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The map label for this gene is alsR [H]

Identifier: 158334234

GI number: 158334234

Start: 1017860

End: 1018756

Strand: Reverse

Name: alsR [H]

Synonym: AM1_1052

Alternate gene names: 158334234

Gene position: 1018756-1017860 (Counterclockwise)

Preceding gene: 158334237

Following gene: 158334219

Centisome position: 15.66

GC content: 49.28

Gene sequence:

>897_bases
ATGGTATGTTCTATAGAGTTTCGGCAACTCCAATCTTTCGTCGTCCTTGCCGAAGAGCTGCATTTTGGACGAGCGGCAGA
TCGCCTAGACATTACTCAGCCAGCTCTGAGTAAACAGATTTTGGTCTTGGAAAAAGCCGTGGGCGTGCAGCTCTTCTTTC
GCACCAAGCGGACGGTAACTCTGACCCATGCAGGGCAAACCTTTTTGCACCAAGCCCGACAACTGCTTCTGCAAAGGGAC
CAGGCAATTCTACTGACCAGACGCACAGGGGATGGTGAAATTGGCCAATTATCGATTGGGTTTACTAAAACCGCAACCCA
AACAGTCCTGCCGCAACTGCTACGGCAATTTGTCCAGCGTTATCCAGAGGTCGATCTAGACCTGCGAGAACTGGCAACGG
AAGCACAAGTAACAGCCCTCAATCAGGACAATATTGATGTTGCTTTTTTGCATCCCCCCATCGATCAACGGGGATTGCAG
TTGCAGATCATTTTGGCAGAAAGTTTTGTCGCAGTACTGCCGCCTCAGCATCCCTTCGTTCACTTAGACGCCATCCCTCT
AGAGGCGTTTGCCAATGAACCCCTTATCGTTCACCCTCGCAGGGAAGGGCCTATTCTTTACGACGGGTTTCAACAAGTCT
GCCAGAGAGCGGGATTTCAACCCAACATCATCAAAGAATCCATTACGTTGCAAACACGCCTATGTCTGGTGGCTGCAGGT
TTAGGAATTACCTTTGTATCGGATCGTTTGCAAGCTTTGGTGGGGACGAATGTCGTTTGTAGACCCATACAAGATTGTCC
GATTCAGCTTGAATTTGGTGCCGCTTGGCGGCAGAATGCGGCAAATCCAGTGCTCCAAAATTTCTTAGAGCTATTGGTTG
GAAAAAACGACGTTTGA

Upstream 100 bases:

>100_bases
CGTTTCACCGCAACTTAGGGTTCTCACTTGACAGCCTATCGAGAAGAAAAAAGATTGTCCAATTCATTTTTGGCATTAAA
CTAATAGCTTGAAGTTATTA

Downstream 100 bases:

>100_bases
ACAGTGAGGCATAACCTATAGATACTCTAGGCGGCTAAGATATTAACTTTCTTAAAAGACTGAAACTTGAGTGATAGTAA
GGTGGTGAGTTTCGCCTTAT

Product: LysR family transcriptional regulator

Products: NA

Alternate protein names: Als operon regulatory protein [H]

Number of amino acids: Translated: 298; Mature: 298

Protein sequence:

>298_residues
MVCSIEFRQLQSFVVLAEELHFGRAADRLDITQPALSKQILVLEKAVGVQLFFRTKRTVTLTHAGQTFLHQARQLLLQRD
QAILLTRRTGDGEIGQLSIGFTKTATQTVLPQLLRQFVQRYPEVDLDLRELATEAQVTALNQDNIDVAFLHPPIDQRGLQ
LQIILAESFVAVLPPQHPFVHLDAIPLEAFANEPLIVHPRREGPILYDGFQQVCQRAGFQPNIIKESITLQTRLCLVAAG
LGITFVSDRLQALVGTNVVCRPIQDCPIQLEFGAAWRQNAANPVLQNFLELLVGKNDV

Sequences:

>Translated_298_residues
MVCSIEFRQLQSFVVLAEELHFGRAADRLDITQPALSKQILVLEKAVGVQLFFRTKRTVTLTHAGQTFLHQARQLLLQRD
QAILLTRRTGDGEIGQLSIGFTKTATQTVLPQLLRQFVQRYPEVDLDLRELATEAQVTALNQDNIDVAFLHPPIDQRGLQ
LQIILAESFVAVLPPQHPFVHLDAIPLEAFANEPLIVHPRREGPILYDGFQQVCQRAGFQPNIIKESITLQTRLCLVAAG
LGITFVSDRLQALVGTNVVCRPIQDCPIQLEFGAAWRQNAANPVLQNFLELLVGKNDV
>Mature_298_residues
MVCSIEFRQLQSFVVLAEELHFGRAADRLDITQPALSKQILVLEKAVGVQLFFRTKRTVTLTHAGQTFLHQARQLLLQRD
QAILLTRRTGDGEIGQLSIGFTKTATQTVLPQLLRQFVQRYPEVDLDLRELATEAQVTALNQDNIDVAFLHPPIDQRGLQ
LQIILAESFVAVLPPQHPFVHLDAIPLEAFANEPLIVHPRREGPILYDGFQQVCQRAGFQPNIIKESITLQTRLCLVAAG
LGITFVSDRLQALVGTNVVCRPIQDCPIQLEFGAAWRQNAANPVLQNFLELLVGKNDV

Specific function: Regulates the expression of the alsSD operon for acetoin biosynthesis [H]

COG id: COG0583

COG function: function code K; Transcriptional regulator

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI2367136, Length=269, Percent_Identity=33.457249070632, Blast_Score=162, Evalue=3e-41,
Organism=Escherichia coli, GI1787879, Length=288, Percent_Identity=34.7222222222222, Blast_Score=160, Evalue=1e-40,
Organism=Escherichia coli, GI1788887, Length=296, Percent_Identity=32.4324324324324, Blast_Score=140, Evalue=1e-34,
Organism=Escherichia coli, GI157672245, Length=300, Percent_Identity=29, Blast_Score=107, Evalue=1e-24,
Organism=Escherichia coli, GI1790399, Length=242, Percent_Identity=29.7520661157025, Blast_Score=105, Evalue=4e-24,
Organism=Escherichia coli, GI1788748, Length=245, Percent_Identity=27.7551020408163, Blast_Score=97, Evalue=1e-21,
Organism=Escherichia coli, GI145693105, Length=298, Percent_Identity=26.8456375838926, Blast_Score=97, Evalue=2e-21,
Organism=Escherichia coli, GI1787601, Length=189, Percent_Identity=29.1005291005291, Blast_Score=86, Evalue=3e-18,
Organism=Escherichia coli, GI87081904, Length=204, Percent_Identity=29.9019607843137, Blast_Score=85, Evalue=6e-18,
Organism=Escherichia coli, GI1787530, Length=251, Percent_Identity=26.6932270916335, Blast_Score=83, Evalue=2e-17,
Organism=Escherichia coli, GI1788297, Length=168, Percent_Identity=35.1190476190476, Blast_Score=83, Evalue=3e-17,
Organism=Escherichia coli, GI1787806, Length=295, Percent_Identity=24.406779661017, Blast_Score=76, Evalue=3e-15,
Organism=Escherichia coli, GI1790262, Length=239, Percent_Identity=27.6150627615063, Blast_Score=72, Evalue=5e-14,
Organism=Escherichia coli, GI1786713, Length=295, Percent_Identity=27.7966101694915, Blast_Score=71, Evalue=9e-14,
Organism=Escherichia coli, GI1790208, Length=124, Percent_Identity=38.7096774193548, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI1789204, Length=254, Percent_Identity=25.1968503937008, Blast_Score=69, Evalue=3e-13,
Organism=Escherichia coli, GI1787589, Length=123, Percent_Identity=34.9593495934959, Blast_Score=69, Evalue=4e-13,
Organism=Escherichia coli, GI1789173, Length=168, Percent_Identity=29.7619047619048, Blast_Score=66, Evalue=3e-12,
Organism=Escherichia coli, GI1789506, Length=260, Percent_Identity=22.6923076923077, Blast_Score=64, Evalue=8e-12,
Organism=Escherichia coli, GI1788296, Length=249, Percent_Identity=24.4979919678715, Blast_Score=63, Evalue=2e-11,
Organism=Escherichia coli, GI87082132, Length=172, Percent_Identity=28.4883720930233, Blast_Score=62, Evalue=6e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 33318; Mature: 33318

Theoretical pI: Translated: 6.62; Mature: 6.62

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
0.3 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
0.3 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVCSIEFRQLQSFVVLAEELHFGRAADRLDITQPALSKQILVLEKAVGVQLFFRTKRTVT
CEECHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHCEEEEEECCCEEE
LTHAGQTFLHQARQLLLQRDQAILLTRRTGDGEIGQLSIGFTKTATQTVLPQLLRQFVQR
EEECCHHHHHHHHHHHHHCCCEEEEEEECCCCCEEEEEECCCHHHHHHHHHHHHHHHHHH
YPEVDLDLRELATEAQVTALNQDNIDVAFLHPPIDQRGLQLQIILAESFVAVLPPQHPFV
CCCCCCCHHHHHHHHHEEEECCCCCEEEEECCCCCCCCCEEEEEEECCHHEECCCCCCEE
HLDAIPLEAFANEPLIVHPRREGPILYDGFQQVCQRAGFQPNIIKESITLQTRLCLVAAG
EEECEEHHHHCCCCEEEECCCCCCEEHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHC
LGITFVSDRLQALVGTNVVCRPIQDCPIQLEFGAAWRQNAANPVLQNFLELLVGKNDV
CCHHHHHHHHHHHHCCCEEEECCCCCCEEEEECCHHHCCCCCHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MVCSIEFRQLQSFVVLAEELHFGRAADRLDITQPALSKQILVLEKAVGVQLFFRTKRTVT
CEECHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHCEEEEEECCCEEE
LTHAGQTFLHQARQLLLQRDQAILLTRRTGDGEIGQLSIGFTKTATQTVLPQLLRQFVQR
EEECCHHHHHHHHHHHHHCCCEEEEEEECCCCCEEEEEECCCHHHHHHHHHHHHHHHHHH
YPEVDLDLRELATEAQVTALNQDNIDVAFLHPPIDQRGLQLQIILAESFVAVLPPQHPFV
CCCCCCCHHHHHHHHHEEEECCCCCEEEEECCCCCCCCCEEEEEEECCHHEECCCCCCEE
HLDAIPLEAFANEPLIVHPRREGPILYDGFQQVCQRAGFQPNIIKESITLQTRLCLVAAG
EEECEEHHHHCCCCEEEECCCCCCEEHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHC
LGITFVSDRLQALVGTNVVCRPIQDCPIQLEFGAAWRQNAANPVLQNFLELLVGKNDV
CCHHHHHHHHHHHHCCCEEEECCCCCCEEEEECCHHHCCCCCHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7685336; 9353933; 9384377 [H]