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The map label for this gene is mprA [H]

Identifier: 158318231

GI number: 158318231

Start: 7897647

End: 7898342

Strand: Direct

Name: mprA [H]

Synonym: Franean1_6496

Alternate gene names: 158318231

Gene position: 7897647-7898342 (Clockwise)

Preceding gene: 158318227

Following gene: 158318232

Centisome position: 87.93

GC content: 70.98

Gene sequence:

>696_bases
ATGCAGCCGTCGAGCCCCCGCATTCTGGTCGTCGACGACGAGAACACACTGTCGGAGCTGCTGTCCATGGCCCTGCGTTA
CGAGGGCTGGGAAGTGCGCACCGCGCAGGACGGGCGCGGCGCGCTGCGCGCCGCCCGCGACTTCCGGCCGGACGCGGTGG
TCCTCGACATCATGCTGCCCGACATGGACGGCCTCGAGGTGCTGCGCAAGCTGCGCGCGGACAGCCCCGAGGTGCCGGTG
CTGTTCCTCACCGCCCGCGACGCCGTCGAGGACCGGGTGGCCGGCCTCACCGCCGGTGGCGACGACTACGTCACCAAGCC
GTTCAGCCTGGAGGAGCTCGTCGCGCGCCTGCGCGGGCTGCTGCGCCGGCTGCACCGCTCGACGATCTGGGACGGCGCGG
TGCTGGTCGTCGGCGACCTCATCATGAACGAGGAGAGCCGCGAGGTCACCCGGGCCGGCCGCGAGATCCGCCTGACGGCG
ACCGAGTTCGAGCTGCTGCGCTACTTCATGCGCAACCCGCGCCGGGTGCTGAGCAAGGCGCAGATCCTCGACCGGGTGTG
GAACTACGACTTCGGCGGCCAGGCGAACGTCGTCGAGCTGTACGTCTCCTACCTGCGCAAGAAGATCGACGCCGGCCGGC
CCGCGATGATCCACACAATGCGCGGCGCCGGCTACGTGCTCCGGCCGGCGACCTGA

Upstream 100 bases:

>100_bases
CCACCGCAGCGGGCCGGCCACCGCGTCGCCCGCGCGGGCGCACAGCCAACCCACAGGAGATGTTCAGGAAGCCCACAGGA
ATGCATCCCATGCTGACGGA

Downstream 100 bases:

>100_bases
CCGGGCCCGTGACGATGACCGGCACCACCGGCACCCACCGGCGGCGCGGCCCGGCCGGCTGGTCGCTGCGTACCAGGCTG
CTCGCGCTGCTCCTCGCGCT

Product: two component transcriptional regulator

Products: NA

Alternate protein names: Mycobacterial persistence regulator A [H]

Number of amino acids: Translated: 231; Mature: 231

Protein sequence:

>231_residues
MQPSSPRILVVDDENTLSELLSMALRYEGWEVRTAQDGRGALRAARDFRPDAVVLDIMLPDMDGLEVLRKLRADSPEVPV
LFLTARDAVEDRVAGLTAGGDDYVTKPFSLEELVARLRGLLRRLHRSTIWDGAVLVVGDLIMNEESREVTRAGREIRLTA
TEFELLRYFMRNPRRVLSKAQILDRVWNYDFGGQANVVELYVSYLRKKIDAGRPAMIHTMRGAGYVLRPAT

Sequences:

>Translated_231_residues
MQPSSPRILVVDDENTLSELLSMALRYEGWEVRTAQDGRGALRAARDFRPDAVVLDIMLPDMDGLEVLRKLRADSPEVPV
LFLTARDAVEDRVAGLTAGGDDYVTKPFSLEELVARLRGLLRRLHRSTIWDGAVLVVGDLIMNEESREVTRAGREIRLTA
TEFELLRYFMRNPRRVLSKAQILDRVWNYDFGGQANVVELYVSYLRKKIDAGRPAMIHTMRGAGYVLRPAT
>Mature_231_residues
MQPSSPRILVVDDENTLSELLSMALRYEGWEVRTAQDGRGALRAARDFRPDAVVLDIMLPDMDGLEVLRKLRADSPEVPV
LFLTARDAVEDRVAGLTAGGDDYVTKPFSLEELVARLRGLLRRLHRSTIWDGAVLVVGDLIMNEESREVTRAGREIRLTA
TEFELLRYFMRNPRRVLSKAQILDRVWNYDFGGQANVVELYVSYLRKKIDAGRPAMIHTMRGAGYVLRPAT

Specific function: Member of the two-component regulatory system mprB/mprA which contributes to maintaining a balance among several systems involved in stress resistance and is required for establishment and maintenance of persistent infection in the host. Functions as a tr

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1786784, Length=222, Percent_Identity=40.0900900900901, Blast_Score=160, Evalue=5e-41,
Organism=Escherichia coli, GI1790860, Length=223, Percent_Identity=38.5650224215247, Blast_Score=147, Evalue=4e-37,
Organism=Escherichia coli, GI1786599, Length=222, Percent_Identity=36.4864864864865, Blast_Score=146, Evalue=1e-36,
Organism=Escherichia coli, GI1790552, Length=221, Percent_Identity=37.5565610859729, Blast_Score=139, Evalue=1e-34,
Organism=Escherichia coli, GI1786911, Length=220, Percent_Identity=37.2727272727273, Blast_Score=138, Evalue=3e-34,
Organism=Escherichia coli, GI87082012, Length=220, Percent_Identity=36.3636363636364, Blast_Score=137, Evalue=6e-34,
Organism=Escherichia coli, GI1789402, Length=221, Percent_Identity=38.0090497737557, Blast_Score=135, Evalue=2e-33,
Organism=Escherichia coli, GI1789809, Length=229, Percent_Identity=34.061135371179, Blast_Score=130, Evalue=9e-32,
Organism=Escherichia coli, GI1787375, Length=222, Percent_Identity=33.7837837837838, Blast_Score=129, Evalue=1e-31,
Organism=Escherichia coli, GI2367329, Length=233, Percent_Identity=36.0515021459227, Blast_Score=114, Evalue=4e-27,
Organism=Escherichia coli, GI1788394, Length=226, Percent_Identity=32.3008849557522, Blast_Score=114, Evalue=6e-27,
Organism=Escherichia coli, GI1790863, Length=231, Percent_Identity=30.7359307359307, Blast_Score=107, Evalue=8e-25,
Organism=Escherichia coli, GI1788550, Length=149, Percent_Identity=37.5838926174497, Blast_Score=102, Evalue=1e-23,
Organism=Escherichia coli, GI1787229, Length=231, Percent_Identity=33.3333333333333, Blast_Score=101, Evalue=5e-23,
Organism=Escherichia coli, GI145693140, Length=233, Percent_Identity=28.755364806867, Blast_Score=82, Evalue=3e-17,
Organism=Escherichia coli, GI1790437, Length=118, Percent_Identity=38.135593220339, Blast_Score=82, Evalue=4e-17,
Organism=Escherichia coli, GI1790299, Length=108, Percent_Identity=34.2592592592593, Blast_Score=72, Evalue=4e-14,
Organism=Escherichia coli, GI1788191, Length=127, Percent_Identity=34.6456692913386, Blast_Score=68, Evalue=6e-13,
Organism=Escherichia coli, GI1788713, Length=123, Percent_Identity=34.1463414634146, Blast_Score=66, Evalue=2e-12,
Organism=Escherichia coli, GI145693157, Length=120, Percent_Identity=31.6666666666667, Blast_Score=62, Evalue=4e-11,
Organism=Saccharomyces cerevisiae, GI6322000, Length=111, Percent_Identity=29.7297297297297, Blast_Score=63, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 26158; Mature: 26158

Theoretical pI: Translated: 7.66; Mature: 7.66

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS00217 SUGAR_TRANSPORT_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQPSSPRILVVDDENTLSELLSMALRYEGWEVRTAQDGRGALRAARDFRPDAVVLDIMLP
CCCCCCEEEEEECCHHHHHHHHHHHHCCCCEEEECCCCHHHHHHHHCCCCCEEEEEEECC
DMDGLEVLRKLRADSPEVPVLFLTARDAVEDRVAGLTAGGDDYVTKPFSLEELVARLRGL
CCCHHHHHHHHHCCCCCCCEEEEECCHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHH
LRRLHRSTIWDGAVLVVGDLIMNEESREVTRAGREIRLTATEFELLRYFMRNPRRVLSKA
HHHHHHHHCCCCHHHHHHHHHHCCCHHHHHHCCCEEEEEHHHHHHHHHHHHCHHHHHHHH
QILDRVWNYDFGGQANVVELYVSYLRKKIDAGRPAMIHTMRGAGYVLRPAT
HHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCCCEEEEECCCCEEECCCC
>Mature Secondary Structure
MQPSSPRILVVDDENTLSELLSMALRYEGWEVRTAQDGRGALRAARDFRPDAVVLDIMLP
CCCCCCEEEEEECCHHHHHHHHHHHHCCCCEEEECCCCHHHHHHHHCCCCCEEEEEEECC
DMDGLEVLRKLRADSPEVPVLFLTARDAVEDRVAGLTAGGDDYVTKPFSLEELVARLRGL
CCCHHHHHHHHHCCCCCCCEEEEECCHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHH
LRRLHRSTIWDGAVLVVGDLIMNEESREVTRAGREIRLTATEFELLRYFMRNPRRVLSKA
HHHHHHHHCCCCHHHHHHHHHHCCCHHHHHHCCCEEEEEHHHHHHHHHHHHCHHHHHHHH
QILDRVWNYDFGGQANVVELYVSYLRKKIDAGRPAMIHTMRGAGYVLRPAT
HHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCCCEEEEECCCCEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA