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The map label for this gene is lysA [H]

Identifier: 158333611

GI number: 158333611

Start: 385914

End: 387296

Strand: Direct

Name: lysA [H]

Synonym: AM1_0412

Alternate gene names: 158333611

Gene position: 385914-387296 (Clockwise)

Preceding gene: 158333610

Following gene: 158333612

Centisome position: 5.93

GC content: 46.35

Gene sequence:

>1383_bases
ATGGTATCCCTCCAACCACCAGATATCAGCTCATCTACTCCAATCGCGGAGACCTCTCCCAATCAACAAATACTTCCCCT
ATCTGCCAAAATTGATCAAACAGGACAGATGGTTATTGGTGGATGTTTGGTTACCGATCTCGTTAAGCAATTTGGCTCTC
CCCTATACATCGTAGATGAACTCACCCTAAGGACTGCCTGCCAACAGTACCGTCTCTCATTTCAAAAATTCTATCCTGGA
CCATCTCAAATCCTCTACGCCTCCAAAGCCTGGAGCTGTATGGCTATCTCCGCACTAGTCGCTAATGAGGGCTTAGGACT
AGATGTAGTATCGGGTGGTGAACTATACACCGCCCTACAAGCAGGCGTGGATCCTGAAACGATCTATTTTCACGGCAATA
ACAAATCAGTGCCTGAGCTGGAAATGGCGCTGTCTTGTGGCTGTACCATCATTGCGGATAACTGGCTTGAATTAGAACAA
CTCACAGAACTCCTCGACACAATCGATGCCTTGCCAAACCCTCCTCGGGTCATGCTCAGAATTACCCCTGGTATTGAATG
CCATACTCATGAATATATTCGAACAGGCCATCTAGATAGTAAATTCGGTTTTGACCCGAACCAAATCGATCAGGCCTTGT
CCTTCGCTCAAAAAAACCCTCAAATTACTTGGGTTGGCTTTCATGCTCATATCGGGTCTCAAATCTTTGAACTGCAACCT
CATCAAGATCTCACCAGTGTGATTGTCGAGTGGTTAGCTAAAGCACAAGCTTTAGGCTTATCCATGAACGAACTCAACAT
CGGTGGCGGTCTAGGCATTCGTTATGTTGAGTCAGATGACCCACCCAGCATCGCTCAATGGTCAGAAATCGTCTGCAACG
GCATTTCACAAGCCTGCCAAACAGCCAATATTCCACTTCCAAAGCTACTCTGCGAACCAGGACGCTCCCTAGTAGGTACA
TCCTGCATTACAGCTTACACGGTGGGAGCCAAAAAGAACATTCCCGATATCCGCACTTATCTTTCTGTAGATGGTGGAAT
GTCCGATAATCCCCGCCCCATTACGTACCAATCCGTTTACAGTGCTGCCATTGCCAACCACATGGACTCTTCTGCCACAG
AGATCGTCACCGTAGCAGGTAAACATTGTGAATCTGGGGATGTCTTGCTGAAAGATATCCCTCTTCCTCCAAGTCAACCC
GGAGATATTCTGGTAGTAATGGGAACAGGAGCATACAATTACAGCATGGCATCCAATTACAATCGAATCTCGCGACCTGC
TGCCGTTCTTGTACAAAACGGAGATGCCAATTTAATTCTTAAGAGAGAAACTTATCAAGACCTTATTCGTCAAGATTGTT
TGCCAAGACATTTAGAGCCATAG

Upstream 100 bases:

>100_bases
GACACGGCAATAGAGACATCTGAATATGATAAGATCCTCGGATGGCTCTTACCGAGTTCAATCCTATCCTGGCAAAGTCT
AAGCCCATTCCGGTTAGTTT

Downstream 100 bases:

>100_bases
GTTGGTTAAACCTCATAGCGATAACCAAGCTAGCCCTCTATTCTCTAATTATTGCACTAATTACTGATAACGCTAAACTG
ACATAGGTATACGAGAAGGT

Product: diaminopimelate decarboxylase

Products: NA

Alternate protein names: DAP decarboxylase [H]

Number of amino acids: Translated: 460; Mature: 460

Protein sequence:

>460_residues
MVSLQPPDISSSTPIAETSPNQQILPLSAKIDQTGQMVIGGCLVTDLVKQFGSPLYIVDELTLRTACQQYRLSFQKFYPG
PSQILYASKAWSCMAISALVANEGLGLDVVSGGELYTALQAGVDPETIYFHGNNKSVPELEMALSCGCTIIADNWLELEQ
LTELLDTIDALPNPPRVMLRITPGIECHTHEYIRTGHLDSKFGFDPNQIDQALSFAQKNPQITWVGFHAHIGSQIFELQP
HQDLTSVIVEWLAKAQALGLSMNELNIGGGLGIRYVESDDPPSIAQWSEIVCNGISQACQTANIPLPKLLCEPGRSLVGT
SCITAYTVGAKKNIPDIRTYLSVDGGMSDNPRPITYQSVYSAAIANHMDSSATEIVTVAGKHCESGDVLLKDIPLPPSQP
GDILVVMGTGAYNYSMASNYNRISRPAAVLVQNGDANLILKRETYQDLIRQDCLPRHLEP

Sequences:

>Translated_460_residues
MVSLQPPDISSSTPIAETSPNQQILPLSAKIDQTGQMVIGGCLVTDLVKQFGSPLYIVDELTLRTACQQYRLSFQKFYPG
PSQILYASKAWSCMAISALVANEGLGLDVVSGGELYTALQAGVDPETIYFHGNNKSVPELEMALSCGCTIIADNWLELEQ
LTELLDTIDALPNPPRVMLRITPGIECHTHEYIRTGHLDSKFGFDPNQIDQALSFAQKNPQITWVGFHAHIGSQIFELQP
HQDLTSVIVEWLAKAQALGLSMNELNIGGGLGIRYVESDDPPSIAQWSEIVCNGISQACQTANIPLPKLLCEPGRSLVGT
SCITAYTVGAKKNIPDIRTYLSVDGGMSDNPRPITYQSVYSAAIANHMDSSATEIVTVAGKHCESGDVLLKDIPLPPSQP
GDILVVMGTGAYNYSMASNYNRISRPAAVLVQNGDANLILKRETYQDLIRQDCLPRHLEP
>Mature_460_residues
MVSLQPPDISSSTPIAETSPNQQILPLSAKIDQTGQMVIGGCLVTDLVKQFGSPLYIVDELTLRTACQQYRLSFQKFYPG
PSQILYASKAWSCMAISALVANEGLGLDVVSGGELYTALQAGVDPETIYFHGNNKSVPELEMALSCGCTIIADNWLELEQ
LTELLDTIDALPNPPRVMLRITPGIECHTHEYIRTGHLDSKFGFDPNQIDQALSFAQKNPQITWVGFHAHIGSQIFELQP
HQDLTSVIVEWLAKAQALGLSMNELNIGGGLGIRYVESDDPPSIAQWSEIVCNGISQACQTANIPLPKLLCEPGRSLVGT
SCITAYTVGAKKNIPDIRTYLSVDGGMSDNPRPITYQSVYSAAIANHMDSSATEIVTVAGKHCESGDVLLKDIPLPPSQP
GDILVVMGTGAYNYSMASNYNRISRPAAVLVQNGDANLILKRETYQDLIRQDCLPRHLEP

Specific function: Lysine biosynthesis; last step. [C]

COG id: COG0019

COG function: function code E; Diaminopimelate decarboxylase

Gene ontology:
GO:0005488: Saccharopine dehydrogenase
GO:0003824: Diaminopimelate decarboxylase
GO:0008836: Diaminopimelate decarboxylase
GO:0009085: Diaminopimelate decarboxylase
GO:0009089: Diaminopimelate decarboxylase
GO:0016829: Diaminopimelate decarboxylase
GO:0016831: Diaminopimelate decarboxylase
GO:0016491: Saccharopine dehydrogenase
GO:0055114: Saccharopine dehydrogenase

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Orn/Lys/Arg decarboxylase class-II family [H]

Homologues:

Organism=Escherichia coli, GI1789203, Length=421, Percent_Identity=29.4536817102138, Blast_Score=138, Evalue=8e-34,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009006
- InterPro:   IPR002986
- InterPro:   IPR022643
- InterPro:   IPR022644
- InterPro:   IPR022653
- InterPro:   IPR000183 [H]

Pfam domain/function: PF02784 Orn_Arg_deC_N; PF00278 Orn_DAP_Arg_deC [H]

EC number: =4.1.1.20 [H]

Molecular weight: Translated: 49985; Mature: 49985

Theoretical pI: Translated: 4.62; Mature: 4.62

Prosite motif: PS00879 ODR_DC_2_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.6 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
2.6 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVSLQPPDISSSTPIAETSPNQQILPLSAKIDQTGQMVIGGCLVTDLVKQFGSPLYIVDE
CCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCEEEHHHHHHHHHHHHCCCEEEEHH
LTLRTACQQYRLSFQKFYPGPSQILYASKAWSCMAISALVANEGLGLDVVSGGELYTALQ
HHHHHHHHHHHHHHHHCCCCHHHEEEECCCCHHHHHHHHHHCCCCCEEEECCCHHHHHHH
AGVDPETIYFHGNNKSVPELEMALSCGCTIIADNWLELEQLTELLDTIDALPNPPRVMLR
CCCCCCEEEEECCCCCCCHHHHHHHCCEEEEECCCCCHHHHHHHHHHHHCCCCCCEEEEE
ITPGIECHTHEYIRTGHLDSKFGFDPNQIDQALSFAQKNPQITWVGFHAHIGSQIFELQP
ECCCCEECCHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCCEEEEEEEHHHCCHHEECCC
HQDLTSVIVEWLAKAQALGLSMNELNIGGGLGIRYVESDDPPSIAQWSEIVCNGISQACQ
CCHHHHHHHHHHHHHHHHCCCHHEEECCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHH
TANIPLPKLLCEPGRSLVGTSCITAYTVGAKKNIPDIRTYLSVDGGMSDNPRPITYQSVY
HCCCCHHHHHHCCCCHHHCCHHHHEEECCCCCCCCHHHHEEEECCCCCCCCCCEEHHHHH
SAAIANHMDSSATEIVTVAGKHCESGDVLLKDIPLPPSQPGDILVVMGTGAYNYSMASNY
HHHHHHHCCCCCCEEEEEECCCCCCCCEEEEECCCCCCCCCCEEEEEECCCEECHHHCCC
NRISRPAAVLVQNGDANLILKRETYQDLIRQDCLPRHLEP
CHHCCCEEEEEECCCCCEEEEHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure
MVSLQPPDISSSTPIAETSPNQQILPLSAKIDQTGQMVIGGCLVTDLVKQFGSPLYIVDE
CCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCEEEHHHHHHHHHHHHCCCEEEEHH
LTLRTACQQYRLSFQKFYPGPSQILYASKAWSCMAISALVANEGLGLDVVSGGELYTALQ
HHHHHHHHHHHHHHHHCCCCHHHEEEECCCCHHHHHHHHHHCCCCCEEEECCCHHHHHHH
AGVDPETIYFHGNNKSVPELEMALSCGCTIIADNWLELEQLTELLDTIDALPNPPRVMLR
CCCCCCEEEEECCCCCCCHHHHHHHCCEEEEECCCCCHHHHHHHHHHHHCCCCCCEEEEE
ITPGIECHTHEYIRTGHLDSKFGFDPNQIDQALSFAQKNPQITWVGFHAHIGSQIFELQP
ECCCCEECCHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCCEEEEEEEHHHCCHHEECCC
HQDLTSVIVEWLAKAQALGLSMNELNIGGGLGIRYVESDDPPSIAQWSEIVCNGISQACQ
CCHHHHHHHHHHHHHHHHCCCHHEEECCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHH
TANIPLPKLLCEPGRSLVGTSCITAYTVGAKKNIPDIRTYLSVDGGMSDNPRPITYQSVY
HCCCCHHHHHHCCCCHHHCCHHHHEEECCCCCCCCHHHHEEEECCCCCCCCCCEEHHHHH
SAAIANHMDSSATEIVTVAGKHCESGDVLLKDIPLPPSQPGDILVVMGTGAYNYSMASNY
HHHHHHHCCCCCCEEEEEECCCCCCCCEEEEECCCCCCCCCCEEEEEECCCEECHHHCCC
NRISRPAAVLVQNGDANLILKRETYQDLIRQDCLPRHLEP
CHHCCCEEEEEECCCCCEEEEHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8590279; 8905231 [H]