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The map label for this gene is hup [H]

Identifier: 158334333

GI number: 158334333

Start: 1122737

End: 1123012

Strand: Direct

Name: hup [H]

Synonym: AM1_1154

Alternate gene names: 158334333

Gene position: 1122737-1123012 (Clockwise)

Preceding gene: 158334332

Following gene: 158334335

Centisome position: 17.26

GC content: 43.48

Gene sequence:

>276_bases
ATGAATAAAGGCGAATTAGTTGACGCTATTGCTGATAAAACAGGAGTAACGAAGAAGCAAGCTGACGTTACGCTCAGTGC
TGCAGTTGATGTCATCATCGATGCCGTTAGCCATGGCGATAAAGTTACTTTAGTCGGATTTGGTAGTTTCGAACCGCGCG
ATCGTAAAGCAAGAAATGGTCGTAATCCGCAAACCGGCAAGAAGCTAAAAATCCCTGCCACCAGAGTTCCTGCCTTTAGT
GCTGGAAAATTGTTTAAAGATAAAGTTGCTCCATAA

Upstream 100 bases:

>100_bases
TTTGGGTTTTCTTTGTTACTTTTGTGCAATTTCTTTGCTATATCTGTTCACTTTTTAAAAACTTGAGATAGAATGCTCGC
AAGGTTTTGAGGATAACTCA

Downstream 100 bases:

>100_bases
GTTTAATCAAATCTCGTAGTTAAATAACTGACTGATAGCAGTTCCAAAGTATAGTTTGGATTCAAATCTTAAAACTAATC
TGCTCAAGTTTTCTGTTGAG

Product: DNA-binding protein HU

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 91; Mature: 91

Protein sequence:

>91_residues
MNKGELVDAIADKTGVTKKQADVTLSAAVDVIIDAVSHGDKVTLVGFGSFEPRDRKARNGRNPQTGKKLKIPATRVPAFS
AGKLFKDKVAP

Sequences:

>Translated_91_residues
MNKGELVDAIADKTGVTKKQADVTLSAAVDVIIDAVSHGDKVTLVGFGSFEPRDRKARNGRNPQTGKKLKIPATRVPAFS
AGKLFKDKVAP
>Mature_91_residues
MNKGELVDAIADKTGVTKKQADVTLSAAVDVIIDAVSHGDKVTLVGFGSFEPRDRKARNGRNPQTGKKLKIPATRVPAFS
AGKLFKDKVAP

Specific function: Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions. It is essential for heterocyst differentiation [H]

COG id: COG0776

COG function: function code L; Bacterial nucleoid DNA-binding protein

Gene ontology:
GO:0003677: DNA-binding protein HU

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the bacterial histone-like protein family [H]

Homologues:

Organism=Escherichia coli, GI1790433, Length=89, Percent_Identity=49.438202247191, Blast_Score=93, Evalue=4e-21,
Organism=Escherichia coli, GI1786644, Length=89, Percent_Identity=47.1910112359551, Blast_Score=87, Evalue=2e-19,
Organism=Escherichia coli, GI1788005, Length=89, Percent_Identity=37.0786516853933, Blast_Score=67, Evalue=2e-13,

Paralogues:

None

Copy number: 1380 Molecules/Cell In: Growth-Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000119
- InterPro:   IPR020816
- InterPro:   IPR010992 [H]

Pfam domain/function: PF00216 Bac_DNA_binding [H]

EC number: NA

Molecular weight: Translated: 9660; Mature: 9660

Theoretical pI: Translated: 10.79; Mature: 10.79

Prosite motif: PS00045 HISTONE_LIKE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
1.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNKGELVDAIADKTGVTKKQADVTLSAAVDVIIDAVSHGDKVTLVGFGSFEPRDRKARNG
CCCCHHHHHHHCCCCCCCCCCCEEHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCHHCCC
RNPQTGKKLKIPATRVPAFSAGKLFKDKVAP
CCCCCCCEEECCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MNKGELVDAIADKTGVTKKQADVTLSAAVDVIIDAVSHGDKVTLVGFGSFEPRDRKARNG
CCCCHHHHHHHCCCCCCCCCCCEEHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCHHCCC
RNPQTGKKLKIPATRVPAFSAGKLFKDKVAP
CCCCCCCEEECCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8655556; 7748931; 11759840 [H]