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The map label for this gene is prs [C]

Identifier: 158318220

GI number: 158318220

Start: 7883699

End: 7884328

Strand: Direct

Name: prs [C]

Synonym: Franean1_6485

Alternate gene names: 158318220

Gene position: 7883699-7884328 (Clockwise)

Preceding gene: 158318219

Following gene: 158318222

Centisome position: 87.77

GC content: 77.78

Gene sequence:

>630_bases
GTGTACCTGTTCGCCGACCGGCGCGAGGCCGGCGCGCTGCTGGCGGACCGGCTCGCCGGCTCCGCCGCGGGCGTGCTCGT
CCTGGGCCTGCCCCGGGGCGGCGTGCCGGTCGCCGCCGAGGTCGCGAGCCGGCTCGGCGCCGAACTGGACGCGCTGACCG
TGCGCAAGCTCGGTGCGCCCGGCCAGCCCGAGTACGCCATCGGGGCGATCGCGACCGGCGGGATCCGCATCGTGAACGAG
CCCGCGATGCTCCGGCTCGGGCTGGCCCCCGGCGTCGTCGACGCCATCGCGGACAGTGAGGAGCACGAGCTCGCGCGCCG
CGAGCACGCGTACCGCGGTGACCGGCCGCCGCCCGCGGTCGCCGGCCGCGAGGTGATCGTCGTCGACGACGGCCTCGCGA
CCGGCGCGACCATGGTCGCGGCCGTGCGGGCGATGCGCTCGGCCGGCGCGGCGCGGGTGACCGCCGCCGTACCGGTCGCC
TCGGGTCAGGGGGCGCAGACCCTGCGGCCAGAGGTCGACGCCCTCGTCTGCCTGGCCGTCCCCGACGGCTTCATGGCCGT
CGGCCCGTACTACCGCGACTTCGGCGCCACCACGGACGACGAGGTCCGCGGACTCCTCTCCCCCGCGTGA

Upstream 100 bases:

>100_bases
CACCCGAGCCGCGACCACCGAGCGGGCCGCGCCACGGAGGACCGGACGACGGATCGCACCACCCGGGTCATGGCGGGCAC
GGCGGGGTAGGCCCACCCAG

Downstream 100 bases:

>100_bases
CGCCTCCGGATCGCGGCGGTGGTCGCGGTACTAACCCGCGACGCCCGCGGCGCGGCGACGGCCGGCCCGCGTCCGCCGCG
GGTCCGGGCTGCCCGCGTCG

Product: phosphoribosyltransferase

Products: AMP; H+; 5-Phospho-alpha-D-ribose 1-diphosphate [C]

Alternate protein names: NA

Number of amino acids: Translated: 209; Mature: 209

Protein sequence:

>209_residues
MYLFADRREAGALLADRLAGSAAGVLVLGLPRGGVPVAAEVASRLGAELDALTVRKLGAPGQPEYAIGAIATGGIRIVNE
PAMLRLGLAPGVVDAIADSEEHELARREHAYRGDRPPPAVAGREVIVVDDGLATGATMVAAVRAMRSAGAARVTAAVPVA
SGQGAQTLRPEVDALVCLAVPDGFMAVGPYYRDFGATTDDEVRGLLSPA

Sequences:

>Translated_209_residues
MYLFADRREAGALLADRLAGSAAGVLVLGLPRGGVPVAAEVASRLGAELDALTVRKLGAPGQPEYAIGAIATGGIRIVNE
PAMLRLGLAPGVVDAIADSEEHELARREHAYRGDRPPPAVAGREVIVVDDGLATGATMVAAVRAMRSAGAARVTAAVPVA
SGQGAQTLRPEVDALVCLAVPDGFMAVGPYYRDFGATTDDEVRGLLSPA
>Mature_209_residues
MYLFADRREAGALLADRLAGSAAGVLVLGLPRGGVPVAAEVASRLGAELDALTVRKLGAPGQPEYAIGAIATGGIRIVNE
PAMLRLGLAPGVVDAIADSEEHELARREHAYRGDRPPPAVAGREVIVVDDGLATGATMVAAVRAMRSAGAARVTAAVPVA
SGQGAQTLRPEVDALVCLAVPDGFMAVGPYYRDFGATTDDEVRGLLSPA

Specific function: Utilized by both the de novo and the salvage pathways by which endogenously formed or exogenously added pyrimidine, purine, or pyridine bases are converted to the corresponding ribonucleoside monophosphates. [C]

COG id: COG1926

COG function: function code R; Predicted phosphoribosyltransferases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the N-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family [H]

Homologues:

None

Paralogues:

None

Copy number: 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR007815
- InterPro:   IPR000836 [H]

Pfam domain/function: PF05139 Erythro_esteras; PF00156 Pribosyltran [H]

EC number: 2.7.6.1 [C]

Molecular weight: Translated: 21316; Mature: 21316

Theoretical pI: Translated: 4.87; Mature: 4.87

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYLFADRREAGALLADRLAGSAAGVLVLGLPRGGVPVAAEVASRLGAELDALTVRKLGAP
CEEECCCCHHHHHHHHHHCCCCCCEEEEECCCCCCCHHHHHHHHHCCCHHHHHHHHCCCC
GQPEYAIGAIATGGIRIVNEPAMLRLGLAPGVVDAIADSEEHELARREHAYRGDRPPPAV
CCCCEEEEEEECCCEEEECCCCEEEECCCCCHHHHHCCCHHHHHHHHHHHHCCCCCCCCC
AGREVIVVDDGLATGATMVAAVRAMRSAGAARVTAAVPVASGQGAQTLRPEVDALVCLAV
CCCEEEEEECCCCCHHHHHHHHHHHHHCCCEEEEEEEECCCCCCCCCCCCCCCEEEEEEC
PDGFMAVGPYYRDFGATTDDEVRGLLSPA
CCCCEECCCHHHHCCCCCCHHHHHHCCCC
>Mature Secondary Structure
MYLFADRREAGALLADRLAGSAAGVLVLGLPRGGVPVAAEVASRLGAELDALTVRKLGAP
CEEECCCCHHHHHHHHHHCCCCCCEEEEECCCCCCCHHHHHHHHHCCCHHHHHHHHCCCC
GQPEYAIGAIATGGIRIVNEPAMLRLGLAPGVVDAIADSEEHELARREHAYRGDRPPPAV
CCCCEEEEEEECCCEEEECCCCEEEECCCCCHHHHHCCCHHHHHHHHHHHHCCCCCCCCC
AGREVIVVDDGLATGATMVAAVRAMRSAGAARVTAAVPVASGQGAQTLRPEVDALVCLAV
CCCEEEEEECCCCCHHHHHHHHHHHHHCCCEEEEEEEECCCCCCCCCCCCCCCEEEEEEC
PDGFMAVGPYYRDFGATTDDEVRGLLSPA
CCCCEECCCHHHHCCCCCCHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; alpha-D-Ribose 5-phosphate [C]

Specific reaction: ATP + alpha-D-Ribose 5-phosphate <==> AMP + H+ + 5-Phospho-alpha-D-ribose 1-diphosphate [C]

General reaction: Diphosphate transfer [C]

Inhibitor: ADP [C]

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]