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The map label for this gene is flp [H]

Identifier: 158333676

GI number: 158333676

Start: 460374

End: 461066

Strand: Reverse

Name: flp [H]

Synonym: AM1_0480

Alternate gene names: 158333676

Gene position: 461066-460374 (Counterclockwise)

Preceding gene: 158333681

Following gene: 158333673

Centisome position: 7.09

GC content: 49.93

Gene sequence:

>693_bases
ATGATAGACACCGCTAACGTGGCAGATTGGTTGGAGATAACCGTGATTTTTCGCGGCTTATCCGCAGAACAACGCCAGGC
CCTGACCCAAATTGCTCAAATTCAATCCTTTAAGAAGGGTGAGCAAATCTTCCGCCAAGACCAAGAAGCGACGGGATTTT
ATGTGGTGAAGTCGGGGCGAGTCAAAGTCTTTCAGATGTCTGCCAATGGCAAAGAGCAAATTTTGAATATTTTTACCGAG
GGGGATAACTTTGCAGATGTCCCTGCTTTAGATGGCCAAGCCTTTCCGGCTTCCGCTGCAGCCCTAGAACCTGCAGACCT
AATTTTTTTCCCGCGCTACCCGTTTCTGGAGTTTCTCCACCACAACCCCGATGTGGCGGTGCAAATGTTGATTAGCCTCT
CTAGCCACCTGCGCCATCTGGCCCAACTGGTTGAGCAATTGTCATTTAAAAGTGTGCCGCAGCGTTTGGCAACCTACCTG
TTAAGTTTGGGTGATACGGCCAGCGATACGGTCTATCTGGACTTAACCAAAAGCCAACTGGCAGCAAGGCTGGGAACTAT
TCCAGCGACCCTGTCTCGGGCGTTTTATCAACTGAGTAGTGATGGCATGATTGCGATCGCAGGTCCCAAAGTAACGATAC
TGGATCGCGATCGCCTCACAGCATTAAGTCAATCCCCAGAATCCTCCGAATAG

Upstream 100 bases:

>100_bases
GGTAATTAAAAGGTGCAGAGTCTAAGCCAGGGGCTAAAGTGTTGTGGAGGTTACGAACGGACCTTCGTCATACTTGGAAT
TCAGGGCAGAGTGTAGGTAG

Downstream 100 bases:

>100_bases
ATACCGTAGACTTTTGGAGGCAAGGCACCAAAACTCAACTACTCTGATGAAATAGCCGTCGGTAATTACGCTTTTTTACT
CAACTCAAAAGCTGTATTGG

Product: cyclic nucleotide-binding domain-containing protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 230; Mature: 230

Protein sequence:

>230_residues
MIDTANVADWLEITVIFRGLSAEQRQALTQIAQIQSFKKGEQIFRQDQEATGFYVVKSGRVKVFQMSANGKEQILNIFTE
GDNFADVPALDGQAFPASAAALEPADLIFFPRYPFLEFLHHNPDVAVQMLISLSSHLRHLAQLVEQLSFKSVPQRLATYL
LSLGDTASDTVYLDLTKSQLAARLGTIPATLSRAFYQLSSDGMIAIAGPKVTILDRDRLTALSQSPESSE

Sequences:

>Translated_230_residues
MIDTANVADWLEITVIFRGLSAEQRQALTQIAQIQSFKKGEQIFRQDQEATGFYVVKSGRVKVFQMSANGKEQILNIFTE
GDNFADVPALDGQAFPASAAALEPADLIFFPRYPFLEFLHHNPDVAVQMLISLSSHLRHLAQLVEQLSFKSVPQRLATYL
LSLGDTASDTVYLDLTKSQLAARLGTIPATLSRAFYQLSSDGMIAIAGPKVTILDRDRLTALSQSPESSE
>Mature_230_residues
MIDTANVADWLEITVIFRGLSAEQRQALTQIAQIQSFKKGEQIFRQDQEATGFYVVKSGRVKVFQMSANGKEQILNIFTE
GDNFADVPALDGQAFPASAAALEPADLIFFPRYPFLEFLHHNPDVAVQMLISLSSHLRHLAQLVEQLSFKSVPQRLATYL
LSLGDTASDTVYLDLTKSQLAARLGTIPATLSRAFYQLSSDGMIAIAGPKVTILDRDRLTALSQSPESSE

Specific function: Global Transcription Factor That Controls The Expression Of Over 100 Target Genes In Response To Anoxia. It Facilitates The Adaptation To Anaerobic Growth Conditions By Regulating The Expression Of Gene Products That Are Involved In Anaerobic Energy Metab

COG id: COG0664

COG function: function code T; cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH crp-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1787595, Length=199, Percent_Identity=24.6231155778894, Blast_Score=71, Evalue=6e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018490
- InterPro:   IPR000595
- InterPro:   IPR001808
- InterPro:   IPR012318
- InterPro:   IPR014710
- InterPro:   IPR018335
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00027 cNMP_binding; PF00325 Crp [H]

EC number: NA

Molecular weight: Translated: 25350; Mature: 25350

Theoretical pI: Translated: 5.04; Mature: 5.04

Prosite motif: PS50042 CNMP_BINDING_3 ; PS51063 HTH_CRP_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIDTANVADWLEITVIFRGLSAEQRQALTQIAQIQSFKKGEQIFRQDQEATGFYVVKSGR
CCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCC
VKVFQMSANGKEQILNIFTEGDNFADVPALDGQAFPASAAALEPADLIFFPRYPFLEFLH
EEEEEECCCCHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEECCCHHHHHHH
HNPDVAVQMLISLSSHLRHLAQLVEQLSFKSVPQRLATYLLSLGDTASDTVYLDLTKSQL
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEHHHHH
AARLGTIPATLSRAFYQLSSDGMIAIAGPKVTILDRDRLTALSQSPESSE
HHHHCCCHHHHHHHHHHHCCCCEEEEECCEEEEEECHHHHHHHCCCCCCC
>Mature Secondary Structure
MIDTANVADWLEITVIFRGLSAEQRQALTQIAQIQSFKKGEQIFRQDQEATGFYVVKSGR
CCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCC
VKVFQMSANGKEQILNIFTEGDNFADVPALDGQAFPASAAALEPADLIFFPRYPFLEFLH
EEEEEECCCCHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEECCCHHHHHHH
HNPDVAVQMLISLSSHLRHLAQLVEQLSFKSVPQRLATYLLSLGDTASDTVYLDLTKSQL
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEHHHHH
AARLGTIPATLSRAFYQLSSDGMIAIAGPKVTILDRDRLTALSQSPESSE
HHHHCCCHHHHHHHHHHHCCCCEEEEECCEEEEEECHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: Fe [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2113923; 8441692 [H]