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The map label for this gene is comP [H]

Identifier: 158318226

GI number: 158318226

Start: 7890564

End: 7892294

Strand: Direct

Name: comP [H]

Synonym: Franean1_6491

Alternate gene names: 158318226

Gene position: 7890564-7892294 (Clockwise)

Preceding gene: 158318225

Following gene: 158318227

Centisome position: 87.85

GC content: 77.47

Gene sequence:

>1731_bases
GTGACCCACCCGCGGCGCCAGCTCCTCACCGCGGCGGCCCTGGCCGGGGCCGCGGTGACCGCCGCGTGCGCCGCCCCACG
GCTGCTCGGTGCCGGAACGCCGCCATGGTCCGCCCCGCTGGCCGTGGACGCCGTCCTGCTCACCGCCGGGGTGGCCGCCG
GCTGGGCGCCCCGCGCGCGGCGCCGTTCCGAACGCGTTCTGACCATCGCCGCCGACCTCGCCTGCCTCGCCGCGATCGCG
GCGGTGGGCCTCGCGGGCGCGCTGGCCACCCTCGGGCACCGCCCGCCGGACGGCGGCGAGAGCTTCACCGGCCCGGTCCT
GATCGCGGCGGCCCTCGCCGCCGTCCTGGCCGCCGGGGCTCGGGCCCGGACGGCGGCGCTCGTCCGGCACGCCGTGCGGG
GCGCCCGGTACGCGCCCGACGACGTCCTGCGGACCTTCGGCGAGGACGCGAGCCGCGGTACCAGCCTGGACGAGGCGCTG
GCCGGGCTGGGTGACGCCCTGCGGCGCAGCCTCTCCCTGCAGCGGGTGGAGATCTGGACCGGCGCGGCCGGGCGCCTCAC
CGCCGCCGTCGTGACGCCGGAGAGCCCACCCGCGACCGCTCCGGACGCCGGTGGGCAGGACGCCGGTAGGCCCGCTGCGG
GCGGTCCCGGTGCTGCGGGCGGTCCCGGTGCCGCCGCCGGCGGGCCCGCCGAGGTCGGCTCGACGATCGCCCTCACCGCC
GGTGATCTCATCGTGCTCGCGCGGACCAGGGTGGCGGGGCCCGGGTGGCTGTCGCTGTGGGTCCCCCAGCTCGCCCGCCG
GTACCTGGACGCCCAGGTACGGGTCGTCCCCGCCCGCGCCGGCGGCGCCCTGCTCGGGATGCTCGTCGCCCAGCGGCCAC
CGGAGGCCCCCCGGTTCTCCGAGGCCGAGGACCGGATGCTCGCCGAGCTCGGGACACGGGTCGGCACCGTCCTGCACAAC
CGCCAGCTCGACGCCAACCTGCGCGACGCACTCACCGACCTGCGGCACGCCAACGAAGAGCTGCGCGGCTCCAGGGCCCG
CCTGGTCGCCACCGCGGACGCCGAGCGACGCCGGATCGAGCGCGATCTCCACGACGGGGCGCAGCAGCAGCTGGTCTCGC
TCGCCGTCGGCCTCCGGCTGGTCCGCGACCTCATCTCGGACGGTGACTCGGACGGCAGCAGCTCGAACGGCAGCAGCTCG
AACGACGGCGACGGGTCCGTGCCCGGCGCGCCGGAACGCGACGAGGACCTGGCCGCCGCCGACGAGCTGCTCACCGCCAT
GGCCGAGCAGGTGACCGAGACGATCACCGAGGTCCGCAACCTCGCGCACGGCATCTACCCGCCGCTGCTGCGGTCCTCGG
GCCTGACCGAGGCGCTGCGGGCCGCCGGGCAGCGTTCCACGGTGGGCGTGACGGTGCGGGCCGACGACATCGGCCGCTAC
CCCCCGGACGTCGAGGCCGCCGTCTACTTCTGCTGCCTGGAGGCGCTGCAGAACGCGGCCAAGCACGCCCCCGGCAGCTC
GGTGGAGGTGACGCTCGGCGAGCGGGAGGGGTCGCTCACCTTCGCCGTGTGGGACGACGGCGCCGGCTTCGAACCGGAGA
GCTCCGCGCGTGGCCACGGCATGACGAACATGGCGGACCGCATCGGCGCGATCGGCGGCACGCTGCGCTGGGAGTCGTCC
CCCGGCTCCGGGACGGGCGTCATCGGCGTCGTGCCCGTGGGTGGCGGCTGA

Upstream 100 bases:

>100_bases
GTGCCGGTGCCGGCACAGGTGCGGCCGGCGCCGGCGCCGGTGCCGGCGCCGCCACGGTTGCGGGCGGCGGCGCCGGTCGT
GGGCGGGCCGAGGTGTCGGC

Downstream 100 bases:

>100_bases
TGGCCGTCCTCGGCGCGATCGGGATGATCGCGCGCAGTGAGCTGCGGCGGCGGTGGGCGGCGCTGATCGCCCTCGGCGTG
CTCATCGGCATGGTCGTCGC

Product: integral membrane sensor signal transduction histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 576; Mature: 575

Protein sequence:

>576_residues
MTHPRRQLLTAAALAGAAVTAACAAPRLLGAGTPPWSAPLAVDAVLLTAGVAAGWAPRARRRSERVLTIAADLACLAAIA
AVGLAGALATLGHRPPDGGESFTGPVLIAAALAAVLAAGARARTAALVRHAVRGARYAPDDVLRTFGEDASRGTSLDEAL
AGLGDALRRSLSLQRVEIWTGAAGRLTAAVVTPESPPATAPDAGGQDAGRPAAGGPGAAGGPGAAAGGPAEVGSTIALTA
GDLIVLARTRVAGPGWLSLWVPQLARRYLDAQVRVVPARAGGALLGMLVAQRPPEAPRFSEAEDRMLAELGTRVGTVLHN
RQLDANLRDALTDLRHANEELRGSRARLVATADAERRRIERDLHDGAQQQLVSLAVGLRLVRDLISDGDSDGSSSNGSSS
NDGDGSVPGAPERDEDLAAADELLTAMAEQVTETITEVRNLAHGIYPPLLRSSGLTEALRAAGQRSTVGVTVRADDIGRY
PPDVEAAVYFCCLEALQNAAKHAPGSSVEVTLGEREGSLTFAVWDDGAGFEPESSARGHGMTNMADRIGAIGGTLRWESS
PGSGTGVIGVVPVGGG

Sequences:

>Translated_576_residues
MTHPRRQLLTAAALAGAAVTAACAAPRLLGAGTPPWSAPLAVDAVLLTAGVAAGWAPRARRRSERVLTIAADLACLAAIA
AVGLAGALATLGHRPPDGGESFTGPVLIAAALAAVLAAGARARTAALVRHAVRGARYAPDDVLRTFGEDASRGTSLDEAL
AGLGDALRRSLSLQRVEIWTGAAGRLTAAVVTPESPPATAPDAGGQDAGRPAAGGPGAAGGPGAAAGGPAEVGSTIALTA
GDLIVLARTRVAGPGWLSLWVPQLARRYLDAQVRVVPARAGGALLGMLVAQRPPEAPRFSEAEDRMLAELGTRVGTVLHN
RQLDANLRDALTDLRHANEELRGSRARLVATADAERRRIERDLHDGAQQQLVSLAVGLRLVRDLISDGDSDGSSSNGSSS
NDGDGSVPGAPERDEDLAAADELLTAMAEQVTETITEVRNLAHGIYPPLLRSSGLTEALRAAGQRSTVGVTVRADDIGRY
PPDVEAAVYFCCLEALQNAAKHAPGSSVEVTLGEREGSLTFAVWDDGAGFEPESSARGHGMTNMADRIGAIGGTLRWESS
PGSGTGVIGVVPVGGG
>Mature_575_residues
THPRRQLLTAAALAGAAVTAACAAPRLLGAGTPPWSAPLAVDAVLLTAGVAAGWAPRARRRSERVLTIAADLACLAAIAA
VGLAGALATLGHRPPDGGESFTGPVLIAAALAAVLAAGARARTAALVRHAVRGARYAPDDVLRTFGEDASRGTSLDEALA
GLGDALRRSLSLQRVEIWTGAAGRLTAAVVTPESPPATAPDAGGQDAGRPAAGGPGAAGGPGAAAGGPAEVGSTIALTAG
DLIVLARTRVAGPGWLSLWVPQLARRYLDAQVRVVPARAGGALLGMLVAQRPPEAPRFSEAEDRMLAELGTRVGTVLHNR
QLDANLRDALTDLRHANEELRGSRARLVATADAERRRIERDLHDGAQQQLVSLAVGLRLVRDLISDGDSDGSSSNGSSSN
DGDGSVPGAPERDEDLAAADELLTAMAEQVTETITEVRNLAHGIYPPLLRSSGLTEALRAAGQRSTVGVTVRADDIGRYP
PDVEAAVYFCCLEALQNAAKHAPGSSVEVTLGEREGSLTFAVWDDGAGFEPESSARGHGMTNMADRIGAIGGTLRWESSP
GSGTGVIGVVPVGGG

Specific function: Sensor in the two-component regulatory system ComP/ComA involved in a major quorum response pathway that regulates the development of genetic competence. Plays a role in sporulation, at least partly interchangeable with that of SpoIIJ. Probably activates

COG id: COG4564

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR011712
- InterPro:   IPR005467 [H]

Pfam domain/function: PF02518 HATPase_c; PF07730 HisKA_3 [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 58684; Mature: 58552

Theoretical pI: Translated: 5.71; Mature: 5.71

Prosite motif: PS00013 PROKAR_LIPOPROTEIN ; PS00533 PORPHOBILINOGEN_DEAM

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTHPRRQLLTAAALAGAAVTAACAAPRLLGAGTPPWSAPLAVDAVLLTAGVAAGWAPRAR
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCCHHHH
RRSERVLTIAADLACLAAIAAVGLAGALATLGHRPPDGGESFTGPVLIAAALAAVLAAGA
HHHHHEEHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHCCC
RARTAALVRHAVRGARYAPDDVLRTFGEDASRGTSLDEALAGLGDALRRSLSLQRVEIWT
HHHHHHHHHHHHHCCCCCCHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHCHHEEEEEE
GAAGRLTAAVVTPESPPATAPDAGGQDAGRPAAGGPGAAGGPGAAAGGPAEVGSTIALTA
CCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHCCEEEEEC
GDLIVLARTRVAGPGWLSLWVPQLARRYLDAQVRVVPARAGGALLGMLVAQRPPEAPRFS
CCEEEEEEHHCCCCCHHHHHHHHHHHHHHCCEEEEEECCCCHHHHHHHHHCCCCCCCCCC
EAEDRMLAELGTRVGTVLHNRQLDANLRDALTDLRHANEELRGSRARLVATADAERRRIE
CHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCEEEEEECCHHHHHHH
RDLHDGAQQQLVSLAVGLRLVRDLISDGDSDGSSSNGSSSNDGDGSVPGAPERDEDLAAA
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHH
DELLTAMAEQVTETITEVRNLAHGIYPPLLRSSGLTEALRAAGQRSTVGVTVRADDIGRY
HHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHCCCHHHHHHHCCCCCEEEEEEEECCCCCC
PPDVEAAVYFCCLEALQNAAKHAPGSSVEVTLGEREGSLTFAVWDDGAGFEPESSARGHG
CCCHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCEEEEEECCCCCCCCCCCCCCCC
MTNMADRIGAIGGTLRWESSPGSGTGVIGVVPVGGG
CHHHHHHHHHCCCEEEECCCCCCCCCEEEEEECCCC
>Mature Secondary Structure 
THPRRQLLTAAALAGAAVTAACAAPRLLGAGTPPWSAPLAVDAVLLTAGVAAGWAPRAR
CCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCCHHHH
RRSERVLTIAADLACLAAIAAVGLAGALATLGHRPPDGGESFTGPVLIAAALAAVLAAGA
HHHHHEEHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHCCC
RARTAALVRHAVRGARYAPDDVLRTFGEDASRGTSLDEALAGLGDALRRSLSLQRVEIWT
HHHHHHHHHHHHHCCCCCCHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHCHHEEEEEE
GAAGRLTAAVVTPESPPATAPDAGGQDAGRPAAGGPGAAGGPGAAAGGPAEVGSTIALTA
CCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHCCEEEEEC
GDLIVLARTRVAGPGWLSLWVPQLARRYLDAQVRVVPARAGGALLGMLVAQRPPEAPRFS
CCEEEEEEHHCCCCCHHHHHHHHHHHHHHCCEEEEEECCCCHHHHHHHHHCCCCCCCCCC
EAEDRMLAELGTRVGTVLHNRQLDANLRDALTDLRHANEELRGSRARLVATADAERRRIE
CHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCEEEEEECCHHHHHHH
RDLHDGAQQQLVSLAVGLRLVRDLISDGDSDGSSSNGSSSNDGDGSVPGAPERDEDLAAA
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHH
DELLTAMAEQVTETITEVRNLAHGIYPPLLRSSGLTEALRAAGQRSTVGVTVRADDIGRY
HHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHCCCHHHHHHHCCCCCEEEEEEEECCCCCC
PPDVEAAVYFCCLEALQNAAKHAPGSSVEVTLGEREGSLTFAVWDDGAGFEPESSARGHG
CCCHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCEEEEEECCCCCCCCCCCCCCCC
MTNMADRIGAIGGTLRWESSPGSGTGVIGVVPVGGG
CHHHHHHHHHCCCEEEECCCCCCCCCEEEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 2116363; 9274030; 9384377; 1715859 [H]