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The map label for this gene is cls1 [H]

Identifier: 158333901

GI number: 158333901

Start: 693681

End: 694838

Strand: Reverse

Name: cls1 [H]

Synonym: AM1_0713

Alternate gene names: 158333901

Gene position: 694838-693681 (Counterclockwise)

Preceding gene: 158333905

Following gene: 158333897

Centisome position: 10.68

GC content: 49.91

Gene sequence:

>1158_bases
TTGGTTCAGCATATGAATTCTGTGGAGCTTCTTGTTGATGCAGATGCCTTTTGGCATCGTCTCCAGAACGATCTACAAGC
GGCTGATCACGAAATTATGCTCCAGATGATGACCTTTGAAGGTGACCGAACCGGCCAGCAAGTAATCGAGGCCATGCTGG
CATCTGAAGCGCCTTGCAAACAGATCCTGGTCGATAACTACACGCGATTTATTCAGAGTGACAAGTTTATCTACCATCCC
AAATATTGGTCAGATCAAGACCTCAAAACTGAAGTCCGCCAGACCCACGCTATGTTTGAAGCCCTTATCCAGGAGGGGGG
GCAGGTCCGATTTACGAATCCTGTCGGGCCCTTCTTGATTCATTTTGTAGGGCGTAGCCATAAAAAGCTGATCGTAATTG
ACAACCAGATTGCCTACATTGGTGGTTTTAACTTCAGCGACCATAACTTTGCTTGGCATGACCTGATGTTTCGGTTAGAA
GACCCAGCCATTGTGGAATTCCTGCGGGCAGATTTTATGGCCACTTGGCAAGATCAATCTCAACCCAGCCACGCTGACTT
CGGGGACTGCGAGTTTTTTCTCCTGAATGGCCGAACGAATGAAGCGACATTTGCAATCTTGCTAGATCTGCTGTGCTCTG
CTCAGAAATCTCTGCATATTATTAGTCCCTATCTCACCTTCCCCTTCTGTGCTGCCTTGGCTGAACTCCCTCAGCGGGGG
GTACCCGTCACTCTACTCACCCCAGAAGGCAACAACAAAGGCACTGTCCGAGATTATCTGTTGTGGGAGGCCCAACGGTC
CGGGTTTGACGTTCGTCTCTACGACGGCATGAGCCATATGAAAGCAGCTCTAGTGGACGATCGCTATCTGGTGGTGGGTT
CGTCTAATTTTGATTTTTTGAGCTATCGCATTGAAGAAGAAGTCCTGGCCATTTTTTCTAATCCCACTGTAATTGAGACG
TTTCGCCAACAGGTCCTAGAACCCGATCTGGCTCGCTGCCGTCCTTTTGATGGCCAAGCCAGTGCTCTGCGAGGCTGGCT
CTCCTATGGCATTCTGCGAGCCGTAGAAACCTTGGCTCTCTTCTCTCGCCGGATTAAATCCACCCAAGTGATTGATACCG
CCGTGCGGGGTTACCCTGTGATGCCGAAGGAATCCTAG

Upstream 100 bases:

>100_bases
TTTTGCTGTGAGAAACAAGCTTTGATACTCTGACCAAAGTAACAACCGCCAAGAGGGTTGCCCGAACACAATCCTTGGTG
GTCTGTGAGTCCCTTATGGT

Downstream 100 bases:

>100_bases
TATCGACACTATTTTGGGGCGGTTTCAATGATTGCGATCGCACCCGCCCTTTTTGCCCAGACCATCCTCCCCTTAATGGC
TCCTAGGAACTGGAGTTCAC

Product: hypothetical protein

Products: Biphosphatidylglycerol; Glycerol. [C]

Alternate protein names: CL synthase 1 [H]

Number of amino acids: Translated: 385; Mature: 385

Protein sequence:

>385_residues
MVQHMNSVELLVDADAFWHRLQNDLQAADHEIMLQMMTFEGDRTGQQVIEAMLASEAPCKQILVDNYTRFIQSDKFIYHP
KYWSDQDLKTEVRQTHAMFEALIQEGGQVRFTNPVGPFLIHFVGRSHKKLIVIDNQIAYIGGFNFSDHNFAWHDLMFRLE
DPAIVEFLRADFMATWQDQSQPSHADFGDCEFFLLNGRTNEATFAILLDLLCSAQKSLHIISPYLTFPFCAALAELPQRG
VPVTLLTPEGNNKGTVRDYLLWEAQRSGFDVRLYDGMSHMKAALVDDRYLVVGSSNFDFLSYRIEEEVLAIFSNPTVIET
FRQQVLEPDLARCRPFDGQASALRGWLSYGILRAVETLALFSRRIKSTQVIDTAVRGYPVMPKES

Sequences:

>Translated_385_residues
MVQHMNSVELLVDADAFWHRLQNDLQAADHEIMLQMMTFEGDRTGQQVIEAMLASEAPCKQILVDNYTRFIQSDKFIYHP
KYWSDQDLKTEVRQTHAMFEALIQEGGQVRFTNPVGPFLIHFVGRSHKKLIVIDNQIAYIGGFNFSDHNFAWHDLMFRLE
DPAIVEFLRADFMATWQDQSQPSHADFGDCEFFLLNGRTNEATFAILLDLLCSAQKSLHIISPYLTFPFCAALAELPQRG
VPVTLLTPEGNNKGTVRDYLLWEAQRSGFDVRLYDGMSHMKAALVDDRYLVVGSSNFDFLSYRIEEEVLAIFSNPTVIET
FRQQVLEPDLARCRPFDGQASALRGWLSYGILRAVETLALFSRRIKSTQVIDTAVRGYPVMPKES
>Mature_385_residues
MVQHMNSVELLVDADAFWHRLQNDLQAADHEIMLQMMTFEGDRTGQQVIEAMLASEAPCKQILVDNYTRFIQSDKFIYHP
KYWSDQDLKTEVRQTHAMFEALIQEGGQVRFTNPVGPFLIHFVGRSHKKLIVIDNQIAYIGGFNFSDHNFAWHDLMFRLE
DPAIVEFLRADFMATWQDQSQPSHADFGDCEFFLLNGRTNEATFAILLDLLCSAQKSLHIISPYLTFPFCAALAELPQRG
VPVTLLTPEGNNKGTVRDYLLWEAQRSGFDVRLYDGMSHMKAALVDDRYLVVGSSNFDFLSYRIEEEVLAIFSNPTVIET
FRQQVLEPDLARCRPFDGQASALRGWLSYGILRAVETLALFSRRIKSTQVIDTAVRGYPVMPKES

Specific function: Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol [H]

COG id: COG1502

COG function: function code I; Phosphatidylserine/phosphatidylglycerophosphate/cardiolipin synthases and related enzymes

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 PLD phosphodiesterase domains [H]

Homologues:

Organism=Escherichia coli, GI1787502, Length=339, Percent_Identity=24.4837758112094, Blast_Score=69, Evalue=6e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022924
- InterPro:   IPR015679
- InterPro:   IPR001736 [H]

Pfam domain/function: PF00614 PLDc [H]

EC number: 2.7.8.- [C]

Molecular weight: Translated: 44036; Mature: 44036

Theoretical pI: Translated: 5.12; Mature: 5.12

Prosite motif: PS50035 PLD

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVQHMNSVELLVDADAFWHRLQNDLQAADHEIMLQMMTFEGDRTGQQVIEAMLASEAPCK
CCCCCCCEEEEEECHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCHH
QILVDNYTRFIQSDKFIYHPKYWSDQDLKTEVRQTHAMFEALIQEGGQVRFTNPVGPFLI
HHHHHHHHHHHCCCCEEECCCCCCCCHHHHHHHHHHHHHHHHHHCCCEEEEECCCHHHHH
HFVGRSHKKLIVIDNQIAYIGGFNFSDHNFAWHDLMFRLEDPAIVEFLRADFMATWQDQS
HHHCCCCCEEEEEECCEEEEECCCCCCCCCCHHHHHEECCCHHHHHHHHHHHHHHCCCCC
QPSHADFGDCEFFLLNGRTNEATFAILLDLLCSAQKSLHIISPYLTFPFCAALAELPQRG
CCCCCCCCCEEEEEEECCCCHHHHHHHHHHHHHHCCCEEEECHHHHHHHHHHHHHCCCCC
VPVTLLTPEGNNKGTVRDYLLWEAQRSGFDVRLYDGMSHMKAALVDDRYLVVGSSNFDFL
CCEEEECCCCCCCCCHHHHHHHHHHCCCCEEEEECCHHHHHHHHCCCCEEEEECCCCCEE
SYRIEEEVLAIFSNPTVIETFRQQVLEPDLARCRPFDGQASALRGWLSYGILRAVETLAL
HHHHHHHHHHHHCCCHHHHHHHHHHCCCCHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHH
FSRRIKSTQVIDTAVRGYPVMPKES
HHHHHHHHHHHHHHHCCCCCCCCCC
>Mature Secondary Structure
MVQHMNSVELLVDADAFWHRLQNDLQAADHEIMLQMMTFEGDRTGQQVIEAMLASEAPCK
CCCCCCCEEEEEECHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCHH
QILVDNYTRFIQSDKFIYHPKYWSDQDLKTEVRQTHAMFEALIQEGGQVRFTNPVGPFLI
HHHHHHHHHHHCCCCEEECCCCCCCCHHHHHHHHHHHHHHHHHHCCCEEEEECCCHHHHH
HFVGRSHKKLIVIDNQIAYIGGFNFSDHNFAWHDLMFRLEDPAIVEFLRADFMATWQDQS
HHHCCCCCEEEEEECCEEEEECCCCCCCCCCHHHHHEECCCHHHHHHHHHHHHHHCCCCC
QPSHADFGDCEFFLLNGRTNEATFAILLDLLCSAQKSLHIISPYLTFPFCAALAELPQRG
CCCCCCCCCEEEEEEECCCCHHHHHHHHHHHHHHCCCEEEECHHHHHHHHHHHHHCCCCC
VPVTLLTPEGNNKGTVRDYLLWEAQRSGFDVRLYDGMSHMKAALVDDRYLVVGSSNFDFL
CCEEEECCCCCCCCCHHHHHHHHHHCCCCEEEEECCHHHHHHHHCCCCEEEEECCCCCEE
SYRIEEEVLAIFSNPTVIETFRQQVLEPDLARCRPFDGQASALRGWLSYGILRAVETLAL
HHHHHHHHHHHHCCCHHHHHHHHHHCCCCHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHH
FSRRIKSTQVIDTAVRGYPVMPKES
HHHHHHHHHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Phosphatidylglycerol [C]

Specific reaction: 2 Phosphatidylglycerol = Biphosphatidylglycerol + Glycerol. [C]

General reaction: Transferring phosphorus-containing groups [C]

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA