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The map label for this gene is uppS [H]

Identifier: 158334147

GI number: 158334147

Start: 938051

End: 938818

Strand: Reverse

Name: uppS [H]

Synonym: AM1_0963

Alternate gene names: 158334147

Gene position: 938818-938051 (Counterclockwise)

Preceding gene: 158334148

Following gene: 158334142

Centisome position: 14.44

GC content: 51.04

Gene sequence:

>768_bases
ATGAACAACTTCGATTACGTTACTCGCCCTACAGATTTAGATCCTGATTGTTTACCCCAACATGTTGCCGTCATTATGGA
TGGCAACGGTCGCTGGGCCAAACGCCAAGGGTTTCCCCGGATTGCGGGTCATCGCCAAGGGGCACGGACTCTCAAAGATT
TAGTGCGCTGCTGCAAAGACTGGGGCATTCCCACCCTGACAGCCTATGCCTTTTCGACGGAAAATTGGCGTCGCCCCTTA
GAAGAAGTTGACTTTCTTTTAGTCTTATTTGAGCGTCTTCTTCGCCAGGAACTGGCCGAAATGGATCGCGAAGGGGTACG
GATTTCCTTTATCGGTGATTTGTCTCCCTTGCCCTCTTCGCTGCGGAAGGAAATCGATCGAGCGGTTTTAGCAACGGCCA
ATAACCGAGCCGTTCATTTCAATGTGGCGGTGAATTATGGCAGCCGAGCCGAACTGACCCAGGCATGTCGTCAAATTGCA
GAGCAGGTTCAGCTGGGTAATATTGAGCCGGGGGCAGTGGATGAGCAACTGATTGAGCAATATCTCTATACCGCTGGTAC
CCCTGACCCTGACTTATTGATTCGCAGCAGTGGCGAACTCCGCTTAAGTAATTACCTACTGTGGCAGTTGGCCTACACGG
AGTTTTACTTTACGGATGTGTTCTGGCCTGATTTTGACCGGGCGGTTTTTCATGAGGCGTTGCAGCACTACCAGATGCGC
GATCGCAGATTTGGAACGGTTAAACTCAAACAGCCCTGTGCAGGTTAA

Upstream 100 bases:

>100_bases
ACCAAACTACTGACCGGGGAATTATTACGAACAGAGAATAACTTCCTCTGACTTGTATGGGCTCCTGATTTAACCAATTG
ATGTCACTGACGCCGTATTA

Downstream 100 bases:

>100_bases
TTCTTTCCATAAACATCTGAAATGGGAGGTGGCCACTGCTCAAAGGGCTTGAGCCTAGAGTCGCCCCTTCCGACGCCTTA
AGGTATTGAACTCATCATCG

Product: undecaprenyl pyrophosphate synthase

Products: NA

Alternate protein names: UPP synthase 2; Di-trans,poly-cis-decaprenylcistransferase 2; Undecaprenyl diphosphate synthase 2; UDS 2 [H]

Number of amino acids: Translated: 255; Mature: 255

Protein sequence:

>255_residues
MNNFDYVTRPTDLDPDCLPQHVAVIMDGNGRWAKRQGFPRIAGHRQGARTLKDLVRCCKDWGIPTLTAYAFSTENWRRPL
EEVDFLLVLFERLLRQELAEMDREGVRISFIGDLSPLPSSLRKEIDRAVLATANNRAVHFNVAVNYGSRAELTQACRQIA
EQVQLGNIEPGAVDEQLIEQYLYTAGTPDPDLLIRSSGELRLSNYLLWQLAYTEFYFTDVFWPDFDRAVFHEALQHYQMR
DRRFGTVKLKQPCAG

Sequences:

>Translated_255_residues
MNNFDYVTRPTDLDPDCLPQHVAVIMDGNGRWAKRQGFPRIAGHRQGARTLKDLVRCCKDWGIPTLTAYAFSTENWRRPL
EEVDFLLVLFERLLRQELAEMDREGVRISFIGDLSPLPSSLRKEIDRAVLATANNRAVHFNVAVNYGSRAELTQACRQIA
EQVQLGNIEPGAVDEQLIEQYLYTAGTPDPDLLIRSSGELRLSNYLLWQLAYTEFYFTDVFWPDFDRAVFHEALQHYQMR
DRRFGTVKLKQPCAG
>Mature_255_residues
MNNFDYVTRPTDLDPDCLPQHVAVIMDGNGRWAKRQGFPRIAGHRQGARTLKDLVRCCKDWGIPTLTAYAFSTENWRRPL
EEVDFLLVLFERLLRQELAEMDREGVRISFIGDLSPLPSSLRKEIDRAVLATANNRAVHFNVAVNYGSRAELTQACRQIA
EQVQLGNIEPGAVDEQLIEQYLYTAGTPDPDLLIRSSGELRLSNYLLWQLAYTEFYFTDVFWPDFDRAVFHEALQHYQMR
DRRFGTVKLKQPCAG

Specific function: Generates undecaprenyl pyrophosphate (UPP) from isopentenyl pyrophosphate (IPP). UPP is the precursor of glycosyl carrier lipid in the biosynthesis of bacterial cell wall polysaccharide components such as peptidoglycan and lipopolysaccharide [H]

COG id: COG0020

COG function: function code I; Undecaprenyl pyrophosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UPP synthase family [H]

Homologues:

Organism=Homo sapiens, GI45580738, Length=226, Percent_Identity=41.5929203539823, Blast_Score=176, Evalue=2e-44,
Organism=Homo sapiens, GI45580742, Length=226, Percent_Identity=41.5929203539823, Blast_Score=176, Evalue=2e-44,
Organism=Escherichia coli, GI1786371, Length=229, Percent_Identity=46.7248908296943, Blast_Score=224, Evalue=3e-60,
Organism=Caenorhabditis elegans, GI71993029, Length=227, Percent_Identity=36.5638766519824, Blast_Score=140, Evalue=8e-34,
Organism=Saccharomyces cerevisiae, GI6319474, Length=215, Percent_Identity=38.6046511627907, Blast_Score=139, Evalue=6e-34,
Organism=Saccharomyces cerevisiae, GI6323748, Length=216, Percent_Identity=35.1851851851852, Blast_Score=114, Evalue=1e-26,
Organism=Drosophila melanogaster, GI18857969, Length=229, Percent_Identity=41.4847161572052, Blast_Score=172, Evalue=2e-43,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001441
- InterPro:   IPR018520 [H]

Pfam domain/function: PF01255 Prenyltransf [H]

EC number: =2.5.1.31 [H]

Molecular weight: Translated: 29356; Mature: 29356

Theoretical pI: Translated: 6.04; Mature: 6.04

Prosite motif: PS01066 UPP_SYNTHETASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNNFDYVTRPTDLDPDCLPQHVAVIMDGNGRWAKRQGFPRIAGHRQGARTLKDLVRCCKD
CCCCCCCCCCCCCCHHHCCCEEEEEECCCCCCHHHCCCCHHHCCCCHHHHHHHHHHHHHH
WGIPTLTAYAFSTENWRRPLEEVDFLLVLFERLLRQELAEMDREGVRISFIGDLSPLPSS
CCCCEEEEEEECCHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEECCCCCCCHH
LRKEIDRAVLATANNRAVHFNVAVNYGSRAELTQACRQIAEQVQLGNIEPGAVDEQLIEQ
HHHHHHHHHHHCCCCCEEEEEEEECCCCHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHH
YLYTAGTPDPDLLIRSSGELRLSNYLLWQLAYTEFYFTDVFWPDFDRAVFHEALQHYQMR
HHHHCCCCCCCEEEECCCCEEHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHH
DRRFGTVKLKQPCAG
HCCCCEEEECCCCCC
>Mature Secondary Structure
MNNFDYVTRPTDLDPDCLPQHVAVIMDGNGRWAKRQGFPRIAGHRQGARTLKDLVRCCKD
CCCCCCCCCCCCCCHHHCCCEEEEEECCCCCCHHHCCCCHHHCCCCHHHHHHHHHHHHHH
WGIPTLTAYAFSTENWRRPLEEVDFLLVLFERLLRQELAEMDREGVRISFIGDLSPLPSS
CCCCEEEEEEECCHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEECCCCCCCHH
LRKEIDRAVLATANNRAVHFNVAVNYGSRAELTQACRQIAEQVQLGNIEPGAVDEQLIEQ
HHHHHHHHHHHCCCCCEEEEEEEECCCCHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHH
YLYTAGTPDPDLLIRSSGELRLSNYLLWQLAYTEFYFTDVFWPDFDRAVFHEALQHYQMR
HHHHCCCCCCCEEEECCCCEEHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHH
DRRFGTVKLKQPCAG
HCCCCEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11759840 [H]