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The map label for this gene is tyrP [H]

Identifier: 158333933

GI number: 158333933

Start: 725055

End: 726329

Strand: Direct

Name: tyrP [H]

Synonym: AM1_0747

Alternate gene names: 158333933

Gene position: 725055-726329 (Clockwise)

Preceding gene: 158333932

Following gene: 158333934

Centisome position: 11.15

GC content: 52.08

Gene sequence:

>1275_bases
TTGCTAACAGAAGACCGACCGTTAATTCAACTTGAGGACTCTAAACAGCCCTTAAAGCAGGGACCAGACCAACGATGGTC
TGCCATCGCCTTAGTGGCTGGAACCACGGTTGGGGCAGGTATTTTAGCCCTACCGGCCATGACTCACCCCGCTGGATTTC
TGCCCTCAACGGTGATGCTGATGGTGGTCTGGGTGTATGCCCTGGTGGCGGCCCTGTTGCTGGCTGAGGTCAATGTCGTC
TGTATGCGCCGATCGGGGCAGGACAATATGGGATTGCTGGGGATGGTCGAACGTACCCTGGGTAAACCCATCGCTAATGT
GGCGGGGGGTGCCTATTTATTCCTGCACTATGCATTACTCGTTGCCTATCTGTCTCAAGGGGGAGATATTCTTTCCAGTG
GGCTGGCCCATCTCGTGGGTGGGGCAGTTCCGGGTTGGGCTGGACCCACAGTGTTTGCCTTGATCTTTGGGGGGCTTCTG
TATTGGGGAAGTGATCAGCTGGTCGCCAAGTTTAACAGCACCTTTGTCGGAATCGTAATTATCACGTTTGTGGCTCTATT
GGTGCTGAGCGGTACTCAGGTTGATCCGGGAGAATTAGTCCATCAAAACTGGCCCGCCATTAGTCCTGCCATCTCGGTCA
TGTTAGTGGCGTTGTTCTATCACAATGTAGTGCCGGTGGTAGCAACCCAACTGGAGGGAGACTTAGGCAAAATCCGCCAG
TCGATTGTGGTGGGGTCTGTGATTCCCCTGCTGATGTTTCTAGTTTGGAATGCAGTCATTTTGGGAAGTATAGGGGGCTT
AGCTAGCTTGAGCGCTGGCAGTGAGGTGTTTGACCCCCTAGAAATACTGCGCAACAATGCTGACTTACCGGGGTTGAGTA
TCGTGGTATCGGTGTTTTCAGAGTTTGCGATCGCAACCTCGTTCATCGGCTTCACCTACGGACTACTAGATTTCCTTAAA
GACGCGTTTCAAGTTCGGGAAATAACACCCGACAATCGCCTCCCCTTTTATTCGATTGTTTTTCTCCCCGCATTGGGACT
CTCCACCTTAAATCCCAATATCTTCTTTACAGCCCTTGACTATGCGGGAGCCTTTAGTATTTCGGTTTTAGGGGGCATCT
TACCGGCGATCATGGCCTGGACGTTACGGTATCGCTCTCCTCTGCAGACTTCACCCCAAACCTTAGTGCCAGGAGGACGG
GGGACGCTGATTATTATGGTGGTTTTGGCCGTGGCCGTGATTGCCATCCAAATTTCAACGATGGTGACAGCTTAA

Upstream 100 bases:

>100_bases
TGAGGTAGATCAGGACAATAGCTCTCACGGTTCTGAGTAAAGCTTGAGTTTCATGAAGTAAGATTACAGTTAATGTAGTC
TCTACTACTTGAGAAAAGAT

Downstream 100 bases:

>100_bases
AGTTATCTTTTTTCCTACTCCTTTAAGAATGTTTGGTATTTCCGACAATTGGGAAATCTAGTGGCTAAGATTGAAATAGC
CTACTAGGTGTACTCAGTAA

Product: tryptophan/tyrosine permease transporter

Products: Proton [Cytoplasm]; L-tyrosine [Cytoplasm] [C]

Alternate protein names: Tyrosine permease [H]

Number of amino acids: Translated: 424; Mature: 424

Protein sequence:

>424_residues
MLTEDRPLIQLEDSKQPLKQGPDQRWSAIALVAGTTVGAGILALPAMTHPAGFLPSTVMLMVVWVYALVAALLLAEVNVV
CMRRSGQDNMGLLGMVERTLGKPIANVAGGAYLFLHYALLVAYLSQGGDILSSGLAHLVGGAVPGWAGPTVFALIFGGLL
YWGSDQLVAKFNSTFVGIVIITFVALLVLSGTQVDPGELVHQNWPAISPAISVMLVALFYHNVVPVVATQLEGDLGKIRQ
SIVVGSVIPLLMFLVWNAVILGSIGGLASLSAGSEVFDPLEILRNNADLPGLSIVVSVFSEFAIATSFIGFTYGLLDFLK
DAFQVREITPDNRLPFYSIVFLPALGLSTLNPNIFFTALDYAGAFSISVLGGILPAIMAWTLRYRSPLQTSPQTLVPGGR
GTLIIMVVLAVAVIAIQISTMVTA

Sequences:

>Translated_424_residues
MLTEDRPLIQLEDSKQPLKQGPDQRWSAIALVAGTTVGAGILALPAMTHPAGFLPSTVMLMVVWVYALVAALLLAEVNVV
CMRRSGQDNMGLLGMVERTLGKPIANVAGGAYLFLHYALLVAYLSQGGDILSSGLAHLVGGAVPGWAGPTVFALIFGGLL
YWGSDQLVAKFNSTFVGIVIITFVALLVLSGTQVDPGELVHQNWPAISPAISVMLVALFYHNVVPVVATQLEGDLGKIRQ
SIVVGSVIPLLMFLVWNAVILGSIGGLASLSAGSEVFDPLEILRNNADLPGLSIVVSVFSEFAIATSFIGFTYGLLDFLK
DAFQVREITPDNRLPFYSIVFLPALGLSTLNPNIFFTALDYAGAFSISVLGGILPAIMAWTLRYRSPLQTSPQTLVPGGR
GTLIIMVVLAVAVIAIQISTMVTA
>Mature_424_residues
MLTEDRPLIQLEDSKQPLKQGPDQRWSAIALVAGTTVGAGILALPAMTHPAGFLPSTVMLMVVWVYALVAALLLAEVNVV
CMRRSGQDNMGLLGMVERTLGKPIANVAGGAYLFLHYALLVAYLSQGGDILSSGLAHLVGGAVPGWAGPTVFALIFGGLL
YWGSDQLVAKFNSTFVGIVIITFVALLVLSGTQVDPGELVHQNWPAISPAISVMLVALFYHNVVPVVATQLEGDLGKIRQ
SIVVGSVIPLLMFLVWNAVILGSIGGLASLSAGSEVFDPLEILRNNADLPGLSIVVSVFSEFAIATSFIGFTYGLLDFLK
DAFQVREITPDNRLPFYSIVFLPALGLSTLNPNIFFTALDYAGAFSISVLGGILPAIMAWTLRYRSPLQTSPQTLVPGGR
GTLIIMVVLAVAVIAIQISTMVTA

Specific function: Involved in transporting tyrosine across the cytoplasmic membrane [H]

COG id: COG0814

COG function: function code E; Amino acid permeases

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid/polyamine transporter 2 family. Mtr/TnaB/TyrP permease subfamily [H]

Homologues:

Organism=Escherichia coli, GI1788218, Length=404, Percent_Identity=33.1683168316832, Blast_Score=166, Evalue=2e-42,
Organism=Escherichia coli, GI1790145, Length=384, Percent_Identity=26.8229166666667, Blast_Score=99, Evalue=4e-22,
Organism=Escherichia coli, GI1789552, Length=389, Percent_Identity=27.2493573264781, Blast_Score=94, Evalue=1e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002091
- InterPro:   IPR013061
- InterPro:   IPR013059
- InterPro:   IPR018227 [H]

Pfam domain/function: PF03222 Trp_Tyr_perm [H]

EC number: NA

Molecular weight: Translated: 44904; Mature: 44904

Theoretical pI: Translated: 5.26; Mature: 5.26

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLTEDRPLIQLEDSKQPLKQGPDQRWSAIALVAGTTVGAGILALPAMTHPAGFLPSTVML
CCCCCCCCEEECCCCCHHHCCCCCHHHEEEEEECCHHHHHHHHHCCCCCCCCCCHHHHHH
MVVWVYALVAALLLAEVNVVCMRRSGQDNMGLLGMVERTLGKPIANVAGGAYLFLHYALL
HHHHHHHHHHHHHHHHHHHHEEECCCCCCCCHHHHHHHHHCCCHHHHCCHHHHHHHHHHH
VAYLSQGGDILSSGLAHLVGGAVPGWAGPTVFALIFGGLLYWGSDQLVAKFNSTFVGIVI
HHHHHCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHCCHHHHHHH
ITFVALLVLSGTQVDPGELVHQNWPAISPAISVMLVALFYHNVVPVVATQLEGDLGKIRQ
HHHHHHHHHCCCCCCHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHH
SIVVGSVIPLLMFLVWNAVILGSIGGLASLSAGSEVFDPLEILRNNADLPGLSIVVSVFS
HHHHHHHHHHHHHHHHHHHHHHCCCCHHHCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHH
EFAIATSFIGFTYGLLDFLKDAFQVREITPDNRLPFYSIVFLPALGLSTLNPNIFFTALD
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCCCCCCCEEEEEEC
YAGAFSISVLGGILPAIMAWTLRYRSPLQTSPQTLVPGGRGTLIIMVVLAVAVIAIQIST
CCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHH
MVTA
HHCC
>Mature Secondary Structure
MLTEDRPLIQLEDSKQPLKQGPDQRWSAIALVAGTTVGAGILALPAMTHPAGFLPSTVML
CCCCCCCCEEECCCCCHHHCCCCCHHHEEEEEECCHHHHHHHHHCCCCCCCCCCHHHHHH
MVVWVYALVAALLLAEVNVVCMRRSGQDNMGLLGMVERTLGKPIANVAGGAYLFLHYALL
HHHHHHHHHHHHHHHHHHHHEEECCCCCCCCHHHHHHHHHCCCHHHHCCHHHHHHHHHHH
VAYLSQGGDILSSGLAHLVGGAVPGWAGPTVFALIFGGLLYWGSDQLVAKFNSTFVGIVI
HHHHHCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHCCHHHHHHH
ITFVALLVLSGTQVDPGELVHQNWPAISPAISVMLVALFYHNVVPVVATQLEGDLGKIRQ
HHHHHHHHHCCCCCCHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHH
SIVVGSVIPLLMFLVWNAVILGSIGGLASLSAGSEVFDPLEILRNNADLPGLSIVVSVFS
HHHHHHHHHHHHHHHHHHHHHHCCCCHHHCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHH
EFAIATSFIGFTYGLLDFLKDAFQVREITPDNRLPFYSIVFLPALGLSTLNPNIFFTALD
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCCCCCCCEEEEEEC
YAGAFSISVLGGILPAIMAWTLRYRSPLQTSPQTLVPGGRGTLIIMVVLAVAVIAIQIST
CCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHH
MVTA
HHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; L-tyrosine [Periplasm] [C]

Specific reaction: Proton [Periplasm] + L-tyrosine [Periplasm] = Proton [Cytoplasm] + L-tyrosine [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3049553; 9097040; 9278503 [H]