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The map label for this gene is mprA [H]

Identifier: 158333593

GI number: 158333593

Start: 367434

End: 367805

Strand: Direct

Name: mprA [H]

Synonym: AM1_0394

Alternate gene names: 158333593

Gene position: 367434-367805 (Clockwise)

Preceding gene: 158333592

Following gene: 158333597

Centisome position: 5.65

GC content: 50.27

Gene sequence:

>372_bases
ATGACCCCCCACATATTGCTGGTTGAAGATGAAGTTAGAATTGCTCAGCTCGTTGAACTGGAATTATCCGATGCAGGGTA
TCAAGTCAATATTGCCCATGATGGCCAAGTCGGCTTAGAACTTGCCCAGGCCATCCAACCAGATGCCATCGTTCTGGATT
GGACCCTGCCAAATTTGACAGGTTTAGAAATATGTCAGCAACTTCGGGCAACCGGGAATGCAGTTCCGATTGTGTTTGCG
ACCGCCATGGATGATCAACCCCATCGTCAAGCGGCTATGGCCGCAGGTGCCAATGCCTATGTTGTCAAACCCTACAGTAT
TAGCGATTTGATGGAGACCCTGACTGCTCAGCTTCCCAGCGCTGCCGCTTAA

Upstream 100 bases:

>100_bases
AGCTGACTATCCCTTATCGGATACTCCTAGGTCGAGCTATAGATTCTAAGGGTTAGAAACGCGCTGGTAATTTCCACCAA
AACAAAACACCTTTAAAACC

Downstream 100 bases:

>100_bases
ATTCCTAGGGAGAATTAACTGTTGGTAAAGACACGGTAACGGTAGTGCCACTAGCAGCTGAAGATTGGATTACTAATTCG
CCACCATGGGTCTCCACAAT

Product: two-component response regulator

Products: NA

Alternate protein names: Mycobacterial persistence regulator A [H]

Number of amino acids: Translated: 123; Mature: 122

Protein sequence:

>123_residues
MTPHILLVEDEVRIAQLVELELSDAGYQVNIAHDGQVGLELAQAIQPDAIVLDWTLPNLTGLEICQQLRATGNAVPIVFA
TAMDDQPHRQAAMAAGANAYVVKPYSISDLMETLTAQLPSAAA

Sequences:

>Translated_123_residues
MTPHILLVEDEVRIAQLVELELSDAGYQVNIAHDGQVGLELAQAIQPDAIVLDWTLPNLTGLEICQQLRATGNAVPIVFA
TAMDDQPHRQAAMAAGANAYVVKPYSISDLMETLTAQLPSAAA
>Mature_122_residues
TPHILLVEDEVRIAQLVELELSDAGYQVNIAHDGQVGLELAQAIQPDAIVLDWTLPNLTGLEICQQLRATGNAVPIVFAT
AMDDQPHRQAAMAAGANAYVVKPYSISDLMETLTAQLPSAAA

Specific function: Member of the two-component regulatory system mprB/mprA which contributes to maintaining a balance among several systems involved in stress resistance and is required for establishment and maintenance of persistent infection in the host. Functions as a tr

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI87082012, Length=115, Percent_Identity=40.8695652173913, Blast_Score=81, Evalue=2e-17,
Organism=Escherichia coli, GI1786784, Length=120, Percent_Identity=33.3333333333333, Blast_Score=80, Evalue=3e-17,
Organism=Escherichia coli, GI1790860, Length=102, Percent_Identity=37.2549019607843, Blast_Score=72, Evalue=1e-14,
Organism=Escherichia coli, GI1788394, Length=105, Percent_Identity=37.1428571428571, Blast_Score=69, Evalue=6e-14,
Organism=Escherichia coli, GI1789809, Length=119, Percent_Identity=31.9327731092437, Blast_Score=69, Evalue=7e-14,
Organism=Escherichia coli, GI1789402, Length=113, Percent_Identity=31.858407079646, Blast_Score=68, Evalue=2e-13,
Organism=Escherichia coli, GI1786911, Length=120, Percent_Identity=35, Blast_Score=67, Evalue=2e-13,
Organism=Escherichia coli, GI1786599, Length=118, Percent_Identity=31.3559322033898, Blast_Score=65, Evalue=9e-13,
Organism=Escherichia coli, GI1788191, Length=115, Percent_Identity=34.7826086956522, Blast_Score=65, Evalue=1e-12,
Organism=Escherichia coli, GI1788550, Length=107, Percent_Identity=26.1682242990654, Blast_Score=64, Evalue=2e-12,
Organism=Escherichia coli, GI1787375, Length=113, Percent_Identity=29.2035398230088, Blast_Score=63, Evalue=6e-12,

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 13133; Mature: 13002

Theoretical pI: Translated: 3.97; Mature: 3.97

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTPHILLVEDEVRIAQLVELELSDAGYQVNIAHDGQVGLELAQAIQPDAIVLDWTLPNLT
CCCCEEEEECCCCEEHHEEEEECCCCEEEEEEECCCHHHHHHHHCCCCEEEEEECCCCCC
GLEICQQLRATGNAVPIVFATAMDDQPHRQAAMAAGANAYVVKPYSISDLMETLTAQLPS
HHHHHHHHHHCCCCEEEEEEEECCCCCHHHHHHHCCCCEEEECCCCHHHHHHHHHHCCCC
AAA
CCC
>Mature Secondary Structure 
TPHILLVEDEVRIAQLVELELSDAGYQVNIAHDGQVGLELAQAIQPDAIVLDWTLPNLT
CCCEEEEECCCCEEHHEEEEECCCCEEEEEEECCCHHHHHHHHCCCCEEEEEECCCCCC
GLEICQQLRATGNAVPIVFATAMDDQPHRQAAMAAGANAYVVKPYSISDLMETLTAQLPS
HHHHHHHHHHCCCCEEEEEEEECCCCCHHHHHHHCCCCEEEECCCCHHHHHHHHHHCCCC
AAA
CCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA