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The map label for this gene is arlS [H]

Identifier: 158318850

GI number: 158318850

Start: 8711815

End: 8713380

Strand: Direct

Name: arlS [H]

Synonym: Franean1_7131

Alternate gene names: 158318850

Gene position: 8711815-8713380 (Clockwise)

Preceding gene: 158318849

Following gene: 158318851

Centisome position: 96.99

GC content: 75.03

Gene sequence:

>1566_bases
GTGGCCGGTCCCGTGGTTGAAGGTGCCGCCACAGGTGATCAGGCGGAGCTGCGCGCCGTTGCCCGAGTGGTAGACCTCCT
GGTCTGGGAAGTCGGCGCGGCCTTCGTGTCCTCGGTGTCGACCGGCCAGCCGCACTACGGGCGGGTGAGCACCTCGGCCG
GCGACGTGCGCTACGTCGCGGTCCCCGTACGCGTGTGGGGCCACCCCGAGCGGGGCGTCTTCGTGTCGGCCGTGTTCGTC
GACCGGGAGCGCGCCGAGGTGGACGAGGTGGGCAGGGTGCTCGGCGTCGTCGGGTTCGGCGCGCTGGCCGTCGCCGGCGC
GGCCGGCTGGATGGTCGCCGGGCGGGTTCTCGCCCCGGTGCGGATGGTCCGCCGGACCGCGCAGACGATCACGGAGACGG
ATCTGTCCCGGCGCATCCCGATCGGCGGCGGGTGGGGCGTCCGCCGGTCGCGCCGTGCCGTGGCCGTGCGGCTCCACGAT
GGAGCCGGTCGGGACAGCGGCGCTGGCTCAGTTGGCGGTGCCGGGGGGAGCCGTGGGCGTCGCGGCCGTCGCCGCCGTCG
CGTCGGCCGGCTCGGCCGGCTCCGCTGGGGCGGGCGGGACGAGATCACGGAGCTGGCGCGGACATTCAACAGCATGCTGG
ATCGCCTCGAGCAGGTGTTCGAGACCCAGCGCGCTTTCGTCGACGACGCCGGCCACGAGCTGCGCACCCCGATCACCATC
ATCCGCGGGCATCTGGAACTGCTCGGCGACGACCCGGACGACCCGGACGACCGGGCCGAGACTGTCGCCCTCGTCCTGGA
CGAGCTCGACCGGATGAGCCGGATGGTCGACGATCTGCTGGTGCTCGCGAAGGCGGAGCGGCCCGACTTTCTGCGCCGCG
AGCCGGTGGACCTCGCCGGGTTCACCACCGACCTGTTCGTGAAGGCGAGGGCGCTGGCCCCGCGCGCGTGGCGGCTGGAC
GCGGTCGGGGACGGCCGGGTGCTCGCCGACCGGCAGCGGCTCACCCAGGCGTTGCTGCAGCTCGCGCAGAACGCGGCCGA
GCACACCCGGACCGGCGACACGATCGCGATCGGCTCGGCCGCCGACGATCGCGTCGCGCGTTTCTGGGTAGCCGACTCCC
GCCCCGGGGTGGCGCCGGGTGACCGGGCGCGCGTCTTCGAGCGTTTCGCCCGCGGTGCCTACACGCGGCCGGCGTCCCCG
GCGGGCGGGGGAGCAGGGCTCGGTCTCGCGATCGTGCGGGCGATCGCGACGGCGCACGGCGGCACCGTACGGGTGAGCGG
CGAGCCAGGCGAGGGCGCGACCTTCACCCTCGAACTGAGCCTGTTCAATCAGGGTTCTCGTGACCACGAGCCGCGTCCCG
CCCTGCCGGGTGGACCCGCCGTGCCGGGCGAAGCGGAACCAGGCGGCGGCGCGCCGGTCGCAACCGGTCCCGATGCCCCC
GCTGTCCACGAAGCCGGCCGCGAGCCTGGACGCGTCGAGCTCGGCGGCCCCGCGGCCGACGGCGGGGAACACCATGGCGC
GGCGGGCGTACGTGGGCGCGGCGGAGCCGGTGGGAGACAGGGATGA

Upstream 100 bases:

>100_bases
CCGACGGAGTGGCCGGCGGGATGACTGACGGGCCTGCCTCATGCCGACCCGGTAGCTCCCGTCAGGCGAGATGGGCGAAG
ATGACGAGGTTGTCGACGTA

Downstream 100 bases:

>100_bases
CGAACCGGGTGCTCATCGCCGAGGACGAGCACCGGATCGCCTCGTTCGTGGCGAAGGAGCTGTGCTCCAACGGCTTCGTG
CCGACCTGCGTGGGCGACGG

Product: integral membrane sensor signal transduction histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 521; Mature: 520

Protein sequence:

>521_residues
MAGPVVEGAATGDQAELRAVARVVDLLVWEVGAAFVSSVSTGQPHYGRVSTSAGDVRYVAVPVRVWGHPERGVFVSAVFV
DRERAEVDEVGRVLGVVGFGALAVAGAAGWMVAGRVLAPVRMVRRTAQTITETDLSRRIPIGGGWGVRRSRRAVAVRLHD
GAGRDSGAGSVGGAGGSRGRRGRRRRRVGRLGRLRWGGRDEITELARTFNSMLDRLEQVFETQRAFVDDAGHELRTPITI
IRGHLELLGDDPDDPDDRAETVALVLDELDRMSRMVDDLLVLAKAERPDFLRREPVDLAGFTTDLFVKARALAPRAWRLD
AVGDGRVLADRQRLTQALLQLAQNAAEHTRTGDTIAIGSAADDRVARFWVADSRPGVAPGDRARVFERFARGAYTRPASP
AGGGAGLGLAIVRAIATAHGGTVRVSGEPGEGATFTLELSLFNQGSRDHEPRPALPGGPAVPGEAEPGGGAPVATGPDAP
AVHEAGREPGRVELGGPAADGGEHHGAAGVRGRGGAGGRQG

Sequences:

>Translated_521_residues
MAGPVVEGAATGDQAELRAVARVVDLLVWEVGAAFVSSVSTGQPHYGRVSTSAGDVRYVAVPVRVWGHPERGVFVSAVFV
DRERAEVDEVGRVLGVVGFGALAVAGAAGWMVAGRVLAPVRMVRRTAQTITETDLSRRIPIGGGWGVRRSRRAVAVRLHD
GAGRDSGAGSVGGAGGSRGRRGRRRRRVGRLGRLRWGGRDEITELARTFNSMLDRLEQVFETQRAFVDDAGHELRTPITI
IRGHLELLGDDPDDPDDRAETVALVLDELDRMSRMVDDLLVLAKAERPDFLRREPVDLAGFTTDLFVKARALAPRAWRLD
AVGDGRVLADRQRLTQALLQLAQNAAEHTRTGDTIAIGSAADDRVARFWVADSRPGVAPGDRARVFERFARGAYTRPASP
AGGGAGLGLAIVRAIATAHGGTVRVSGEPGEGATFTLELSLFNQGSRDHEPRPALPGGPAVPGEAEPGGGAPVATGPDAP
AVHEAGREPGRVELGGPAADGGEHHGAAGVRGRGGAGGRQG
>Mature_520_residues
AGPVVEGAATGDQAELRAVARVVDLLVWEVGAAFVSSVSTGQPHYGRVSTSAGDVRYVAVPVRVWGHPERGVFVSAVFVD
RERAEVDEVGRVLGVVGFGALAVAGAAGWMVAGRVLAPVRMVRRTAQTITETDLSRRIPIGGGWGVRRSRRAVAVRLHDG
AGRDSGAGSVGGAGGSRGRRGRRRRRVGRLGRLRWGGRDEITELARTFNSMLDRLEQVFETQRAFVDDAGHELRTPITII
RGHLELLGDDPDDPDDRAETVALVLDELDRMSRMVDDLLVLAKAERPDFLRREPVDLAGFTTDLFVKARALAPRAWRLDA
VGDGRVLADRQRLTQALLQLAQNAAEHTRTGDTIAIGSAADDRVARFWVADSRPGVAPGDRARVFERFARGAYTRPASPA
GGGAGLGLAIVRAIATAHGGTVRVSGEPGEGATFTLELSLFNQGSRDHEPRPALPGGPAVPGEAEPGGGAPVATGPDAPA
VHEAGREPGRVELGGPAADGGEHHGAAGVRGRGGAGGRQG

Specific function: Member of the two-component regulatory system ArlS/ArlR involved in the regulation of adhesion, autolysis, multidrug resistance and virulence. ArlS probably functions as a sensor protein kinase which is autophosphorylated at a histidine residue and transf

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1786783, Length=242, Percent_Identity=34.7107438016529, Blast_Score=119, Evalue=6e-28,
Organism=Escherichia coli, GI1788393, Length=249, Percent_Identity=34.136546184739, Blast_Score=117, Evalue=2e-27,
Organism=Escherichia coli, GI1786600, Length=226, Percent_Identity=30.5309734513274, Blast_Score=99, Evalue=5e-22,
Organism=Escherichia coli, GI1788549, Length=232, Percent_Identity=29.7413793103448, Blast_Score=92, Evalue=7e-20,
Organism=Escherichia coli, GI1787894, Length=240, Percent_Identity=31.25, Blast_Score=89, Evalue=6e-19,
Organism=Escherichia coli, GI1788279, Length=224, Percent_Identity=28.125, Blast_Score=85, Evalue=1e-17,
Organism=Escherichia coli, GI1790346, Length=246, Percent_Identity=28.8617886178862, Blast_Score=83, Evalue=5e-17,
Organism=Escherichia coli, GI1789403, Length=232, Percent_Identity=28.448275862069, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI1790436, Length=213, Percent_Identity=29.5774647887324, Blast_Score=78, Evalue=1e-15,
Organism=Escherichia coli, GI48994928, Length=259, Percent_Identity=28.5714285714286, Blast_Score=72, Evalue=6e-14,
Organism=Escherichia coli, GI1786912, Length=229, Percent_Identity=27.9475982532751, Blast_Score=70, Evalue=3e-13,
Organism=Escherichia coli, GI1790861, Length=234, Percent_Identity=29.4871794871795, Blast_Score=67, Evalue=3e-12,
Organism=Escherichia coli, GI87082128, Length=227, Percent_Identity=26.8722466960352, Blast_Score=66, Evalue=6e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 54766; Mature: 54635

Theoretical pI: Translated: 10.38; Mature: 10.38

Prosite motif: PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
1.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAGPVVEGAATGDQAELRAVARVVDLLVWEVGAAFVSSVSTGQPHYGRVSTSAGDVRYVA
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEECCCCCEEEEE
VPVRVWGHPERGVFVSAVFVDRERAEVDEVGRVLGVVGFGALAVAGAAGWMVAGRVLAPV
EEEEECCCCCCCEEEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RMVRRTAQTITETDLSRRIPIGGGWGVRRSRRAVAVRLHDGAGRDSGAGSVGGAGGSRGR
HHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEEEECCCCCCCCCCCCCCCCCCCCH
RGRRRRRVGRLGRLRWGGRDEITELARTFNSMLDRLEQVFETQRAFVDDAGHELRTPITI
HHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHCCHHH
IRGHLELLGDDPDDPDDRAETVALVLDELDRMSRMVDDLLVLAKAERPDFLRREPVDLAG
HHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHCCCCCHHC
FTTDLFVKARALAPRAWRLDAVGDGRVLADRQRLTQALLQLAQNAAEHTRTGDTIAIGSA
CHHHHHHHHHHCCCCCEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCC
ADDRVARFWVADSRPGVAPGDRARVFERFARGAYTRPASPAGGGAGLGLAIVRAIATAHG
CCCCEEEEEEECCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHCCC
GTVRVSGEPGEGATFTLELSLFNQGSRDHEPRPALPGGPAVPGEAEPGGGAPVATGPDAP
CEEEECCCCCCCCEEEEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
AVHEAGREPGRVELGGPAADGGEHHGAAGVRGRGGAGGRQG
HHHHCCCCCCEEEECCCCCCCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
AGPVVEGAATGDQAELRAVARVVDLLVWEVGAAFVSSVSTGQPHYGRVSTSAGDVRYVA
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEECCCCCEEEEE
VPVRVWGHPERGVFVSAVFVDRERAEVDEVGRVLGVVGFGALAVAGAAGWMVAGRVLAPV
EEEEECCCCCCCEEEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RMVRRTAQTITETDLSRRIPIGGGWGVRRSRRAVAVRLHDGAGRDSGAGSVGGAGGSRGR
HHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEEEECCCCCCCCCCCCCCCCCCCCH
RGRRRRRVGRLGRLRWGGRDEITELARTFNSMLDRLEQVFETQRAFVDDAGHELRTPITI
HHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHCCHHH
IRGHLELLGDDPDDPDDRAETVALVLDELDRMSRMVDDLLVLAKAERPDFLRREPVDLAG
HHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHCCCCCHHC
FTTDLFVKARALAPRAWRLDAVGDGRVLADRQRLTQALLQLAQNAAEHTRTGDTIAIGSA
CHHHHHHHHHHCCCCCEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCC
ADDRVARFWVADSRPGVAPGDRARVFERFARGAYTRPASPAGGGAGLGLAIVRAIATAHG
CCCCEEEEEEECCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHCCC
GTVRVSGEPGEGATFTLELSLFNQGSRDHEPRPALPGGPAVPGEAEPGGGAPVATGPDAP
CEEEECCCCCCCCEEEEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
AVHEAGREPGRVELGGPAADGGEHHGAAGVRGRGGAGGRQG
HHHHCCCCCCEEEECCCCCCCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA