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The map label for this gene is fabG [C]

Identifier: 158334491

GI number: 158334491

Start: 1301548

End: 1302483

Strand: Reverse

Name: fabG [C]

Synonym: AM1_1315

Alternate gene names: 158334491

Gene position: 1302483-1301548 (Counterclockwise)

Preceding gene: 158334492

Following gene: 158334489

Centisome position: 20.03

GC content: 53.74

Gene sequence:

>936_bases
ATGAAATTTGATCGCAACTCTACGACGACCGACGTGCTCAATGGTATCGATCTGTCGGGCAAAACCGTCCTTGTAACTGG
AGCATCAACAGGCCTTGGGGCCGAAACTGCCCGCGCTCTTGCTGCTTGCGGTGCTGATGTTACCCTCGTTGCGAGATCGA
AGGCCAAGCTTTCCAATGTCGCCAACGAAATTCAATCTGAAACGGGTCGTTTACCCGAAATTGCGACCTTGGAACTGGAC
AAGCCCGCCACGATTCGCCGCTTCGCGGAAGACTGGCTTAGTCGCCACGAAAAACTCGATATTCTGATCAACAACGCAGG
CATTATGGCACCTCCGTTGACTCGTACCGCTGAGGGCTGGGAAAGCCAGTTTGCAACGAACCATCTGGGTCACTTTCTGC
TGACTAATTTGCTGGCCGATGCCACCAAGGCCTCAGGAGAAGCCCGCGTTATCAACCTGTCATCTGCTGGGCACTGGTAT
TCAACGGTAGATTTGGAAGATCCGAATTTTCAGAACCGCGACTATGAAGCGCTTCAAGCCTATGGTCAATCAAAAACGGC
AAACATCTGGTTCACGGTAGAACTCGCCCGCCGTTGGGCAGATCGTGGTGTGACCAGCTTTGCGGTACACCCAGGTGGTA
TCCAGACCGAGCTTGGCCGTAATCTGGAACCGGAAGTGGCCAAGACCTTTGAGAAGATGATCAAGGATTATCCGGATATC
TGGAAGACGGTCCCTCAAGGGGCGGCAACATCCTGCTGGGCCACGACATCGCCTGATCTGAGCGGCAAAACGGGCCTGTA
TCTGGAAGATTGTCACATTTCTGAACCGGGTGGTGGAGATGTGACCGATGGTGGATACGCTCCACATGCCTACGATGCTG
ATGGCGCAAAGCAGCTTTGGGTGCTTTCGAACGATCTGCTGGGCACGGAGTTCTGA

Upstream 100 bases:

>100_bases
AACGTGGCACTTTAGCGTTCCGGAGCATCGCAGCGCCGCAGCCAAACTCACTATTCTGAGAGTCTCGTCAATAACACCTT
AGGAGAAAATAAGACGAACT

Downstream 100 bases:

>100_bases
GATTAAACGCAATGGCTAGACCTTCACCGGGGTCGAAACCAATCTCTCAAGAAACCCCGATCACCGCCGAAAGCTTGGTG
GACGTTTTGGAAATCCAATG

Product: short chain dehydrogenase/reductase family oxidoreductase

Products: (3R)-hydroxyacyl-[acyl-carrier-protein]; NADP; NADPH; Proton; beta-ketoacyl-ACP [C]

Alternate protein names: NA

Number of amino acids: Translated: 311; Mature: 311

Protein sequence:

>311_residues
MKFDRNSTTTDVLNGIDLSGKTVLVTGASTGLGAETARALAACGADVTLVARSKAKLSNVANEIQSETGRLPEIATLELD
KPATIRRFAEDWLSRHEKLDILINNAGIMAPPLTRTAEGWESQFATNHLGHFLLTNLLADATKASGEARVINLSSAGHWY
STVDLEDPNFQNRDYEALQAYGQSKTANIWFTVELARRWADRGVTSFAVHPGGIQTELGRNLEPEVAKTFEKMIKDYPDI
WKTVPQGAATSCWATTSPDLSGKTGLYLEDCHISEPGGGDVTDGGYAPHAYDADGAKQLWVLSNDLLGTEF

Sequences:

>Translated_311_residues
MKFDRNSTTTDVLNGIDLSGKTVLVTGASTGLGAETARALAACGADVTLVARSKAKLSNVANEIQSETGRLPEIATLELD
KPATIRRFAEDWLSRHEKLDILINNAGIMAPPLTRTAEGWESQFATNHLGHFLLTNLLADATKASGEARVINLSSAGHWY
STVDLEDPNFQNRDYEALQAYGQSKTANIWFTVELARRWADRGVTSFAVHPGGIQTELGRNLEPEVAKTFEKMIKDYPDI
WKTVPQGAATSCWATTSPDLSGKTGLYLEDCHISEPGGGDVTDGGYAPHAYDADGAKQLWVLSNDLLGTEF
>Mature_311_residues
MKFDRNSTTTDVLNGIDLSGKTVLVTGASTGLGAETARALAACGADVTLVARSKAKLSNVANEIQSETGRLPEIATLELD
KPATIRRFAEDWLSRHEKLDILINNAGIMAPPLTRTAEGWESQFATNHLGHFLLTNLLADATKASGEARVINLSSAGHWY
STVDLEDPNFQNRDYEALQAYGQSKTANIWFTVELARRWADRGVTSFAVHPGGIQTELGRNLEPEVAKTFEKMIKDYPDI
WKTVPQGAATSCWATTSPDLSGKTGLYLEDCHISEPGGGDVTDGGYAPHAYDADGAKQLWVLSNDLLGTEF

Specific function: Fatty acid biosynthesis pathway; first reduction step. [C]

COG id: COG1028

COG function: function code IQR; Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Homo sapiens, GI166795268, Length=296, Percent_Identity=40.2027027027027, Blast_Score=177, Evalue=1e-44,
Organism=Homo sapiens, GI186928839, Length=296, Percent_Identity=38.1756756756757, Blast_Score=176, Evalue=2e-44,
Organism=Homo sapiens, GI7706523, Length=320, Percent_Identity=35, Blast_Score=173, Evalue=2e-43,
Organism=Homo sapiens, GI225579078, Length=302, Percent_Identity=40.7284768211921, Blast_Score=173, Evalue=2e-43,
Organism=Homo sapiens, GI10190746, Length=306, Percent_Identity=36.6013071895425, Blast_Score=170, Evalue=2e-42,
Organism=Homo sapiens, GI19923931, Length=237, Percent_Identity=41.7721518987342, Blast_Score=139, Evalue=2e-33,
Organism=Homo sapiens, GI146231950, Length=297, Percent_Identity=34.006734006734, Blast_Score=128, Evalue=5e-30,
Organism=Homo sapiens, GI193804850, Length=298, Percent_Identity=33.5570469798658, Blast_Score=124, Evalue=9e-29,
Organism=Homo sapiens, GI13375997, Length=182, Percent_Identity=29.1208791208791, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI72534732, Length=195, Percent_Identity=28.2051282051282, Blast_Score=70, Evalue=3e-12,
Organism=Escherichia coli, GI1787335, Length=209, Percent_Identity=32.5358851674641, Blast_Score=72, Evalue=6e-14,
Organism=Escherichia coli, GI1787526, Length=144, Percent_Identity=31.25, Blast_Score=65, Evalue=5e-12,
Organism=Caenorhabditis elegans, GI71992402, Length=279, Percent_Identity=31.5412186379928, Blast_Score=132, Evalue=2e-31,
Organism=Caenorhabditis elegans, GI193207620, Length=320, Percent_Identity=29.6875, Blast_Score=131, Evalue=4e-31,
Organism=Caenorhabditis elegans, GI17532805, Length=283, Percent_Identity=30.7420494699647, Blast_Score=127, Evalue=8e-30,
Organism=Caenorhabditis elegans, GI17558006, Length=304, Percent_Identity=32.2368421052632, Blast_Score=122, Evalue=3e-28,
Organism=Caenorhabditis elegans, GI17532791, Length=322, Percent_Identity=27.0186335403727, Blast_Score=118, Evalue=5e-27,
Organism=Caenorhabditis elegans, GI17535059, Length=282, Percent_Identity=29.7872340425532, Blast_Score=117, Evalue=1e-26,
Organism=Caenorhabditis elegans, GI32565532, Length=223, Percent_Identity=32.2869955156951, Blast_Score=108, Evalue=3e-24,
Organism=Caenorhabditis elegans, GI17505416, Length=272, Percent_Identity=30.5147058823529, Blast_Score=99, Evalue=2e-21,
Organism=Caenorhabditis elegans, GI72001364, Length=278, Percent_Identity=27.6978417266187, Blast_Score=83, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI115533172, Length=306, Percent_Identity=25.8169934640523, Blast_Score=65, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI115533174, Length=294, Percent_Identity=26.1904761904762, Blast_Score=65, Evalue=3e-11,
Organism=Saccharomyces cerevisiae, GI6324820, Length=225, Percent_Identity=30.6666666666667, Blast_Score=86, Evalue=9e-18,
Organism=Saccharomyces cerevisiae, GI6324148, Length=318, Percent_Identity=27.6729559748428, Blast_Score=78, Evalue=2e-15,
Organism=Drosophila melanogaster, GI20129347, Length=317, Percent_Identity=33.4384858044164, Blast_Score=174, Evalue=7e-44,
Organism=Drosophila melanogaster, GI22024069, Length=275, Percent_Identity=40.3636363636364, Blast_Score=167, Evalue=7e-42,
Organism=Drosophila melanogaster, GI28573296, Length=286, Percent_Identity=39.5104895104895, Blast_Score=164, Evalue=1e-40,
Organism=Drosophila melanogaster, GI24586328, Length=289, Percent_Identity=37.7162629757785, Blast_Score=161, Evalue=5e-40,
Organism=Drosophila melanogaster, GI19921754, Length=264, Percent_Identity=38.6363636363636, Blast_Score=159, Evalue=3e-39,
Organism=Drosophila melanogaster, GI45554248, Length=261, Percent_Identity=40.9961685823755, Blast_Score=157, Evalue=1e-38,
Organism=Drosophila melanogaster, GI24640117, Length=261, Percent_Identity=40.9961685823755, Blast_Score=157, Evalue=1e-38,
Organism=Drosophila melanogaster, GI161076371, Length=260, Percent_Identity=40, Blast_Score=154, Evalue=6e-38,
Organism=Drosophila melanogaster, GI45553409, Length=256, Percent_Identity=35.9375, Blast_Score=140, Evalue=1e-33,
Organism=Drosophila melanogaster, GI24647948, Length=256, Percent_Identity=35.9375, Blast_Score=140, Evalue=1e-33,
Organism=Drosophila melanogaster, GI24647946, Length=256, Percent_Identity=35.9375, Blast_Score=139, Evalue=2e-33,
Organism=Drosophila melanogaster, GI24656154, Length=299, Percent_Identity=31.7725752508361, Blast_Score=119, Evalue=3e-27,
Organism=Drosophila melanogaster, GI19922628, Length=299, Percent_Identity=31.7725752508361, Blast_Score=119, Evalue=3e-27,
Organism=Drosophila melanogaster, GI24647931, Length=286, Percent_Identity=29.020979020979, Blast_Score=91, Evalue=9e-19,
Organism=Drosophila melanogaster, GI28571526, Length=200, Percent_Identity=30, Blast_Score=81, Evalue=9e-16,
Organism=Drosophila melanogaster, GI23397609, Length=229, Percent_Identity=30.5676855895196, Blast_Score=80, Evalue=1e-15,
Organism=Drosophila melanogaster, GI24644339, Length=205, Percent_Identity=30.7317073170732, Blast_Score=79, Evalue=3e-15,
Organism=Drosophila melanogaster, GI21357041, Length=203, Percent_Identity=30.0492610837438, Blast_Score=78, Evalue=7e-15,
Organism=Drosophila melanogaster, GI21358495, Length=210, Percent_Identity=28.0952380952381, Blast_Score=68, Evalue=7e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040
- InterPro:   IPR020904 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: 1.1.1.100 [C]

Molecular weight: Translated: 33671; Mature: 33671

Theoretical pI: Translated: 4.77; Mature: 4.77

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKFDRNSTTTDVLNGIDLSGKTVLVTGASTGLGAETARALAACGADVTLVARSKAKLSNV
CCCCCCCCHHHHHCCCCCCCCEEEEECCCCCCCHHHHHHHHHCCCCEEEEEHHHHHHHHH
ANEIQSETGRLPEIATLELDKPATIRRFAEDWLSRHEKLDILINNAGIMAPPLTRTAEGW
HHHHHHHHCCCCCEEEEECCCCHHHHHHHHHHHHHCCEEEEEEECCCCCCCCCCCCHHHH
ESQFATNHLGHFLLTNLLADATKASGEARVINLSSAGHWYSTVDLEDPNFQNRDYEALQA
HHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCEEEEEECCCCCCCCCCHHHHHH
YGQSKTANIWFTVELARRWADRGVTSFAVHPGGIQTELGRNLEPEVAKTFEKMIKDYPDI
HCCCCCCEEEEEHHHHHHHHHCCCEEEEECCCCCHHHHCCCCCHHHHHHHHHHHHHHHHH
WKTVPQGAATSCWATTSPDLSGKTGLYLEDCHISEPGGGDVTDGGYAPHAYDADGAKQLW
HHHCCCCCCCCCCCCCCCCCCCCCCCEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCEEE
VLSNDLLGTEF
EEECCCCCCCC
>Mature Secondary Structure
MKFDRNSTTTDVLNGIDLSGKTVLVTGASTGLGAETARALAACGADVTLVARSKAKLSNV
CCCCCCCCHHHHHCCCCCCCCEEEEECCCCCCCHHHHHHHHHCCCCEEEEEHHHHHHHHH
ANEIQSETGRLPEIATLELDKPATIRRFAEDWLSRHEKLDILINNAGIMAPPLTRTAEGW
HHHHHHHHCCCCCEEEEECCCCHHHHHHHHHHHHHCCEEEEEEECCCCCCCCCCCCHHHH
ESQFATNHLGHFLLTNLLADATKASGEARVINLSSAGHWYSTVDLEDPNFQNRDYEALQA
HHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCEEEEEECCCCCCCCCCHHHHHH
YGQSKTANIWFTVELARRWADRGVTSFAVHPGGIQTELGRNLEPEVAKTFEKMIKDYPDI
HCCCCCCEEEEEHHHHHHHHHCCCEEEEECCCCCHHHHCCCCCHHHHHHHHHHHHHHHHH
WKTVPQGAATSCWATTSPDLSGKTGLYLEDCHISEPGGGDVTDGGYAPHAYDADGAKQLW
HHHCCCCCCCCCCCCCCCCCCCCCCCEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCEEE
VLSNDLLGTEF
EEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NADPH [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Oxoacyl-[acyl-carrier-protein]; NADPH; D-3-hydroxy-acyl-ACP; NADP [C]

Specific reaction: Oxoacyl-[acyl-carrier-protein] + NADPH = (3R)-hydroxyacyl-[acyl-carrier-protein] + NADP+ D-3-hydroxy-acyl-ACP + NADP = NADPH + Proton + beta-ketoacyl-ACP [C]

General reaction: Redox reaction [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8383668 [H]