Click here to switch to the map view.

The map label for this gene is tdh [H]

Identifier: 158318873

GI number: 158318873

Start: 8735572

End: 8736627

Strand: Reverse

Name: tdh [H]

Synonym: Franean1_7154

Alternate gene names: 158318873

Gene position: 8736627-8735572 (Counterclockwise)

Preceding gene: 158318874

Following gene: 158318872

Centisome position: 97.27

GC content: 69.41

Gene sequence:

>1056_bases
ATGAGAGCCGCTGTGCTGCGGGAGGGAGTCGTCGAGGCCCGGGTCATCGACGACCCGGTGCCGGGGCCGGGCCAGCTGCT
GGTGCGGTCGCTCGCGTGTGGGATCTGCGCGTCGGACATCCACTTCATGGATCATCTGGAAGCGGGCGTCGACGATGACA
GCGGGATGTCGACCTACGACCGTGATGTCGACATCGTCATGGGTCACGAGTACTGCGCCGAGGTCGTCGACTACGGCCCC
GGCACCGAGCGGCGGATCCCCGTGGGCGCCCGGGTGAGCTCGCTGCCGGTGCTGTCCACGGCCACCGGGCGGAAGATCAT
CGGGCAGAATCCGGAGTCGCCCGGCGGGTTCGGTGAGTATCTCCTGCTCGACGAGGCCATGACCCGGGTCGCGGTCTCCG
AGCTCCCGAACGAGATCGTGTGCATCGCGGACGCGGTCTCGGTCGGCTTGTCGGCCGCCTCCCGAGCGCAGGTGACGGCG
AAGGAGGTGCCGCTGGTCATCGGCTGCGGGGCGATCGCTCTGTCCGTGATCGCGCAGCTGAAGCGGCTGGGGGTCGGGCC
GATCCTGGCGGTGGACTTCGTCGCCTCGCGTCGCGAGACCGCGCTGGCCATGGGAGCGGACGTGGTCATCGACCCCGCCG
CGGTGTCCCCGTACCAGGCCTGGCGTGACGTGGCCTACGGGTCGCCCGAGGCGATGAGGGAACTGATGGCGGTCGCCGGC
CTGCCGGGATGCGTCGTGTTCGAGTGCGTCGGTATTCCCGGTGTCCTGGATTCGATCATCAAGGGCTGCGAGCGCAACAC
CCGGATCTTCTCGGTGGGAGGTCCGCCGGAAGGCGATCACCTGCACACCCTCACCGCCAAGCGGAAAGGCATCAACATCC
AGTTCGGGGGCGGCCCGTCGATGCAGCACTGGGACGAGGCATTCGCGGCGGTCGGCTCGGGCGACCTCGACGTCACACCG
ATGCTCGGCCGAACCGTCGGGCTCGACGACGTCGCCGAGGCGCTCAACGCCTCCCGCGACGCCAACGGACCCGTCCGCAT
CGTCGTCGTGCCCTGA

Upstream 100 bases:

>100_bases
GTCTCCCGAAAAATTTCAGGACGATGTCTTCTATAACTGGTTTGGTGTCGCTACAGTCCCGTGACGGGAGCACGTCCTGA
TCGCTGACGAGGGAGCGCCG

Downstream 100 bases:

>100_bases
ACCGGGTCCCCCGCACACGTTCGGAAGGACTGATGGATGAGTGAGATCGAGGAGCTGCGCGCCGCTGTCGAGACGCTGGC
GGCAAGGGTCCGGCTGCTGG

Product: alcohol dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 351; Mature: 351

Protein sequence:

>351_residues
MRAAVLREGVVEARVIDDPVPGPGQLLVRSLACGICASDIHFMDHLEAGVDDDSGMSTYDRDVDIVMGHEYCAEVVDYGP
GTERRIPVGARVSSLPVLSTATGRKIIGQNPESPGGFGEYLLLDEAMTRVAVSELPNEIVCIADAVSVGLSAASRAQVTA
KEVPLVIGCGAIALSVIAQLKRLGVGPILAVDFVASRRETALAMGADVVIDPAAVSPYQAWRDVAYGSPEAMRELMAVAG
LPGCVVFECVGIPGVLDSIIKGCERNTRIFSVGGPPEGDHLHTLTAKRKGINIQFGGGPSMQHWDEAFAAVGSGDLDVTP
MLGRTVGLDDVAEALNASRDANGPVRIVVVP

Sequences:

>Translated_351_residues
MRAAVLREGVVEARVIDDPVPGPGQLLVRSLACGICASDIHFMDHLEAGVDDDSGMSTYDRDVDIVMGHEYCAEVVDYGP
GTERRIPVGARVSSLPVLSTATGRKIIGQNPESPGGFGEYLLLDEAMTRVAVSELPNEIVCIADAVSVGLSAASRAQVTA
KEVPLVIGCGAIALSVIAQLKRLGVGPILAVDFVASRRETALAMGADVVIDPAAVSPYQAWRDVAYGSPEAMRELMAVAG
LPGCVVFECVGIPGVLDSIIKGCERNTRIFSVGGPPEGDHLHTLTAKRKGINIQFGGGPSMQHWDEAFAAVGSGDLDVTP
MLGRTVGLDDVAEALNASRDANGPVRIVVVP
>Mature_351_residues
MRAAVLREGVVEARVIDDPVPGPGQLLVRSLACGICASDIHFMDHLEAGVDDDSGMSTYDRDVDIVMGHEYCAEVVDYGP
GTERRIPVGARVSSLPVLSTATGRKIIGQNPESPGGFGEYLLLDEAMTRVAVSELPNEIVCIADAVSVGLSAASRAQVTA
KEVPLVIGCGAIALSVIAQLKRLGVGPILAVDFVASRRETALAMGADVVIDPAAVSPYQAWRDVAYGSPEAMRELMAVAG
LPGCVVFECVGIPGVLDSIIKGCERNTRIFSVGGPPEGDHLHTLTAKRKGINIQFGGGPSMQHWDEAFAAVGSGDLDVTP
MLGRTVGLDDVAEALNASRDANGPVRIVVVP

Specific function: Threonine catabolism; first step. [C]

COG id: COG1063

COG function: function code ER; Threonine dehydrogenase and related Zn-dependent dehydrogenases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI156627571, Length=340, Percent_Identity=23.5294117647059, Blast_Score=70, Evalue=2e-12,
Organism=Escherichia coli, GI1790045, Length=340, Percent_Identity=25.5882352941176, Blast_Score=72, Evalue=5e-14,
Organism=Escherichia coli, GI1788073, Length=337, Percent_Identity=24.6290801186944, Blast_Score=62, Evalue=5e-11,
Organism=Escherichia coli, GI87082125, Length=212, Percent_Identity=25.9433962264151, Blast_Score=62, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR011032
- InterPro:   IPR004627
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: =1.1.1.103 [H]

Molecular weight: Translated: 36646; Mature: 36646

Theoretical pI: Translated: 4.49; Mature: 4.49

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRAAVLREGVVEARVIDDPVPGPGQLLVRSLACGICASDIHFMDHLEAGVDDDSGMSTYD
CCCHHHHHCCHHEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCC
RDVDIVMGHEYCAEVVDYGPGTERRIPVGARVSSLPVLSTATGRKIIGQNPESPGGFGEY
CCEEEEECHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEECCCCCHHCCCCCCCCCCCCHH
LLLDEAMTRVAVSELPNEIVCIADAVSVGLSAASRAQVTAKEVPLVIGCGAIALSVIAQL
HHHHHHHHHHHHHHCCCCEEEEHHHHHHHHHHHHHHHHHHHHCCEEEEHHHHHHHHHHHH
KRLGVGPILAVDFVASRRETALAMGADVVIDPAAVSPYQAWRDVAYGSPEAMRELMAVAG
HHCCCCCHHHHHHHHHHHHHHHHCCCCEEEECCCCCHHHHHHHHCCCCHHHHHHHHHHHC
LPGCVVFECVGIPGVLDSIIKGCERNTRIFSVGGPPEGDHLHTLTAKRKGINIQFGGGPS
CCHHEEHEECCCCHHHHHHHHCCCCCCEEEECCCCCCCCCEEEEEHHCCCCEEEECCCCC
MQHWDEAFAAVGSGDLDVTPMLGRTVGLDDVAEALNASRDANGPVRIVVVP
HHHHHHHHHHCCCCCCCCCHHCCCCCCHHHHHHHHHCCCCCCCCEEEEEEC
>Mature Secondary Structure
MRAAVLREGVVEARVIDDPVPGPGQLLVRSLACGICASDIHFMDHLEAGVDDDSGMSTYD
CCCHHHHHCCHHEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCC
RDVDIVMGHEYCAEVVDYGPGTERRIPVGARVSSLPVLSTATGRKIIGQNPESPGGFGEY
CCEEEEECHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEECCCCCHHCCCCCCCCCCCCHH
LLLDEAMTRVAVSELPNEIVCIADAVSVGLSAASRAQVTAKEVPLVIGCGAIALSVIAQL
HHHHHHHHHHHHHHCCCCEEEEHHHHHHHHHHHHHHHHHHHHCCEEEEHHHHHHHHHHHH
KRLGVGPILAVDFVASRRETALAMGADVVIDPAAVSPYQAWRDVAYGSPEAMRELMAVAG
HHCCCCCHHHHHHHHHHHHHHHHCCCCEEEECCCCCHHHHHHHHCCCCHHHHHHHHHHHC
LPGCVVFECVGIPGVLDSIIKGCERNTRIFSVGGPPEGDHLHTLTAKRKGINIQFGGGPS
CCHHEEHEECCCCHHHHHHHHCCCCCCEEEECCCCCCCCCEEEEEHHCCCCEEEECCCCC
MQHWDEAFAAVGSGDLDVTPMLGRTVGLDDVAEALNASRDANGPVRIVVVP
HHHHHHHHHHCCCCCCCCCHHCCCCCCHHHHHHHHHCCCCCCCCEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA