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The map label for this gene is uvrC

Identifier: 158334297

GI number: 158334297

Start: 1093112

End: 1094992

Strand: Reverse

Name: uvrC

Synonym: AM1_1116

Alternate gene names: 158334297

Gene position: 1094992-1093112 (Counterclockwise)

Preceding gene: 158334298

Following gene: 158334296

Centisome position: 16.84

GC content: 49.87

Gene sequence:

>1881_bases
GTGACCGATGCCGTTTCGACCACCACCCTGCTTAAAGATCGTGATCGCCTAGAAGCCAGGCTAAAAGAGATCCCGCCCGA
GCCAGGCGTGTATTTTATGCGAGATGCCAATGATGACATCTTGTATATTGGCAAGTCCAAAAAACTCAGAAATCGCGTTC
GCTCCTATTTTCGACAAATTCAAGACCACCCACCTCGAATTGAGCTGATGGTTCATCAGGTGGCGGATATTGAGTTTATT
GTGACGGATACCGAAGCAGAGGCGTTGGCCTTAGAAGCCAATCTGATCAAACAGCATCAGCCTCACTTTAATGTTTTGCT
TAAAGACGATAAAAAGTATCCCTATCTATGTGTCACTTGGTCCCAAACTTACCCTCGCATCTTTATTACTCGCAAACGGC
GGTTAGGCAAGGCCCAAGATAAATACTACGGCCCCTATGTTGACGTGTGGCAGCTTCGTCAAACCCTGCGGTTGGTCAAG
CGCCTGTTTCCCCTACGACAACGACGAAAGCCCCTGTTCAAAGATCGCCCCTGCCTTAATTATGAAATTGGTCGCTGCCC
TGGGGTTTGCCAAGCTCTGATTACACCAGAAGCCTATCGCCAGATCCTGCAAAAAGTTGTGATGATTTTCCAGGGCCGTA
CCAGTGAATTGATTAACACCCTGTCGCTACAAATGGAGCAAGCTGCTGAAGATCTTAATTTTGAACAAGCAGCGCGGCTT
CGAGATCAGATTAAAGGCTTACAGGGCTTGGGGGTTGACCAAAAAGTTGCCTTGCCCGATGACACCGTATCGCGAGATGC
GATCGCCCTCGCTGCTGACGATCAAATTGCCTGTGTTCAACTCTTCCAGATTCGGTCCGGGCGTTTAGTGGGCCGGTTGG
GATTTATGGCGGATGCCCAATCGGGCTCCCTGGGGATGATTCTGCAGCATGTATTAGAAGCCCATTACGGTAGCGCTGAG
CCAGTAGAGCTACCCTTGGAAATTTTGGTGCAAACTGAGTTACCGGAAACGGAACTATTAGCCAGCTATCTCAGCCAGCG
AAAGGAACGCAAAGTCAGTATTACCTGTCCCCAACGGCAGATCAAAGCTGAACTGATCGAAATGGTCGAACGCAATGCCC
AATATGAGTTAGCCCGGACCCAAAAAAGCCGAGATCGCACCCTCAACGCCCTCCAAGACCTAGCCGAACTTTTAGATCTG
CCCGAGCTACCGCACCGGATTGAATGCTATGACATCTCTCATATCCAAGGGTCAGATGCCGTAGCTTCTCAAGTGGTCTT
TATCGACGGCTTACCTGCTAAGCAACATTATCGACGGTACAAAATTCGAAATCCCAACGTTAAGGCTGGTCACTCAGATG
ATTTTGCCAGTCTAGCGGAAGTCCTACATCGGCGCTTTCGCCAGTACCATCTATCCCCAGAACAACCTCGACAAGGCACC
TCCGACTGGCCTGACCTAGTGGTCATTGATGGGGGTAAAGGGCAATTATCAGCGGTTTTAGAGTCGTTGACGAAAATTGA
AGTCGTTGAAGATCTACAGATTATCAGTCTGGCTAAGCAACGGGAAGAGATTTTTCAGCCTGGAGAAAGCCAGCCTTTGC
CCACGGATCCTGAACAACCTGGCGTCCAACTCATTCGCCGATTACGGGATGAAGCCCATCGCTTTGCCATCAGTTTTCAT
CGCAAGAAGCGATTAGAGCGAATGCGGCGCTCGCGGCTAGATGATATCCCAGGGCTTGGCCACCACCGCCAAAAGGAACT
ACTCGCGGCTTTTCGGTCCATTGACTACATTCGGGAAGCTAGCCCAGAGCAATTAAAAGCCGTCCCGACCATTGGCCCTC
AACTTGCTCAGAAAATCTATGATTATTTCCATCCCGCTTAA

Upstream 100 bases:

>100_bases
TTGAGAGGCTTAAGACCTTCACACCTCAATTTGTATGTGACGAAGAGTAAGACGTTTTAGGATTAGAAGAAATCGCTTAT
TGGAACAGTGACGCATAATC

Downstream 100 bases:

>100_bases
AAAAGATGACGTTAGTTTATCTTTTAATAAAAACAATAAAGGGTTTTCATGGGATATTTTTCCCGAGAATACTATTGATG
CATCTCTCAAATCAGGGAAT

Product: excinuclease ABC subunit C

Products: NA

Alternate protein names: Protein uvrC; Excinuclease ABC subunit C

Number of amino acids: Translated: 626; Mature: 625

Protein sequence:

>626_residues
MTDAVSTTTLLKDRDRLEARLKEIPPEPGVYFMRDANDDILYIGKSKKLRNRVRSYFRQIQDHPPRIELMVHQVADIEFI
VTDTEAEALALEANLIKQHQPHFNVLLKDDKKYPYLCVTWSQTYPRIFITRKRRLGKAQDKYYGPYVDVWQLRQTLRLVK
RLFPLRQRRKPLFKDRPCLNYEIGRCPGVCQALITPEAYRQILQKVVMIFQGRTSELINTLSLQMEQAAEDLNFEQAARL
RDQIKGLQGLGVDQKVALPDDTVSRDAIALAADDQIACVQLFQIRSGRLVGRLGFMADAQSGSLGMILQHVLEAHYGSAE
PVELPLEILVQTELPETELLASYLSQRKERKVSITCPQRQIKAELIEMVERNAQYELARTQKSRDRTLNALQDLAELLDL
PELPHRIECYDISHIQGSDAVASQVVFIDGLPAKQHYRRYKIRNPNVKAGHSDDFASLAEVLHRRFRQYHLSPEQPRQGT
SDWPDLVVIDGGKGQLSAVLESLTKIEVVEDLQIISLAKQREEIFQPGESQPLPTDPEQPGVQLIRRLRDEAHRFAISFH
RKKRLERMRRSRLDDIPGLGHHRQKELLAAFRSIDYIREASPEQLKAVPTIGPQLAQKIYDYFHPA

Sequences:

>Translated_626_residues
MTDAVSTTTLLKDRDRLEARLKEIPPEPGVYFMRDANDDILYIGKSKKLRNRVRSYFRQIQDHPPRIELMVHQVADIEFI
VTDTEAEALALEANLIKQHQPHFNVLLKDDKKYPYLCVTWSQTYPRIFITRKRRLGKAQDKYYGPYVDVWQLRQTLRLVK
RLFPLRQRRKPLFKDRPCLNYEIGRCPGVCQALITPEAYRQILQKVVMIFQGRTSELINTLSLQMEQAAEDLNFEQAARL
RDQIKGLQGLGVDQKVALPDDTVSRDAIALAADDQIACVQLFQIRSGRLVGRLGFMADAQSGSLGMILQHVLEAHYGSAE
PVELPLEILVQTELPETELLASYLSQRKERKVSITCPQRQIKAELIEMVERNAQYELARTQKSRDRTLNALQDLAELLDL
PELPHRIECYDISHIQGSDAVASQVVFIDGLPAKQHYRRYKIRNPNVKAGHSDDFASLAEVLHRRFRQYHLSPEQPRQGT
SDWPDLVVIDGGKGQLSAVLESLTKIEVVEDLQIISLAKQREEIFQPGESQPLPTDPEQPGVQLIRRLRDEAHRFAISFH
RKKRLERMRRSRLDDIPGLGHHRQKELLAAFRSIDYIREASPEQLKAVPTIGPQLAQKIYDYFHPA
>Mature_625_residues
TDAVSTTTLLKDRDRLEARLKEIPPEPGVYFMRDANDDILYIGKSKKLRNRVRSYFRQIQDHPPRIELMVHQVADIEFIV
TDTEAEALALEANLIKQHQPHFNVLLKDDKKYPYLCVTWSQTYPRIFITRKRRLGKAQDKYYGPYVDVWQLRQTLRLVKR
LFPLRQRRKPLFKDRPCLNYEIGRCPGVCQALITPEAYRQILQKVVMIFQGRTSELINTLSLQMEQAAEDLNFEQAARLR
DQIKGLQGLGVDQKVALPDDTVSRDAIALAADDQIACVQLFQIRSGRLVGRLGFMADAQSGSLGMILQHVLEAHYGSAEP
VELPLEILVQTELPETELLASYLSQRKERKVSITCPQRQIKAELIEMVERNAQYELARTQKSRDRTLNALQDLAELLDLP
ELPHRIECYDISHIQGSDAVASQVVFIDGLPAKQHYRRYKIRNPNVKAGHSDDFASLAEVLHRRFRQYHLSPEQPRQGTS
DWPDLVVIDGGKGQLSAVLESLTKIEVVEDLQIISLAKQREEIFQPGESQPLPTDPEQPGVQLIRRLRDEAHRFAISFHR
KKRLERMRRSRLDDIPGLGHHRQKELLAAFRSIDYIREASPEQLKAVPTIGPQLAQKIYDYFHPA

Specific function: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision

COG id: COG0322

COG function: function code L; Nuclease subunit of the excinuclease complex

Gene ontology:
GO:0003677: UvrABC system protein C
GO:0004518: UvrABC system protein C
GO:0005622: UvrABC system protein C
GO:0005737: UvrABC system protein C
GO:0006281: UvrABC system protein C
GO:0006289: UvrABC system protein C
GO:0006974: UvrABC system protein C
GO:0009380: UvrABC system protein C
GO:0009381: UvrABC system protein C
GO:0009432: UvrABC system protein C

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 UVR domain

Homologues:

Organism=Escherichia coli, GI87081999, Length=629, Percent_Identity=35.1351351351351, Blast_Score=353, Evalue=3e-98,
Organism=Escherichia coli, GI1788037, Length=181, Percent_Identity=30.3867403314917, Blast_Score=69, Evalue=8e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): UVRC_ACAM1 (B0C2T9)

Other databases:

- EMBL:   CP000828
- RefSeq:   YP_001515469.1
- ProteinModelPortal:   B0C2T9
- GeneID:   5679941
- GenomeReviews:   CP000828_GR
- KEGG:   amr:AM1_1116
- HOGENOM:   HBG566029
- OMA:   DVLYVGK
- ProtClustDB:   PRK00558
- BioCyc:   AMAR329726:AM1_1116-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00203
- InterPro:   IPR003583
- InterPro:   IPR010994
- InterPro:   IPR001943
- InterPro:   IPR009055
- InterPro:   IPR004791
- InterPro:   IPR001162
- InterPro:   IPR000305
- SMART:   SM00465
- SMART:   SM00278
- TIGRFAMs:   TIGR00194

Pfam domain/function: PF01541 GIY-YIG; PF02151 UVR; PF08459 UvrC_HhH_N; SSF47781 RuvA_2_like; SSF46600 UvrB_C; SSF82771 UvrC_N

EC number: NA

Molecular weight: Translated: 72082; Mature: 71951

Theoretical pI: Translated: 8.86; Mature: 8.86

Prosite motif: PS50151 UVR; PS50164 UVRC_1; PS50165 UVRC_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDAVSTTTLLKDRDRLEARLKEIPPEPGVYFMRDANDDILYIGKSKKLRNRVRSYFRQI
CCCCHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCEEEECCCHHHHHHHHHHHHHH
QDHPPRIELMVHQVADIEFIVTDTEAEALALEANLIKQHQPHFNVLLKDDKKYPYLCVTW
HCCCCHHHHHHHHHCCEEEEEECCCHHHHHHHHHHHHHCCCCCEEEEECCCCCCEEEEEE
SQTYPRIFITRKRRLGKAQDKYYGPYVDVWQLRQTLRLVKRLFPLRQRRKPLFKDRPCLN
CCCCCEEEEEEHHHCCCHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCC
YEIGRCPGVCQALITPEAYRQILQKVVMIFQGRTSELINTLSLQMEQAAEDLNFEQAARL
CCCCCCCHHHHHHCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCHHHHHHH
RDQIKGLQGLGVDQKVALPDDTVSRDAIALAADDQIACVQLFQIRSGRLVGRLGFMADAQ
HHHHCCHHCCCCCCEECCCCCCCCCCEEEEECCCCHHHHHHHHHHCCCCEEHHHHHCCCC
SGSLGMILQHVLEAHYGSAEPVELPLEILVQTELPETELLASYLSQRKERKVSITCPQRQ
CCCHHHHHHHHHHHHCCCCCCCCCCHHHEEECCCCHHHHHHHHHHHHHHCCEEEECCHHH
IKAELIEMVERNAQYELARTQKSRDRTLNALQDLAELLDLPELPHRIECYDISHIQGSDA
HHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEECCCCCCHH
VASQVVFIDGLPAKQHYRRYKIRNPNVKAGHSDDFASLAEVLHRRFRQYHLSPEQPRQGT
HHHEEEEEECCCHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCC
SDWPDLVVIDGGKGQLSAVLESLTKIEVVEDLQIISLAKQREEIFQPGESQPLPTDPEQP
CCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCH
GVQLIRRLRDEAHRFAISFHRKKRLERMRRSRLDDIPGLGHHRQKELLAAFRSIDYIREA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHC
SPEQLKAVPTIGPQLAQKIYDYFHPA
CHHHHHCCCCCCHHHHHHHHHHHCCC
>Mature Secondary Structure 
TDAVSTTTLLKDRDRLEARLKEIPPEPGVYFMRDANDDILYIGKSKKLRNRVRSYFRQI
CCCHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCEEEECCCHHHHHHHHHHHHHH
QDHPPRIELMVHQVADIEFIVTDTEAEALALEANLIKQHQPHFNVLLKDDKKYPYLCVTW
HCCCCHHHHHHHHHCCEEEEEECCCHHHHHHHHHHHHHCCCCCEEEEECCCCCCEEEEEE
SQTYPRIFITRKRRLGKAQDKYYGPYVDVWQLRQTLRLVKRLFPLRQRRKPLFKDRPCLN
CCCCCEEEEEEHHHCCCHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCC
YEIGRCPGVCQALITPEAYRQILQKVVMIFQGRTSELINTLSLQMEQAAEDLNFEQAARL
CCCCCCCHHHHHHCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCHHHHHHH
RDQIKGLQGLGVDQKVALPDDTVSRDAIALAADDQIACVQLFQIRSGRLVGRLGFMADAQ
HHHHCCHHCCCCCCEECCCCCCCCCCEEEEECCCCHHHHHHHHHHCCCCEEHHHHHCCCC
SGSLGMILQHVLEAHYGSAEPVELPLEILVQTELPETELLASYLSQRKERKVSITCPQRQ
CCCHHHHHHHHHHHHCCCCCCCCCCHHHEEECCCCHHHHHHHHHHHHHHCCEEEECCHHH
IKAELIEMVERNAQYELARTQKSRDRTLNALQDLAELLDLPELPHRIECYDISHIQGSDA
HHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEECCCCCCHH
VASQVVFIDGLPAKQHYRRYKIRNPNVKAGHSDDFASLAEVLHRRFRQYHLSPEQPRQGT
HHHEEEEEECCCHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCC
SDWPDLVVIDGGKGQLSAVLESLTKIEVVEDLQIISLAKQREEIFQPGESQPLPTDPEQP
CCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCH
GVQLIRRLRDEAHRFAISFHRKKRLERMRRSRLDDIPGLGHHRQKELLAAFRSIDYIREA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHC
SPEQLKAVPTIGPQLAQKIYDYFHPA
CHHHHHCCCCCCHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA