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The map label for this gene is myrA [H]

Identifier: 158317863

GI number: 158317863

Start: 7449005

End: 7449940

Strand: Reverse

Name: myrA [H]

Synonym: Franean1_6121

Alternate gene names: 158317863

Gene position: 7449940-7449005 (Counterclockwise)

Preceding gene: 158317864

Following gene: 158317862

Centisome position: 82.94

GC content: 75.85

Gene sequence:

>936_bases
ATGATCCATCCAGCTCTGCGCCTCCTGCGGTGCCCCGTCTGCGCGGCGCCCCTGGCCGACCCGGCGGGTGCCGTGCGGTG
CGCCGCGGGGCACTCCTTCGACGTCGAACGGTCCGGCTACCTGAACCTGCGTACGGGCCGGGCCCGCCGGGTGTCCGGGG
ACACCGCCGAGATGGTCCAGGCCCGGGTCGACTTCCTCGGGGGTGGCCACTACGCGCCGCTCACCGCCCGCCTGGTCCAA
CTTGCCGCGGCCCGGACGGGGGGCGGGCGGACGCCGGCCGATGCTCCGCCAGCCGATCACCCGGCGGTCAGTGATCCGGC
GGCAGGTGATCCGGCGGCCGGTGCTCCCGAGCTCGTGCTGGAGATCGGCGCCGGCACCGCCCACCACCTCGCGGCCGTCG
TGGACGCGGGGCCGCGGCGGCTCGGGATCGCCGTCGACGTGTCGAAGTACGCGCTGCGCCGCGCGGCACGGGCCCATCCG
CGAATCGGTGCCGTGGCCTTCGACGTGGCCGACCGCTGGCCGCTGCCCGACGCGTCCGTCGACGTCCTGCTGGACGTCTT
CGCGCCGCGCAACCTCGCGGAGATGCGCCGGCTGCTGCGTCCGGGGGGCATGCTGCTCCTGGTCACACCCGGCGAGGGTC
ACCTGGCGGAGCTACGGGAGCCGCTCGGGCTCGTCGGCGTCCAGCCGGGTAAGCGGGAACGGCTGGCGGACGAGCTGTCC
GGCCGGTTCGACCGGCTCTCGTCCGAGACGCTGACCCGTACCCTCCAGCTCGGCGTGGACGAGGTCGTCGACGTGGCTCT
CATGGGCCCCACCGGGCATCACACGGGCGCGCCCGAGCTGCGCCGGCGCCTGGCCGCGGTGTGGCCCCCCGGCCGGGCCG
CGATGGACGTCACCGCCTCCTTCGTCATCGACCGCGCGCAGGCGCCCGAGGCCTGA

Upstream 100 bases:

>100_bases
TCCGGGGAGCTCCTCCGGGTGGAGTACAGCGAGCCCAACGGGCCCACCGCCAACGCGCCCGGCTCCGTCGGCGCGTGAGG
GCCGGCCCCCACCGCGTCGG

Downstream 100 bases:

>100_bases
CCTGTGGCGGGCCGGCGGTGCCGGAACCGGCGGTGCCGGAACCGCCGGCCCGGTGGGCGGTCCCGATGCGCCGGCCGGGC
CGGAGCGCCTGGACCGCGTC

Product: type 11 methyltransferase

Products: S-adenosyl-L-homocysteine +rRNA containing Nmethylguanine [C]

Alternate protein names: NA

Number of amino acids: Translated: 311; Mature: 311

Protein sequence:

>311_residues
MIHPALRLLRCPVCAAPLADPAGAVRCAAGHSFDVERSGYLNLRTGRARRVSGDTAEMVQARVDFLGGGHYAPLTARLVQ
LAAARTGGGRTPADAPPADHPAVSDPAAGDPAAGAPELVLEIGAGTAHHLAAVVDAGPRRLGIAVDVSKYALRRAARAHP
RIGAVAFDVADRWPLPDASVDVLLDVFAPRNLAEMRRLLRPGGMLLLVTPGEGHLAELREPLGLVGVQPGKRERLADELS
GRFDRLSSETLTRTLQLGVDEVVDVALMGPTGHHTGAPELRRRLAAVWPPGRAAMDVTASFVIDRAQAPEA

Sequences:

>Translated_311_residues
MIHPALRLLRCPVCAAPLADPAGAVRCAAGHSFDVERSGYLNLRTGRARRVSGDTAEMVQARVDFLGGGHYAPLTARLVQ
LAAARTGGGRTPADAPPADHPAVSDPAAGDPAAGAPELVLEIGAGTAHHLAAVVDAGPRRLGIAVDVSKYALRRAARAHP
RIGAVAFDVADRWPLPDASVDVLLDVFAPRNLAEMRRLLRPGGMLLLVTPGEGHLAELREPLGLVGVQPGKRERLADELS
GRFDRLSSETLTRTLQLGVDEVVDVALMGPTGHHTGAPELRRRLAAVWPPGRAAMDVTASFVIDRAQAPEA
>Mature_311_residues
MIHPALRLLRCPVCAAPLADPAGAVRCAAGHSFDVERSGYLNLRTGRARRVSGDTAEMVQARVDFLGGGHYAPLTARLVQ
LAAARTGGGRTPADAPPADHPAVSDPAAGDPAAGAPELVLEIGAGTAHHLAAVVDAGPRRLGIAVDVSKYALRRAARAHP
RIGAVAFDVADRWPLPDASVDVLLDVFAPRNLAEMRRLLRPGGMLLLVTPGEGHLAELREPLGLVGVQPGKRERLADELS
GRFDRLSSETLTRTLQLGVDEVVDVALMGPTGHHTGAPELRRRLAAVWPPGRAAMDVTASFVIDRAQAPEA

Specific function: Confers strong resistance to mycinamicin (MM) and tylosin (TY). May function as methyltransferase [H]

COG id: COG0500

COG function: function code QR; SAM-dependent methyltransferases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the methyltransferase superfamily. RlmA family [H]

Homologues:

Organism=Escherichia coli, GI1788125, Length=303, Percent_Identity=31.6831683168317, Blast_Score=125, Evalue=5e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013216
- InterPro:   IPR016718 [H]

Pfam domain/function: PF08241 Methyltransf_11 [H]

EC number: 2.1.1.51 [C]

Molecular weight: Translated: 32666; Mature: 32666

Theoretical pI: Translated: 8.15; Mature: 8.15

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIHPALRLLRCPVCAAPLADPAGAVRCAAGHSFDVERSGYLNLRTGRARRVSGDTAEMVQ
CCCHHHHHHHCCCCCCCCCCCCCCEEECCCCCCCCCCCCEEEEECCCCEECCCCHHHHHH
ARVDFLGGGHYAPLTARLVQLAAARTGGGRTPADAPPADHPAVSDPAAGDPAAGAPELVL
HHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEE
EIGAGTAHHLAAVVDAGPRRLGIAVDVSKYALRRAARAHPRIGAVAFDVADRWPLPDASV
EECCCCHHHHHHHHCCCCCCEEEEEEHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCHH
DVLLDVFAPRNLAEMRRLLRPGGMLLLVTPGEGHLAELREPLGLVGVQPGKRERLADELS
HHHHHHHCCCCHHHHHHHHCCCCEEEEEECCCCHHHHHHCCCCEECCCCCHHHHHHHHHH
GRFDRLSSETLTRTLQLGVDEVVDVALMGPTGHHTGAPELRRRLAAVWPPGRAAMDVTAS
HHHHHHHHHHHHHHHHHCHHHHHHEEEECCCCCCCCCHHHHHHHHHCCCCCCHHHHHHHH
FVIDRAQAPEA
HHHCCCCCCCC
>Mature Secondary Structure
MIHPALRLLRCPVCAAPLADPAGAVRCAAGHSFDVERSGYLNLRTGRARRVSGDTAEMVQ
CCCHHHHHHHCCCCCCCCCCCCCCEEECCCCCCCCCCCCEEEEECCCCEECCCCHHHHHH
ARVDFLGGGHYAPLTARLVQLAAARTGGGRTPADAPPADHPAVSDPAAGDPAAGAPELVL
HHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEE
EIGAGTAHHLAAVVDAGPRRLGIAVDVSKYALRRAARAHPRIGAVAFDVADRWPLPDASV
EECCCCHHHHHHHHCCCCCCEEEEEEHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCHH
DVLLDVFAPRNLAEMRRLLRPGGMLLLVTPGEGHLAELREPLGLVGVQPGKRERLADELS
HHHHHHHCCCCHHHHHHHHCCCCEEEEEECCCCHHHHHHCCCCEECCCCCHHHHHHHHHH
GRFDRLSSETLTRTLQLGVDEVVDVALMGPTGHHTGAPELRRRLAAVWPPGRAAMDVTAS
HHHHHHHHHHHHHHHHHCHHHHHHEEEECCCCCCCCCHHHHHHHHHCCCCCCHHHHHHHH
FVIDRAQAPEA
HHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: Unidentified protein factor B [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: S-Adenosyl-L-methionine; rRNA [C]

Specific reaction: S-Adenosyl-L-methionine + rRNA = S-adenosyl-L-homocysteine +rRNA containing Nmethylguanine [C]

General reaction: Methyl group transfer [C]

Inhibitor: Mg2+; Unidentified protein factor A1 [C]

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8163173 [H]