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The map label for this gene is yitJ [H]

Identifier: 158333977

GI number: 158333977

Start: 771168

End: 772130

Strand: Reverse

Name: yitJ [H]

Synonym: AM1_0791

Alternate gene names: 158333977

Gene position: 772130-771168 (Counterclockwise)

Preceding gene: 158333978

Following gene: 158333976

Centisome position: 11.87

GC content: 48.81

Gene sequence:

>963_bases
ATGACCTCTCCTATTGCTCCTGTTCATGATCTATCTGAACAGCTATCCTCCCCGATTGCACATCGATTCCAGGCTGCAAT
TCATGCTGGAGAGTTTTTAGTGACCGCAGAGGTGATGCCTCCTAAAGGTGGTTCCATCCAGCATATGCTGGACCAGGCCC
TCCACCTCAAAGATTGGGTTCATGCAGTTAATATTACTGACGGTAGTCGAGCAGTTCTTAGAATGAGCTCTTTAGCCGTT
GCTGCTATCTTGCGGCAGCAGGGAATTGAACCGATTTGTCAGATGGCCTGCCGTGATCGCAACCGGATTGCCCTCCAAGC
TGATCTAATGGGAGCCCATGCCTTGGGGATTCACAACATCTTGGCCCTGACGGGAGATCCCATCAAGGCAGGAGATTTCC
CTAAAGCAAAAGGGGTGTTTGATCTAGAGTCCATTCGCTTGTTGAACATCATTCGACAGCTCAACAATGGCTTGGATGGA
AATGAGAAACCTCTTCCTGATGGCCCAACCCACCTCTTAGTGGGTGCCGCTGTAGATCCGCAATTGGCGAGCTGGTCAGG
GTTACAAAGCCGATTTGAGAAGAAAGTGATGGCGGGGGCTGAATTTTTCCAAAGTCAATTAATCGTTGACTTTGATCGCC
TGGAAAAATTTATGACAGAAATTGCGACCCCTGCCAAAAAACCGATCTTGGCAGGGATTTTTCTGCTTAAATCTGCCAAG
AATGCCCAATTTATTAATCGCTGTGTTCCTGGGGTTAATATTCCAGATGCCATCATCAACCGTTTGGATAAAGCCACCGA
TCCGCTGCAAGAAGGAATTGCGATCGCATCTGAGCAAGTCCAACAGGCCCGTCAACTCTGCCAGGGGGTCCATATGATGG
CGGTCCGTCGAGAAGACTTGATTCCTCAAATACTGGAGCAGGCAGGCGTTACACCTGTAAGACAAACTCAAACCATCTCA
TGA

Upstream 100 bases:

>100_bases
AGTATTGAAACTGATTTAAATTTTTTTCATACCTATTTATTTTTCATACCTGTTTTTTTAGGTATAAAGACACCCTTTAT
TGCTAACCTGTGAATCTTTT

Downstream 100 bases:

>100_bases
GTTTTTGCCATTTAGAGTGCCAATAGAAGTAGCTTCAACGTTTTTCGTTTTTCTCCGTTGGTTACAATGGCATTACTCTG
AGCTAGCATTCTGTATGATT

Product: methylenetetrahydrofolate reductase

Products: NA

Alternate protein names: Homocysteine S-methyltransferase; S-methylmethionine:homocysteine methyltransferase; 5,10-methylenetetrahydrofolate reductase [H]

Number of amino acids: Translated: 320; Mature: 319

Protein sequence:

>320_residues
MTSPIAPVHDLSEQLSSPIAHRFQAAIHAGEFLVTAEVMPPKGGSIQHMLDQALHLKDWVHAVNITDGSRAVLRMSSLAV
AAILRQQGIEPICQMACRDRNRIALQADLMGAHALGIHNILALTGDPIKAGDFPKAKGVFDLESIRLLNIIRQLNNGLDG
NEKPLPDGPTHLLVGAAVDPQLASWSGLQSRFEKKVMAGAEFFQSQLIVDFDRLEKFMTEIATPAKKPILAGIFLLKSAK
NAQFINRCVPGVNIPDAIINRLDKATDPLQEGIAIASEQVQQARQLCQGVHMMAVRREDLIPQILEQAGVTPVRQTQTIS

Sequences:

>Translated_320_residues
MTSPIAPVHDLSEQLSSPIAHRFQAAIHAGEFLVTAEVMPPKGGSIQHMLDQALHLKDWVHAVNITDGSRAVLRMSSLAV
AAILRQQGIEPICQMACRDRNRIALQADLMGAHALGIHNILALTGDPIKAGDFPKAKGVFDLESIRLLNIIRQLNNGLDG
NEKPLPDGPTHLLVGAAVDPQLASWSGLQSRFEKKVMAGAEFFQSQLIVDFDRLEKFMTEIATPAKKPILAGIFLLKSAK
NAQFINRCVPGVNIPDAIINRLDKATDPLQEGIAIASEQVQQARQLCQGVHMMAVRREDLIPQILEQAGVTPVRQTQTIS
>Mature_319_residues
TSPIAPVHDLSEQLSSPIAHRFQAAIHAGEFLVTAEVMPPKGGSIQHMLDQALHLKDWVHAVNITDGSRAVLRMSSLAVA
AILRQQGIEPICQMACRDRNRIALQADLMGAHALGIHNILALTGDPIKAGDFPKAKGVFDLESIRLLNIIRQLNNGLDGN
EKPLPDGPTHLLVGAAVDPQLASWSGLQSRFEKKVMAGAEFFQSQLIVDFDRLEKFMTEIATPAKKPILAGIFLLKSAKN
AQFINRCVPGVNIPDAIINRLDKATDPLQEGIAIASEQVQQARQLCQGVHMMAVRREDLIPQILEQAGVTPVRQTQTIS

Specific function: Unknown

COG id: COG0685

COG function: function code E; 5,10-methylenetetrahydrofolate reductase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 Hcy-binding domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003171
- InterPro:   IPR003726 [H]

Pfam domain/function: PF02219 MTHFR; PF02574 S-methyl_trans [H]

EC number: =2.1.1.10; =1.5.1.20 [H]

Molecular weight: Translated: 34843; Mature: 34712

Theoretical pI: Translated: 7.33; Mature: 7.33

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTSPIAPVHDLSEQLSSPIAHRFQAAIHAGEFLVTAEVMPPKGGSIQHMLDQALHLKDWV
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEEECCCCCCCHHHHHHHHHHHHHHH
HAVNITDGSRAVLRMSSLAVAAILRQQGIEPICQMACRDRNRIALQADLMGAHALGIHNI
HEECCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCCEEEEHHHHHHHHHHHHHH
LALTGDPIKAGDFPKAKGVFDLESIRLLNIIRQLNNGLDGNEKPLPDGPTHLLVGAAVDP
HHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEECCCCC
QLASWSGLQSRFEKKVMAGAEFFQSQLIVDFDRLEKFMTEIATPAKKPILAGIFLLKSAK
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCC
NAQFINRCVPGVNIPDAIINRLDKATDPLQEGIAIASEQVQQARQLCQGVHMMAVRREDL
CHHHHHHHCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IPQILEQAGVTPVRQTQTIS
HHHHHHHCCCCCCCCCCCCC
>Mature Secondary Structure 
TSPIAPVHDLSEQLSSPIAHRFQAAIHAGEFLVTAEVMPPKGGSIQHMLDQALHLKDWV
CCCCCHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEEECCCCCCCHHHHHHHHHHHHHHH
HAVNITDGSRAVLRMSSLAVAAILRQQGIEPICQMACRDRNRIALQADLMGAHALGIHNI
HEECCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCCEEEEHHHHHHHHHHHHHH
LALTGDPIKAGDFPKAKGVFDLESIRLLNIIRQLNNGLDGNEKPLPDGPTHLLVGAAVDP
HHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEECCCCC
QLASWSGLQSRFEKKVMAGAEFFQSQLIVDFDRLEKFMTEIATPAKKPILAGIFLLKSAK
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCC
NAQFINRCVPGVNIPDAIINRLDKATDPLQEGIAIASEQVQQARQLCQGVHMMAVRREDL
CHHHHHHHCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IPQILEQAGVTPVRQTQTIS
HHHHHHHCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9353932; 9384377 [H]