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The map label for this gene is kmo [H]

Identifier: 158334158

GI number: 158334158

Start: 948660

End: 950063

Strand: Direct

Name: kmo [H]

Synonym: AM1_0975

Alternate gene names: 158334158

Gene position: 948660-950063 (Clockwise)

Preceding gene: 158334157

Following gene: 158334165

Centisome position: 14.59

GC content: 47.51

Gene sequence:

>1404_bases
GTGGATCAGCGCTGGAACTCAAGCATGGTAGAGACTCAGTCCGCGAACGCTTCACCATCTCCTGAAGGCAGAAAAGTTGT
GATTGTGGGGGGTGGGCCAACCGGCACACTGGCTGCTTTGTATTTAGCCCAGATGGGTTGGCAAGTTTTTGTTTACGAGC
GGCGCAGTGCTGATTTTAGAGTATCTAGCAATCGACGGTCCTTTAATATTATTCTGAGCCGTCGGGGACAAAAAGCTCTG
AAGGACATTGGCGTAGAGCTACCGCCGGAAAAACAGGTCTTTCTCCAAGGAAATGTTCGACATACTGCCAAAGGGGCAAA
TCTCGGTAAAGGGTTTCAGGATGCCGTGTCAGTCGATCGCACTACCCTGGCTCAGTGTCTTATTGAGGAGGGGCAGCATC
GTTTTCCAGAAAACATTCAATACCACTTTGAGCAAACCTTGCTGCAGGTCAATTTTCAGGATAAGACAGCGTTGTTTCAA
GGCAAACAAGATCAAAATCAGCAAACCTTTGACTTATTAATTGGTGCAGATGGTGTCTACAGTACCGTCAGGACTTCAAT
GGAATCGCAGATTCAGGGATTCGAAGTCCAGCAAAACCAAGACAATATGATGTACAAAATCTGTGATTTAGGGTTTGCGA
AAAATCTACCCGGCGCAGAGGAAAAGTGGGCAGAGAGTTTTCATACCTGGCCGAATGCCCAACCCCTGACGTTACTCGCT
CCCCCTAGTACCGATGGCTCTCTCAAAGGGGTATTGATCTTGCCTCAAGTGGGAGACATCACTTATGAGACCCTGCAATC
AGAAGCAGATATATTGGCCTTATTTCAAGAGAAGTTTCCTGATGTTTTCCCAAATCTAGAGCAAACGGGTTTACCGTCAC
AGTTTGCCCAAGATTTATTGTCACAAAAGGCGGCCCACGGAGGAATCACCACCCAGTGCAATCAATTTGAAGGTGGTGAC
TGCGTGGTTCTGTTAGGAGATGCGGCCCACTCGGTGTGGCCCTCCTTGGGGCAAGGGTGTAATGTCGCCCTGGAAAGCTG
CCGCATTTTTGCCGAGATTCTGGCCCAAACCAAAGGAGATTTATCCCTCGCGTTACCCGCCTATACCGAAGCCCGAAAGC
CTGATACGGATGCAGTGGCTCAGCTATCAGAAATTGGCTTTGGAGGGAATAAACGAGCAAGTAGTCTCCTGTTTATCAGC
AAAGTAGTGATCCTGATGTTTCTGCATAAATTACTCCCCAGATGGTTTCAAAAATATGCTCTCTTCCAACTTGGAGATGC
TGACGTTCCTTATTCCAACATATGGCAGCAAGTTCAGCGTCAAAATAACCAATTGCGCCTTGTATTAACGACACTAATCG
GTAGTATTCCTGTGATCTGGTTAGTGCTTTTGAGAATCGCCTAA

Upstream 100 bases:

>100_bases
CAAAGGATAGCCTGTTAGCAGCACCTGAAGGTCAAATCTCGCCTCGTTTTAATCACACGAATCAAGCACGGGAGTGCCAC
CGATGGCGCTGTAAGATGAA

Downstream 100 bases:

>100_bases
GCTGCAATGCTAGGAGATGGGTTAGAGATGCCCTCTTCTGTCTGTGGTAGGGGCGCTAAACGTCCATCTTCCATGTAGAT
AATCCGATCGGCAATGTCCA

Product: kynurenine 3-monooxygenase

Products: NA

Alternate protein names: Kynurenine 3-hydroxylase [H]

Number of amino acids: Translated: 467; Mature: 467

Protein sequence:

>467_residues
MDQRWNSSMVETQSANASPSPEGRKVVIVGGGPTGTLAALYLAQMGWQVFVYERRSADFRVSSNRRSFNIILSRRGQKAL
KDIGVELPPEKQVFLQGNVRHTAKGANLGKGFQDAVSVDRTTLAQCLIEEGQHRFPENIQYHFEQTLLQVNFQDKTALFQ
GKQDQNQQTFDLLIGADGVYSTVRTSMESQIQGFEVQQNQDNMMYKICDLGFAKNLPGAEEKWAESFHTWPNAQPLTLLA
PPSTDGSLKGVLILPQVGDITYETLQSEADILALFQEKFPDVFPNLEQTGLPSQFAQDLLSQKAAHGGITTQCNQFEGGD
CVVLLGDAAHSVWPSLGQGCNVALESCRIFAEILAQTKGDLSLALPAYTEARKPDTDAVAQLSEIGFGGNKRASSLLFIS
KVVILMFLHKLLPRWFQKYALFQLGDADVPYSNIWQQVQRQNNQLRLVLTTLIGSIPVIWLVLLRIA

Sequences:

>Translated_467_residues
MDQRWNSSMVETQSANASPSPEGRKVVIVGGGPTGTLAALYLAQMGWQVFVYERRSADFRVSSNRRSFNIILSRRGQKAL
KDIGVELPPEKQVFLQGNVRHTAKGANLGKGFQDAVSVDRTTLAQCLIEEGQHRFPENIQYHFEQTLLQVNFQDKTALFQ
GKQDQNQQTFDLLIGADGVYSTVRTSMESQIQGFEVQQNQDNMMYKICDLGFAKNLPGAEEKWAESFHTWPNAQPLTLLA
PPSTDGSLKGVLILPQVGDITYETLQSEADILALFQEKFPDVFPNLEQTGLPSQFAQDLLSQKAAHGGITTQCNQFEGGD
CVVLLGDAAHSVWPSLGQGCNVALESCRIFAEILAQTKGDLSLALPAYTEARKPDTDAVAQLSEIGFGGNKRASSLLFIS
KVVILMFLHKLLPRWFQKYALFQLGDADVPYSNIWQQVQRQNNQLRLVLTTLIGSIPVIWLVLLRIA
>Mature_467_residues
MDQRWNSSMVETQSANASPSPEGRKVVIVGGGPTGTLAALYLAQMGWQVFVYERRSADFRVSSNRRSFNIILSRRGQKAL
KDIGVELPPEKQVFLQGNVRHTAKGANLGKGFQDAVSVDRTTLAQCLIEEGQHRFPENIQYHFEQTLLQVNFQDKTALFQ
GKQDQNQQTFDLLIGADGVYSTVRTSMESQIQGFEVQQNQDNMMYKICDLGFAKNLPGAEEKWAESFHTWPNAQPLTLLA
PPSTDGSLKGVLILPQVGDITYETLQSEADILALFQEKFPDVFPNLEQTGLPSQFAQDLLSQKAAHGGITTQCNQFEGGD
CVVLLGDAAHSVWPSLGQGCNVALESCRIFAEILAQTKGDLSLALPAYTEARKPDTDAVAQLSEIGFGGNKRASSLLFIS
KVVILMFLHKLLPRWFQKYALFQLGDADVPYSNIWQQVQRQNNQLRLVLTTLIGSIPVIWLVLLRIA

Specific function: Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid [H]

COG id: COG0654

COG function: function code HC; 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases

Gene ontology:
GO:0004497: Kynurenine 3-monooxygenase, putative
GO:0008152: Kynurenine 3-monooxygenase, putative
GO:0016491: Kynurenine 3-monooxygenase, putative
GO:0055114: Kynurenine 3-monooxygenase, putative

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the aromatic-ring hydroxylase family. KMO subfamily [H]

Homologues:

Organism=Homo sapiens, GI187960045, Length=402, Percent_Identity=31.8407960199005, Blast_Score=171, Evalue=2e-42,
Organism=Caenorhabditis elegans, GI17562934, Length=477, Percent_Identity=27.6729559748428, Blast_Score=154, Evalue=7e-38,
Organism=Caenorhabditis elegans, GI212646493, Length=375, Percent_Identity=25.6, Blast_Score=110, Evalue=2e-24,
Organism=Caenorhabditis elegans, GI193208447, Length=339, Percent_Identity=23.0088495575221, Blast_Score=88, Evalue=1e-17,
Organism=Saccharomyces cerevisiae, GI6319372, Length=459, Percent_Identity=23.7472766884532, Blast_Score=131, Evalue=3e-31,
Organism=Drosophila melanogaster, GI28573964, Length=474, Percent_Identity=26.3713080168776, Blast_Score=130, Evalue=2e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002938
- InterPro:   IPR003042 [H]

Pfam domain/function: PF01494 FAD_binding_3 [H]

EC number: =1.14.13.9 [H]

Molecular weight: Translated: 51779; Mature: 51779

Theoretical pI: Translated: 5.94; Mature: 5.94

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDQRWNSSMVETQSANASPSPEGRKVVIVGGGPTGTLAALYLAQMGWQVFVYERRSADFR
CCCCCCCCHHHCCCCCCCCCCCCCEEEEECCCCCHHHHHHHHHHCCCEEEEEECCCCCEE
VSSNRRSFNIILSRRGQKALKDIGVELPPEKQVFLQGNVRHTAKGANLGKGFQDAVSVDR
EECCCCEEEEEEECCCHHHHHHCCCCCCCCCEEEEECCCEECCCCCCCCCCHHHHHHHHH
TTLAQCLIEEGQHRFPENIQYHFEQTLLQVNFQDKTALFQGKQDQNQQTFDLLIGADGVY
HHHHHHHHHHHHHCCCHHHHHHHHHHHHEECCCCHHHHHCCCCCCCCCEEEEEEECCHHH
STVRTSMESQIQGFEVQQNQDNMMYKICDLGFAKNLPGAEEKWAESFHTWPNAQPLTLLA
HHHHHHHHHHHCCCEEECCCCCCEEHHHHCCHHCCCCCCHHHHHHHHCCCCCCCCEEEEE
PPSTDGSLKGVLILPQVGDITYETLQSEADILALFQEKFPDVFPNLEQTGLPSQFAQDLL
CCCCCCCCCEEEEECCCCCCHHHHHHCCHHHHHHHHHHCHHHCCCCHHCCCCHHHHHHHH
SQKAAHGGITTQCNQFEGGDCVVLLGDAAHSVWPSLGQGCNVALESCRIFAEILAQTKGD
HHHHHCCCCCCCCCCCCCCCEEEEECCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCC
LSLALPAYTEARKPDTDAVAQLSEIGFGGNKRASSLLFISKVVILMFLHKLLPRWFQKYA
EEEECCCHHCCCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LFQLGDADVPYSNIWQQVQRQNNQLRLVLTTLIGSIPVIWLVLLRIA
HHHCCCCCCCHHHHHHHHHHCCCCEEEHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MDQRWNSSMVETQSANASPSPEGRKVVIVGGGPTGTLAALYLAQMGWQVFVYERRSADFR
CCCCCCCCHHHCCCCCCCCCCCCCEEEEECCCCCHHHHHHHHHHCCCEEEEEECCCCCEE
VSSNRRSFNIILSRRGQKALKDIGVELPPEKQVFLQGNVRHTAKGANLGKGFQDAVSVDR
EECCCCEEEEEEECCCHHHHHHCCCCCCCCCEEEEECCCEECCCCCCCCCCHHHHHHHHH
TTLAQCLIEEGQHRFPENIQYHFEQTLLQVNFQDKTALFQGKQDQNQQTFDLLIGADGVY
HHHHHHHHHHHHHCCCHHHHHHHHHHHHEECCCCHHHHHCCCCCCCCCEEEEEEECCHHH
STVRTSMESQIQGFEVQQNQDNMMYKICDLGFAKNLPGAEEKWAESFHTWPNAQPLTLLA
HHHHHHHHHHHCCCEEECCCCCCEEHHHHCCHHCCCCCCHHHHHHHHCCCCCCCCEEEEE
PPSTDGSLKGVLILPQVGDITYETLQSEADILALFQEKFPDVFPNLEQTGLPSQFAQDLL
CCCCCCCCCEEEEECCCCCCHHHHHHCCHHHHHHHHHHCHHHCCCCHHCCCCHHHHHHHH
SQKAAHGGITTQCNQFEGGDCVVLLGDAAHSVWPSLGQGCNVALESCRIFAEILAQTKGD
HHHHHCCCCCCCCCCCCCCCEEEEECCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCC
LSLALPAYTEARKPDTDAVAQLSEIGFGGNKRASSLLFISKVVILMFLHKLLPRWFQKYA
EEEECCCHHCCCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LFQLGDADVPYSNIWQQVQRQNNQLRLVLTTLIGSIPVIWLVLLRIA
HHHCCCCCCCHHHHHHHHHHCCCCEEEHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA