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The map label for this gene is typA [H]

Identifier: 158333297

GI number: 158333297

Start: 63308

End: 65101

Strand: Reverse

Name: typA [H]

Synonym: AM1_0067

Alternate gene names: 158333297

Gene position: 65101-63308 (Counterclockwise)

Preceding gene: 158333301

Following gene: 158333296

Centisome position: 1.0

GC content: 50.5

Gene sequence:

>1794_bases
ATGACGCTCCTTCCGATTCGTAACGTCGCCATTATTGCCCACGTTGATCACGGCAAAACGACCCTCGTTGATGCCCTACT
GAAGCAAGCCGGCACCTTCCGTGAAGGAGAGGATGTTCCCGATTGCGTCATGGACTCTAACGATTTAGAGCGGGAACGGG
GTATTACCATTTTGTCCAAGAATACGGCGGTTACCTACAAAGAGACCCTGATTAATATTGTTGATACCCCAGGACACGCT
GACTTTGGCGGGGAAGTGGAACGGGTGTTAGGCATGGTGGATGGCTGTCTGCTGATTGTGGATGCCAACGAAGGCCCTAT
GCCCCAAACGCGGTTTGTATTGAAAAAAGCCTTGGAAAAGGGTTTACGGCCGATTGTTCTCGTGAATAAAATTGACCGTC
CCCAAGCGGATCCTCATGGTGCAGTAGACAAGGTCCTTGATCTATTTATAGAACTGGGAGCGGATGATGATCAGTGCGAT
TTCCCTTATCTATTTGCCTCTGGCTTGGATGGCTATGCCAAGGAAGATTTAGACGCCCCTGGCGAGGATATGAAACCACT
GTTTGAGTCATTCCTCCACCATGTTCCACCCCCAGTTGGTGATCCTGAGAAGCCCTTACAGCTACAGGTCACCACCCTGG
ACTATTCCGATTATCTAGGCCGGATTGTGATTGGCAAAATTCACAATGGCACGATCAATATGGGACAGCAGGCTGCCTTA
ATCAATGAACATGGCGAGATGGTCAAAGCCAAAGTCAGCAAGTTGATGGGGTTTGAAGGTCTACAGAGAGTTGAGTTAGC
GACTGCTTCTGCCGGTAACCTGGTTGCGATCGCAGGGTTTGCCAATGCCAATATCGGCGAAACCATTACCTGTCCCAACG
AACCCCAAGCCCTTCCCCTAATTAAGGTGGATGAACCTACCCTGCAAATGACTTTCTGCGTCAACGACTCGCCATTTGCG
GGTCAGGAAGGAGACTTTGTCACCTCAAGACAAATTCGCGATCGCTTGATGCGTGAGCTGGAAACCAACGTCGCGCTGCG
GGTCGAAGAAACGGATTCCCCCGATCGATTTGCTGTTTCCGGCCGAGGTGAATTGCACTTGGGCATTTTGATTGAAACCA
TGCGCCGAGAAGGGTATGAGTTTCAAGTATCCCAACCTCAGGTGATTTATCGGGAAGTGAATGGTCAGCCCTGTGAACCC
TATGAGTATTTGGTGCTAGATGTTCCTGAAGAGGCTGTGGGGGGCTGTATTGAGCGCTTGGGACAACGCCGGGGCGAAAT
GCAGGATATGCAGGTGAGCAATGGCCGCACCCAACTCGAATTTGTGATTCCAGCCCGAGGCTTGATTGGTTTTAGAGGCG
AGTTTATGCGCCTAACCCGAGGCGATGGCATTATGAACCACAGCTTCTTGGAGTACCGAGAGATGGCTGGGGATATTTCG
TCTCGACGGAATGGGGTAATTATTGCCTTTGAGGAAGGAACGGCTACGTTCTATGCCCTTAAGAATGCGGAAGATCGAGG
CTCTTTCTTTATTGAGCCGGGGGTCAAAGTCTACAAAGGCATGATTGTGGGTGAGCATAACCGTCCTCAGAATCTGGATC
TCAACGTTTGCAAAACCAAGCACCTCACCAATCACCGTAGTTCAACGGGCGATGAGCTAGTACAGCTGCAAGCACCGGTT
GATATGAGCCTAGAGCGGGCGCTGGAATATATCGGTCCAGATGAACTAGTGGAGGTCACTCCTGAATCGGTACGTCTACG
AAAACTAGAAAAGAAAAAGCTCGCCAAGCGTTAG

Upstream 100 bases:

>100_bases
TTGTTAAATAAAATTAAAGTTTTTCCGAGTCTGGCCGAAAGTATTCTTTCAGATTTGCAAAACCGAAGTTGATCCAACAT
CTGTATCTTTGGAACCTAGT

Downstream 100 bases:

>100_bases
GGTTATGGGTTGGAAGACTCAATTTTGGTAAGGTTGTGTGCAACCTCGTTAATCAATGGCCAGGATTGAGGCATTCTCCC
TTTTCATGAAACCTTGTCGT

Product: GTP-binding protein TypA/BipA

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 597; Mature: 596

Protein sequence:

>597_residues
MTLLPIRNVAIIAHVDHGKTTLVDALLKQAGTFREGEDVPDCVMDSNDLERERGITILSKNTAVTYKETLINIVDTPGHA
DFGGEVERVLGMVDGCLLIVDANEGPMPQTRFVLKKALEKGLRPIVLVNKIDRPQADPHGAVDKVLDLFIELGADDDQCD
FPYLFASGLDGYAKEDLDAPGEDMKPLFESFLHHVPPPVGDPEKPLQLQVTTLDYSDYLGRIVIGKIHNGTINMGQQAAL
INEHGEMVKAKVSKLMGFEGLQRVELATASAGNLVAIAGFANANIGETITCPNEPQALPLIKVDEPTLQMTFCVNDSPFA
GQEGDFVTSRQIRDRLMRELETNVALRVEETDSPDRFAVSGRGELHLGILIETMRREGYEFQVSQPQVIYREVNGQPCEP
YEYLVLDVPEEAVGGCIERLGQRRGEMQDMQVSNGRTQLEFVIPARGLIGFRGEFMRLTRGDGIMNHSFLEYREMAGDIS
SRRNGVIIAFEEGTATFYALKNAEDRGSFFIEPGVKVYKGMIVGEHNRPQNLDLNVCKTKHLTNHRSSTGDELVQLQAPV
DMSLERALEYIGPDELVEVTPESVRLRKLEKKKLAKR

Sequences:

>Translated_597_residues
MTLLPIRNVAIIAHVDHGKTTLVDALLKQAGTFREGEDVPDCVMDSNDLERERGITILSKNTAVTYKETLINIVDTPGHA
DFGGEVERVLGMVDGCLLIVDANEGPMPQTRFVLKKALEKGLRPIVLVNKIDRPQADPHGAVDKVLDLFIELGADDDQCD
FPYLFASGLDGYAKEDLDAPGEDMKPLFESFLHHVPPPVGDPEKPLQLQVTTLDYSDYLGRIVIGKIHNGTINMGQQAAL
INEHGEMVKAKVSKLMGFEGLQRVELATASAGNLVAIAGFANANIGETITCPNEPQALPLIKVDEPTLQMTFCVNDSPFA
GQEGDFVTSRQIRDRLMRELETNVALRVEETDSPDRFAVSGRGELHLGILIETMRREGYEFQVSQPQVIYREVNGQPCEP
YEYLVLDVPEEAVGGCIERLGQRRGEMQDMQVSNGRTQLEFVIPARGLIGFRGEFMRLTRGDGIMNHSFLEYREMAGDIS
SRRNGVIIAFEEGTATFYALKNAEDRGSFFIEPGVKVYKGMIVGEHNRPQNLDLNVCKTKHLTNHRSSTGDELVQLQAPV
DMSLERALEYIGPDELVEVTPESVRLRKLEKKKLAKR
>Mature_596_residues
TLLPIRNVAIIAHVDHGKTTLVDALLKQAGTFREGEDVPDCVMDSNDLERERGITILSKNTAVTYKETLINIVDTPGHAD
FGGEVERVLGMVDGCLLIVDANEGPMPQTRFVLKKALEKGLRPIVLVNKIDRPQADPHGAVDKVLDLFIELGADDDQCDF
PYLFASGLDGYAKEDLDAPGEDMKPLFESFLHHVPPPVGDPEKPLQLQVTTLDYSDYLGRIVIGKIHNGTINMGQQAALI
NEHGEMVKAKVSKLMGFEGLQRVELATASAGNLVAIAGFANANIGETITCPNEPQALPLIKVDEPTLQMTFCVNDSPFAG
QEGDFVTSRQIRDRLMRELETNVALRVEETDSPDRFAVSGRGELHLGILIETMRREGYEFQVSQPQVIYREVNGQPCEPY
EYLVLDVPEEAVGGCIERLGQRRGEMQDMQVSNGRTQLEFVIPARGLIGFRGEFMRLTRGDGIMNHSFLEYREMAGDISS
RRNGVIIAFEEGTATFYALKNAEDRGSFFIEPGVKVYKGMIVGEHNRPQNLDLNVCKTKHLTNHRSSTGDELVQLQAPVD
MSLERALEYIGPDELVEVTPESVRLRKLEKKKLAKR

Specific function: Not known; probably interacts with the ribosomes in a GTP dependent manner [H]

COG id: COG1217

COG function: function code T; Predicted membrane GTPase involved in stress response

Gene ontology:
GO:0000166: GTP-binding protein TypA/BipA
GO:0003924: GTP-binding protein TypA/BipA
GO:0005525: GTP-binding protein TypA/BipA
GO:0005622: GTP-binding protein TypA/BipA
GO:0006184: GTP-binding protein TypA/BipA

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GTP-binding elongation factor family. TypA subfamily [H]

Homologues:

Organism=Homo sapiens, GI157426893, Length=312, Percent_Identity=31.7307692307692, Blast_Score=130, Evalue=4e-30,
Organism=Homo sapiens, GI94966754, Length=132, Percent_Identity=44.6969696969697, Blast_Score=121, Evalue=2e-27,
Organism=Homo sapiens, GI18390331, Length=145, Percent_Identity=41.3793103448276, Blast_Score=106, Evalue=5e-23,
Organism=Homo sapiens, GI25306287, Length=462, Percent_Identity=26.8398268398268, Blast_Score=102, Evalue=8e-22,
Organism=Homo sapiens, GI34147630, Length=270, Percent_Identity=30.3703703703704, Blast_Score=102, Evalue=1e-21,
Organism=Homo sapiens, GI4503483, Length=144, Percent_Identity=37.5, Blast_Score=101, Evalue=2e-21,
Organism=Homo sapiens, GI25306283, Length=142, Percent_Identity=39.4366197183099, Blast_Score=92, Evalue=1e-18,
Organism=Homo sapiens, GI19923640, Length=142, Percent_Identity=39.4366197183099, Blast_Score=92, Evalue=1e-18,
Organism=Homo sapiens, GI310132016, Length=110, Percent_Identity=42.7272727272727, Blast_Score=91, Evalue=2e-18,
Organism=Homo sapiens, GI310110807, Length=110, Percent_Identity=42.7272727272727, Blast_Score=91, Evalue=2e-18,
Organism=Homo sapiens, GI310123363, Length=110, Percent_Identity=42.7272727272727, Blast_Score=91, Evalue=2e-18,
Organism=Homo sapiens, GI217272894, Length=134, Percent_Identity=41.044776119403, Blast_Score=91, Evalue=3e-18,
Organism=Homo sapiens, GI217272892, Length=134, Percent_Identity=41.044776119403, Blast_Score=91, Evalue=3e-18,
Organism=Homo sapiens, GI94966752, Length=128, Percent_Identity=32.8125, Blast_Score=82, Evalue=1e-15,
Organism=Escherichia coli, GI48994988, Length=585, Percent_Identity=53.8461538461538, Blast_Score=638, Evalue=0.0,
Organism=Escherichia coli, GI1788922, Length=543, Percent_Identity=29.4659300184162, Blast_Score=154, Evalue=2e-38,
Organism=Escherichia coli, GI1789738, Length=148, Percent_Identity=38.5135135135135, Blast_Score=91, Evalue=2e-19,
Organism=Escherichia coli, GI1790835, Length=302, Percent_Identity=27.1523178807947, Blast_Score=90, Evalue=5e-19,
Organism=Escherichia coli, GI1789737, Length=242, Percent_Identity=29.3388429752066, Blast_Score=76, Evalue=5e-15,
Organism=Escherichia coli, GI1790412, Length=242, Percent_Identity=29.3388429752066, Blast_Score=76, Evalue=5e-15,
Organism=Caenorhabditis elegans, GI17557151, Length=399, Percent_Identity=29.0726817042606, Blast_Score=127, Evalue=1e-29,
Organism=Caenorhabditis elegans, GI17556745, Length=142, Percent_Identity=40.1408450704225, Blast_Score=106, Evalue=4e-23,
Organism=Caenorhabditis elegans, GI17533571, Length=144, Percent_Identity=45.1388888888889, Blast_Score=105, Evalue=5e-23,
Organism=Caenorhabditis elegans, GI71988811, Length=136, Percent_Identity=39.7058823529412, Blast_Score=101, Evalue=1e-21,
Organism=Caenorhabditis elegans, GI71988819, Length=136, Percent_Identity=39.7058823529412, Blast_Score=100, Evalue=2e-21,
Organism=Caenorhabditis elegans, GI17506493, Length=217, Percent_Identity=31.3364055299539, Blast_Score=99, Evalue=6e-21,
Organism=Caenorhabditis elegans, GI17552882, Length=155, Percent_Identity=33.5483870967742, Blast_Score=92, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI17556456, Length=269, Percent_Identity=29.7397769516729, Blast_Score=86, Evalue=5e-17,
Organism=Caenorhabditis elegans, GI71994658, Length=156, Percent_Identity=35.8974358974359, Blast_Score=72, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6323320, Length=507, Percent_Identity=27.4161735700197, Blast_Score=148, Evalue=2e-36,
Organism=Saccharomyces cerevisiae, GI6324707, Length=146, Percent_Identity=41.0958904109589, Blast_Score=109, Evalue=1e-24,
Organism=Saccharomyces cerevisiae, GI6320593, Length=146, Percent_Identity=41.0958904109589, Blast_Score=109, Evalue=1e-24,
Organism=Saccharomyces cerevisiae, GI6322359, Length=151, Percent_Identity=39.7350993377483, Blast_Score=102, Evalue=2e-22,
Organism=Saccharomyces cerevisiae, GI6323098, Length=149, Percent_Identity=39.5973154362416, Blast_Score=99, Evalue=2e-21,
Organism=Saccharomyces cerevisiae, GI6324761, Length=273, Percent_Identity=28.9377289377289, Blast_Score=97, Evalue=6e-21,
Organism=Saccharomyces cerevisiae, GI6324166, Length=142, Percent_Identity=37.3239436619718, Blast_Score=87, Evalue=8e-18,
Organism=Drosophila melanogaster, GI78706572, Length=500, Percent_Identity=27.4, Blast_Score=126, Evalue=3e-29,
Organism=Drosophila melanogaster, GI24582462, Length=145, Percent_Identity=41.3793103448276, Blast_Score=108, Evalue=8e-24,
Organism=Drosophila melanogaster, GI28574573, Length=187, Percent_Identity=37.4331550802139, Blast_Score=106, Evalue=4e-23,
Organism=Drosophila melanogaster, GI24585711, Length=148, Percent_Identity=37.1621621621622, Blast_Score=100, Evalue=4e-21,
Organism=Drosophila melanogaster, GI24585713, Length=148, Percent_Identity=37.1621621621622, Blast_Score=100, Evalue=4e-21,
Organism=Drosophila melanogaster, GI24585709, Length=148, Percent_Identity=37.1621621621622, Blast_Score=100, Evalue=5e-21,
Organism=Drosophila melanogaster, GI281363316, Length=271, Percent_Identity=28.7822878228782, Blast_Score=95, Evalue=2e-19,
Organism=Drosophila melanogaster, GI17864358, Length=271, Percent_Identity=28.7822878228782, Blast_Score=95, Evalue=2e-19,
Organism=Drosophila melanogaster, GI21357743, Length=192, Percent_Identity=38.0208333333333, Blast_Score=93, Evalue=5e-19,
Organism=Drosophila melanogaster, GI221458488, Length=144, Percent_Identity=41.6666666666667, Blast_Score=91, Evalue=3e-18,
Organism=Drosophila melanogaster, GI19921738, Length=277, Percent_Identity=29.2418772563177, Blast_Score=87, Evalue=2e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009022
- InterPro:   IPR000795
- InterPro:   IPR005225
- InterPro:   IPR000640
- InterPro:   IPR004161
- InterPro:   IPR009000
- InterPro:   IPR006298 [H]

Pfam domain/function: PF00679 EFG_C; PF00009 GTP_EFTU; PF03144 GTP_EFTU_D2 [H]

EC number: NA

Molecular weight: Translated: 66241; Mature: 66109

Theoretical pI: Translated: 4.73; Mature: 4.73

Prosite motif: PS00301 EFACTOR_GTP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTLLPIRNVAIIAHVDHGKTTLVDALLKQAGTFREGEDVPDCVMDSNDLERERGITILSK
CCEEEECCEEEEEEECCCHHHHHHHHHHHCCCCCCCCCCCHHHCCCCCCHHHCCEEEEEC
NTAVTYKETLINIVDTPGHADFGGEVERVLGMVDGCLLIVDANEGPMPQTRFVLKKALEK
CCEEEEHHHHHEEECCCCCCCCCHHHHHHHHHHCCEEEEEECCCCCCCHHHHHHHHHHHH
GLRPIVLVNKIDRPQADPHGAVDKVLDLFIELGADDDQCDFPYLFASGLDGYAKEDLDAP
CCCEEEEEECCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCHHHCCCCCCHHHCCCCC
GEDMKPLFESFLHHVPPPVGDPEKPLQLQVTTLDYSDYLGRIVIGKIHNGTINMGQQAAL
CCHHHHHHHHHHHHCCCCCCCCCCCEEEEEEEECHHHCCCEEEEEEEECCEECCCCCCHH
INEHGEMVKAKVSKLMGFEGLQRVELATASAGNLVAIAGFANANIGETITCPNEPQALPL
HHHHHHHHHHHHHHHHCCCCCHHEEEEECCCCCEEEEEEECCCCCCCEEECCCCCCEEEE
IKVDEPTLQMTFCVNDSPFAGQEGDFVTSRQIRDRLMRELETNVALRVEETDSPDRFAVS
EEECCCCEEEEEEECCCCCCCCCCCEECHHHHHHHHHHHHCCCEEEEEECCCCCCEEEEC
GRGELHLGILIETMRREGYEFQVSQPQVIYREVNGQPCEPYEYLVLDVPEEAVGGCIERL
CCCCEEEHHHHHHHHHCCCEEEECCCEEEEEECCCCCCCCCEEEEEECCHHHHHHHHHHH
GQRRGEMQDMQVSNGRTQLEFVIPARGLIGFRGEFMRLTRGDGIMNHSFLEYREMAGDIS
HHHCCCCCCEEECCCCEEEEEEECCCCCCCCCCCEEEEECCCCCCCCHHHHHHHHHCCHH
SRRNGVIIAFEEGTATFYALKNAEDRGSFFIEPGVKVYKGMIVGEHNRPQNLDLNVCKTK
CCCCCEEEEEECCCEEEEEEECCCCCCCEEECCCHHEEEEEEEECCCCCCCCCEEEECHH
HLTNHRSSTGDELVQLQAPVDMSLERALEYIGPDELVEVTPESVRLRKLEKKKLAKR
HHCCCCCCCCCCEEEEECCCCHHHHHHHHHCCCHHHEECCCHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
TLLPIRNVAIIAHVDHGKTTLVDALLKQAGTFREGEDVPDCVMDSNDLERERGITILSK
CEEEECCEEEEEEECCCHHHHHHHHHHHCCCCCCCCCCCHHHCCCCCCHHHCCEEEEEC
NTAVTYKETLINIVDTPGHADFGGEVERVLGMVDGCLLIVDANEGPMPQTRFVLKKALEK
CCEEEEHHHHHEEECCCCCCCCCHHHHHHHHHHCCEEEEEECCCCCCCHHHHHHHHHHHH
GLRPIVLVNKIDRPQADPHGAVDKVLDLFIELGADDDQCDFPYLFASGLDGYAKEDLDAP
CCCEEEEEECCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCHHHCCCCCCHHHCCCCC
GEDMKPLFESFLHHVPPPVGDPEKPLQLQVTTLDYSDYLGRIVIGKIHNGTINMGQQAAL
CCHHHHHHHHHHHHCCCCCCCCCCCEEEEEEEECHHHCCCEEEEEEEECCEECCCCCCHH
INEHGEMVKAKVSKLMGFEGLQRVELATASAGNLVAIAGFANANIGETITCPNEPQALPL
HHHHHHHHHHHHHHHHCCCCCHHEEEEECCCCCEEEEEEECCCCCCCEEECCCCCCEEEE
IKVDEPTLQMTFCVNDSPFAGQEGDFVTSRQIRDRLMRELETNVALRVEETDSPDRFAVS
EEECCCCEEEEEEECCCCCCCCCCCEECHHHHHHHHHHHHCCCEEEEEECCCCCCEEEEC
GRGELHLGILIETMRREGYEFQVSQPQVIYREVNGQPCEPYEYLVLDVPEEAVGGCIERL
CCCCEEEHHHHHHHHHCCCEEEECCCEEEEEECCCCCCCCCEEEEEECCHHHHHHHHHHH
GQRRGEMQDMQVSNGRTQLEFVIPARGLIGFRGEFMRLTRGDGIMNHSFLEYREMAGDIS
HHHCCCCCCEEECCCCEEEEEEECCCCCCCCCCCEEEEECCCCCCCCHHHHHHHHHCCHH
SRRNGVIIAFEEGTATFYALKNAEDRGSFFIEPGVKVYKGMIVGEHNRPQNLDLNVCKTK
CCCCCEEEEEECCCEEEEEEECCCCCCCEEECCCHHEEEEEEEECCCCCCCCCEEEECHH
HLTNHRSSTGDELVQLQAPVDMSLERALEYIGPDELVEVTPESVRLRKLEKKKLAKR
HHCCCCCCCCCCEEEEECCCCHHHHHHHHHCCCHHHEECCCHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]