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The map label for this gene is phrB [H]

Identifier: 158333885

GI number: 158333885

Start: 678336

End: 679733

Strand: Reverse

Name: phrB [H]

Synonym: AM1_0697

Alternate gene names: 158333885

Gene position: 679733-678336 (Counterclockwise)

Preceding gene: 158333889

Following gene: 158333884

Centisome position: 10.45

GC content: 50.72

Gene sequence:

>1398_bases
ATGGCAAATTCGCTGATTGAGGAAGAACGCATCCAGATCCTGAATAAACAGGACGTACAGCCCGGTGGTTATGTTCTGTA
CTGGATGCAGCAGTCTCAGCGGGCCGAATACAATCATGCCTTGGAATATGCCATTCAGCGGGCCAATGATCTTCAACAGC
CTGTGGTGGTTTGCTTTGGCCTGATGGCCGATTATCCCGGTTCCAATCTGCGCCATTACACCTTTATGTTGGAAGGCTTG
CAGGATACGGAGCAAGCGCTGATTCAACGGGGCATCAAGTTTGTAATGCGCTACGGCAATCCGGATCAAATTGCCTTGGA
GTTAGGGAAAGATGCTTCGTTGGTGGTTTGCGATCGCGGCTATCTTCGTTTCCAACGCCAGTGGCGGGACAATGTCGCTC
AGAATGCTCCCTGCCAAGTGGTGCAAGTGGAATCGGAAGTGGTGGTGCCTGTAGAAACCGCCTCCGTCAAAGCCGATTAT
GCTGCCCGCACCATCCGTCCTCGCATCCATCGTCACTTAGATCGCTTTCTGGTTCCCTTTGCCTCAACCCCAGTTCAACA
CTCCTCCCTCCATCTAGATCTAAAGTCTTTAGATCTCAGCAATATTGAGGCTGTTCTAGCTAAGCTGCCTTTAGACTGCA
GCGTGCCCCCCGTCAGTTCCCTGTTCCAAGGCGGTACGACTCGGGCTAAGGAAATCCTGGAGAAATTTCTGCAAAAATCT
TTTGCCATCTACGCCGATCATCGCAATCAGCCCCAAACGGATGATGTCTCTTATATGAGCCAATATCTGCACTTTGGCCA
AATCTCTCCCCTGTATTTGGCCCTGCAGATTCAATCCATGGGCAATGTTCCTCGTGACAACGTTGATACCTATATCGAAG
AGCTGATTGTGCGGCGGGAGCTGGCCATGAACTTTGCCTACTACACCCCTGACTACGATGCCTATAGTTGTCTCCCCAAC
TGGGCCAAAACGACCTTAGACAACCATCGTCACGATCCCAGAACGCCCTGTTATTCCCTAGAACAGCTGGATGAATCTCG
CACCGAAGACCCCTATTGGAATGCCGCCATGAGGGAAATGAAGCATACGGGCTATATGCATAACTACATGCGCATGTATT
GGGGTAAAAAGATTATTGAATGGACTGAGACCCCAGAGTTGGCCTTCCAAACCGCCTTGGACCTCAACAACAAATACTTT
ATCGATGGCCGCGACGCCAATTCCTACACGGGCGTGGCCTGGGTATTTGGTGTCCATGATCGGGGCTGGCGGGAACGTCC
TATATTTGGCACCGTTCGCTATATGGCCGCTAGCGGCCTCAAACGCAAATGCGATATTGATGGCTATATTAAAAAGGTCA
ATCAGCGGGTTAAAGCCCTCAATCCCTCCCTGAAATAA

Upstream 100 bases:

>100_bases
CATCAAACTGAAAGAAATGCTCATCTAAGAGGTGACGTCCCCATAGATCTTCATCTGAATTCTGCGTTATCACAAATAAG
GCAGAGCAATGATAGAAGAA

Downstream 100 bases:

>100_bases
CAGATAAGTTCCTAAGAAGCGGCTTAAAATCAGGACTCTCGATTGACACTAGGGTTGGAGGACCGTCTTCTGCTAACGTA
TCCAATAGTGTATCGCTAAC

Product: deoxyribodipyrimidine photolyase

Products: NA

Alternate protein names: DNA photolyase; Photoreactivating enzyme [H]

Number of amino acids: Translated: 465; Mature: 464

Protein sequence:

>465_residues
MANSLIEEERIQILNKQDVQPGGYVLYWMQQSQRAEYNHALEYAIQRANDLQQPVVVCFGLMADYPGSNLRHYTFMLEGL
QDTEQALIQRGIKFVMRYGNPDQIALELGKDASLVVCDRGYLRFQRQWRDNVAQNAPCQVVQVESEVVVPVETASVKADY
AARTIRPRIHRHLDRFLVPFASTPVQHSSLHLDLKSLDLSNIEAVLAKLPLDCSVPPVSSLFQGGTTRAKEILEKFLQKS
FAIYADHRNQPQTDDVSYMSQYLHFGQISPLYLALQIQSMGNVPRDNVDTYIEELIVRRELAMNFAYYTPDYDAYSCLPN
WAKTTLDNHRHDPRTPCYSLEQLDESRTEDPYWNAAMREMKHTGYMHNYMRMYWGKKIIEWTETPELAFQTALDLNNKYF
IDGRDANSYTGVAWVFGVHDRGWRERPIFGTVRYMAASGLKRKCDIDGYIKKVNQRVKALNPSLK

Sequences:

>Translated_465_residues
MANSLIEEERIQILNKQDVQPGGYVLYWMQQSQRAEYNHALEYAIQRANDLQQPVVVCFGLMADYPGSNLRHYTFMLEGL
QDTEQALIQRGIKFVMRYGNPDQIALELGKDASLVVCDRGYLRFQRQWRDNVAQNAPCQVVQVESEVVVPVETASVKADY
AARTIRPRIHRHLDRFLVPFASTPVQHSSLHLDLKSLDLSNIEAVLAKLPLDCSVPPVSSLFQGGTTRAKEILEKFLQKS
FAIYADHRNQPQTDDVSYMSQYLHFGQISPLYLALQIQSMGNVPRDNVDTYIEELIVRRELAMNFAYYTPDYDAYSCLPN
WAKTTLDNHRHDPRTPCYSLEQLDESRTEDPYWNAAMREMKHTGYMHNYMRMYWGKKIIEWTETPELAFQTALDLNNKYF
IDGRDANSYTGVAWVFGVHDRGWRERPIFGTVRYMAASGLKRKCDIDGYIKKVNQRVKALNPSLK
>Mature_464_residues
ANSLIEEERIQILNKQDVQPGGYVLYWMQQSQRAEYNHALEYAIQRANDLQQPVVVCFGLMADYPGSNLRHYTFMLEGLQ
DTEQALIQRGIKFVMRYGNPDQIALELGKDASLVVCDRGYLRFQRQWRDNVAQNAPCQVVQVESEVVVPVETASVKADYA
ARTIRPRIHRHLDRFLVPFASTPVQHSSLHLDLKSLDLSNIEAVLAKLPLDCSVPPVSSLFQGGTTRAKEILEKFLQKSF
AIYADHRNQPQTDDVSYMSQYLHFGQISPLYLALQIQSMGNVPRDNVDTYIEELIVRRELAMNFAYYTPDYDAYSCLPNW
AKTTLDNHRHDPRTPCYSLEQLDESRTEDPYWNAAMREMKHTGYMHNYMRMYWGKKIIEWTETPELAFQTALDLNNKYFI
DGRDANSYTGVAWVFGVHDRGWRERPIFGTVRYMAASGLKRKCDIDGYIKKVNQRVKALNPSLK

Specific function: Involved in repair of UV radiation-induced DNA damage. Catalyzes the light-dependent monomerization (300-600 nm) of cyclobutyl pyrimidine dimers (in cis-syn configuration), which are formed between adjacent bases on the same DNA strand upon exposure to ul

COG id: COG0415

COG function: function code L; Deoxyribodipyrimidine photolyase

Gene ontology:
GO:0003904: Deoxyribodipyrimidine photolyase
GO:0003913: Deoxyribodipyrimidine photolyase
GO:0006281: Deoxyribodipyrimidine photolyase
GO:0016829: Deoxyribodipyrimidine photolyase

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 DNA photolyase domain [H]

Homologues:

Organism=Drosophila melanogaster, GI24586398, Length=460, Percent_Identity=40, Blast_Score=327, Evalue=8e-90,
Organism=Drosophila melanogaster, GI24586396, Length=460, Percent_Identity=40, Blast_Score=327, Evalue=9e-90,
Organism=Drosophila melanogaster, GI24586404, Length=157, Percent_Identity=50.3184713375796, Blast_Score=174, Evalue=1e-43,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008148
- InterPro:   IPR006050
- InterPro:   IPR005101
- InterPro:   IPR014729 [H]

Pfam domain/function: PF00875 DNA_photolyase; PF03441 FAD_binding_7 [H]

EC number: =4.1.99.3 [H]

Molecular weight: Translated: 53763; Mature: 53632

Theoretical pI: Translated: 6.99; Mature: 6.99

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MANSLIEEERIQILNKQDVQPGGYVLYWMQQSQRAEYNHALEYAIQRANDLQQPVVVCFG
CCCCHHHHHHHHHHHHCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
LMADYPGSNLRHYTFMLEGLQDTEQALIQRGIKFVMRYGNPDQIALELGKDASLVVCDRG
HHHCCCCCCCEEHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCEEEEECCH
YLRFQRQWRDNVAQNAPCQVVQVESEVVVPVETASVKADYAARTIRPRIHRHLDRFLVPF
HHHHHHHHHHHHCCCCCEEEEEECCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHCC
ASTPVQHSSLHLDLKSLDLSNIEAVLAKLPLDCSVPPVSSLFQGGTTRAKEILEKFLQKS
CCCCCCCCEEEEEHHHCCHHHHHHHHHHCCCCCCCCCHHHHHCCCCHHHHHHHHHHHHHH
FAIYADHRNQPQTDDVSYMSQYLHFGQISPLYLALQIQSMGNVPRDNVDTYIEELIVRRE
HEEEECCCCCCCCCHHHHHHHHHHCCCCCCEEEEEEEHHCCCCCCCHHHHHHHHHHHHHH
LAMNFAYYTPDYDAYSCLPNWAKTTLDNHRHDPRTPCYSLEQLDESRTEDPYWNAAMREM
HHHHEEEECCCCCHHHCCCHHHHHHHHCCCCCCCCCCHHHHHHHHCCCCCCHHHHHHHHH
KHTGYMHNYMRMYWGKKIIEWTETPELAFQTALDLNNKYFIDGRDANSYTGVAWVFGVHD
HHHHHHHHHHHHHHCCHHEECCCCHHHHHHHHHCCCCEEEEECCCCCCCCCEEEEEECCC
RGWRERPIFGTVRYMAASGLKRKCDIDGYIKKVNQRVKALNPSLK
CCCCCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure 
ANSLIEEERIQILNKQDVQPGGYVLYWMQQSQRAEYNHALEYAIQRANDLQQPVVVCFG
CCCHHHHHHHHHHHHCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
LMADYPGSNLRHYTFMLEGLQDTEQALIQRGIKFVMRYGNPDQIALELGKDASLVVCDRG
HHHCCCCCCCEEHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCEEEEECCH
YLRFQRQWRDNVAQNAPCQVVQVESEVVVPVETASVKADYAARTIRPRIHRHLDRFLVPF
HHHHHHHHHHHHCCCCCEEEEEECCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHCC
ASTPVQHSSLHLDLKSLDLSNIEAVLAKLPLDCSVPPVSSLFQGGTTRAKEILEKFLQKS
CCCCCCCCEEEEEHHHCCHHHHHHHHHHCCCCCCCCCHHHHHCCCCHHHHHHHHHHHHHH
FAIYADHRNQPQTDDVSYMSQYLHFGQISPLYLALQIQSMGNVPRDNVDTYIEELIVRRE
HEEEECCCCCCCCCHHHHHHHHHHCCCCCCEEEEEEEHHCCCCCCCHHHHHHHHHHHHHH
LAMNFAYYTPDYDAYSCLPNWAKTTLDNHRHDPRTPCYSLEQLDESRTEDPYWNAAMREM
HHHHEEEECCCCCHHHCCCHHHHHHHHCCCCCCCCCCHHHHHHHHCCCCCCHHHHHHHHH
KHTGYMHNYMRMYWGKKIIEWTETPELAFQTALDLNNKYFIDGRDANSYTGVAWVFGVHD
HHHHHHHHHHHHHHCCHHEECCCCHHHHHHHHHCCCCEEEEECCCCCCCCCEEEEEECCC
RGWRERPIFGTVRYMAASGLKRKCDIDGYIKKVNQRVKALNPSLK
CCCCCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2668276 [H]