Click here to switch to the map view.

The map label for this gene is yjcE [H]

Identifier: 158334144

GI number: 158334144

Start: 935065

End: 936645

Strand: Direct

Name: yjcE [H]

Synonym: AM1_0960

Alternate gene names: 158334144

Gene position: 935065-936645 (Clockwise)

Preceding gene: 158334143

Following gene: 158334145

Centisome position: 14.38

GC content: 48.07

Gene sequence:

>1581_bases
ATGCTGTTGAGCAATCCGATTGTGGCTGAGATGGCGATGGAAGCAGAAGATGCGATCGCAAATAATCTCAAACAATTTTT
GCTGGTATTATCCGTCTCGTTGAGTGTTGCCACGCTTCCCCAGGTATTTAGCTGGTTTCGGCAAATTCCCTATACCCTTT
TGCTGGTAATCGTGGGCTTGTGCTTAGCCTTTGTAGATGTCCGCTTAGTGGATTTATCCCCAGAGCTGATTCTAGCCATC
TTTTTGCCACCGCTGCTGTTTGAAGCTGCCTGGAATCTGAAATGGTCCGACCTTAAAAAAGATCTATTTCCCATCTGTCT
CTATGCCGTTTTTGGCGTGGTGATCACGATTGGTGGTGTTGCATTCGGCTTAAATAAATTTGCCGGGATTTCCCTTACCA
CCGCATTGTTAATTGGAGCTAGCTTATCAGCCACTGATCCCGTTTCTGTTATTGCCTTATTCCGGGAACTTGGAGCAGGC
AAACGCCTTAAAACCCTGATGGAAGGGGAAAGCCTTTTTAACGATGGTATGGCGGTTGTAGCCTTTAGTTTTCTGGTGGG
TTTACCCTTGGGGGTCAGTACCTTTGAGCCGTCTCAGGTTTTAGGACAACTGCTGGCGGTCATTGGTATTGGTATTGGTG
TTGGCTCTCTGATTGGGTTTGGCATTTCCTACCTTACCCAACGGTTTGATCTCCCTCTCGTGGAGCAGTCCCTAACCCTC
GTATCAGCCTATGGCACCTATCTGCTAACGGAAGACTTGGGCGGTTCTGGCGTCATCGGTGTAGTCACAACAGGCTTGGT
GCTAGGAAACTTCGGTTCCCGGATTGGCATGAACCCCAGGACTCGATTGATTGTCACAGAGTTTTGGGATTTTCTCGCTT
TCTTCGTCAACTCCATCGTCTTTTTACTGATTGGGGATCAGATTCGGTTTGCCATCTTAGGGAATAACTTAAGAACCATC
GTCGTCACCATTTTGGGAATGCTGGTGACTCGGGCCATCTCCATTTATGTTCTGGGCCTATTTAGTAATGTCACTGCGAA
GTCCGAGATTCCCATTAAAGATCAGACGGTTCTCTGGTGGGGGGGCTTACGGGGTTCCGTCTCCATTGCCCTGGCTTTGA
GTGTGCCTGCAGTGTTGGGAGAACGAGAAGAGATTATAGCTACGGTATTTGGAGTCGTGTTATTCACCTTGTTGGTGCAA
GGACTCACAACGAAGTTCCTCCTCCAAGGGCTGGGATTAATTAGCGATCAGACCCAACAACAGGATTATTTAGCTGCGAC
TGCTCGGCGAGCAGCCCTCTCCCGCGTTTTAGATTATCTAGAGAAAGGGGACGCTAGACCGGGGATTGAACCTGAGTTCT
ATCGGTATCAGACAGCCTTAGTCGAGGGACAGTTGGCCAAACTGGAGTCTGAATTGGACGACATGCAAAAAAAATATCCT
GAACTAAAGGAATTTACGGCAGAACAACTGAAAGAAGAATTACTGGCCATTGAGGCAGATACCTATGCTGAGTTTGTACG
AGCCGGTCGCCTCAATAAAGAGTTGGCTCCTTTCTTGGCAGAGGTCTTTATCCCGGAATAG

Upstream 100 bases:

>100_bases
GTCAAGATTTTGGCCTGAACAGGGTAGCCTATAAGGGGCTAATGGCTTATTTGTGCCGTTGTCCTTAGCCAAAGCAAATG
TTTGTGGGGAATAGTACTGA

Downstream 100 bases:

>100_bases
AGGGAGTTTGGATGTAACGGAAAACAACGGTCCCTTAGCATAGCCCTCAATTTTGAGTATTCTAGGCTAACAAGGTTCCT
CAATGTTTTTACTCCGATAC

Product: Na+/H+ antiporter

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 526; Mature: 526

Protein sequence:

>526_residues
MLLSNPIVAEMAMEAEDAIANNLKQFLLVLSVSLSVATLPQVFSWFRQIPYTLLLVIVGLCLAFVDVRLVDLSPELILAI
FLPPLLFEAAWNLKWSDLKKDLFPICLYAVFGVVITIGGVAFGLNKFAGISLTTALLIGASLSATDPVSVIALFRELGAG
KRLKTLMEGESLFNDGMAVVAFSFLVGLPLGVSTFEPSQVLGQLLAVIGIGIGVGSLIGFGISYLTQRFDLPLVEQSLTL
VSAYGTYLLTEDLGGSGVIGVVTTGLVLGNFGSRIGMNPRTRLIVTEFWDFLAFFVNSIVFLLIGDQIRFAILGNNLRTI
VVTILGMLVTRAISIYVLGLFSNVTAKSEIPIKDQTVLWWGGLRGSVSIALALSVPAVLGEREEIIATVFGVVLFTLLVQ
GLTTKFLLQGLGLISDQTQQQDYLAATARRAALSRVLDYLEKGDARPGIEPEFYRYQTALVEGQLAKLESELDDMQKKYP
ELKEFTAEQLKEELLAIEADTYAEFVRAGRLNKELAPFLAEVFIPE

Sequences:

>Translated_526_residues
MLLSNPIVAEMAMEAEDAIANNLKQFLLVLSVSLSVATLPQVFSWFRQIPYTLLLVIVGLCLAFVDVRLVDLSPELILAI
FLPPLLFEAAWNLKWSDLKKDLFPICLYAVFGVVITIGGVAFGLNKFAGISLTTALLIGASLSATDPVSVIALFRELGAG
KRLKTLMEGESLFNDGMAVVAFSFLVGLPLGVSTFEPSQVLGQLLAVIGIGIGVGSLIGFGISYLTQRFDLPLVEQSLTL
VSAYGTYLLTEDLGGSGVIGVVTTGLVLGNFGSRIGMNPRTRLIVTEFWDFLAFFVNSIVFLLIGDQIRFAILGNNLRTI
VVTILGMLVTRAISIYVLGLFSNVTAKSEIPIKDQTVLWWGGLRGSVSIALALSVPAVLGEREEIIATVFGVVLFTLLVQ
GLTTKFLLQGLGLISDQTQQQDYLAATARRAALSRVLDYLEKGDARPGIEPEFYRYQTALVEGQLAKLESELDDMQKKYP
ELKEFTAEQLKEELLAIEADTYAEFVRAGRLNKELAPFLAEVFIPE
>Mature_526_residues
MLLSNPIVAEMAMEAEDAIANNLKQFLLVLSVSLSVATLPQVFSWFRQIPYTLLLVIVGLCLAFVDVRLVDLSPELILAI
FLPPLLFEAAWNLKWSDLKKDLFPICLYAVFGVVITIGGVAFGLNKFAGISLTTALLIGASLSATDPVSVIALFRELGAG
KRLKTLMEGESLFNDGMAVVAFSFLVGLPLGVSTFEPSQVLGQLLAVIGIGIGVGSLIGFGISYLTQRFDLPLVEQSLTL
VSAYGTYLLTEDLGGSGVIGVVTTGLVLGNFGSRIGMNPRTRLIVTEFWDFLAFFVNSIVFLLIGDQIRFAILGNNLRTI
VVTILGMLVTRAISIYVLGLFSNVTAKSEIPIKDQTVLWWGGLRGSVSIALALSVPAVLGEREEIIATVFGVVLFTLLVQ
GLTTKFLLQGLGLISDQTQQQDYLAATARRAALSRVLDYLEKGDARPGIEPEFYRYQTALVEGQLAKLESELDDMQKKYP
ELKEFTAEQLKEELLAIEADTYAEFVRAGRLNKELAPFLAEVFIPE

Specific function: Unknown

COG id: COG0025

COG function: function code P; NhaP-type Na+/H+ and K+/H+ antiporters

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family [H]

Homologues:

Organism=Homo sapiens, GI14211919, Length=369, Percent_Identity=28.4552845528455, Blast_Score=129, Evalue=7e-30,
Organism=Homo sapiens, GI294997330, Length=412, Percent_Identity=28.3980582524272, Blast_Score=127, Evalue=4e-29,
Organism=Homo sapiens, GI110227626, Length=380, Percent_Identity=29.2105263157895, Blast_Score=125, Evalue=8e-29,
Organism=Homo sapiens, GI5454070, Length=378, Percent_Identity=29.3650793650794, Blast_Score=125, Evalue=1e-28,
Organism=Homo sapiens, GI27734935, Length=388, Percent_Identity=26.8041237113402, Blast_Score=125, Evalue=1e-28,
Organism=Homo sapiens, GI41872703, Length=366, Percent_Identity=26.2295081967213, Blast_Score=121, Evalue=2e-27,
Organism=Homo sapiens, GI15529998, Length=418, Percent_Identity=24.8803827751196, Blast_Score=118, Evalue=1e-26,
Organism=Homo sapiens, GI148727259, Length=419, Percent_Identity=25.2983293556086, Blast_Score=110, Evalue=5e-24,
Organism=Homo sapiens, GI194239733, Length=365, Percent_Identity=27.1232876712329, Blast_Score=96, Evalue=7e-20,
Organism=Homo sapiens, GI27777632, Length=494, Percent_Identity=23.4817813765182, Blast_Score=95, Evalue=2e-19,
Organism=Homo sapiens, GI4759144, Length=381, Percent_Identity=27.5590551181102, Blast_Score=83, Evalue=6e-16,
Organism=Escherichia coli, GI1790501, Length=481, Percent_Identity=27.027027027027, Blast_Score=116, Evalue=4e-27,
Organism=Caenorhabditis elegans, GI71999817, Length=442, Percent_Identity=26.2443438914027, Blast_Score=115, Evalue=6e-26,
Organism=Caenorhabditis elegans, GI71999819, Length=442, Percent_Identity=26.2443438914027, Blast_Score=115, Evalue=6e-26,
Organism=Caenorhabditis elegans, GI25150332, Length=475, Percent_Identity=24, Blast_Score=115, Evalue=6e-26,
Organism=Caenorhabditis elegans, GI71999821, Length=415, Percent_Identity=26.2650602409639, Blast_Score=113, Evalue=2e-25,
Organism=Caenorhabditis elegans, GI71987535, Length=420, Percent_Identity=25.2380952380952, Blast_Score=112, Evalue=5e-25,
Organism=Caenorhabditis elegans, GI71987537, Length=420, Percent_Identity=25.2380952380952, Blast_Score=112, Evalue=6e-25,
Organism=Caenorhabditis elegans, GI71980847, Length=385, Percent_Identity=25.7142857142857, Blast_Score=112, Evalue=6e-25,
Organism=Caenorhabditis elegans, GI71993590, Length=357, Percent_Identity=26.6106442577031, Blast_Score=108, Evalue=5e-24,
Organism=Caenorhabditis elegans, GI71993582, Length=357, Percent_Identity=26.6106442577031, Blast_Score=108, Evalue=9e-24,
Organism=Caenorhabditis elegans, GI71990924, Length=375, Percent_Identity=25.8666666666667, Blast_Score=104, Evalue=1e-22,
Organism=Caenorhabditis elegans, GI71990932, Length=358, Percent_Identity=26.8156424581006, Blast_Score=104, Evalue=1e-22,
Organism=Caenorhabditis elegans, GI25147678, Length=499, Percent_Identity=23.0460921843687, Blast_Score=103, Evalue=3e-22,
Organism=Caenorhabditis elegans, GI71992107, Length=316, Percent_Identity=24.6835443037975, Blast_Score=102, Evalue=4e-22,
Organism=Caenorhabditis elegans, GI71992101, Length=316, Percent_Identity=24.6835443037975, Blast_Score=102, Evalue=4e-22,
Organism=Caenorhabditis elegans, GI71987559, Length=425, Percent_Identity=25.1764705882353, Blast_Score=96, Evalue=5e-20,
Organism=Caenorhabditis elegans, GI71987545, Length=425, Percent_Identity=25.1764705882353, Blast_Score=95, Evalue=1e-19,
Organism=Saccharomyces cerevisiae, GI6320663, Length=432, Percent_Identity=25.6944444444444, Blast_Score=110, Evalue=5e-25,
Organism=Drosophila melanogaster, GI221473212, Length=383, Percent_Identity=28.4595300261097, Blast_Score=131, Evalue=1e-30,
Organism=Drosophila melanogaster, GI281364513, Length=383, Percent_Identity=28.4595300261097, Blast_Score=130, Evalue=2e-30,
Organism=Drosophila melanogaster, GI221473222, Length=383, Percent_Identity=28.4595300261097, Blast_Score=130, Evalue=2e-30,
Organism=Drosophila melanogaster, GI221473215, Length=383, Percent_Identity=28.4595300261097, Blast_Score=130, Evalue=2e-30,
Organism=Drosophila melanogaster, GI281360447, Length=477, Percent_Identity=25.7861635220126, Blast_Score=125, Evalue=1e-28,
Organism=Drosophila melanogaster, GI221510738, Length=439, Percent_Identity=26.1958997722096, Blast_Score=109, Evalue=6e-24,
Organism=Drosophila melanogaster, GI221510734, Length=399, Percent_Identity=27.8195488721804, Blast_Score=108, Evalue=1e-23,
Organism=Drosophila melanogaster, GI221510736, Length=400, Percent_Identity=27.75, Blast_Score=102, Evalue=8e-22,
Organism=Drosophila melanogaster, GI221510732, Length=400, Percent_Identity=27.75, Blast_Score=102, Evalue=9e-22,
Organism=Drosophila melanogaster, GI24585580, Length=400, Percent_Identity=27.75, Blast_Score=101, Evalue=1e-21,
Organism=Drosophila melanogaster, GI24585578, Length=400, Percent_Identity=27.75, Blast_Score=101, Evalue=1e-21,
Organism=Drosophila melanogaster, GI221510740, Length=400, Percent_Identity=27.75, Blast_Score=100, Evalue=2e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006153
- InterPro:   IPR018422
- InterPro:   IPR004705 [H]

Pfam domain/function: PF00999 Na_H_Exchanger [H]

EC number: NA

Molecular weight: Translated: 57205; Mature: 57205

Theoretical pI: Translated: 4.46; Mature: 4.46

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCC
>Mature Secondary Structure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HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8265357; 9278503 [H]