGGATGGATGCTTTAACCCATGCAATTGAGT
CCTACTCTTCCGTCAATCGATTCAGTGACGCTGAACGAGATGCCAAGCTGGCGATCAAACTGCTACTTGAGTATCTACCT
GTTGTCTATGAAGACGAAAATAACCCTGAAGCTCGCCAATTGGTCGCCCTTGCCTCCTTCCTCGCTGGTTACTCGTTTAA
TAAGTCGGGCCTTGGCTATGTGCACGCGATTTCGCATCAGATCAGTGCTCACTACAACACGCCGCACGGACTGACCAATG
CCGTCATTCTGCCAAAAATCTTGCGATTCAACAAAACAGTTTGCGCAGACCGCTTTGCCAATCTGGAGCGCATGCTGAGT
GGCACAAGTGCTGGCTCTGATGAGCAACTGGCCGACAGATTTATCGCCCGAGTCGATGCTTTAGGTCAGCAACTGAATAT
TCCTAGCGGGTTCAAAGAACTTGAGGCGAAGCACTTCGACGCGATTACCAGCAAGGCGCTCCTAGAAGCTAAGTCATTCT
ATGCCGTGCCAAGGCTGATGAACCGAGCACAGTGTAAAGAAATTCTCGCTTCAATCTCAGAAGGAGTTAAAGCCGAAAGT
CCTATAACACAACAGCTTGCCTCCATCACTATTTAA

Upstream 100 bases:

>100_bases
TACAGTGTAATAAAAACAAAGGTGGTCCGGGAAAGAGAAAGCCCAGCTAAACCCGCCAAGTGTGCAAAGCAACCTTCATC
ACCACGTAAGGACTTGAACC

Downstream 100 bases:

>100_bases
CTGACGGCAGGCATCCTTTAACACTTATCCATTATGGAGAGATCTCAACATGAATACCCCAGTTGTTACCCCTGAGAATC
GTCATGAAGTGCCGAATCGT

Product: alcohol dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 411; Mature: 411

Protein sequence:

>411_residues
MLKRLTNLSLKMFTVLFPSEKPLLFTGANSTIQLASLAQASGSKRPLLVTEKFLLQLGLLDEVLEYFKNEGCEVTIFDGI
IPNPTYEVIEEGIRACQKNDCDSVFAVGGGSTIDAAKVIAACYSNEVGVEQVVGLLKVKKPTLPFYTVPTTSGTGSEVTN
SAVISETTTHQKKFVVDPKLIPSAAALDANMLKSLPPHITAATGMDALTHAIESYSSVNRFSDAERDAKLAIKLLLEYLP
VVYEDENNPEARQLVALASFLAGYSFNKSGLGYVHAISHQISAHYNTPHGLTNAVILPKILRFNKTVCADRFANLERMLS
GTSAGSDEQLADRFIARVDALGQQLNIPSGFKELEAKHFDAITSKALLEAKSFYAVPRLMNRAQCKEILASISEGVKAES
PITQQLASITI

Sequences:

>Translated_411_residues
MLKRLTNLSLKMFTVLFPSEKPLLFTGANSTIQLASLAQASGSKRPLLVTEKFLLQLGLLDEVLEYFKNEGCEVTIFDGI
IPNPTYEVIEEGIRACQKNDCDSVFAVGGGSTIDAAKVIAACYSNEVGVEQVVGLLKVKKPTLPFYTVPTTSGTGSEVTN
SAVISETTTHQKKFVVDPKLIPSAAALDANMLKSLPPHITAATGMDALTHAIESYSSVNRFSDAERDAKLAIKLLLEYLP
VVYEDENNPEARQLVALASFLAGYSFNKSGLGYVHAISHQISAHYNTPHGLTNAVILPKILRFNKTVCADRFANLERMLS
GTSAGSDEQLADRFIARVDALGQQLNIPSGFKELEAKHFDAITSKALLEAKSFYAVPRLMNRAQCKEILASISEGVKAES
PITQQLASITI
>Mature_411_residues
MLKRLTNLSLKMFTVLFPSEKPLLFTGANSTIQLASLAQASGSKRPLLVTEKFLLQLGLLDEVLEYFKNEGCEVTIFDGI
IPNPTYEVIEEGIRACQKNDCDSVFAVGGGSTIDAAKVIAACYSNEVGVEQVVGLLKVKKPTLPFYTVPTTSGTGSEVTN
SAVISETTTHQKKFVVDPKLIPSAAALDANMLKSLPPHITAATGMDALTHAIESYSSVNRFSDAERDAKLAIKLLLEYLP
VVYEDENNPEARQLVALASFLAGYSFNKSGLGYVHAISHQISAHYNTPHGLTNAVILPKILRFNKTVCADRFANLERMLS
GTSAGSDEQLADRFIARVDALGQQLNIPSGFKELEAKHFDAITSKALLEAKSFYAVPRLMNRAQCKEILASISEGVKAES
PITQQLASITI

Specific function: Unknown

COG id: COG1454

COG function: function code C; Alcohol dehydrogenase, class IV

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the iron-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI133922590, Length=346, Percent_Identity=27.4566473988439, Blast_Score=87, Evalue=4e-17,
Organism=Escherichia coli, GI48994951, Length=350, Percent_Identity=36.5714285714286, Blast_Score=236, Evalue=2e-63,
Organism=Escherichia coli, GI1789163, Length=341, Percent_Identity=34.3108504398827, Blast_Score=206, Evalue=3e-54,
Organism=Escherichia coli, GI87082107, Length=364, Percent_Identity=33.2417582417582, Blast_Score=196, Evalue=3e-51,
Organism=Escherichia coli, GI1787493, Length=384, Percent_Identity=32.5520833333333, Blast_Score=183, Evalue=2e-47,
Organism=Escherichia coli, GI1789386, Length=303, Percent_Identity=29.042904290429, Blast_Score=108, Evalue=5e-25,
Organism=Caenorhabditis elegans, GI17537053, Length=418, Percent_Identity=26.0765550239234, Blast_Score=116, Evalue=2e-26,
Organism=Saccharomyces cerevisiae, GI6321181, Length=353, Percent_Identity=32.8611898016997, Blast_Score=185, Evalue=1e-47,
Organism=Drosophila melanogaster, GI24657991, Length=396, Percent_Identity=26.5151515151515, Blast_Score=100, Evalue=3e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001670
- InterPro:   IPR018211 [H]

Pfam domain/function: PF00465 Fe-ADH [H]

EC number: =1.1.1.1 [H]

Molecular weight: Translated: 44516; Mature: 44516

Theoretical pI: Translated: 6.52; Mature: 6.52

Prosite motif: PS00060 ADH_IRON_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLKRLTNLSLKMFTVLFPSEKPLLFTGANSTIQLASLAQASGSKRPLLVTEKFLLQLGLL
CCCCHHCCHHEEEEEECCCCCCEEEECCCCEEEHHHHHHHCCCCCCEEHHHHHHHHHHHH
DEVLEYFKNEGCEVTIFDGIIPNPTYEVIEEGIRACQKNDCDSVFAVGGGSTIDAAKVIA
HHHHHHHHCCCCEEEEECCCCCCCHHHHHHHHHHHHCCCCCCCEEEECCCCCHHHHHHHH
ACYSNEVGVEQVVGLLKVKKPTLPFYTVPTTSGTGSEVTNSAVISETTTHQKKFVVDPKL
HHHCCCCCHHHHHHHHHHCCCCCCEEECCCCCCCCCHHHCCHHHCCCCCCCCEEEECCCC
IPSAAALDANMLKSLPPHITAATGMDALTHAIESYSSVNRFSDAERDAKLAIKLLLEYLP
CCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
VVYEDENNPEARQLVALASFLAGYSFNKSGLGYVHAISHQISAHYNTPHGLTNAVILPKI
EEECCCCCHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHH
LRFNKTVCADRFANLERMLSGTSAGSDEQLADRFIARVDALGQQLNIPSGFKELEAKHFD
HHHCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHH
AITSKALLEAKSFYAVPRLMNRAQCKEILASISEGVKAESPITQQLASITI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCC
>Mature Secondary Structure
MLKRLTNLSLKMFTVLFPSEKPLLFTGANSTIQLASLAQASGSKRPLLVTEKFLLQLGLL
CCCCHHCCHHEEEEEECCCCCCEEEECCCCEEEHHHHHHHCCCCCCEEHHHHHHHHHHHH
DEVLEYFKNEGCEVTIFDGIIPNPTYEVIEEGIRACQKNDCDSVFAVGGGSTIDAAKVIA
HHHHHHHHCCCCEEEEECCCCCCCHHHHHHHHHHHHCCCCCCCEEEECCCCCHHHHHHHH
ACYSNEVGVEQVVGLLKVKKPTLPFYTVPTTSGTGSEVTNSAVISETTTHQKKFVVDPKL
HHHCCCCCHHHHHHHHHHCCCCCCEEECCCCCCCCCHHHCCHHHCCCCCCCCEEEECCCC
IPSAAALDANMLKSLPPHITAATGMDALTHAIESYSSVNRFSDAERDAKLAIKLLLEYLP
CCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
VVYEDENNPEARQLVALASFLAGYSFNKSGLGYVHAISHQISAHYNTPHGLTNAVILPKI
EEECCCCCHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHH
LRFNKTVCADRFANLERMLSGTSAGSDEQLADRFIARVDALGQQLNIPSGFKELEAKHFD
HHHCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHH
AITSKALLEAKSFYAVPRLMNRAQCKEILASISEGVKAESPITQQLASITI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8041620; 9278503; 7768815 [H]