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The map label for this gene is mprA [H]

Identifier: 158333980

GI number: 158333980

Start: 772831

End: 773538

Strand: Reverse

Name: mprA [H]

Synonym: AM1_0794

Alternate gene names: 158333980

Gene position: 773538-772831 (Counterclockwise)

Preceding gene: 158333981

Following gene: 158333979

Centisome position: 11.89

GC content: 49.01

Gene sequence:

>708_bases
ATGTCTGACCTGTCACAGGTGATGCCAGGGAATCTGCCCCATGTTTTGCTGGTGATCGATCAGCCCCAGCTATCTCGGCG
CTTGCGTGATACGTTTCTAGCCCAGGGCTTTTATGTCACGGTGGTTGGGGATGCAGAAGATGCGATCGCCCACTGCAAAA
CCCAACCCCCTGCATTAGCCATGATTGATCAACAAATTTCGGAACAATCAGGAGTACAGCTCTGTCGTCAGTTGAGAGCT
GAAGGGGTCAGTATCCCCCTGTTACTGCTGATGGAAAAAGATTCGCGGGAGGATCGGATCGTCTGCCTAGAGGCTGGAGC
GGATGATTATATCCTTAGCCCTCATGCCGGGGAAGTGCTATTGCAGCGGGTACGACAGTACTTTAAATCAGATTCTGGCT
TGCCATCGAAAGTCCTCAGTTTCCAAGATTTACAGCTCGATTTAGCCACCCGTCGTGCGCAACGGAGAAGCAGAACCATA
GAACTGACCATGAAAGAATTTGAGCTGTTGAGATATCTAATGGAGCATCCTCGGGAAATATTAACCCGTGAGCAAATTTT
AGAAAATGTTTGGGGATTCGATTTTCGGGGGGAGTCGAATGTGATTGAAGTCTATATCCGCTATTTGCGGCTTAAGGTGC
AGGTTGCCCCTGAAAAGCGTCTTATTCATACTGTTCGTGGAGTTGGATATGTCCTCCGAGAAGCCTAA

Upstream 100 bases:

>100_bases
ATCCGTCTTTGATGCGGAATATCGCGTGATCAAACCACCCCAACGACCGAAAGTGGATGATGACTGGGATGAGTTTGATG
ATTCCTATCGAGAAGACTAA

Downstream 100 bases:

>100_bases
TCAACATCGAATATTACACCTGTTTGGTCTAATTGCTGGGGTCCTGATGCTGGGGTGTCAACCCCTGAACCAAGCGACAG
AGGCGACAACTCCCCAGCCA

Product: two-component transcriptional regulator

Products: NA

Alternate protein names: Mycobacterial persistence regulator A [H]

Number of amino acids: Translated: 235; Mature: 234

Protein sequence:

>235_residues
MSDLSQVMPGNLPHVLLVIDQPQLSRRLRDTFLAQGFYVTVVGDAEDAIAHCKTQPPALAMIDQQISEQSGVQLCRQLRA
EGVSIPLLLLMEKDSREDRIVCLEAGADDYILSPHAGEVLLQRVRQYFKSDSGLPSKVLSFQDLQLDLATRRAQRRSRTI
ELTMKEFELLRYLMEHPREILTREQILENVWGFDFRGESNVIEVYIRYLRLKVQVAPEKRLIHTVRGVGYVLREA

Sequences:

>Translated_235_residues
MSDLSQVMPGNLPHVLLVIDQPQLSRRLRDTFLAQGFYVTVVGDAEDAIAHCKTQPPALAMIDQQISEQSGVQLCRQLRA
EGVSIPLLLLMEKDSREDRIVCLEAGADDYILSPHAGEVLLQRVRQYFKSDSGLPSKVLSFQDLQLDLATRRAQRRSRTI
ELTMKEFELLRYLMEHPREILTREQILENVWGFDFRGESNVIEVYIRYLRLKVQVAPEKRLIHTVRGVGYVLREA
>Mature_234_residues
SDLSQVMPGNLPHVLLVIDQPQLSRRLRDTFLAQGFYVTVVGDAEDAIAHCKTQPPALAMIDQQISEQSGVQLCRQLRAE
GVSIPLLLLMEKDSREDRIVCLEAGADDYILSPHAGEVLLQRVRQYFKSDSGLPSKVLSFQDLQLDLATRRAQRRSRTIE
LTMKEFELLRYLMEHPREILTREQILENVWGFDFRGESNVIEVYIRYLRLKVQVAPEKRLIHTVRGVGYVLREA

Specific function: Member of the two-component regulatory system mprB/mprA which contributes to maintaining a balance among several systems involved in stress resistance and is required for establishment and maintenance of persistent infection in the host. Functions as a tr

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1786784, Length=219, Percent_Identity=33.3333333333333, Blast_Score=122, Evalue=2e-29,
Organism=Escherichia coli, GI1786599, Length=219, Percent_Identity=30.5936073059361, Blast_Score=120, Evalue=6e-29,
Organism=Escherichia coli, GI1789809, Length=228, Percent_Identity=33.7719298245614, Blast_Score=115, Evalue=2e-27,
Organism=Escherichia coli, GI87082012, Length=216, Percent_Identity=31.4814814814815, Blast_Score=112, Evalue=3e-26,
Organism=Escherichia coli, GI1787375, Length=218, Percent_Identity=29.8165137614679, Blast_Score=111, Evalue=5e-26,
Organism=Escherichia coli, GI1788394, Length=226, Percent_Identity=30.9734513274336, Blast_Score=107, Evalue=8e-25,
Organism=Escherichia coli, GI1786911, Length=222, Percent_Identity=29.7297297297297, Blast_Score=104, Evalue=5e-24,
Organism=Escherichia coli, GI1790860, Length=222, Percent_Identity=29.2792792792793, Blast_Score=99, Evalue=3e-22,
Organism=Escherichia coli, GI1790552, Length=218, Percent_Identity=28.8990825688073, Blast_Score=90, Evalue=1e-19,
Organism=Escherichia coli, GI1789402, Length=220, Percent_Identity=27.7272727272727, Blast_Score=87, Evalue=1e-18,
Organism=Escherichia coli, GI1787229, Length=231, Percent_Identity=29.004329004329, Blast_Score=82, Evalue=2e-17,
Organism=Escherichia coli, GI1790863, Length=228, Percent_Identity=26.3157894736842, Blast_Score=82, Evalue=4e-17,
Organism=Escherichia coli, GI145693140, Length=191, Percent_Identity=32.4607329842932, Blast_Score=81, Evalue=6e-17,
Organism=Escherichia coli, GI2367329, Length=235, Percent_Identity=29.3617021276596, Blast_Score=79, Evalue=2e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 26972; Mature: 26840

Theoretical pI: Translated: 6.68; Mature: 6.68

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDLSQVMPGNLPHVLLVIDQPQLSRRLRDTFLAQGFYVTVVGDAEDAIAHCKTQPPALA
CCCHHHHCCCCCCEEEEEECCHHHHHHHHHHHHHCCEEEEEECCCHHHHHHCCCCCCHHH
MIDQQISEQSGVQLCRQLRAEGVSIPLLLLMEKDSREDRIVCLEAGADDYILSPHAGEVL
HHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCEEEEEECCCCCEEECCCHHHHH
LQRVRQYFKSDSGLPSKVLSFQDLQLDLATRRAQRRSRTIELTMKEFELLRYLMEHPREI
HHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCHHHH
LTREQILENVWGFDFRGESNVIEVYIRYLRLKVQVAPEKRLIHTVRGVGYVLREA
HHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHEEECCHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
SDLSQVMPGNLPHVLLVIDQPQLSRRLRDTFLAQGFYVTVVGDAEDAIAHCKTQPPALA
CCHHHHCCCCCCEEEEEECCHHHHHHHHHHHHHCCEEEEEECCCHHHHHHCCCCCCHHH
MIDQQISEQSGVQLCRQLRAEGVSIPLLLLMEKDSREDRIVCLEAGADDYILSPHAGEVL
HHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCEEEEEECCCCCEEECCCHHHHH
LQRVRQYFKSDSGLPSKVLSFQDLQLDLATRRAQRRSRTIELTMKEFELLRYLMEHPREI
HHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCHHHH
LTREQILENVWGFDFRGESNVIEVYIRYLRLKVQVAPEKRLIHTVRGVGYVLREA
HHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHEEECCHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA