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The map label for this gene is frmA [H]

Identifier: 158318573

GI number: 158318573

Start: 8341658

End: 8342734

Strand: Reverse

Name: frmA [H]

Synonym: Franean1_6841

Alternate gene names: 158318573

Gene position: 8342734-8341658 (Counterclockwise)

Preceding gene: 158318576

Following gene: 158318571

Centisome position: 92.88

GC content: 72.42

Gene sequence:

>1077_bases
GTGCGGGTCGCTGTCGCGTACGAGGCCGAGAAGCCGCTGGTCGTCGAGGATCTCGACCAGCCCGCCGTGGGCCCGCGGGA
TGTGCTCGTGCGCATCGCCGCGAGCGGTATCTGCCATACCGACCTCCACGTCATCAACGGGCACTCGCCGCTGCCGCTGC
CGATCGTTCCCGGTCACGAGGCGTGCGGTGTGGTCGAGGAGGTGGGCTCCGAGGTCCGCCGGGTGAAGGTGGGCCAGCGG
GTGCTCGCCGCGGTGTCGCCGGCCTGCGGCACCTGCTGGTGGTGCGTCAACGGCATGTCCAACCACTGCGAGCTCGGCGG
GCCGGTCAAGGCGGCGCCGCGGTTCACGCTGGCCGACGGCCGCACCGCGGCCGCCGTGTGCGGCTGCGGCACGTTCGCCG
AGGCGATGGTGGTCGACGAGGCCTCGGTCGTGCCGACCAACACCGACCTGGCCGACGAGGAGCTGGCGCTGCTCGGCTGC
GGGGTGACCACCGGGCTCGGCGCGGCGCTCATCACCGCCGGCGTGACCCCCGGCTCGTCCGTCGCGGTGATCGGCTGTGG
CGGGGTCGGGCAGTCGGTGATCCAGGGCGCGCGTATCTCCGGCGCGGCCACCATCATCGGCATCGACCTCGTGCCCGCCC
GCCGCGAGGCCAGCCTGCGGGTCGGCGCGACCCACGTGGTCGACCCGGCGGAGGCCGACCCGGTCGAGCAGGTGCGCGCG
CTGACCGAGGGGCGCGGTGTGGACTTCAGCTTCGAGGTCGTCGGCCTGCCCAACCTGATGGTGCAGGCCTTCGACATGGC
ACGTAAACAGGGAGCGGTCACGCTGGTCGGCATGCCGACCACGACCGCGACCCTGACCCTGCCGGCCATCTCGGCGATCT
TCTCCGGCAAGCGCCTCGCCGGTTCCGTGGTGGGCGGCGCCCAGATCCTGCGTGACATGCCCAGGTTCATCCGGCTGGCC
GAGACCGGCCAGCTCGACCTCGGCGGCATGGTGTCCAACCGGATCCGGCTGGACGACATCAACGAGGGCATCGCGCTGCT
CGACCGCGCCGAGGGCACCCGGACCGTGATCATCTAA

Upstream 100 bases:

>100_bases
ACGGACCTCTTGTGGAGTGAGCGGTTACTGAAATATCCTCGGCGTTGCGCGCGGCCCCCTCACGGTCCCTGGGCCGGCGG
TGCTGATGGGAGGATCGCCA

Downstream 100 bases:

>100_bases
CGGCGGTCGTCTGAAGGTTGCGCCGAGAGCCGACCCCGGGTGACCCTCGGACAGGGGCTCGCCGCCGACGTGTCGTGTCG
GGAGGGAACGCGAACTTGAC

Product: alcohol dehydrogenase

Products: NA

Alternate protein names: Alcohol dehydrogenase class-3; Alcohol dehydrogenase class-III; Glutathione-dependent formaldehyde dehydrogenase; FALDH; FDH; GSH-FDH [H]

Number of amino acids: Translated: 358; Mature: 358

Protein sequence:

>358_residues
MRVAVAYEAEKPLVVEDLDQPAVGPRDVLVRIAASGICHTDLHVINGHSPLPLPIVPGHEACGVVEEVGSEVRRVKVGQR
VLAAVSPACGTCWWCVNGMSNHCELGGPVKAAPRFTLADGRTAAAVCGCGTFAEAMVVDEASVVPTNTDLADEELALLGC
GVTTGLGAALITAGVTPGSSVAVIGCGGVGQSVIQGARISGAATIIGIDLVPARREASLRVGATHVVDPAEADPVEQVRA
LTEGRGVDFSFEVVGLPNLMVQAFDMARKQGAVTLVGMPTTTATLTLPAISAIFSGKRLAGSVVGGAQILRDMPRFIRLA
ETGQLDLGGMVSNRIRLDDINEGIALLDRAEGTRTVII

Sequences:

>Translated_358_residues
MRVAVAYEAEKPLVVEDLDQPAVGPRDVLVRIAASGICHTDLHVINGHSPLPLPIVPGHEACGVVEEVGSEVRRVKVGQR
VLAAVSPACGTCWWCVNGMSNHCELGGPVKAAPRFTLADGRTAAAVCGCGTFAEAMVVDEASVVPTNTDLADEELALLGC
GVTTGLGAALITAGVTPGSSVAVIGCGGVGQSVIQGARISGAATIIGIDLVPARREASLRVGATHVVDPAEADPVEQVRA
LTEGRGVDFSFEVVGLPNLMVQAFDMARKQGAVTLVGMPTTTATLTLPAISAIFSGKRLAGSVVGGAQILRDMPRFIRLA
ETGQLDLGGMVSNRIRLDDINEGIALLDRAEGTRTVII
>Mature_358_residues
MRVAVAYEAEKPLVVEDLDQPAVGPRDVLVRIAASGICHTDLHVINGHSPLPLPIVPGHEACGVVEEVGSEVRRVKVGQR
VLAAVSPACGTCWWCVNGMSNHCELGGPVKAAPRFTLADGRTAAAVCGCGTFAEAMVVDEASVVPTNTDLADEELALLGC
GVTTGLGAALITAGVTPGSSVAVIGCGGVGQSVIQGARISGAATIIGIDLVPARREASLRVGATHVVDPAEADPVEQVRA
LTEGRGVDFSFEVVGLPNLMVQAFDMARKQGAVTLVGMPTTTATLTLPAISAIFSGKRLAGSVVGGAQILRDMPRFIRLA
ETGQLDLGGMVSNRIRLDDINEGIALLDRAEGTRTVII

Specific function: Has High Formaldehyde Dehydrogenase Activity In The Presence Of Glutathione And Catalyzes The Oxidation Of Normal Alcohols In A Reaction That Is Not Gsh-Dependent. In Addition, Hemithiolacetals Other Than Those Formed From Gsh, Including Omega-Thiol Fatty

COG id: COG1062

COG function: function code C; Zn-dependent alcohol dehydrogenases, class III

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily [H]

Homologues:

Organism=Homo sapiens, GI34577061, Length=366, Percent_Identity=35.2459016393443, Blast_Score=218, Evalue=9e-57,
Organism=Homo sapiens, GI4501933, Length=366, Percent_Identity=34.6994535519126, Blast_Score=216, Evalue=2e-56,
Organism=Homo sapiens, GI4501929, Length=369, Percent_Identity=34.6883468834688, Blast_Score=207, Evalue=1e-53,
Organism=Homo sapiens, GI262073058, Length=364, Percent_Identity=34.3406593406593, Blast_Score=207, Evalue=1e-53,
Organism=Homo sapiens, GI71743840, Length=364, Percent_Identity=34.3406593406593, Blast_Score=207, Evalue=2e-53,
Organism=Homo sapiens, GI71565154, Length=365, Percent_Identity=31.5068493150685, Blast_Score=192, Evalue=4e-49,
Organism=Homo sapiens, GI71565152, Length=372, Percent_Identity=32.258064516129, Blast_Score=192, Evalue=5e-49,
Organism=Homo sapiens, GI156523966, Length=368, Percent_Identity=31.7934782608696, Blast_Score=190, Evalue=1e-48,
Organism=Homo sapiens, GI4501939, Length=358, Percent_Identity=32.4022346368715, Blast_Score=187, Evalue=2e-47,
Organism=Escherichia coli, GI1786552, Length=366, Percent_Identity=35.5191256830601, Blast_Score=188, Evalue=5e-49,
Organism=Escherichia coli, GI1790045, Length=364, Percent_Identity=25.2747252747253, Blast_Score=114, Evalue=1e-26,
Organism=Escherichia coli, GI1786518, Length=364, Percent_Identity=30.4945054945055, Blast_Score=101, Evalue=8e-23,
Organism=Escherichia coli, GI1788073, Length=356, Percent_Identity=26.4044943820225, Blast_Score=100, Evalue=3e-22,
Organism=Escherichia coli, GI1788075, Length=344, Percent_Identity=27.906976744186, Blast_Score=95, Evalue=6e-21,
Organism=Escherichia coli, GI1786825, Length=267, Percent_Identity=32.2097378277154, Blast_Score=89, Evalue=4e-19,
Organism=Escherichia coli, GI87082125, Length=347, Percent_Identity=25.6484149855908, Blast_Score=87, Evalue=2e-18,
Organism=Escherichia coli, GI226510992, Length=341, Percent_Identity=27.5659824046921, Blast_Score=84, Evalue=2e-17,
Organism=Escherichia coli, GI1788407, Length=258, Percent_Identity=28.2945736434109, Blast_Score=82, Evalue=7e-17,
Organism=Escherichia coli, GI1790718, Length=335, Percent_Identity=25.3731343283582, Blast_Score=82, Evalue=8e-17,
Organism=Escherichia coli, GI87081918, Length=291, Percent_Identity=28.8659793814433, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI87082401, Length=320, Percent_Identity=29.6875, Blast_Score=75, Evalue=7e-15,
Organism=Escherichia coli, GI1787863, Length=359, Percent_Identity=23.9554317548747, Blast_Score=74, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI25146526, Length=375, Percent_Identity=32.5333333333333, Blast_Score=194, Evalue=8e-50,
Organism=Caenorhabditis elegans, GI71997431, Length=377, Percent_Identity=32.3607427055703, Blast_Score=189, Evalue=1e-48,
Organism=Caenorhabditis elegans, GI17565904, Length=348, Percent_Identity=32.4712643678161, Blast_Score=177, Evalue=5e-45,
Organism=Caenorhabditis elegans, GI17562584, Length=313, Percent_Identity=28.4345047923323, Blast_Score=88, Evalue=6e-18,
Organism=Caenorhabditis elegans, GI71988145, Length=338, Percent_Identity=28.1065088757396, Blast_Score=86, Evalue=3e-17,
Organism=Caenorhabditis elegans, GI17562876, Length=353, Percent_Identity=24.6458923512748, Blast_Score=79, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17562582, Length=306, Percent_Identity=29.4117647058824, Blast_Score=78, Evalue=5e-15,
Organism=Caenorhabditis elegans, GI17562878, Length=209, Percent_Identity=29.6650717703349, Blast_Score=69, Evalue=5e-12,
Organism=Saccharomyces cerevisiae, GI6320033, Length=371, Percent_Identity=35.8490566037736, Blast_Score=207, Evalue=2e-54,
Organism=Saccharomyces cerevisiae, GI6319621, Length=358, Percent_Identity=30.7262569832402, Blast_Score=106, Evalue=5e-24,
Organism=Saccharomyces cerevisiae, GI6323961, Length=323, Percent_Identity=30.6501547987616, Blast_Score=100, Evalue=2e-22,
Organism=Saccharomyces cerevisiae, GI6323729, Length=325, Percent_Identity=29.5384615384615, Blast_Score=99, Evalue=1e-21,
Organism=Saccharomyces cerevisiae, GI6324486, Length=319, Percent_Identity=30.0940438871473, Blast_Score=94, Evalue=3e-20,
Organism=Saccharomyces cerevisiae, GI6319258, Length=390, Percent_Identity=24.1025641025641, Blast_Score=81, Evalue=2e-16,
Organism=Saccharomyces cerevisiae, GI6319257, Length=391, Percent_Identity=25.3196930946292, Blast_Score=78, Evalue=3e-15,
Organism=Drosophila melanogaster, GI17737895, Length=368, Percent_Identity=33.1521739130435, Blast_Score=192, Evalue=3e-49,
Organism=Drosophila melanogaster, GI17137530, Length=213, Percent_Identity=31.924882629108, Blast_Score=73, Evalue=4e-13,
Organism=Drosophila melanogaster, GI17737897, Length=213, Percent_Identity=31.924882629108, Blast_Score=70, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014183
- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR011032
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: =1.1.1.284; =1.1.1.1 [H]

Molecular weight: Translated: 36817; Mature: 36817

Theoretical pI: Translated: 4.93; Mature: 4.93

Prosite motif: PS00059 ADH_ZINC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.8 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
2.8 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRVAVAYEAEKPLVVEDLDQPAVGPRDVLVRIAASGICHTDLHVINGHSPLPLPIVPGHE
CEEEEEECCCCCEEEECCCCCCCCHHHHHHHHHHCCCEECCEEEECCCCCCCCEECCCCH
ACGVVEEVGSEVRRVKVGQRVLAAVSPACGTCWWCVNGMSNHCELGGPVKAAPRFTLADG
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHEECCCCCCCCCCCCCCCCCCEEEECCC
RTAAAVCGCGTFAEAMVVDEASVVPTNTDLADEELALLGCGVTTGLGAALITAGVTPGSS
CCEEEEECCCHHHHHEEECCCCCCCCCCCCCCCCEEEEECCHHHHHHHHHHHCCCCCCCC
VAVIGCGGVGQSVIQGARISGAATIIGIDLVPARREASLRVGATHVVDPAEADPVEQVRA
EEEEEECCCCHHHHCCCCCCCCEEEEEEEECCCCCCCCEEECCEEECCCCCCCHHHHHHH
LTEGRGVDFSFEVVGLPNLMVQAFDMARKQGAVTLVGMPTTTATLTLPAISAIFSGKRLA
HHCCCCCCEEEEEECCCHHHHHHHHHHHHCCCEEEEECCCCCEEEEHHHHHHHHCCCHHH
GSVVGGAQILRDMPRFIRLAETGQLDLGGMVSNRIRLDDINEGIALLDRAEGTRTVII
HHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHCCCEEECCCCCCCEEEECCCCCEEEEC
>Mature Secondary Structure
MRVAVAYEAEKPLVVEDLDQPAVGPRDVLVRIAASGICHTDLHVINGHSPLPLPIVPGHE
CEEEEEECCCCCEEEECCCCCCCCHHHHHHHHHHCCCEECCEEEECCCCCCCCEECCCCH
ACGVVEEVGSEVRRVKVGQRVLAAVSPACGTCWWCVNGMSNHCELGGPVKAAPRFTLADG
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHEECCCCCCCCCCCCCCCCCCEEEECCC
RTAAAVCGCGTFAEAMVVDEASVVPTNTDLADEELALLGCGVTTGLGAALITAGVTPGSS
CCEEEEECCCHHHHHEEECCCCCCCCCCCCCCCCEEEEECCHHHHHHHHHHHCCCCCCCC
VAVIGCGGVGQSVIQGARISGAATIIGIDLVPARREASLRVGATHVVDPAEADPVEQVRA
EEEEEECCCCHHHHCCCCCCCCEEEEEEEECCCCCCCCEEECCEEECCCCCCCHHHHHHH
LTEGRGVDFSFEVVGLPNLMVQAFDMARKQGAVTLVGMPTTTATLTLPAISAIFSGKRLA
HHCCCCCCEEEEEECCCHHHHHHHHHHHHCCCEEEEECCCCCEEEEHHHHHHHHCCCHHH
GSVVGGAQILRDMPRFIRLAETGQLDLGGMVSNRIRLDDINEGIALLDRAEGTRTVII
HHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHCCCEEECCCCCCCEEEECCCCCEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]