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The map label for this gene is trxA [H]

Identifier: 158319046

GI number: 158319046

Start: 8965122

End: 8965448

Strand: Direct

Name: trxA [H]

Synonym: Franean1_7329

Alternate gene names: 158319046

Gene position: 8965122-8965448 (Clockwise)

Preceding gene: 158319045

Following gene: 158319047

Centisome position: 99.81

GC content: 65.14

Gene sequence:

>327_bases
ATGGCAGGCTCCACCCCCGCGGTGACGGACGGCACGTTCGCCGCCGAGGTGCTCAAGAGCGACAAGCCCGTACTCGTCGA
CTTCTGGGCCGAGTGGTGCGGCCCGTGCAAGATGGTCGCGCCGGTACTGGAGGAGATCGCCAAGGAGCACGGCGAGAAGC
TCCGGATCGTCAAGCTCAACATCGACGAGAACCCGGAGGTCGCGCGGCAGTACCAGATCATGTCGATCCCGACGATGGCC
GTCTTCGTCAACGGCGAGATCGACAAGAGCATCGTCGGCGCCAAGCCGAAGGCCGCGCTGCTGCGCGACCTGTCGTCCTA
CATCTGA

Upstream 100 bases:

>100_bases
CTGACGCGGACCAACCTGTGCTGTGGCGGGAGCCCCGCCACAGCACAGCCGTCAGCCACCAGTCCAAAGACACAAGAGCG
CAAACCCTGAGGAGAACGCC

Downstream 100 bases:

>100_bases
TCCAGACCGCGCCCGGCCCCGCCCGGGCCGGGCCAGCGCACTCCGCCGGCCATGGTCGACCTCGACGGCCCGCTCCGATC
TCGGAGCGGGCCGTCTTCGT

Product: thioredoxin

Products: NA

Alternate protein names: Trx [H]

Number of amino acids: Translated: 108; Mature: 107

Protein sequence:

>108_residues
MAGSTPAVTDGTFAAEVLKSDKPVLVDFWAEWCGPCKMVAPVLEEIAKEHGEKLRIVKLNIDENPEVARQYQIMSIPTMA
VFVNGEIDKSIVGAKPKAALLRDLSSYI

Sequences:

>Translated_108_residues
MAGSTPAVTDGTFAAEVLKSDKPVLVDFWAEWCGPCKMVAPVLEEIAKEHGEKLRIVKLNIDENPEVARQYQIMSIPTMA
VFVNGEIDKSIVGAKPKAALLRDLSSYI
>Mature_107_residues
AGSTPAVTDGTFAAEVLKSDKPVLVDFWAEWCGPCKMVAPVLEEIAKEHGEKLRIVKLNIDENPEVARQYQIMSIPTMAV
FVNGEIDKSIVGAKPKAALLRDLSSYI

Specific function: Component of the thioredoxin-thioredoxin reductase system. Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions [H]

COG id: COG0526

COG function: function code OC; Thiol-disulfide isomerase and thioredoxins

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain [H]

Homologues:

Organism=Homo sapiens, GI21361403, Length=99, Percent_Identity=39.3939393939394, Blast_Score=79, Evalue=8e-16,
Organism=Escherichia coli, GI87082331, Length=93, Percent_Identity=55.9139784946236, Blast_Score=115, Evalue=4e-28,
Organism=Escherichia coli, GI1788936, Length=88, Percent_Identity=44.3181818181818, Blast_Score=91, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI17509965, Length=67, Percent_Identity=44.7761194029851, Blast_Score=74, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI212646193, Length=74, Percent_Identity=43.2432432432432, Blast_Score=74, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI71998175, Length=75, Percent_Identity=37.3333333333333, Blast_Score=67, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6323072, Length=81, Percent_Identity=40.7407407407407, Blast_Score=76, Evalue=1e-15,
Organism=Saccharomyces cerevisiae, GI6321648, Length=78, Percent_Identity=42.3076923076923, Blast_Score=75, Evalue=1e-15,
Organism=Saccharomyces cerevisiae, GI6319925, Length=95, Percent_Identity=32.6315789473684, Blast_Score=74, Evalue=4e-15,
Organism=Drosophila melanogaster, GI28573567, Length=92, Percent_Identity=39.1304347826087, Blast_Score=83, Evalue=4e-17,
Organism=Drosophila melanogaster, GI24639826, Length=79, Percent_Identity=37.9746835443038, Blast_Score=82, Evalue=8e-17,
Organism=Drosophila melanogaster, GI24664269, Length=65, Percent_Identity=41.5384615384615, Blast_Score=73, Evalue=3e-14,
Organism=Drosophila melanogaster, GI17648013, Length=78, Percent_Identity=38.4615384615385, Blast_Score=71, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24583090, Length=78, Percent_Identity=38.4615384615385, Blast_Score=71, Evalue=2e-13,
Organism=Drosophila melanogaster, GI21358065, Length=81, Percent_Identity=38.2716049382716, Blast_Score=65, Evalue=1e-11,

Paralogues:

None

Copy number: 3,500 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005746
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR017937
- InterPro:   IPR013766
- InterPro:   IPR012335 [H]

Pfam domain/function: PF00085 Thioredoxin [H]

EC number: NA

Molecular weight: Translated: 11803; Mature: 11672

Theoretical pI: Translated: 4.85; Mature: 4.85

Prosite motif: PS00194 THIOREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAGSTPAVTDGTFAAEVLKSDKPVLVDFWAEWCGPCKMVAPVLEEIAKEHGEKLRIVKLN
CCCCCCCCCCCHHHHHHHCCCCCEEEEHHHHHCCCHHHHHHHHHHHHHHCCCEEEEEEEE
IDENPEVARQYQIMSIPTMAVFVNGEIDKSIVGAKPKAALLRDLSSYI
CCCCHHHHHHHHHEECCEEEEEECCCCCCHHCCCCCHHHHHHHHHHCC
>Mature Secondary Structure 
AGSTPAVTDGTFAAEVLKSDKPVLVDFWAEWCGPCKMVAPVLEEIAKEHGEKLRIVKLN
CCCCCCCCCCHHHHHHHCCCCCEEEEHHHHHCCCHHHHHHHHHHHHHHCCCEEEEEEEE
IDENPEVARQYQIMSIPTMAVFVNGEIDKSIVGAKPKAALLRDLSSYI
CCCCHHHHHHHHHEECCEEEEEECCCCCCHHCCCCCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Reduction reactions; participates in dithiol-disulfide exchange reactions [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9795152; 10671452; 12000953 [H]