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The map label for this gene is uppS [H]

Identifier: 158333613

GI number: 158333613

Start: 388320

End: 389072

Strand: Direct

Name: uppS [H]

Synonym: AM1_0414

Alternate gene names: 158333613

Gene position: 388320-389072 (Clockwise)

Preceding gene: 158333612

Following gene: 158333620

Centisome position: 5.97

GC content: 44.62

Gene sequence:

>753_bases
ATGACGTTAAATTCAAGTCTTCCAAAGCAACTCCCTTCAGACCTAGATGTTCAGCGACTACCCAAACATGTCGCCGTCAT
CATGGATGGTAATGGGCGATGGGCCAAGCAGAGAGGATTACCCCGCATTGTCGGACATCGTCGTGGGGTAGATACCCTGA
AGTCACTCCTGCGTTGTTGCAAAGATTGGGGAGTCCAAGCACTCACAGCGTATGCTTTTTCCACAGAGAATTGGGGACGT
CCGCTTGATGAAGTGGAATTCTTGATGATGCTATTTGAAAGGGTTTTGCGTCGCGAATTACAAGAGATGATTGATGAAGG
CGTACAAATACACTTTGTCGGTGATTTAGAAGCTCTGCCGTTGACGCTACAAACAGAAATACAGCGAGCAATGACTGCGA
CAAAAGACAATCACACCATCAAATTTATCGTCGCCACTAATTACGGAGGTCGTAGAGAAATTATTCAAGCATGCCGCAAT
ATTGCCTCTAAAGTTCAGCATAATCAAATCAACCTGGATGATATTGATGAAAGCTTATTTGAGCGGCATCTATATACAGC
CGGAATTATAGACCCAGACCTGTTAATTCGAACCAGTGGAGAAATGAGAGTCAGTAATTTCCTCTTGTGGCAAATGGCCT
ATGCGGAACTCTATGTTACCAAGACCCTGTGGCCAGACTTCGATCGAGATGAGTTCCATCAAGCCCTTAAAGACTTCCAA
GATAGGCATCGAAGATTTGGTAAAGTCAACTAA

Upstream 100 bases:

>100_bases
TTGTCACCCCAAGCTTGAGAAGTTTAGGCAGGAAAATCAGAAAACAAATCTTTTCTTTGCTTTCTCTCATATTCCCATTG
CTCAAATCTCGCAAGAATAT

Downstream 100 bases:

>100_bases
TCATTTAGTAAGATGCTGCATATTTTGCATAAATTACTGATAAGCCTAAGTAAGCCCAGTTCAGATTAAGTCCATTTTTT
AAGGTTCTTCTACTGAAGAA

Product: undecaprenyl pyrophosphate synthase

Products: NA

Alternate protein names: UPP synthase; Di-trans,poly-cis-decaprenylcistransferase; Undecaprenyl diphosphate synthase; UDS [H]

Number of amino acids: Translated: 250; Mature: 249

Protein sequence:

>250_residues
MTLNSSLPKQLPSDLDVQRLPKHVAVIMDGNGRWAKQRGLPRIVGHRRGVDTLKSLLRCCKDWGVQALTAYAFSTENWGR
PLDEVEFLMMLFERVLRRELQEMIDEGVQIHFVGDLEALPLTLQTEIQRAMTATKDNHTIKFIVATNYGGRREIIQACRN
IASKVQHNQINLDDIDESLFERHLYTAGIIDPDLLIRTSGEMRVSNFLLWQMAYAELYVTKTLWPDFDRDEFHQALKDFQ
DRHRRFGKVN

Sequences:

>Translated_250_residues
MTLNSSLPKQLPSDLDVQRLPKHVAVIMDGNGRWAKQRGLPRIVGHRRGVDTLKSLLRCCKDWGVQALTAYAFSTENWGR
PLDEVEFLMMLFERVLRRELQEMIDEGVQIHFVGDLEALPLTLQTEIQRAMTATKDNHTIKFIVATNYGGRREIIQACRN
IASKVQHNQINLDDIDESLFERHLYTAGIIDPDLLIRTSGEMRVSNFLLWQMAYAELYVTKTLWPDFDRDEFHQALKDFQ
DRHRRFGKVN
>Mature_249_residues
TLNSSLPKQLPSDLDVQRLPKHVAVIMDGNGRWAKQRGLPRIVGHRRGVDTLKSLLRCCKDWGVQALTAYAFSTENWGRP
LDEVEFLMMLFERVLRRELQEMIDEGVQIHFVGDLEALPLTLQTEIQRAMTATKDNHTIKFIVATNYGGRREIIQACRNI
ASKVQHNQINLDDIDESLFERHLYTAGIIDPDLLIRTSGEMRVSNFLLWQMAYAELYVTKTLWPDFDRDEFHQALKDFQD
RHRRFGKVN

Specific function: Generates undecaprenyl pyrophosphate (UPP) from isopentenyl pyrophosphate (IPP). UPP is the precursor of glycosyl carrier lipid in the biosynthesis of bacterial cell wall polysaccharide components such as peptidoglycan and lipopolysaccharide [H]

COG id: COG0020

COG function: function code I; Undecaprenyl pyrophosphate synthase

Gene ontology:
GO:0008834: Undecaprenyl diphosphate synthase
GO:0016740: Undecaprenyl diphosphate synthase
GO:0016765: Undecaprenyl diphosphate synthase
GO:0004845: Uracil phosphoribosyltransferase
GO:0005524: Uracil phosphoribosyltransferase
GO:0006223: Uracil phosphoribosyltransferase
GO:0016757: Uracil phosphoribosyltransferase
GO:0016773: Uracil phosphoribosyltransferase

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UPP synthase family [H]

Homologues:

Organism=Homo sapiens, GI45580742, Length=228, Percent_Identity=41.2280701754386, Blast_Score=163, Evalue=1e-40,
Organism=Homo sapiens, GI45580738, Length=228, Percent_Identity=41.2280701754386, Blast_Score=163, Evalue=1e-40,
Organism=Escherichia coli, GI1786371, Length=234, Percent_Identity=44.4444444444444, Blast_Score=213, Evalue=1e-56,
Organism=Caenorhabditis elegans, GI71993029, Length=226, Percent_Identity=34.9557522123894, Blast_Score=134, Evalue=6e-32,
Organism=Saccharomyces cerevisiae, GI6319474, Length=213, Percent_Identity=38.9671361502347, Blast_Score=128, Evalue=9e-31,
Organism=Saccharomyces cerevisiae, GI6323748, Length=221, Percent_Identity=35.7466063348416, Blast_Score=112, Evalue=7e-26,
Organism=Drosophila melanogaster, GI18857969, Length=211, Percent_Identity=41.7061611374408, Blast_Score=153, Evalue=9e-38,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001441
- InterPro:   IPR018520 [H]

Pfam domain/function: PF01255 Prenyltransf [H]

EC number: =2.5.1.31 [H]

Molecular weight: Translated: 29052; Mature: 28921

Theoretical pI: Translated: 7.25; Mature: 7.25

Prosite motif: PS01066 UPP_SYNTHETASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTLNSSLPKQLPSDLDVQRLPKHVAVIMDGNGRWAKQRGLPRIVGHRRGVDTLKSLLRCC
CCCCCCCHHHCCCCCCHHHCCCCEEEEECCCCCCHHHCCCHHHHHCCCCHHHHHHHHHHH
KDWGVQALTAYAFSTENWGRPLDEVEFLMMLFERVLRRELQEMIDEGVQIHFVGDLEALP
HHHCHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCC
LTLQTEIQRAMTATKDNHTIKFIVATNYGGRREIIQACRNIASKVQHNQINLDDIDESLF
HHHHHHHHHHHHHCCCCCEEEEEEEECCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHH
ERHLYTAGIIDPDLLIRTSGEMRVSNFLLWQMAYAELYVTKTLWPDFDRDEFHQALKDFQ
HHHHHHCCCCCCCCEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHH
DRHRRFGKVN
HHHHHCCCCC
>Mature Secondary Structure 
TLNSSLPKQLPSDLDVQRLPKHVAVIMDGNGRWAKQRGLPRIVGHRRGVDTLKSLLRCC
CCCCCCHHHCCCCCCHHHCCCCEEEEECCCCCCHHHCCCHHHHHCCCCHHHHHHHHHHH
KDWGVQALTAYAFSTENWGRPLDEVEFLMMLFERVLRRELQEMIDEGVQIHFVGDLEALP
HHHCHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCC
LTLQTEIQRAMTATKDNHTIKFIVATNYGGRREIIQACRNIASKVQHNQINLDDIDESLF
HHHHHHHHHHHHHCCCCCEEEEEEEECCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHH
ERHLYTAGIIDPDLLIRTSGEMRVSNFLLWQMAYAELYVTKTLWPDFDRDEFHQALKDFQ
HHHHHHCCCCCCCCEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHH
DRHRRFGKVN
HHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12240834 [H]