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The map label for this gene is devS [H]

Identifier: 158318669

GI number: 158318669

Start: 8451033

End: 8452775

Strand: Direct

Name: devS [H]

Synonym: Franean1_6937

Alternate gene names: 158318669

Gene position: 8451033-8452775 (Clockwise)

Preceding gene: 158318668

Following gene: 158318670

Centisome position: 94.09

GC content: 72.46

Gene sequence:

>1743_bases
ATGTTCCCCACGGTGGCCCGTCTCGAACTCGACGACCTGCTCAGCCAACTCGTCGACCGCGCCCAGGACGTTCTCGCCAC
CCAGGGCCGGCTGCGCGGCCTGCTGCACGCGAACCGGGTCATCGCCACCGACCTGCGACTGCCTGTCCTACTCCGGCACA
TCGTCGAGGCCGCAACGGATCTGCTGGGTGCCCGCTACGGCGCACTCGGCGTCGTGGCCCCCGACCGCACACTCGAGGAA
TTCGTCCACGTCGGCATGACCGACGCGGACGTGGAGCGGATCGGCCACCTGCCCACCGGTCACGGCCTGCTCGGCATCCT
GATCGACGACCCGCGGCCGCGCCGCGCCGACGACATCGCCCATGACCCGGCGTCCCAGGGCTTCCCGGCCGGGCATCCGC
CGATGCGGACCTTCCTCGGCGTCCCGATCACTGTGCGGGGCGAGGTGTTCGGCAATCTCTACCTCACCGACAAACGCGAC
GGCGTCCCCTTCACCGCGGAGGACGAGGAGCTCGCCCAGGCCCTGGCCGCCAACGCCGGGGTGGCGATCGCGAACGCGCG
GCTCTACCACGAGGCGCAGCAGCGGCACCTGTGGATGACCGCCTCGGCGGAGATCAGCCGTCAGGTGATGGTCGGCGCCG
ACAACGCGCTCGCCACCCTCGTGCACCGGGTGCAGGAGGTCGCCGACGCCCCCTTCGTCGCCCTCGCGCTGCACACCACG
AACCAGGGCACTGCGGACGGAGGCGATCGGAGCAAGGAGGCCGGGTACGCGCGCGTCGCCGTCGCCGTCACGGAGCGTCA
CGTTACCGGCTCGGCCCACGCCGGTCTGGGCACCGATGCCAGCCGTGCCGGCCGCCTGATTCCCCTCGAGCACACCCTGA
CCGGCCGGGTGATCGCCGAGCAGCAGGCTCTTCGCGTCGACGACTCGGAGCTCGACGCGCTCCCCGACGAGCGCGCGGCA
CGCACCGGGCCGCTCATGGTCGTCCCGCTCGTCGCCGGCGGCGACCAGTGCGGCGGAGCGCTGCTCATCGGCCGCGACCG
CGGCGTCCGCGCCTTCACCGACGGCGACCTCGACATGGCGGCAGGCTTCGCCGGCCACGTCGCCGTAGCCCTCGAGCTCG
CCCGGGCCCGAGCCGACCAGGAACACCTGCGGGTACTCGCCGACCGCGGCCGGATCGCCCGTGACCTGCACGACCACGTC
ATCCAGCGGATGTTCGCCGTCGCGCTCGGCATGCAGGATCTCGCCCAGTACGAGAACCCCTCCAACGCCGGCCGGCTCAA
CGGCTACGTCGAGGACATCGACGCGACCATCAAGGACATCCGCCGTTCCATCTTCGAGCTGCGCGGACAGAGCCCCACCA
AGCGCGGTCGCCTGCGCGCCGGCCTCAACAAGATCGCGGACGACGTTCGGCTGGCCCTCGGCTTCGCCCCCGCCATCTCC
CTGACCGGGCCCCTCGACACCGTCGCGGACGACCAGCTCACCGACCATCTGCTCGCCGTCACCCGCGAGGCCCTCACGAA
CACCGCCCGCCACGCCCACGCGACCAGCGTCGAGGTGCGGCTGGCCGTGGACGGGGACATGGTCACCCTGGACGCCGTCG
ACAACGGGGTCGGCATCGGTGACACCACCCGCCGCAGCGGCCTGGACAACCTGCGCGCCCGCGCCGAGAGCCTCGGCGGC
ACCTTCACCGCCACGACACCGCCCACCGGCGGCACCCACCTCCGCTGGGCCGCCCCGTTCTGA

Upstream 100 bases:

>100_bases
GTCGGGCGGGACACCGGCGACCGAACCGTCGACCAGGGAGTCCCCGTGGTCGGCGCCGGGTGGACCGGCGCCCGCCGGAC
CGCCCGTCGGCGACGGGCTG

Downstream 100 bases:

>100_bases
TTCCTGCTGCACCTCCGGCGCTGCCCGGTTCCTGCGGCACCTCCGGGGCCCGGCGCGGGATGACCATCTCCGACTCCGGG
TAGCCCTCCGAGTACACAGA

Product: GAF sensor signal transduction histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 580; Mature: 580

Protein sequence:

>580_residues
MFPTVARLELDDLLSQLVDRAQDVLATQGRLRGLLHANRVIATDLRLPVLLRHIVEAATDLLGARYGALGVVAPDRTLEE
FVHVGMTDADVERIGHLPTGHGLLGILIDDPRPRRADDIAHDPASQGFPAGHPPMRTFLGVPITVRGEVFGNLYLTDKRD
GVPFTAEDEELAQALAANAGVAIANARLYHEAQQRHLWMTASAEISRQVMVGADNALATLVHRVQEVADAPFVALALHTT
NQGTADGGDRSKEAGYARVAVAVTERHVTGSAHAGLGTDASRAGRLIPLEHTLTGRVIAEQQALRVDDSELDALPDERAA
RTGPLMVVPLVAGGDQCGGALLIGRDRGVRAFTDGDLDMAAGFAGHVAVALELARARADQEHLRVLADRGRIARDLHDHV
IQRMFAVALGMQDLAQYENPSNAGRLNGYVEDIDATIKDIRRSIFELRGQSPTKRGRLRAGLNKIADDVRLALGFAPAIS
LTGPLDTVADDQLTDHLLAVTREALTNTARHAHATSVEVRLAVDGDMVTLDAVDNGVGIGDTTRRSGLDNLRARAESLGG
TFTATTPPTGGTHLRWAAPF

Sequences:

>Translated_580_residues
MFPTVARLELDDLLSQLVDRAQDVLATQGRLRGLLHANRVIATDLRLPVLLRHIVEAATDLLGARYGALGVVAPDRTLEE
FVHVGMTDADVERIGHLPTGHGLLGILIDDPRPRRADDIAHDPASQGFPAGHPPMRTFLGVPITVRGEVFGNLYLTDKRD
GVPFTAEDEELAQALAANAGVAIANARLYHEAQQRHLWMTASAEISRQVMVGADNALATLVHRVQEVADAPFVALALHTT
NQGTADGGDRSKEAGYARVAVAVTERHVTGSAHAGLGTDASRAGRLIPLEHTLTGRVIAEQQALRVDDSELDALPDERAA
RTGPLMVVPLVAGGDQCGGALLIGRDRGVRAFTDGDLDMAAGFAGHVAVALELARARADQEHLRVLADRGRIARDLHDHV
IQRMFAVALGMQDLAQYENPSNAGRLNGYVEDIDATIKDIRRSIFELRGQSPTKRGRLRAGLNKIADDVRLALGFAPAIS
LTGPLDTVADDQLTDHLLAVTREALTNTARHAHATSVEVRLAVDGDMVTLDAVDNGVGIGDTTRRSGLDNLRARAESLGG
TFTATTPPTGGTHLRWAAPF
>Mature_580_residues
MFPTVARLELDDLLSQLVDRAQDVLATQGRLRGLLHANRVIATDLRLPVLLRHIVEAATDLLGARYGALGVVAPDRTLEE
FVHVGMTDADVERIGHLPTGHGLLGILIDDPRPRRADDIAHDPASQGFPAGHPPMRTFLGVPITVRGEVFGNLYLTDKRD
GVPFTAEDEELAQALAANAGVAIANARLYHEAQQRHLWMTASAEISRQVMVGADNALATLVHRVQEVADAPFVALALHTT
NQGTADGGDRSKEAGYARVAVAVTERHVTGSAHAGLGTDASRAGRLIPLEHTLTGRVIAEQQALRVDDSELDALPDERAA
RTGPLMVVPLVAGGDQCGGALLIGRDRGVRAFTDGDLDMAAGFAGHVAVALELARARADQEHLRVLADRGRIARDLHDHV
IQRMFAVALGMQDLAQYENPSNAGRLNGYVEDIDATIKDIRRSIFELRGQSPTKRGRLRAGLNKIADDVRLALGFAPAIS
LTGPLDTVADDQLTDHLLAVTREALTNTARHAHATSVEVRLAVDGDMVTLDAVDNGVGIGDTTRRSGLDNLRARAESLGG
TFTATTPPTGGTHLRWAAPF

Specific function: Member of the two-component regulatory system devR/devS (dosR/dosS) involved in onset of the dormancy response. May act as a redox sensor (rather than a direct hypoxia sensor); the normal (aerobic growth) state is the Fe(3+) form, while the reduced (anaer

COG id: COG2203

COG function: function code T; FOG: GAF domain

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1787474, Length=217, Percent_Identity=30.8755760368664, Blast_Score=77, Evalue=3e-15,
Organism=Escherichia coli, GI1788812, Length=214, Percent_Identity=29.9065420560748, Blast_Score=76, Evalue=5e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016030
- InterPro:   IPR003594
- InterPro:   IPR003018
- InterPro:   IPR011712
- InterPro:   IPR005467 [H]

Pfam domain/function: PF01590 GAF; PF02518 HATPase_c; PF07730 HisKA_3 [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 61973; Mature: 61973

Theoretical pI: Translated: 6.04; Mature: 6.04

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFPTVARLELDDLLSQLVDRAQDVLATQGRLRGLLHANRVIATDLRLPVLLRHIVEAATD
CCCCCHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEECCHHHHHHHHHHHHHHH
LLGARYGALGVVAPDRTLEEFVHVGMTDADVERIGHLPTGHGLLGILIDDPRPRRADDIA
HHHHHCCCEEEECCCHHHHHHHHCCCCHHHHHHHCCCCCCCCEEEEEECCCCCCCCCCCC
HDPASQGFPAGHPPMRTFLGVPITVRGEVFGNLYLTDKRDGVPFTAEDEELAQALAANAG
CCCCCCCCCCCCCCHHHHHCCCEEEECEEEEEEEEECCCCCCCCCCCHHHHHHHHHHCCC
VAIANARLYHEAQQRHLWMTASAEISRQVMVGADNALATLVHRVQEVADAPFVALALHTT
EEEHHHHHHHHHHHCEEEEEECHHHCCEEEECCCHHHHHHHHHHHHHHCCCEEEEEEEEC
NQGTADGGDRSKEAGYARVAVAVTERHVTGSAHAGLGTDASRAGRLIPLEHTLTGRVIAE
CCCCCCCCCCCCCCCCEEEEEEEEEHCCCCCCCCCCCCCHHHCCCEEEECCCCCCHHHHH
QQALRVDDSELDALPDERAARTGPLMVVPLVAGGDQCGGALLIGRDRGVRAFTDGDLDMA
HHHHCCCCHHHHCCCCHHHHCCCCEEEEEEEECCCCCCCEEEEECCCCCEEEECCCHHHH
AGFAGHVAVALELARARADQEHLRVLADRGRIARDLHDHVIQRMFAVALGMQDLAQYENP
CCHHHHHHHHHHHHHHHCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCHHHHHHCCCC
SNAGRLNGYVEDIDATIKDIRRSIFELRGQSPTKRGRLRAGLNKIADDVRLALGFAPAIS
CCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCEE
LTGPLDTVADDQLTDHLLAVTREALTNTARHAHATSVEVRLAVDGDMVTLDAVDNGVGIG
CCCCCCHHCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEECCCEEEEEECCCCCCCC
DTTRRSGLDNLRARAESLGGTFTATTPPTGGTHLRWAAPF
CCHHHCCHHHHHHHHHHCCCEEEECCCCCCCCEEEEECCC
>Mature Secondary Structure
MFPTVARLELDDLLSQLVDRAQDVLATQGRLRGLLHANRVIATDLRLPVLLRHIVEAATD
CCCCCHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEECCHHHHHHHHHHHHHHH
LLGARYGALGVVAPDRTLEEFVHVGMTDADVERIGHLPTGHGLLGILIDDPRPRRADDIA
HHHHHCCCEEEECCCHHHHHHHHCCCCHHHHHHHCCCCCCCCEEEEEECCCCCCCCCCCC
HDPASQGFPAGHPPMRTFLGVPITVRGEVFGNLYLTDKRDGVPFTAEDEELAQALAANAG
CCCCCCCCCCCCCCHHHHHCCCEEEECEEEEEEEEECCCCCCCCCCCHHHHHHHHHHCCC
VAIANARLYHEAQQRHLWMTASAEISRQVMVGADNALATLVHRVQEVADAPFVALALHTT
EEEHHHHHHHHHHHCEEEEEECHHHCCEEEECCCHHHHHHHHHHHHHHCCCEEEEEEEEC
NQGTADGGDRSKEAGYARVAVAVTERHVTGSAHAGLGTDASRAGRLIPLEHTLTGRVIAE
CCCCCCCCCCCCCCCCEEEEEEEEEHCCCCCCCCCCCCCHHHCCCEEEECCCCCCHHHHH
QQALRVDDSELDALPDERAARTGPLMVVPLVAGGDQCGGALLIGRDRGVRAFTDGDLDMA
HHHHCCCCHHHHCCCCHHHHCCCCEEEEEEEECCCCCCCEEEEECCCCCEEEECCCHHHH
AGFAGHVAVALELARARADQEHLRVLADRGRIARDLHDHVIQRMFAVALGMQDLAQYENP
CCHHHHHHHHHHHHHHHCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCHHHHHHCCCC
SNAGRLNGYVEDIDATIKDIRRSIFELRGQSPTKRGRLRAGLNKIADDVRLALGFAPAIS
CCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCEE
LTGPLDTVADDQLTDHLLAVTREALTNTARHAHATSVEVRLAVDGDMVTLDAVDNGVGIG
CCCCCCHHCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEECCCEEEEEECCCCCCCC
DTTRRSGLDNLRARAESLGGTFTATTPPTGGTHLRWAAPF
CCHHHCCHHHHHHHHHHCCCEEEECCCCCCCCEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]