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The map label for this gene is yngJ [H]

Identifier: 158318582

GI number: 158318582

Start: 8350859

End: 8351995

Strand: Reverse

Name: yngJ [H]

Synonym: Franean1_6850

Alternate gene names: 158318582

Gene position: 8351995-8350859 (Counterclockwise)

Preceding gene: 158318584

Following gene: 158318581

Centisome position: 92.99

GC content: 73.44

Gene sequence:

>1137_bases
ATGGGCGAGGGCGTGGCGACCCTGCGCCGGGAGCTTCGTCAGCTGGTCCGCGAGCACGTGCCACCCGACTTCCTCGGTGC
CTTCACCGCCGACCCCGCTGACCTCGAGGTCGCCCAGGCGTTCTGCCGGACCCTCGCGGAGCGCGGCCTGCTGTGCATGG
CCTGGCCCCGCGAGTTCGGCGGGCGCGAGTCGTCGCCGTGGGAGCAGATGGCCGTCCGCGAGGAGATGTGGGCCCTGCAC
GAGCCGCGCGGCGCGCAGTACATGGGCGTCAACTGGGTCGGTCCGACGATCATGCGGCACGGCACGGCCGAGCAGCAGGC
CCGCCACCTGCCTCCGATCTCCCGCGGAGAGGTGATCTGGTGCCAGGGCTTCAGCGAGCCCGAGGCGGGCTCTGACCTCG
CCTCCCTGCGCACCACCGCCCGCCGCGACGGCGACGGCTGGCGGGTCACCGGCCAGAAGGTCTGGACCTCCTACGCCACG
ATGGCGCAGTGGTGCTTCCTGCTGGCCCGGACCTCCAAGGGCGCCCGCCGGCAGCAGGGCCTCACGGTCTTCCTGGTGCC
GATGTCCGACCCCGCGATCGAGGTCCGTCCCATCGCCAGCATGATCGGCCCGCACCACCTCAACGAGGTGTTCTTCGACG
AGCTGCGGGTGACCGAGGCGGACGTCCTCGGCACCGTGGACGAGGGCTGGTCGCTCGTCCAGGAGGTGCTGGCCTTCGAA
CGGGTGGGTATCGCCCGCTACGCCCGGGTCGAGCGGCTGCTGCACGAGGCTCCCGCCGCCCTCGGTGACCAGTGGGAGAA
GCTCCCCGAGGAGCTGCGCGGCCGCTGGGCCCGGATGCTCGTGCACGCCCGCCGGGCCCGGCTGCTCGCCTACCGCGTCG
TGGCACTGCAGGCCAGCGGCCGGATCAGGCCCGACGACTCGGCCGCCTACCGGATCGCGGTGACCCGGCTGGACCAGGAG
AGCGCGGAGGTGCTCATGGACATCGTCGCCGAGGCGTCCCTGCCCGACGAGGCGGGCCGCCGGTTCCGCCGCGCGGTCGC
CGACCACCGGCGCTACTCGGTGTCGGCCACCGTGGCCTCGGGCAGCGTGGAGATGCAGCGGATCCTGATGGCGCGCGCCC
TGCTGGCGGCGTCGTGA

Upstream 100 bases:

>100_bases
CGGCGGCTGATCGACACCCTGCGAGCATACCGCTCGTTATCCTTATAAGTATTGAAGGTTGACGCGATTCGGACTACTTT
TCCGGTCCATGGAGTACGAG

Downstream 100 bases:

>100_bases
CCGCCGTCCTGGGCACGGCCACGAGCACGGACATGAACACCGAGCTGAGCGACGAGGCCGCCGAGTACGGCCGGACGGCC
CTGCGCGCCTTCGAGGCGGC

Product: acyl-CoA dehydrogenase domain-containing protein

Products: gamma-butyrobetaine; Acceptor; gamma-butyrobetainyl-CoA [C]

Alternate protein names: NA

Number of amino acids: Translated: 378; Mature: 377

Protein sequence:

>378_residues
MGEGVATLRRELRQLVREHVPPDFLGAFTADPADLEVAQAFCRTLAERGLLCMAWPREFGGRESSPWEQMAVREEMWALH
EPRGAQYMGVNWVGPTIMRHGTAEQQARHLPPISRGEVIWCQGFSEPEAGSDLASLRTTARRDGDGWRVTGQKVWTSYAT
MAQWCFLLARTSKGARRQQGLTVFLVPMSDPAIEVRPIASMIGPHHLNEVFFDELRVTEADVLGTVDEGWSLVQEVLAFE
RVGIARYARVERLLHEAPAALGDQWEKLPEELRGRWARMLVHARRARLLAYRVVALQASGRIRPDDSAAYRIAVTRLDQE
SAEVLMDIVAEASLPDEAGRRFRRAVADHRRYSVSATVASGSVEMQRILMARALLAAS

Sequences:

>Translated_378_residues
MGEGVATLRRELRQLVREHVPPDFLGAFTADPADLEVAQAFCRTLAERGLLCMAWPREFGGRESSPWEQMAVREEMWALH
EPRGAQYMGVNWVGPTIMRHGTAEQQARHLPPISRGEVIWCQGFSEPEAGSDLASLRTTARRDGDGWRVTGQKVWTSYAT
MAQWCFLLARTSKGARRQQGLTVFLVPMSDPAIEVRPIASMIGPHHLNEVFFDELRVTEADVLGTVDEGWSLVQEVLAFE
RVGIARYARVERLLHEAPAALGDQWEKLPEELRGRWARMLVHARRARLLAYRVVALQASGRIRPDDSAAYRIAVTRLDQE
SAEVLMDIVAEASLPDEAGRRFRRAVADHRRYSVSATVASGSVEMQRILMARALLAAS
>Mature_377_residues
GEGVATLRRELRQLVREHVPPDFLGAFTADPADLEVAQAFCRTLAERGLLCMAWPREFGGRESSPWEQMAVREEMWALHE
PRGAQYMGVNWVGPTIMRHGTAEQQARHLPPISRGEVIWCQGFSEPEAGSDLASLRTTARRDGDGWRVTGQKVWTSYATM
AQWCFLLARTSKGARRQQGLTVFLVPMSDPAIEVRPIASMIGPHHLNEVFFDELRVTEADVLGTVDEGWSLVQEVLAFER
VGIARYARVERLLHEAPAALGDQWEKLPEELRGRWARMLVHARRARLLAYRVVALQASGRIRPDDSAAYRIAVTRLDQES
AEVLMDIVAEASLPDEAGRRFRRAVADHRRYSVSATVASGSVEMQRILMARALLAAS

Specific function: Catalyzes the reduction of crotonobetainyl-CoA to gamma-butyrobetainyl-CoA. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the acyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4557233, Length=350, Percent_Identity=26.2857142857143, Blast_Score=103, Evalue=2e-22,
Organism=Homo sapiens, GI226958412, Length=387, Percent_Identity=24.5478036175711, Blast_Score=95, Evalue=1e-19,
Organism=Homo sapiens, GI226958414, Length=355, Percent_Identity=25.0704225352113, Blast_Score=92, Evalue=5e-19,
Organism=Homo sapiens, GI76496475, Length=258, Percent_Identity=29.0697674418605, Blast_Score=82, Evalue=9e-16,
Organism=Homo sapiens, GI4557235, Length=258, Percent_Identity=29.0697674418605, Blast_Score=82, Evalue=9e-16,
Organism=Homo sapiens, GI4501859, Length=242, Percent_Identity=26.8595041322314, Blast_Score=81, Evalue=2e-15,
Organism=Homo sapiens, GI4501857, Length=245, Percent_Identity=26.9387755102041, Blast_Score=80, Evalue=3e-15,
Organism=Escherichia coli, GI1786223, Length=347, Percent_Identity=24.7838616714697, Blast_Score=84, Evalue=1e-17,
Organism=Escherichia coli, GI87081958, Length=249, Percent_Identity=26.9076305220884, Blast_Score=79, Evalue=6e-16,
Organism=Caenorhabditis elegans, GI17538396, Length=390, Percent_Identity=24.8717948717949, Blast_Score=107, Evalue=1e-23,
Organism=Caenorhabditis elegans, GI17508101, Length=203, Percent_Identity=32.512315270936, Blast_Score=106, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI17506239, Length=204, Percent_Identity=30.8823529411765, Blast_Score=96, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI32563615, Length=195, Percent_Identity=30.7692307692308, Blast_Score=91, Evalue=7e-19,
Organism=Caenorhabditis elegans, GI71990804, Length=218, Percent_Identity=27.0642201834862, Blast_Score=84, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI17551932, Length=370, Percent_Identity=22.7027027027027, Blast_Score=80, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI17505929, Length=377, Percent_Identity=24.4031830238727, Blast_Score=80, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17569725, Length=357, Percent_Identity=22.1288515406162, Blast_Score=77, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17534899, Length=351, Percent_Identity=22.2222222222222, Blast_Score=74, Evalue=1e-13,
Organism=Drosophila melanogaster, GI24666513, Length=315, Percent_Identity=27.6190476190476, Blast_Score=100, Evalue=1e-21,
Organism=Drosophila melanogaster, GI24646207, Length=349, Percent_Identity=25.5014326647564, Blast_Score=100, Evalue=3e-21,
Organism=Drosophila melanogaster, GI21355753, Length=349, Percent_Identity=26.0744985673352, Blast_Score=88, Evalue=7e-18,
Organism=Drosophila melanogaster, GI21356377, Length=347, Percent_Identity=23.9193083573487, Blast_Score=85, Evalue=7e-17,
Organism=Drosophila melanogaster, GI281363737, Length=236, Percent_Identity=24.1525423728814, Blast_Score=75, Evalue=6e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006089
- InterPro:   IPR006092
- InterPro:   IPR006090
- InterPro:   IPR006091
- InterPro:   IPR009075
- InterPro:   IPR013786
- InterPro:   IPR009100 [H]

Pfam domain/function: PF00441 Acyl-CoA_dh_1; PF02770 Acyl-CoA_dh_M; PF02771 Acyl-CoA_dh_N [H]

EC number: 1.3.99.- [C]

Molecular weight: Translated: 42390; Mature: 42259

Theoretical pI: Translated: 7.29; Mature: 7.29

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGEGVATLRRELRQLVREHVPPDFLGAFTADPADLEVAQAFCRTLAERGLLCMAWPREFG
CCCCHHHHHHHHHHHHHHCCCHHHHHHCCCCCCHHHHHHHHHHHHHHCCCEEEECCHHHC
GRESSPWEQMAVREEMWALHEPRGAQYMGVNWVGPTIMRHGTAEQQARHLPPISRGEVIW
CCCCCCHHHHHHHHHHHHHCCCCCCCEEECCCCCHHHHHCCCHHHHHHCCCCCCCCCEEE
CQGFSEPEAGSDLASLRTTARRDGDGWRVTGQKVWTSYATMAQWCFLLARTSKGARRQQG
ECCCCCCCCCCHHHHHHHHHHCCCCCEEEEHHHHHHHHHHHHHHHHHHHHCCCCCHHHCC
LTVFLVPMSDPAIEVRPIASMIGPHHLNEVFFDELRVTEADVLGTVDEGWSLVQEVLAFE
CEEEEEECCCCCEEHHHHHHHHCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHH
RVGIARYARVERLLHEAPAALGDQWEKLPEELRGRWARMLVHARRARLLAYRVVALQASG
HHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCC
RIRPDDSAAYRIAVTRLDQESAEVLMDIVAEASLPDEAGRRFRRAVADHRRYSVSATVAS
CCCCCCCCEEEEEEECCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHEEEEEEEEC
GSVEMQRILMARALLAAS
CHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
GEGVATLRRELRQLVREHVPPDFLGAFTADPADLEVAQAFCRTLAERGLLCMAWPREFG
CCCHHHHHHHHHHHHHHCCCHHHHHHCCCCCCHHHHHHHHHHHHHHCCCEEEECCHHHC
GRESSPWEQMAVREEMWALHEPRGAQYMGVNWVGPTIMRHGTAEQQARHLPPISRGEVIW
CCCCCCHHHHHHHHHHHHHCCCCCCCEEECCCCCHHHHHCCCHHHHHHCCCCCCCCCEEE
CQGFSEPEAGSDLASLRTTARRDGDGWRVTGQKVWTSYATMAQWCFLLARTSKGARRQQG
ECCCCCCCCCCHHHHHHHHHHCCCCCEEEEHHHHHHHHHHHHHHHHHHHHCCCCCHHHCC
LTVFLVPMSDPAIEVRPIASMIGPHHLNEVFFDELRVTEADVLGTVDEGWSLVQEVLAFE
CEEEEEECCCCCEEHHHHHHHHCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHH
RVGIARYARVERLLHEAPAALGDQWEKLPEELRGRWARMLVHARRARLLAYRVVALQASG
HHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCC
RIRPDDSAAYRIAVTRLDQESAEVLMDIVAEASLPDEAGRRFRRAVADHRRYSVSATVAS
CCCCCCCCEEEEEEECCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHEEEEEEEEC
GSVEMQRILMARALLAAS
CHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: crotono-betaine; reduced acceptor; crotonobetainyl-CoA [C]

Specific reaction: reduced acceptor + crotono-betaine = Acceptor + gamma-butyrobetaine reduced acceptor + crotonobetainyl-CoA = Acceptor + gamma-butyrobetainyl-CoA [C]

General reaction: Oxidoreductases; Acting on the CH-CH group of donors; With other acceptors [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9387222; 9384377 [H]