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The map label for this gene is hrcA

Identifier: 158334322

GI number: 158334322

Start: 1111366

End: 1112469

Strand: Reverse

Name: hrcA

Synonym: AM1_1142

Alternate gene names: 158334322

Gene position: 1112469-1111366 (Counterclockwise)

Preceding gene: 158334323

Following gene: 158334321

Centisome position: 17.11

GC content: 47.64

Gene sequence:

>1104_bases
ATGGACCTTAGCCTTACTAACCGTCAACAACAAGTTTTGCGGGCAACCGTGGATCACTACATTGCTACGGCTGAACCGGT
CGGGTCTAAAGCTTTAGCACGGGAATATGCTTTGAGTATTAGTCCAGCGACCATCCGCAATGTGATGGGGAGATTAGAGG
AAGAAGGCTTGCTCTTTCAACCCCATACTTCAGCGGGTCGTGTCCCTTCAGACTTTGGCTATCGGCATTATGTGGATGAA
CTGGTGATGCCCTCAACCACATTGATGTCCCAGATTAAACAAGCCCTTGATCAAAAGCTACGGACTGACAGCTGGATTTT
TGAAGTGCTGCTTCGCGATGCTGCTCAAATTCTCGCGACCTTGAGTGGCTGTGTGGCTTTGATCACCCTGCCTCAAGCCG
CGACCTCCACTATCCGCCATCTCCATCTCGTCCAGGTTGAGCCCCATCGGGTCATGTTGATTCTAGTGACCGATGCCTAC
GAGACTCAGTCCGTGATGATGGAATTACCCCACTCGGCCTGGGATGAAGTGGATCCAGATCGAATTGAACAGGAACTGCA
GATTCTCTCTAATTTTTTGAACCACCATTTTGTGGGGAGCTCATTGCAAGACTTAGTTGCGCTGGATCCATGTGAACTGG
ATCGGGAATTTCAAAAATACACTGATTTCTTAAAAATATTGCTGACGGATCTGACACAACAGTGTAAATCCCTCAGTCCT
AAAAATATCTTAGTGGGTGGTTTAGCTGAGGTTTTGCGACAGCCTGAATTCTCTGAATTACAGCAGGCTCAGACCTTAAT
TCACTTATTAGAAGATGGCCAAGATCTGCTTCGACCTCTTTTTAATGAGTTGATGGCTGATGAGATTAAACAGGGGGCTG
ATGTGGTGCCTCGGAGTACAAAAGTCAACGTTCGCATCGGCTCAGAAAATAGCCTTGAGTCTATTCAGGCCTATTCCCTG
GTCTCTTCAACCTATCAAAAAGGCGAATTGCCAATGGGAAGTGTTGGCGTACTTGGGCCCACTCGTATGGCTTATGAGAA
AGTCATCGCTCTGGTAACAGTGACCGCCGATTATCTATCTACCTGTCTCACCCAGGTCGCTTAA

Upstream 100 bases:

>100_bases
ACGTCAAGAATGTCAGTGGTGGCATTGATGCTTATTCAATGAAGGTAGACACCAGCATCCCGCGCTACTAAAGTCTGAAC
GCACTTTTTACCCAAGTTCT

Downstream 100 bases:

>100_bases
AGGTTATTTTATTTTTTAGAATAAATATGACCTTCTGAGAAAAAGTCAGGTGGCATCGCTGACTTTTTTTCGAAGATCTC
TGACCTTTTCTGTCTGTTTA

Product: heat-inducible transcription repressor

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 367; Mature: 367

Protein sequence:

>367_residues
MDLSLTNRQQQVLRATVDHYIATAEPVGSKALAREYALSISPATIRNVMGRLEEEGLLFQPHTSAGRVPSDFGYRHYVDE
LVMPSTTLMSQIKQALDQKLRTDSWIFEVLLRDAAQILATLSGCVALITLPQAATSTIRHLHLVQVEPHRVMLILVTDAY
ETQSVMMELPHSAWDEVDPDRIEQELQILSNFLNHHFVGSSLQDLVALDPCELDREFQKYTDFLKILLTDLTQQCKSLSP
KNILVGGLAEVLRQPEFSELQQAQTLIHLLEDGQDLLRPLFNELMADEIKQGADVVPRSTKVNVRIGSENSLESIQAYSL
VSSTYQKGELPMGSVGVLGPTRMAYEKVIALVTVTADYLSTCLTQVA

Sequences:

>Translated_367_residues
MDLSLTNRQQQVLRATVDHYIATAEPVGSKALAREYALSISPATIRNVMGRLEEEGLLFQPHTSAGRVPSDFGYRHYVDE
LVMPSTTLMSQIKQALDQKLRTDSWIFEVLLRDAAQILATLSGCVALITLPQAATSTIRHLHLVQVEPHRVMLILVTDAY
ETQSVMMELPHSAWDEVDPDRIEQELQILSNFLNHHFVGSSLQDLVALDPCELDREFQKYTDFLKILLTDLTQQCKSLSP
KNILVGGLAEVLRQPEFSELQQAQTLIHLLEDGQDLLRPLFNELMADEIKQGADVVPRSTKVNVRIGSENSLESIQAYSL
VSSTYQKGELPMGSVGVLGPTRMAYEKVIALVTVTADYLSTCLTQVA
>Mature_367_residues
MDLSLTNRQQQVLRATVDHYIATAEPVGSKALAREYALSISPATIRNVMGRLEEEGLLFQPHTSAGRVPSDFGYRHYVDE
LVMPSTTLMSQIKQALDQKLRTDSWIFEVLLRDAAQILATLSGCVALITLPQAATSTIRHLHLVQVEPHRVMLILVTDAY
ETQSVMMELPHSAWDEVDPDRIEQELQILSNFLNHHFVGSSLQDLVALDPCELDREFQKYTDFLKILLTDLTQQCKSLSP
KNILVGGLAEVLRQPEFSELQQAQTLIHLLEDGQDLLRPLFNELMADEIKQGADVVPRSTKVNVRIGSENSLESIQAYSL
VSSTYQKGELPMGSVGVLGPTRMAYEKVIALVTVTADYLSTCLTQVA

Specific function: Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons

COG id: COG1420

COG function: function code K; Transcriptional regulator of heat shock gene

Gene ontology:
GO:0003677: Heat-inducible transcription repressor hrcA
GO:0006351: Heat-inducible transcription repressor hrcA
GO:0006355: Heat-inducible transcription repressor hrcA
GO:0006950: Heat-inducible transcription repressor hrcA

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the hrcA family

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HRCA_ACAM1 (B0C2W4)

Other databases:

- EMBL:   CP000828
- RefSeq:   YP_001515494.1
- ProteinModelPortal:   B0C2W4
- SMR:   B0C2W4
- GeneID:   5679966
- GenomeReviews:   CP000828_GR
- KEGG:   amr:AM1_1142
- HOGENOM:   HBG729878
- OMA:   LEQPHTS
- ProtClustDB:   PRK00082
- BioCyc:   AMAR329726:AM1_1142-MONOMER
- GO:   GO:0006350
- HAMAP:   MF_00081
- InterPro:   IPR002571
- InterPro:   IPR021153
- InterPro:   IPR011991
- Gene3D:   G3DSA:1.10.10.10
- PIRSF:   PIRSF005485
- TIGRFAMs:   TIGR00331

Pfam domain/function: PF01628 HrcA

EC number: NA

Molecular weight: Translated: 40913; Mature: 40913

Theoretical pI: Translated: 4.75; Mature: 4.75

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDLSLTNRQQQVLRATVDHYIATAEPVGSKALAREYALSISPATIRNVMGRLEEEGLLFQ
CCCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHCCCEEC
PHTSAGRVPSDFGYRHYVDELVMPSTTLMSQIKQALDQKLRTDSWIFEVLLRDAAQILAT
CCCCCCCCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LSGCVALITLPQAATSTIRHLHLVQVEPHRVMLILVTDAYETQSVMMELPHSAWDEVDPD
HHHHHHHHHCCHHHHHHHHHHEEEEECCCEEEEEEEECCHHHHHHHHHCCCHHCCCCCHH
RIEQELQILSNFLNHHFVGSSLQDLVALDPCELDREFQKYTDFLKILLTDLTQQCKSLSP
HHHHHHHHHHHHHHHHHCCCCHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
KNILVGGLAEVLRQPEFSELQQAQTLIHLLEDGQDLLRPLFNELMADEIKQGADVVPRST
CHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCCCCCC
KVNVRIGSENSLESIQAYSLVSSTYQKGELPMGSVGVLGPTRMAYEKVIALVTVTADYLS
EEEEEECCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHH
TCLTQVA
HHHHHCC
>Mature Secondary Structure
MDLSLTNRQQQVLRATVDHYIATAEPVGSKALAREYALSISPATIRNVMGRLEEEGLLFQ
CCCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHCCCEEC
PHTSAGRVPSDFGYRHYVDELVMPSTTLMSQIKQALDQKLRTDSWIFEVLLRDAAQILAT
CCCCCCCCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LSGCVALITLPQAATSTIRHLHLVQVEPHRVMLILVTDAYETQSVMMELPHSAWDEVDPD
HHHHHHHHHCCHHHHHHHHHHEEEEECCCEEEEEEEECCHHHHHHHHHCCCHHCCCCCHH
RIEQELQILSNFLNHHFVGSSLQDLVALDPCELDREFQKYTDFLKILLTDLTQQCKSLSP
HHHHHHHHHHHHHHHHHCCCCHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
KNILVGGLAEVLRQPEFSELQQAQTLIHLLEDGQDLLRPLFNELMADEIKQGADVVPRST
CHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCCCCCC
KVNVRIGSENSLESIQAYSLVSSTYQKGELPMGSVGVLGPTRMAYEKVIALVTVTADYLS
EEEEEECCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHH
TCLTQVA
HHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA