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The map label for this gene is fadA [H]

Identifier: 158318212

GI number: 158318212

Start: 7874674

End: 7875867

Strand: Direct

Name: fadA [H]

Synonym: Franean1_6477

Alternate gene names: 158318212

Gene position: 7874674-7875867 (Clockwise)

Preceding gene: 158318203

Following gene: 158318217

Centisome position: 87.67

GC content: 74.2

Gene sequence:

>1194_bases
ATGCGTGACGCCGTCGTCGTCGAAGCGGTGCGGTCCCCGATCGGGCGGGGACGCGCCAGCGGCAGCCTCGCCCCCGTCCA
CCCCATCGACCTGCTGGCGCACAGCATCTCCGCGGCCGTCGAGCGGTCCGGCGTCGATCCGGCGCTGATCGACGACGTCA
TCGCCGGCTGCGTGACCCAGAGCGGGGAGCAGGCCGCGAACATCGCCCGCTGGGCGACCCTGGCCGCCGGACTGCCCGAG
TCGGTGCCCGGGACCACCGTCGACCGCCAGTGCGGCTCGTCCCAGCAGGCCGTCCACTTCGCCGCGCAGGGCGTCATCGC
CGGCGCCTACGACATGGTCCTGGCCTGTGGTGTCGAGTCGATGGGGCGGGTCCCGATGGGCTCCGCGACGCTCCCCGGAG
ACAGCCACGGCACCCGGATCAACGCCCGCTACCCGGACGGGCTGATCTCGCAGGGCATCAGCGCCGAGCTGATCGGCGCG
CGGCGGGGCCTCGGCCGCGCCGAGATGGACGAGTTCGCCCTCGCCAGCCACCAGCGCGCCGCCACCGCGGCCCGGGATGG
CCTGTTCACCCCGGAGATCGCGCCGGTGAAGGTCACCGGGCCGGACGGGTCGGTCGTCGAGTTCTCCGCCGACGAGGGCA
TCCGCCCGGCGTCGAGCACGCAGGCCCTCGCGGGTCTGCGCCCGGCCTTCTACGACGAGGCCACCGCCGCGCGTTTCCCG
GAGATCGGCTGGAACGTGACGGCCGGCAACGCCTCGCAGATCAGCGACGGCTCCGCCGCGCTGCTGATCACCACCTCGGA
GCGGGCCCGCGAACTGGGGCTGCGCCCGCTCGCCCGGCTGCACAGCTTCGCCGTCGTCGGCGACGACCCGTTCCTGATGC
TGCGCGGCGTCATCCCCGCCACCCGCCGGGTGCTGGAGCGCTCGGGCCTGAGCCTGGACGACATCGACCTGTTCGAGGTG
AACGAGGCCTTCGCCGCGGTCGTGCTGGACTGGCGCGCCGAGATCGGCGCATCGGCGGAGAAGGTCAACGCCCGGGGCGG
CGCGATCGCGCTCGGCCACCCGCTCGGCGCCAGCGGCGCCCGGATCATGACGACCCTCGTGCACGCGCTGCACCAGACCG
GCGGCCGGTTCGGGCTGCAGACGATGTGCGAGGCGGGCGGCCTCGCGAACGCGACCATCATCGAGCGCCTCTGA

Upstream 100 bases:

>100_bases
GGTCACAGCTCCATCAGTTGCCTTTTCCAACTAACTGCGCGCACACTGGGAAAACCAGTGAGTTTGGTTTTCGAACTCAC
TCCTGGAGAAGGAGCCTCCG

Downstream 100 bases:

>100_bases
TCAGGCACCCCTGACAGGTGCATGCTCCGGGTGGGCGATCGGCCGGCGCCGCGGCCGATCGCCGGCCTATCCTTGGCCGG
TGCCCGCATACGAGTACCGA

Product: acetyl-CoA acetyltransferase

Products: NA

Alternate protein names: Acetyl-CoA acyltransferase; Beta-ketothiolase; Fatty acid oxidation complex subunit beta [H]

Number of amino acids: Translated: 397; Mature: 397

Protein sequence:

>397_residues
MRDAVVVEAVRSPIGRGRASGSLAPVHPIDLLAHSISAAVERSGVDPALIDDVIAGCVTQSGEQAANIARWATLAAGLPE
SVPGTTVDRQCGSSQQAVHFAAQGVIAGAYDMVLACGVESMGRVPMGSATLPGDSHGTRINARYPDGLISQGISAELIGA
RRGLGRAEMDEFALASHQRAATAARDGLFTPEIAPVKVTGPDGSVVEFSADEGIRPASSTQALAGLRPAFYDEATAARFP
EIGWNVTAGNASQISDGSAALLITTSERARELGLRPLARLHSFAVVGDDPFLMLRGVIPATRRVLERSGLSLDDIDLFEV
NEAFAAVVLDWRAEIGASAEKVNARGGAIALGHPLGASGARIMTTLVHALHQTGGRFGLQTMCEAGGLANATIIERL

Sequences:

>Translated_397_residues
MRDAVVVEAVRSPIGRGRASGSLAPVHPIDLLAHSISAAVERSGVDPALIDDVIAGCVTQSGEQAANIARWATLAAGLPE
SVPGTTVDRQCGSSQQAVHFAAQGVIAGAYDMVLACGVESMGRVPMGSATLPGDSHGTRINARYPDGLISQGISAELIGA
RRGLGRAEMDEFALASHQRAATAARDGLFTPEIAPVKVTGPDGSVVEFSADEGIRPASSTQALAGLRPAFYDEATAARFP
EIGWNVTAGNASQISDGSAALLITTSERARELGLRPLARLHSFAVVGDDPFLMLRGVIPATRRVLERSGLSLDDIDLFEV
NEAFAAVVLDWRAEIGASAEKVNARGGAIALGHPLGASGARIMTTLVHALHQTGGRFGLQTMCEAGGLANATIIERL
>Mature_397_residues
MRDAVVVEAVRSPIGRGRASGSLAPVHPIDLLAHSISAAVERSGVDPALIDDVIAGCVTQSGEQAANIARWATLAAGLPE
SVPGTTVDRQCGSSQQAVHFAAQGVIAGAYDMVLACGVESMGRVPMGSATLPGDSHGTRINARYPDGLISQGISAELIGA
RRGLGRAEMDEFALASHQRAATAARDGLFTPEIAPVKVTGPDGSVVEFSADEGIRPASSTQALAGLRPAFYDEATAARFP
EIGWNVTAGNASQISDGSAALLITTSERARELGLRPLARLHSFAVVGDDPFLMLRGVIPATRRVLERSGLSLDDIDLFEV
NEAFAAVVLDWRAEIGASAEKVNARGGAIALGHPLGASGARIMTTLVHALHQTGGRFGLQTMCEAGGLANATIIERL

Specific function: Catalyzes the final step of fatty acid oxidation in which acetyl-CoA is released and the CoA ester of a fatty acid two carbons shorter is formed [H]

COG id: COG0183

COG function: function code I; Acetyl-CoA acetyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiolase family [H]

Homologues:

Organism=Homo sapiens, GI4501853, Length=400, Percent_Identity=39.75, Blast_Score=245, Evalue=5e-65,
Organism=Homo sapiens, GI148539872, Length=400, Percent_Identity=37.5, Blast_Score=225, Evalue=5e-59,
Organism=Homo sapiens, GI167614485, Length=407, Percent_Identity=34.8894348894349, Blast_Score=219, Evalue=5e-57,
Organism=Homo sapiens, GI4557237, Length=406, Percent_Identity=35.7142857142857, Blast_Score=211, Evalue=1e-54,
Organism=Homo sapiens, GI4504327, Length=439, Percent_Identity=33.9407744874715, Blast_Score=200, Evalue=2e-51,
Organism=Homo sapiens, GI194353979, Length=395, Percent_Identity=29.3670886075949, Blast_Score=134, Evalue=2e-31,
Organism=Escherichia coli, GI48994986, Length=402, Percent_Identity=43.5323383084577, Blast_Score=287, Evalue=8e-79,
Organism=Escherichia coli, GI1787663, Length=413, Percent_Identity=42.6150121065375, Blast_Score=278, Evalue=5e-76,
Organism=Escherichia coli, GI1788554, Length=409, Percent_Identity=44.2542787286064, Blast_Score=260, Evalue=1e-70,
Organism=Escherichia coli, GI87082165, Length=408, Percent_Identity=39.7058823529412, Blast_Score=241, Evalue=6e-65,
Organism=Escherichia coli, GI1788683, Length=434, Percent_Identity=32.7188940092166, Blast_Score=153, Evalue=1e-38,
Organism=Caenorhabditis elegans, GI133906874, Length=393, Percent_Identity=37.9134860050891, Blast_Score=230, Evalue=1e-60,
Organism=Caenorhabditis elegans, GI17535921, Length=406, Percent_Identity=34.9753694581281, Blast_Score=206, Evalue=1e-53,
Organism=Caenorhabditis elegans, GI25147385, Length=404, Percent_Identity=33.6633663366337, Blast_Score=196, Evalue=2e-50,
Organism=Caenorhabditis elegans, GI17551802, Length=442, Percent_Identity=31.6742081447964, Blast_Score=174, Evalue=6e-44,
Organism=Caenorhabditis elegans, GI17535917, Length=402, Percent_Identity=29.8507462686567, Blast_Score=142, Evalue=4e-34,
Organism=Saccharomyces cerevisiae, GI6322031, Length=402, Percent_Identity=38.8059701492537, Blast_Score=220, Evalue=3e-58,
Organism=Saccharomyces cerevisiae, GI6325229, Length=422, Percent_Identity=31.9905213270142, Blast_Score=174, Evalue=2e-44,
Organism=Drosophila melanogaster, GI24655093, Length=405, Percent_Identity=36.5432098765432, Blast_Score=235, Evalue=4e-62,
Organism=Drosophila melanogaster, GI24640423, Length=406, Percent_Identity=34.4827586206897, Blast_Score=205, Evalue=4e-53,
Organism=Drosophila melanogaster, GI17648125, Length=392, Percent_Identity=33.9285714285714, Blast_Score=198, Evalue=6e-51,
Organism=Drosophila melanogaster, GI17137578, Length=439, Percent_Identity=33.2574031890661, Blast_Score=194, Evalue=1e-49,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012805
- InterPro:   IPR002155
- InterPro:   IPR016039
- InterPro:   IPR016038
- InterPro:   IPR020615
- InterPro:   IPR020610
- InterPro:   IPR020617
- InterPro:   IPR020613
- InterPro:   IPR020616 [H]

Pfam domain/function: PF02803 Thiolase_C; PF00108 Thiolase_N [H]

EC number: =2.3.1.16 [H]

Molecular weight: Translated: 41063; Mature: 41063

Theoretical pI: Translated: 5.41; Mature: 5.41

Prosite motif: PS00737 THIOLASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRDAVVVEAVRSPIGRGRASGSLAPVHPIDLLAHSISAAVERSGVDPALIDDVIAGCVTQ
CCCHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHC
SGEQAANIARWATLAAGLPESVPGTTVDRQCGSSQQAVHFAAQGVIAGAYDMVLACGVES
CCHHHHHHHHHHHHHCCCCCCCCCCCHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCHHH
MGRVPMGSATLPGDSHGTRINARYPDGLISQGISAELIGARRGLGRAEMDEFALASHQRA
HCCCCCCCCCCCCCCCCCEEECCCCCHHHHCCCCHHHHHHHCCCCHHHHHHHHHHHHHHH
ATAARDGLFTPEIAPVKVTGPDGSVVEFSADEGIRPASSTQALAGLRPAFYDEATAARFP
HHHHHCCCCCCCCCEEEEECCCCCEEEECCCCCCCCCCCHHHHHCCCCHHHCCHHHHCCC
EIGWNVTAGNASQISDGSAALLITTSERARELGLRPLARLHSFAVVGDDPFLMLRGVIPA
CCCCEEECCCCCCCCCCCEEEEEECCHHHHHHCCHHHHHHHHEEEECCCHHEEHHHCCHH
TRRVLERSGLSLDDIDLFEVNEAFAAVVLDWRAEIGASAEKVNARGGAIALGHPLGASGA
HHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHCCCCCEEEECCCCCCCCH
RIMTTLVHALHQTGGRFGLQTMCEAGGLANATIIERL
HHHHHHHHHHHHCCCCCCHHHHHHCCCCCCHHHHHCC
>Mature Secondary Structure
MRDAVVVEAVRSPIGRGRASGSLAPVHPIDLLAHSISAAVERSGVDPALIDDVIAGCVTQ
CCCHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHC
SGEQAANIARWATLAAGLPESVPGTTVDRQCGSSQQAVHFAAQGVIAGAYDMVLACGVES
CCHHHHHHHHHHHHHCCCCCCCCCCCHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCHHH
MGRVPMGSATLPGDSHGTRINARYPDGLISQGISAELIGARRGLGRAEMDEFALASHQRA
HCCCCCCCCCCCCCCCCCEEECCCCCHHHHCCCCHHHHHHHCCCCHHHHHHHHHHHHHHH
ATAARDGLFTPEIAPVKVTGPDGSVVEFSADEGIRPASSTQALAGLRPAFYDEATAARFP
HHHHHCCCCCCCCCEEEEECCCCCEEEECCCCCCCCCCCHHHHHCCCCHHHCCHHHHCCC
EIGWNVTAGNASQISDGSAALLITTSERARELGLRPLARLHSFAVVGDDPFLMLRGVIPA
CCCCEEECCCCCCCCCCCEEEEEECCHHHHHHCCHHHHHHHHEEEECCCHHEEHHHCCHH
TRRVLERSGLSLDDIDLFEVNEAFAAVVLDWRAEIGASAEKVNARGGAIALGHPLGASGA
HHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHCCCCCEEEECCCCCCCCH
RIMTTLVHALHQTGGRFGLQTMCEAGGLANATIIERL
HHHHHHHHHHHHCCCCCCHHHHHHCCCCCCHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA