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The map label for this gene is folP [H]

Identifier: 158333416

GI number: 158333416

Start: 190047

End: 190907

Strand: Reverse

Name: folP [H]

Synonym: AM1_0188

Alternate gene names: 158333416

Gene position: 190907-190047 (Counterclockwise)

Preceding gene: 158333417

Following gene: 158333415

Centisome position: 2.94

GC content: 51.57

Gene sequence:

>861_bases
ATGAATGTTCCTGCCCATATTCCATCCTGGACGCTTCGCAATCAAACCTTTGCCTGGGGAAGTCGCACCTATTTAATGGG
AATTTTGAACGTAACCCCGGATAGTTTTAGTGATGGTGGCCAATTTAACTCCCAATCCGCAGCTCTATCTCAGGCCCATC
ACCTGGTAAAAGCTGGTATCGACATTCTCGATATTGGGGGGCAATCCACTCGTCCTCAAGCCATTGAAATTGCTGAGGCA
GAAGAGTTAGATCGGGTCATTCCTGTTATTCAGGCGATTCGGTCTCAACTAGACGTTCCCATTTCGGTGGATACGACACG
ATCCTCCGTAGCAGCAGCTGCGATCGCAGCCGGAGCCGATCTCGTCAACGATGTCTCGGGTGGCACTTATGATCCACAGA
TGTTGTCCACCGTTGCCCATCTACAGGTCCCGATTATTTTGATGCATATGCGGGGCACCCCCCAAACCATGCAACAACTC
ACAGCCTATCAGGACATGATTAAGGACATTATTGACTTCTTGCAACAGCAAATCGATGCTGCCCTGGTCGCGGGCATCCC
TAGAGAGTTCCTGGCGATTGATCCAGGCATTGGGTTTGCTAAAACTGGCCCCCAAAACCTATCCCTACTGCGCGAAATCG
CACAGTTTAAGGTTTTAGGTTGTCCTATTCTGGTGGGACCTTCCCGAAAGAGCTTTATCGGTCAAATCCTAAATCAGCCA
GATCCGCAACAACGCGTATGGGGAACGGCTGCTGCCTGTTGCGCGGCCATTCAAGGTGGTGCCGACATCCTCCGCATTCA
TGATGGAGCAGCCATGAGGGAGGTTTGCCAGGTAGCAGACGCGATTTGGCGGACCGTGTGA

Upstream 100 bases:

>100_bases
GGCTTCTCTTGTAAATGCATCCATGTAAATATTTACAGGAGTTTTGAACCTTAAACTGTTCAGTGAATGAGTGCTGTGCC
ATCCCCTTTTATCTATACCT

Downstream 100 bases:

>100_bases
TCGATGCAAAGTCCTTTTGTTAAGATTGACTTAGAGCGTCTCTGGCTTTTATTCTGAGACTAACGTAAACTTTCTTAACA
TTTCCGGATCACCAACCATG

Product: dihydropteroate synthase

Products: NA

Alternate protein names: DHPS; Dihydropteroate pyrophosphorylase [H]

Number of amino acids: Translated: 286; Mature: 286

Protein sequence:

>286_residues
MNVPAHIPSWTLRNQTFAWGSRTYLMGILNVTPDSFSDGGQFNSQSAALSQAHHLVKAGIDILDIGGQSTRPQAIEIAEA
EELDRVIPVIQAIRSQLDVPISVDTTRSSVAAAAIAAGADLVNDVSGGTYDPQMLSTVAHLQVPIILMHMRGTPQTMQQL
TAYQDMIKDIIDFLQQQIDAALVAGIPREFLAIDPGIGFAKTGPQNLSLLREIAQFKVLGCPILVGPSRKSFIGQILNQP
DPQQRVWGTAAACCAAIQGGADILRIHDGAAMREVCQVADAIWRTV

Sequences:

>Translated_286_residues
MNVPAHIPSWTLRNQTFAWGSRTYLMGILNVTPDSFSDGGQFNSQSAALSQAHHLVKAGIDILDIGGQSTRPQAIEIAEA
EELDRVIPVIQAIRSQLDVPISVDTTRSSVAAAAIAAGADLVNDVSGGTYDPQMLSTVAHLQVPIILMHMRGTPQTMQQL
TAYQDMIKDIIDFLQQQIDAALVAGIPREFLAIDPGIGFAKTGPQNLSLLREIAQFKVLGCPILVGPSRKSFIGQILNQP
DPQQRVWGTAAACCAAIQGGADILRIHDGAAMREVCQVADAIWRTV
>Mature_286_residues
MNVPAHIPSWTLRNQTFAWGSRTYLMGILNVTPDSFSDGGQFNSQSAALSQAHHLVKAGIDILDIGGQSTRPQAIEIAEA
EELDRVIPVIQAIRSQLDVPISVDTTRSSVAAAAIAAGADLVNDVSGGTYDPQMLSTVAHLQVPIILMHMRGTPQTMQQL
TAYQDMIKDIIDFLQQQIDAALVAGIPREFLAIDPGIGFAKTGPQNLSLLREIAQFKVLGCPILVGPSRKSFIGQILNQP
DPQQRVWGTAAACCAAIQGGADILRIHDGAAMREVCQVADAIWRTV

Specific function: DHPS catalyzes the formation of the immediate precursor of folic acid. It is implicated in resistance to sulfonamide [H]

COG id: COG0294

COG function: function code H; Dihydropteroate synthase and related enzymes

Gene ontology:
GO:0004156: Dihydropteroate synthase
GO:0009396: Dihydropteroate synthase
GO:0042558: Dihydropteroate synthase
GO:0044237: Dihydropteroate synthase

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 pterin-binding domain [H]

Homologues:

Organism=Escherichia coli, GI87082224, Length=272, Percent_Identity=43.0147058823529, Blast_Score=216, Evalue=2e-57,
Organism=Saccharomyces cerevisiae, GI6324073, Length=320, Percent_Identity=36.5625, Blast_Score=186, Evalue=3e-48,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006390
- InterPro:   IPR011005
- InterPro:   IPR000489 [H]

Pfam domain/function: PF00809 Pterin_bind [H]

EC number: =2.5.1.15 [H]

Molecular weight: Translated: 30697; Mature: 30697

Theoretical pI: Translated: 5.24; Mature: 5.24

Prosite motif: PS50972 PTERIN_BINDING ; PS00792 DHPS_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNVPAHIPSWTLRNQTFAWGSRTYLMGILNVTPDSFSDGGQFNSQSAALSQAHHLVKAGI
CCCCCCCCCCEECCCEECCCCCEEEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHCC
DILDIGGQSTRPQAIEIAEAEELDRVIPVIQAIRSQLDVPISVDTTRSSVAAAAIAAGAD
CEEECCCCCCCCCCEEHHHHHHHHHHHHHHHHHHHHCCCCEEECCCHHHHHHHHHHHHHH
LVNDVSGGTYDPQMLSTVAHLQVPIILMHMRGTPQTMQQLTAYQDMIKDIIDFLQQQIDA
HHHHCCCCCCCHHHHHHHHHHHHCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
ALVAGIPREFLAIDPGIGFAKTGPQNLSLLREIAQFKVLGCPILVGPSRKSFIGQILNQP
HHHHCCCHHHEEECCCCCCCCCCCHHHHHHHHHHHHHHHCCCEEECCCHHHHHHHHHCCC
DPQQRVWGTAAACCAAIQGGADILRIHDGAAMREVCQVADAIWRTV
CHHHHHHHHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MNVPAHIPSWTLRNQTFAWGSRTYLMGILNVTPDSFSDGGQFNSQSAALSQAHHLVKAGI
CCCCCCCCCCEECCCEECCCCCEEEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHCC
DILDIGGQSTRPQAIEIAEAEELDRVIPVIQAIRSQLDVPISVDTTRSSVAAAAIAAGAD
CEEECCCCCCCCCCEEHHHHHHHHHHHHHHHHHHHHCCCCEEECCCHHHHHHHHHHHHHH
LVNDVSGGTYDPQMLSTVAHLQVPIILMHMRGTPQTMQQLTAYQDMIKDIIDFLQQQIDA
HHHHCCCCCCCHHHHHHHHHHHHCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
ALVAGIPREFLAIDPGIGFAKTGPQNLSLLREIAQFKVLGCPILVGPSRKSFIGQILNQP
HHHHCCCHHHEEECCCCCCCCCCCHHHHHHHHHHHHHHHCCCEEECCCHHHHHHHHHCCC
DPQQRVWGTAAACCAAIQGGADILRIHDGAAMREVCQVADAIWRTV
CHHHHHHHHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]