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The map label for this gene is tcmA [H]

Identifier: 158318558

GI number: 158318558

Start: 8318701

End: 8320272

Strand: Direct

Name: tcmA [H]

Synonym: Franean1_6826

Alternate gene names: 158318558

Gene position: 8318701-8320272 (Clockwise)

Preceding gene: 158318554

Following gene: 158318559

Centisome position: 92.61

GC content: 71.82

Gene sequence:

>1572_bases
ATGGACGCCAGCGAAGTCTCGAACGGAGCGAGCCCGGACTCCGGCCCGGGCTCCGGAGCCGGGACGGACGCTCCGTCACG
AGCCAGCGCCATCGTCGCCGTCCTGGCCGCGGTCGGCGTCCTGGTCTCGCTCATGCAGACGCTGATGGTGCCGCTGATCC
CGGTACTGCCGAAGCTCCTGCACTCCAACGCGAGCGACGCGTCCTGGGCCATCACGGCGACCCTGCTCACCGGGGCCGTC
GCGAACCCGGTCTTCGGCCGGCTCGGCGACCTGTTCGGCAAGCGGCGGATGCTCCTGCTCTCCGGCTACATCCTCGTGGC
GGGCTCGCTGGTCTGTGCCCTGACCGACTCCCTGGTGCCGATCGTGGCAGGCCGGGCCCTGCAGGGCCTCGGCCTGGCGA
TCATCCCGCTGGGCATCAGCATCATGCGTGACCTTCTCCCGCCGAAGCGGCTGATCCCGGCCATGGCCCTGATGAGCTCG
TCGCTCGGCATCGGCGGCGCGCTGGGACTGCCGATCGCGGCGATCGTCGCGCAGAACCTCGACTGGCATGTGCTGTTCTG
GGGTTCGGCCATCGCCACCCTGATCCTCGTGGCGCTGGTCACGGTCGTGGTCCCCGAGTCCCCCGTCCGGGGTTCCGGCA
GCTTCGACCTGCCCGGAGCAGTGGCCCTCTCCGCGGGCCTCGTCGCGCTGCTGCTCGCCGTGTCGAAGGGAAGCACCTGG
GGCTGGTCCAGCGCCACCACCCTGGGGCTGTTCGGAGCCGCGGTCGCCGTCCTGCTGGCCTGGGGCCGGTGGGAGACCCG
CGCGAAGGCCCCGCTGGTCGACCTGCGCACCTCGACCCGGCGCCCGGTGCTCCTGACGAACCTGTCCTCCACCGTGCTGG
GCTTCGCGATGTACGCGATGTCGCTGATCTGCCCGCAGATCATGCAGCTACCCAGGGCCACCGGGCACGGCCTCGGCCAG
TCACTGCTCGCCACCGGCCTGTGGATGGCGCCGGCGGGGCTGATGATGATGGTCGTCTCGCCCTTCGCTGGACGCCTGAT
CACCGCCCGCGGGCCGAAGGTCGCCCTCCTCTCCGGCACAGCTGTGATGACCGTCGGATACGTCGCCGCGCTCGGGCTGA
TGGGCAGCCCCGTGGGCGTCCTGGTCATCGCCTGTTCGATCAGCGGCGGCGTGGGGCTCGCCTACGCGGCGATGCCAACC
CTGATCATGGCCTCGGTGCCCGCTTCCGAAGGCGCCGCCGCCAACGGCCTCAACACCCTGATGCGCTCCATCGGGACGTC
GACGGCCAGTGCCGTGATCGGCGTCGTGCTGGCGAACATGACCATCTCCTTCGGGACGACGCAGGTCCCGTCACTGACCG
GCCTGCGCGTCGGCTTCCTGATCGGCGCCGGCGCCGCACTGGTGGCCTTCCTGGTAGCCCTCGCCATCCCGGCCCGCAAG
TCGGCCGCACCCGCCTCCGTCGTTCCCGACCAGCGCAGCCCGCACGACCGGTCGACCGGGGCCGCTGGGGCCGCCGCCGG
TTCCGTGGCGGAGGGCGCCGCAGCGACGGACGCGGTCGAGGCAAGGGCCTGA

Upstream 100 bases:

>100_bases
CTGCCCGAGGTGTGACCAAGAACCCACCGGCCGTACACGGACATCACGTCGATGTGCGTGATACACATAGTTGTACTGTA
CAGCTAATCTTGGGGTGCAC

Downstream 100 bases:

>100_bases
GCGACTGACTGCCCCGGCCCATACCCGGCGGAGCCCCGCGCGGACGGGGCCCCACTGCCCGGAGACGTGTGGCCGCTAAC
CCGCCGTGGGAAGCTCCACG

Product: major facilitator transporter

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 523; Mature: 523

Protein sequence:

>523_residues
MDASEVSNGASPDSGPGSGAGTDAPSRASAIVAVLAAVGVLVSLMQTLMVPLIPVLPKLLHSNASDASWAITATLLTGAV
ANPVFGRLGDLFGKRRMLLLSGYILVAGSLVCALTDSLVPIVAGRALQGLGLAIIPLGISIMRDLLPPKRLIPAMALMSS
SLGIGGALGLPIAAIVAQNLDWHVLFWGSAIATLILVALVTVVVPESPVRGSGSFDLPGAVALSAGLVALLLAVSKGSTW
GWSSATTLGLFGAAVAVLLAWGRWETRAKAPLVDLRTSTRRPVLLTNLSSTVLGFAMYAMSLICPQIMQLPRATGHGLGQ
SLLATGLWMAPAGLMMMVVSPFAGRLITARGPKVALLSGTAVMTVGYVAALGLMGSPVGVLVIACSISGGVGLAYAAMPT
LIMASVPASEGAAANGLNTLMRSIGTSTASAVIGVVLANMTISFGTTQVPSLTGLRVGFLIGAGAALVAFLVALAIPARK
SAAPASVVPDQRSPHDRSTGAAGAAAGSVAEGAAATDAVEARA

Sequences:

>Translated_523_residues
MDASEVSNGASPDSGPGSGAGTDAPSRASAIVAVLAAVGVLVSLMQTLMVPLIPVLPKLLHSNASDASWAITATLLTGAV
ANPVFGRLGDLFGKRRMLLLSGYILVAGSLVCALTDSLVPIVAGRALQGLGLAIIPLGISIMRDLLPPKRLIPAMALMSS
SLGIGGALGLPIAAIVAQNLDWHVLFWGSAIATLILVALVTVVVPESPVRGSGSFDLPGAVALSAGLVALLLAVSKGSTW
GWSSATTLGLFGAAVAVLLAWGRWETRAKAPLVDLRTSTRRPVLLTNLSSTVLGFAMYAMSLICPQIMQLPRATGHGLGQ
SLLATGLWMAPAGLMMMVVSPFAGRLITARGPKVALLSGTAVMTVGYVAALGLMGSPVGVLVIACSISGGVGLAYAAMPT
LIMASVPASEGAAANGLNTLMRSIGTSTASAVIGVVLANMTISFGTTQVPSLTGLRVGFLIGAGAALVAFLVALAIPARK
SAAPASVVPDQRSPHDRSTGAAGAAAGSVAEGAAATDAVEARA
>Mature_523_residues
MDASEVSNGASPDSGPGSGAGTDAPSRASAIVAVLAAVGVLVSLMQTLMVPLIPVLPKLLHSNASDASWAITATLLTGAV
ANPVFGRLGDLFGKRRMLLLSGYILVAGSLVCALTDSLVPIVAGRALQGLGLAIIPLGISIMRDLLPPKRLIPAMALMSS
SLGIGGALGLPIAAIVAQNLDWHVLFWGSAIATLILVALVTVVVPESPVRGSGSFDLPGAVALSAGLVALLLAVSKGSTW
GWSSATTLGLFGAAVAVLLAWGRWETRAKAPLVDLRTSTRRPVLLTNLSSTVLGFAMYAMSLICPQIMQLPRATGHGLGQ
SLLATGLWMAPAGLMMMVVSPFAGRLITARGPKVALLSGTAVMTVGYVAALGLMGSPVGVLVIACSISGGVGLAYAAMPT
LIMASVPASEGAAANGLNTLMRSIGTSTASAVIGVVLANMTISFGTTQVPSLTGLRVGFLIGAGAALVAFLVALAIPARK
SAAPASVVPDQRSPHDRSTGAAGAAAGSVAEGAAATDAVEARA

Specific function: Resistance to tetracenomycin C by an active tetracenomycin C efflux system which is probably energized by transmembrane electrochemical gradients [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. EmrB family [H]

Homologues:

Organism=Escherichia coli, GI87081983, Length=433, Percent_Identity=26.7898383371824, Blast_Score=98, Evalue=1e-21,
Organism=Escherichia coli, GI1788710, Length=394, Percent_Identity=26.6497461928934, Blast_Score=89, Evalue=6e-19,
Organism=Escherichia coli, GI87081738, Length=132, Percent_Identity=37.1212121212121, Blast_Score=68, Evalue=2e-12,
Organism=Escherichia coli, GI1789042, Length=393, Percent_Identity=22.1374045801527, Blast_Score=65, Evalue=9e-12,
Organism=Saccharomyces cerevisiae, GI6324954, Length=416, Percent_Identity=24.7596153846154, Blast_Score=74, Evalue=4e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004638
- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 52202; Mature: 52202

Theoretical pI: Translated: 10.60; Mature: 10.60

Prosite motif: PS50850 MFS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDASEVSNGASPDSGPGSGAGTDAPSRASAIVAVLAAVGVLVSLMQTLMVPLIPVLPKLL
CCCHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
HSNASDASWAITATLLTGAVANPVFGRLGDLFGKRRMLLLSGYILVAGSLVCALTDSLVP
HCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IVAGRALQGLGLAIIPLGISIMRDLLPPKRLIPAMALMSSSLGIGGALGLPIAAIVAQNL
HHHHHHHHCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCC
DWHVLFWGSAIATLILVALVTVVVPESPVRGSGSFDLPGAVALSAGLVALLLAVSKGSTW
CEEEEEHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCC
GWSSATTLGLFGAAVAVLLAWGRWETRAKAPLVDLRTSTRRPVLLTNLSSTVLGFAMYAM
CCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCEEECCCCCCCCEEEECHHHHHHHHHHHHH
SLICPQIMQLPRATGHGLGQSLLATGLWMAPAGLMMMVVSPFAGRLITARGPKVALLSGT
HHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCEEECCCCEEEEECCH
AVMTVGYVAALGLMGSPVGVLVIACSISGGVGLAYAAMPTLIMASVPASEGAAANGLNTL
HHHHHHHHHHHHHCCCCHHHEEEEEECCCCCHHHHHHHHHHHHHCCCCCCCCCHHHHHHH
MRSIGTSTASAVIGVVLANMTISFGTTQVPSLTGLRVGFLIGAGAALVAFLVALAIPARK
HHHHCCHHHHHHHHHHHHHHHEECCCCCCCCCCCHHHHHHHHCHHHHHHHHHHHHCCCCC
SAAPASVVPDQRSPHDRSTGAAGAAAGSVAEGAAATDAVEARA
CCCCCCCCCCCCCCCCCCCCCCCCCCCCHHCCCHHHHHHHCCC
>Mature Secondary Structure
MDASEVSNGASPDSGPGSGAGTDAPSRASAIVAVLAAVGVLVSLMQTLMVPLIPVLPKLL
CCCHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
HSNASDASWAITATLLTGAVANPVFGRLGDLFGKRRMLLLSGYILVAGSLVCALTDSLVP
HCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IVAGRALQGLGLAIIPLGISIMRDLLPPKRLIPAMALMSSSLGIGGALGLPIAAIVAQNL
HHHHHHHHCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCC
DWHVLFWGSAIATLILVALVTVVVPESPVRGSGSFDLPGAVALSAGLVALLLAVSKGSTW
CEEEEEHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCC
GWSSATTLGLFGAAVAVLLAWGRWETRAKAPLVDLRTSTRRPVLLTNLSSTVLGFAMYAM
CCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCEEECCCCCCCCEEEECHHHHHHHHHHHHH
SLICPQIMQLPRATGHGLGQSLLATGLWMAPAGLMMMVVSPFAGRLITARGPKVALLSGT
HHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCEEECCCCEEEEECCH
AVMTVGYVAALGLMGSPVGVLVIACSISGGVGLAYAAMPTLIMASVPASEGAAANGLNTL
HHHHHHHHHHHHHCCCCHHHEEEEEECCCCCHHHHHHHHHHHHHCCCCCCCCCHHHHHHH
MRSIGTSTASAVIGVVLANMTISFGTTQVPSLTGLRVGFLIGAGAALVAFLVALAIPARK
HHHHCCHHHHHHHHHHHHHHHEECCCCCCCCCCCHHHHHHHHCHHHHHHHHHHHHCCCCC
SAAPASVVPDQRSPHDRSTGAAGAAAGSVAEGAAATDAVEARA
CCCCCCCCCCCCCCCCCCCCCCCCCCCCHHCCCHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1592819 [H]