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The map label for this gene is fabH

Identifier: 158333843

GI number: 158333843

Start: 640096

End: 641094

Strand: Direct

Name: fabH

Synonym: AM1_0653

Alternate gene names: 158333843

Gene position: 640096-641094 (Clockwise)

Preceding gene: 158333842

Following gene: 158333844

Centisome position: 9.84

GC content: 52.95

Gene sequence:

>999_bases
GTGCAGCAAATGGCCACTGGATTGGCAGTTACTGGGTGCGGCTCTGCTGCTCCTGAGACTTCCCTGGATAATCATGGTCT
GAGCCAAATCGTTGATACCTCTGATGAGTGGATTGCAAGCCGAACGGGCATCCGATCTCGGCACCTCGCGGGTCCAGATG
ACACGTTGGCAAAACTGGGTGCGATCGCAGCCCAAAATGCCTTAGAGATGGCCCAAGTGGAAGCCACTGATCTTGATCTA
ATACTGCTGGCCACTTCGACCCCTGACGATTTGTTTGGTAGTGCCTGTCAGATTCAGGCTGCAATTGGTGCAAAGCATGC
CGTTGCCTTTGACCTCACTGCTGCCTGTTCTGGGTTTGTATTTGGCATGATTACGGCTGCCCAATTTATCCGCACGGGGG
TCTACCGCAATGTCCTCCTGGTCGGAGCTGATGTGCTCTCTCGTTGGGTAGACTGGACCGATCGTCGATCTTGTGTCCTC
TTTGGGGACGGAGCAGGCGCGGTGGTTCTCCAAGCCAATGACACCGATCGCCTGCTCGGATTTGCTTTACACAGCGACGG
CTGTTTACATGATTGCCTCAATGTCCAATATCAGGGCGAGGCACGTCCCTTGACTGGGGAAATTAATGTTAGTCAAGGGA
CATATCAACCTATTTCCATGAATGGGAAGGAAGTCTACCGGTTTGCAGTGAATCGAGTGCCTGAAGTCGTGGAGAAGGCT
CTCTTTCAGTCGGACTTAAAAACGGACGATATTGATTGGTTGCTCTTGCACCAGGCAAATCAGCGCATTCTCGATGCGGT
GGCCAAGCGCCTCAAGGTGCCTGCTGAGAAGGTGATTAGTAATATCGCCAACTATGGCAATACCTCTGCCGCTACGATTC
CTTTAGCGTTGGACGCAACGGTTCGCAAAGGTCATATCAAACCTGGAGATACGATTGCGGCCTCTGGATTTGGGGCTGGC
TTGAGTTGGGGCGCGGCTATCTTTCAGTGGCAGCGCTAG

Upstream 100 bases:

>100_bases
CCATTCGGTTGGCAAAAGAAGCTGCGGATAATCAGGTATCCCAGCGAATTCAGTCTTGCTATCAACAGACGGTGACAGCC
GCCTCCAATGGAGAATAAAC

Downstream 100 bases:

>100_bases
TTGTCGGTTCACAATTTTCTTAAACTGCTGCTGCTAGCCGCTATCTGGGGTAGTTCGTTTCTGTTTACCCGAATTGCAGC
ACCAGAATGGGGGCCGATTT

Product: 3-oxoacyl-[acyl-carrier-protein] synthase 3

Products: NA

Alternate protein names: 3-oxoacyl-[acyl-carrier-protein] synthase III; Beta-ketoacyl-ACP synthase III; KAS III

Number of amino acids: Translated: 332; Mature: 332

Protein sequence:

>332_residues
MQQMATGLAVTGCGSAAPETSLDNHGLSQIVDTSDEWIASRTGIRSRHLAGPDDTLAKLGAIAAQNALEMAQVEATDLDL
ILLATSTPDDLFGSACQIQAAIGAKHAVAFDLTAACSGFVFGMITAAQFIRTGVYRNVLLVGADVLSRWVDWTDRRSCVL
FGDGAGAVVLQANDTDRLLGFALHSDGCLHDCLNVQYQGEARPLTGEINVSQGTYQPISMNGKEVYRFAVNRVPEVVEKA
LFQSDLKTDDIDWLLLHQANQRILDAVAKRLKVPAEKVISNIANYGNTSAATIPLALDATVRKGHIKPGDTIAASGFGAG
LSWGAAIFQWQR

Sequences:

>Translated_332_residues
MQQMATGLAVTGCGSAAPETSLDNHGLSQIVDTSDEWIASRTGIRSRHLAGPDDTLAKLGAIAAQNALEMAQVEATDLDL
ILLATSTPDDLFGSACQIQAAIGAKHAVAFDLTAACSGFVFGMITAAQFIRTGVYRNVLLVGADVLSRWVDWTDRRSCVL
FGDGAGAVVLQANDTDRLLGFALHSDGCLHDCLNVQYQGEARPLTGEINVSQGTYQPISMNGKEVYRFAVNRVPEVVEKA
LFQSDLKTDDIDWLLLHQANQRILDAVAKRLKVPAEKVISNIANYGNTSAATIPLALDATVRKGHIKPGDTIAASGFGAG
LSWGAAIFQWQR
>Mature_332_residues
MQQMATGLAVTGCGSAAPETSLDNHGLSQIVDTSDEWIASRTGIRSRHLAGPDDTLAKLGAIAAQNALEMAQVEATDLDL
ILLATSTPDDLFGSACQIQAAIGAKHAVAFDLTAACSGFVFGMITAAQFIRTGVYRNVLLVGADVLSRWVDWTDRRSCVL
FGDGAGAVVLQANDTDRLLGFALHSDGCLHDCLNVQYQGEARPLTGEINVSQGTYQPISMNGKEVYRFAVNRVPEVVEKA
LFQSDLKTDDIDWLLLHQANQRILDAVAKRLKVPAEKVISNIANYGNTSAATIPLALDATVRKGHIKPGDTIAASGFGAG
LSWGAAIFQWQR

Specific function: Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the

COG id: COG0332

COG function: function code I; 3-oxoacyl-[acyl-carrier-protein] synthase III

Gene ontology:

Cell location: Cytoplasm (Probable)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the fabH family

Homologues:

Organism=Escherichia coli, GI1787333, Length=322, Percent_Identity=40.6832298136646, Blast_Score=259, Evalue=2e-70,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): FABH_ACAM1 (B0CE67)

Other databases:

- EMBL:   CP000828
- RefSeq:   YP_001515015.1
- ProteinModelPortal:   B0CE67
- SMR:   B0CE67
- GeneID:   5679481
- GenomeReviews:   CP000828_GR
- KEGG:   amr:AM1_0653
- HOGENOM:   HBG649927
- OMA:   YIVPHQA
- BioCyc:   AMAR329726:AM1_0653-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_01815
- InterPro:   IPR013751
- InterPro:   IPR013747
- InterPro:   IPR004655
- InterPro:   IPR016039
- InterPro:   IPR016038
- Gene3D:   G3DSA:3.40.47.10
- TIGRFAMs:   TIGR00747

Pfam domain/function: PF08545 ACP_syn_III; PF08541 ACP_syn_III_C; SSF53901 Thiolase-like

EC number: =2.3.1.180

Molecular weight: Translated: 35382; Mature: 35382

Theoretical pI: Translated: 5.13; Mature: 5.13

Prosite motif: NA

Important sites: ACT_SITE 116-116 ACT_SITE 257-257 ACT_SITE 287-287

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQQMATGLAVTGCGSAAPETSLDNHGLSQIVDTSDEWIASRTGIRSRHLAGPDDTLAKLG
CCCHHCCEEEECCCCCCCCCCCCCCCHHHHHCCCHHHHHHHCCCCCCCCCCCCHHHHHHH
AIAAQNALEMAQVEATDLDLILLATSTPDDLFGSACQIQAAIGAKHAVAFDLTAACSGFV
HHHHHHHHHHHHHCCCCCEEEEEEECCCHHHCCCHHEEEHHHCCCHHHEEEHHHHHHHHH
FGMITAAQFIRTGVYRNVLLVGADVLSRWVDWTDRRSCVLFGDGAGAVVLQANDTDRLLG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCEEEEEECCCCCEEE
FALHSDGCLHDCLNVQYQGEARPLTGEINVSQGTYQPISMNGKEVYRFAVNRVPEVVEKA
EEECCCCHHHHHHCCEECCCCCCCEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHH
LFQSDLKTDDIDWLLLHQANQRILDAVAKRLKVPAEKVISNIANYGNTSAATIPLALDAT
HHHHCCCCCCCCEEEEEHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCEEEEEEEECH
VRKGHIKPGDTIAASGFGAGLSWGAAIFQWQR
HHCCCCCCCCEEEECCCCCCHHHHHHHHCCCC
>Mature Secondary Structure
MQQMATGLAVTGCGSAAPETSLDNHGLSQIVDTSDEWIASRTGIRSRHLAGPDDTLAKLG
CCCHHCCEEEECCCCCCCCCCCCCCCHHHHHCCCHHHHHHHCCCCCCCCCCCCHHHHHHH
AIAAQNALEMAQVEATDLDLILLATSTPDDLFGSACQIQAAIGAKHAVAFDLTAACSGFV
HHHHHHHHHHHHHCCCCCEEEEEEECCCHHHCCCHHEEEHHHCCCHHHEEEHHHHHHHHH
FGMITAAQFIRTGVYRNVLLVGADVLSRWVDWTDRRSCVLFGDGAGAVVLQANDTDRLLG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCEEEEEECCCCCEEE
FALHSDGCLHDCLNVQYQGEARPLTGEINVSQGTYQPISMNGKEVYRFAVNRVPEVVEKA
EEECCCCHHHHHHCCEECCCCCCCEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHH
LFQSDLKTDDIDWLLLHQANQRILDAVAKRLKVPAEKVISNIANYGNTSAATIPLALDAT
HHHHCCCCCCCCEEEEEHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCEEEEEEEECH
VRKGHIKPGDTIAASGFGAGLSWGAAIFQWQR
HHCCCCCCCCEEEECCCCCCHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA