Click here to switch to the map view.

The map label for this gene is cyaA [H]

Identifier: 158333890

GI number: 158333890

Start: 683610

End: 685598

Strand: Reverse

Name: cyaA [H]

Synonym: AM1_0702

Alternate gene names: 158333890

Gene position: 685598-683610 (Counterclockwise)

Preceding gene: 158333897

Following gene: 158333889

Centisome position: 10.54

GC content: 51.13

Gene sequence:

>1989_bases
TTGGCTCAGTTTTTCCATCAACTCCGATCTCGTTGGCCGAATCTCGCCATCGCTCTCCTTGCCGGACTCGCCGTGAGCGG
TGGCGTTCTAGGAATTCGGCAAGTCACCCGCTGGCAAATCGGTTTCCTGCGGGTTGAAGGGCTCCAGTCCCTGGAACTGT
CCGCATATGATCACTTTGTTCAAGCCCAACCCGACTTGGGTCAAGATTCAAGACTCCTCGTTGTCGGAATCACCGAAGCG
GACATTCAATCCATCGGCCAGTGGCCCATTCCTGACAGCGTACTGGCTGATGCCTTCAAAAAACTACAAACCCACCGGCC
CCGAGTTATCGGTCTAGATATTTGGCGTAATCTTCCCATTCCCAATCTCAAAGAATCGACCCAAACTAACGGCCATGCCC
AACTCATTCAACAGATGAAGGGGTCTGACCGAGTGGTTGTGATTACTAAATTCGGATCTGAGGATGAAGCTAGTATCCCT
CCTCCCGATGGCGTACCAGAAGCACAGGTCGGATTCAACGATACTGTCGTTGATTCGGGTGGAGTTGTCCGTCGGAATTT
GCTCTATCAAGAGGACTATTTTCCATCCTTTGCCCTAAGGATGGCCCTCCGGTACCTCAAGGATGACGGCAAAGAAGATA
AACCCAGCGAGGTTGACCCAAATGTCCTACAAATTGGTCCAACGGTATTTTGGCCGCTGCAAAGCAATGATGGCTCTTAT
ATCAATGCGGATACCCGAGGCTATCAGATTTTAATTAACTATCGATCTGCCCACGAGAGTGTAGAGCAGGTCAGCCTGTC
TCAGGTGTTAGCCGGCCAGGTAGATTCTAATTTGATTAAAGACCGTATCATCCTAATCGGTACGACGGCAGAAAGCGGCA
AAGATCTATTCCATACGCCCTATAGTTCTAGCCTTGACGATCAGCAAACCATGCCAGGGGTGGTGATCCATGCCCAAATG
GTCAGTCAATTCCTAGATGCAGCAGACGGCACCCGCAACCTGATTTCCGTCTGGCCAGAACCGGGGGAAATGGTTTGGAT
TTTGGGTTGGGCGCTGATCGGGAGCCTACTGGCCTGGGGCGTTCGTCATCCGATGGGCTTGGTGCTGGGCAGCGGCATCG
CCTTAATTGTCCTGTATAGCGTCTGTCGAATCCTGTTCGCACAGCAAATTTGGATTCCCTTGGTCCCTCCTTTCCTCGCG
TTTGTCGGCGCAACGGGCATTGTGGTGATTTACAATGCCCAGCAGGCTCAGCGGCAACAGAAGATGGTGATGAAACTGTT
GGGTCAAAGTACTTCCCCCGAAATTGCTGAGACCCTCTGGCAACGACGCGATGAGCTTTTAGAAGATGGCAAGCTCACAG
GCCAGAGAATCACGGCCACCCTCTTGTTTACGGATTTAAAGGGGTTTAGCACTATTTCGGAAAAAATGTCTCCAGAACAG
CTGCTGGAATGGCTCAATGAATACTTAGAAGCCATGACTCAGAGTGTGCAAGCCCATCATGGAGTGATTAATAAATTTAC
GGGGGATGGGGTGATGGCCGTCTTTGGTGCACCGATTGCCCATGAAGAACAAGCTGCGATCGCAAAAGACACCCAAAATG
CCGTAGCCTGTGCGTTAGATATGGGCAAACGCCTGGACGAACTCAACCCCCAATGGCAAAAAAGCGGGTTACCCGCCGTT
CAGATGCGGGCTGGTATCTTTACCGGATCGGTGGTGGTAGGAAGTTTGGGTAGTAAAACTCGCTTAGAATATGGCGTGAT
TGGGGATAGCGTCAATACCGCCTCCCGCCTGGAAAGCTTAGATAAGCAACGCCAAAGCTCCTCGTGCCGGGTATTGATTG
CCAAAGAAACCCTTGAGTACTTAGACAATCAGTTTGAAGTCGAGAACTGGGGAACCTTAGCCCTGAAAGGGAAAGTCGAA
CGGGTGGACGTTTACCGAGTGATCTCTGCACTCCAATCCCCCAATACTGATGGAGATTCTGAAGCGTAA

Upstream 100 bases:

>100_bases
CGATCGCTTAAGGTTGCGATCAAATAGTCGGCCATATTAATTCATCAGGACTATCGCTCTACACTATACTCATACCGCAA
CCCCATGATTTTTTGGCATC

Downstream 100 bases:

>100_bases
CTTTAGACGGATGTATGGCCTGGATGGAAAAGAACAACAGGATTTTCCTCGTCAGACCCCCCCAGGGTTTGATAGCTTAA
GATACAGGATAAATTCGCTA

Product: adenylate cyclase

Products: NA

Alternate protein names: ATP pyrophosphate-lyase 1; Adenylyl cyclase 1 [H]

Number of amino acids: Translated: 662; Mature: 661

Protein sequence:

>662_residues
MAQFFHQLRSRWPNLAIALLAGLAVSGGVLGIRQVTRWQIGFLRVEGLQSLELSAYDHFVQAQPDLGQDSRLLVVGITEA
DIQSIGQWPIPDSVLADAFKKLQTHRPRVIGLDIWRNLPIPNLKESTQTNGHAQLIQQMKGSDRVVVITKFGSEDEASIP
PPDGVPEAQVGFNDTVVDSGGVVRRNLLYQEDYFPSFALRMALRYLKDDGKEDKPSEVDPNVLQIGPTVFWPLQSNDGSY
INADTRGYQILINYRSAHESVEQVSLSQVLAGQVDSNLIKDRIILIGTTAESGKDLFHTPYSSSLDDQQTMPGVVIHAQM
VSQFLDAADGTRNLISVWPEPGEMVWILGWALIGSLLAWGVRHPMGLVLGSGIALIVLYSVCRILFAQQIWIPLVPPFLA
FVGATGIVVIYNAQQAQRQQKMVMKLLGQSTSPEIAETLWQRRDELLEDGKLTGQRITATLLFTDLKGFSTISEKMSPEQ
LLEWLNEYLEAMTQSVQAHHGVINKFTGDGVMAVFGAPIAHEEQAAIAKDTQNAVACALDMGKRLDELNPQWQKSGLPAV
QMRAGIFTGSVVVGSLGSKTRLEYGVIGDSVNTASRLESLDKQRQSSSCRVLIAKETLEYLDNQFEVENWGTLALKGKVE
RVDVYRVISALQSPNTDGDSEA

Sequences:

>Translated_662_residues
MAQFFHQLRSRWPNLAIALLAGLAVSGGVLGIRQVTRWQIGFLRVEGLQSLELSAYDHFVQAQPDLGQDSRLLVVGITEA
DIQSIGQWPIPDSVLADAFKKLQTHRPRVIGLDIWRNLPIPNLKESTQTNGHAQLIQQMKGSDRVVVITKFGSEDEASIP
PPDGVPEAQVGFNDTVVDSGGVVRRNLLYQEDYFPSFALRMALRYLKDDGKEDKPSEVDPNVLQIGPTVFWPLQSNDGSY
INADTRGYQILINYRSAHESVEQVSLSQVLAGQVDSNLIKDRIILIGTTAESGKDLFHTPYSSSLDDQQTMPGVVIHAQM
VSQFLDAADGTRNLISVWPEPGEMVWILGWALIGSLLAWGVRHPMGLVLGSGIALIVLYSVCRILFAQQIWIPLVPPFLA
FVGATGIVVIYNAQQAQRQQKMVMKLLGQSTSPEIAETLWQRRDELLEDGKLTGQRITATLLFTDLKGFSTISEKMSPEQ
LLEWLNEYLEAMTQSVQAHHGVINKFTGDGVMAVFGAPIAHEEQAAIAKDTQNAVACALDMGKRLDELNPQWQKSGLPAV
QMRAGIFTGSVVVGSLGSKTRLEYGVIGDSVNTASRLESLDKQRQSSSCRVLIAKETLEYLDNQFEVENWGTLALKGKVE
RVDVYRVISALQSPNTDGDSEA
>Mature_661_residues
AQFFHQLRSRWPNLAIALLAGLAVSGGVLGIRQVTRWQIGFLRVEGLQSLELSAYDHFVQAQPDLGQDSRLLVVGITEAD
IQSIGQWPIPDSVLADAFKKLQTHRPRVIGLDIWRNLPIPNLKESTQTNGHAQLIQQMKGSDRVVVITKFGSEDEASIPP
PDGVPEAQVGFNDTVVDSGGVVRRNLLYQEDYFPSFALRMALRYLKDDGKEDKPSEVDPNVLQIGPTVFWPLQSNDGSYI
NADTRGYQILINYRSAHESVEQVSLSQVLAGQVDSNLIKDRIILIGTTAESGKDLFHTPYSSSLDDQQTMPGVVIHAQMV
SQFLDAADGTRNLISVWPEPGEMVWILGWALIGSLLAWGVRHPMGLVLGSGIALIVLYSVCRILFAQQIWIPLVPPFLAF
VGATGIVVIYNAQQAQRQQKMVMKLLGQSTSPEIAETLWQRRDELLEDGKLTGQRITATLLFTDLKGFSTISEKMSPEQL
LEWLNEYLEAMTQSVQAHHGVINKFTGDGVMAVFGAPIAHEEQAAIAKDTQNAVACALDMGKRLDELNPQWQKSGLPAVQ
MRAGIFTGSVVVGSLGSKTRLEYGVIGDSVNTASRLESLDKQRQSSSCRVLIAKETLEYLDNQFEVENWGTLALKGKVER
VDVYRVISALQSPNTDGDSEA

Specific function: Plays essential roles in regulation of cellular metabolism by catalyzing the synthesis of a second messenger, cAMP [H]

COG id: NA

COG function: NA

Gene ontology:
GO:0006796: Adenylate cyclase, putative
GO:0005622: Adenylate cyclase, putative
GO:0009190: Adenylate cyclase, putative
GO:0016849: Adenylate cyclase, putative
GO:0035556: Adenylate cyclase, putative

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HAMP domain [H]

Homologues:

Organism=Homo sapiens, GI4557257, Length=217, Percent_Identity=27.1889400921659, Blast_Score=76, Evalue=8e-14,
Organism=Homo sapiens, GI34486092, Length=219, Percent_Identity=23.2876712328767, Blast_Score=75, Evalue=1e-13,
Organism=Homo sapiens, GI10947061, Length=215, Percent_Identity=23.2558139534884, Blast_Score=75, Evalue=1e-13,
Organism=Homo sapiens, GI10181096, Length=215, Percent_Identity=23.2558139534884, Blast_Score=75, Evalue=1e-13,
Organism=Homo sapiens, GI148536830, Length=220, Percent_Identity=25.4545454545455, Blast_Score=75, Evalue=2e-13,
Organism=Homo sapiens, GI4557255, Length=170, Percent_Identity=28.8235294117647, Blast_Score=71, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI17534657, Length=188, Percent_Identity=30.3191489361702, Blast_Score=69, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI193207841, Length=217, Percent_Identity=27.6497695852535, Blast_Score=68, Evalue=1e-11,
Organism=Drosophila melanogaster, GI161078020, Length=184, Percent_Identity=32.6086956521739, Blast_Score=81, Evalue=2e-15,
Organism=Drosophila melanogaster, GI24585694, Length=313, Percent_Identity=25.8785942492013, Blast_Score=79, Evalue=8e-15,
Organism=Drosophila melanogaster, GI85725044, Length=273, Percent_Identity=26.7399267399267, Blast_Score=78, Evalue=2e-14,
Organism=Drosophila melanogaster, GI281366320, Length=217, Percent_Identity=28.5714285714286, Blast_Score=75, Evalue=2e-13,
Organism=Drosophila melanogaster, GI161084260, Length=217, Percent_Identity=28.5714285714286, Blast_Score=74, Evalue=3e-13,
Organism=Drosophila melanogaster, GI24667100, Length=179, Percent_Identity=31.8435754189944, Blast_Score=71, Evalue=3e-12,
Organism=Drosophila melanogaster, GI221330468, Length=187, Percent_Identity=26.7379679144385, Blast_Score=67, Evalue=3e-11,
Organism=Drosophila melanogaster, GI221330470, Length=187, Percent_Identity=26.7379679144385, Blast_Score=67, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001054
- InterPro:   IPR003660 [H]

Pfam domain/function: PF00211 Guanylate_cyc; PF00672 HAMP [H]

EC number: =4.6.1.1 [H]

Molecular weight: Translated: 72926; Mature: 72795

Theoretical pI: Translated: 4.97; Mature: 4.97

Prosite motif: PS50125 GUANYLATE_CYCLASES_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAQFFHQLRSRWPNLAIALLAGLAVSGGVLGIRQVTRWQIGFLRVEGLQSLELSAYDHFV
CHHHHHHHHHHCCCHHHHHHHHHHHCCCHHHHHHHHHHHHEEEEECCCCHHHHHHHHHHH
QAQPDLGQDSRLLVVGITEADIQSIGQWPIPDSVLADAFKKLQTHRPRVIGLDIWRNLPI
HCCCCCCCCCEEEEEEECHHHHHHCCCCCCCHHHHHHHHHHHHHCCCEEEEEHHHCCCCC
PNLKESTQTNGHAQLIQQMKGSDRVVVITKFGSEDEASIPPPDGVPEAQVGFNDTVVDSG
CCCCHHCCCCHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCEECCC
GVVRRNLLYQEDYFPSFALRMALRYLKDDGKEDKPSEVDPNVLQIGPTVFWPLQSNDGSY
CCHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEECCEEEEEEECCCCCE
INADTRGYQILINYRSAHESVEQVSLSQVLAGQVDSNLIKDRIILIGTTAESGKDLFHTP
EECCCCCEEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEEECCCCCCCCEECC
YSSSLDDQQTMPGVVIHAQMVSQFLDAADGTRNLISVWPEPGEMVWILGWALIGSLLAWG
CCCCCCCHHCCCCCEEEHHHHHHHHHHCCCCCCCEEECCCCCCEEEHHHHHHHHHHHHHH
VRHPMGLVLGSGIALIVLYSVCRILFAQQIWIPLVPPFLAFVGATGIVVIYNAQQAQRQQ
HHCCHHHHHHCHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHCCCCEEEEECCHHHHHHH
KMVMKLLGQSTSPEIAETLWQRRDELLEDGKLTGQRITATLLFTDLKGFSTISEKMSPEQ
HHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCCHHEEEEEEEHHHCCHHHHHHCCCHHH
LLEWLNEYLEAMTQSVQAHHGVINKFTGDGVMAVFGAPIAHEEQAAIAKDTQNAVACALD
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCCCHHHHHHHCCCHHHHHHHH
MGKRLDELNPQWQKSGLPAVQMRAGIFTGSVVVGSLGSKTRLEYGVIGDSVNTASRLESL
HHHHHHHCCCCHHHCCCCHHHHHHCCEECCHHEECCCCCCEEEEEECCCCCCHHHHHHHH
DKQRQSSSCRVLIAKETLEYLDNQFEVENWGTLALKGKVERVDVYRVISALQSPNTDGDS
HHHHCCCCCEEEEHHHHHHHHCCCEEECCCCEEEEECCHHHHHHHHHHHHHHCCCCCCCC
EA
CC
>Mature Secondary Structure 
AQFFHQLRSRWPNLAIALLAGLAVSGGVLGIRQVTRWQIGFLRVEGLQSLELSAYDHFV
HHHHHHHHHHCCCHHHHHHHHHHHCCCHHHHHHHHHHHHEEEEECCCCHHHHHHHHHHH
QAQPDLGQDSRLLVVGITEADIQSIGQWPIPDSVLADAFKKLQTHRPRVIGLDIWRNLPI
HCCCCCCCCCEEEEEEECHHHHHHCCCCCCCHHHHHHHHHHHHHCCCEEEEEHHHCCCCC
PNLKESTQTNGHAQLIQQMKGSDRVVVITKFGSEDEASIPPPDGVPEAQVGFNDTVVDSG
CCCCHHCCCCHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCEECCC
GVVRRNLLYQEDYFPSFALRMALRYLKDDGKEDKPSEVDPNVLQIGPTVFWPLQSNDGSY
CCHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEECCEEEEEEECCCCCE
INADTRGYQILINYRSAHESVEQVSLSQVLAGQVDSNLIKDRIILIGTTAESGKDLFHTP
EECCCCCEEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEEECCCCCCCCEECC
YSSSLDDQQTMPGVVIHAQMVSQFLDAADGTRNLISVWPEPGEMVWILGWALIGSLLAWG
CCCCCCCHHCCCCCEEEHHHHHHHHHHCCCCCCCEEECCCCCCEEEHHHHHHHHHHHHHH
VRHPMGLVLGSGIALIVLYSVCRILFAQQIWIPLVPPFLAFVGATGIVVIYNAQQAQRQQ
HHCCHHHHHHCHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHCCCCEEEEECCHHHHHHH
KMVMKLLGQSTSPEIAETLWQRRDELLEDGKLTGQRITATLLFTDLKGFSTISEKMSPEQ
HHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCCHHEEEEEEEHHHCCHHHHHHCCCHHH
LLEWLNEYLEAMTQSVQAHHGVINKFTGDGVMAVFGAPIAHEEQAAIAKDTQNAVACALD
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCCCHHHHHHHCCCHHHHHHHH
MGKRLDELNPQWQKSGLPAVQMRAGIFTGSVVVGSLGSKTRLEYGVIGDSVNTASRLESL
HHHHHHHCCCCHHHCCCCHHHHHHCCEECCHHEECCCCCCEEEEEECCCCCCHHHHHHHH
DKQRQSSSCRVLIAKETLEYLDNQFEVENWGTLALKGKVERVDVYRVISALQSPNTDGDS
HHHHCCCCCEEEEHHHHHHHHCCCEEECCCCEEEEECCHHHHHHHHHHHHHHCCCCCCCC
EA
CC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11481430; 1970565 [H]