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The map label for this gene is cysG [H]

Identifier: 158317844

GI number: 158317844

Start: 7428946

End: 7430658

Strand: Reverse

Name: cysG [H]

Synonym: Franean1_6102

Alternate gene names: 158317844

Gene position: 7430658-7428946 (Counterclockwise)

Preceding gene: 158317845

Following gene: 158317842

Centisome position: 82.73

GC content: 77.23

Gene sequence:

>1713_bases
GTGCACGCCGTGGCAGTCGTGACACCTGGGCCGCAAGCCCGTGGATCCGGGTCGGATCCGGCACCTTCCCAGGTCAGTCG
GCCCGGCGAGGTGTGGCTGGTGGGGGCTGGGCCGGGTGATCCCGGGCTGCTGACGGTCCGCGGGCGGGAGCTGCTCGCCA
CCGCCGACGTCGTCGTCACCGACCGCCTGGCCGCGGCCGTCCTCCTCGACGTCGCCCGGCCGGACGCCCGCGTCATCCAC
GTGGGCAAGAGCCCGACGACGTCCCGCAGCCAGGACGAGGTCAACGCGCTGCTGGTCGAGCACGCGCGCGCCGGCGCCCG
GGTGGTGCGGCTCAAAGGCGGCGACCCGTTCCTGCTTGGCCGGGGCGGCGAGGAGGCCGAGGCCTGCGCCGCCGCCGGTG
TCAGCTGCACCGTGGTCCCCGGCGTGACCTCCGCGATCGCCGTGCCCGCGTATGCCGGCATCCCCGTCACGCACCGTGGC
GTCGCGCAGGATCTCGCGATCATCTCCGGCCACCTGCCGCCGGGGCACCCCGAGTCGACGGTCGACTGGGCCGCGCTCGG
TGCCTCCCGCGCCACGATCGTCGTGCTCATGGGGGTCGCCCGGCTGGTCGACATCGTCGACGCGCTGCTGGCGGGCGGAC
GTCCGCCCGGGACCCCGGCCGCTGTCATCGAGCGCGGCACGACTCCGGCACAGCGGGTGCTCCGCACGACCCTGGACGCC
CTCGTCGTCGACGCCGTGGCCTTCGGGCTGCGCTCCCCGGCGGTGCTGGTCGTCGGCGAGGTCGCCGCGCGCCGGGACGC
TGCCGTCCCCATCCCGCCGGTGGTCGAGGCTGACGCCGATCACGGAGAGCGGGTCCCTGACGGGTACGGCACGGGGGACA
CGCGCGTCCCCGACGGGCAGGGCATTTCCGACGGTCGGGGCGTCTCCGGCGGGCAGGGCGGCCGCGCCTCGTCGGGGCGG
CCCGGGGTGGCCGGCGACGCTCCGCTGGCGGGCATCCGCGTCCTCGTCCCGCGCACCAGGGCGCGGCAGGGGCTGCTCGC
CCGCAGGCTGCGCGAGCTGGGCGGCGAGGCCGTCGAGACGGTGGTCAGCCGGCTCGTCCCGACCGGGGACGCGACGCCGC
TGCGCGAGGCGCTTCCAGGTGCGGACGGCCTCGTGCTGGCTGACTCCGACGAGGTCGCCGCAGTGGTCTCGCTGCTGCGG
GGCGCGGGTACGGACGTGCGGGCGCTCGCCGGGCTGACGCTCGTCGCGGCATCCGCCTCGGCCGCCGCCGCGCTCGACGC
GCTGGGGCTGGCCTGCGCGCGGTCGTCGGCCGAGGTCCAGGTCGCCCACACGGTGGTGACGGAGGTCCCGGTGCCCGGGC
TGCGGGTGGTGATCTGCGGGGCCGCGCCGCCGCCGGTGGGGATCCGGACGCTGCGTCGCGTGCGGCTGCTCGCCGACGCG
CCCGCCGAGGCCGACCCGCGGATCGCCGAGGAACTGCGCCACGGTGACGTCGACGCCGTCGCGCTGGCGTCGTCGACGGC
GGCCCGCTGCCTGGTCGAACTGTACGGTCCGTTGCCGGACAGTGTCCTCGTCGCCGCGATGGGCCGGCGCACCGCGCAGG
CCTGCGAGGCTGTTGGCCTGCGGGTGGACGCGATCCCGTCCGAGCCGGGGATCTACCCGCTCGCGGCGGCGGTCGCCGAT
CTCGTGGCCGGCCGGCGAGCGCCGACGGCGTAG

Upstream 100 bases:

>100_bases
ACGACCAAGACCGAGTGCGGCATCCACTAGTTCGCTTGGCTCGCAACCGGGAGCCGGGTGGTGCACAGTTCGGGGCGGGT
GGCCAGGACCACGCTGTACC

Downstream 100 bases:

>100_bases
CCCAGGGCGTCGGCAGACCCGGTCGGGGGCCTGCCGGCGTCGTGGGGCCGGCGGCCGGGCGGGCGGGGTGGGCACTGCCG
TGGCCTTAGCGGTACCCCGC

Product: uroporphyrin-III C-methyltransferase

Products: NA

Alternate protein names: Uroporphyrinogen-III C-methyltransferase; Urogen III methylase; SUMT; Uroporphyrinogen III methylase; UROM; Precorrin-2 dehydrogenase; Sirohydrochlorin ferrochelatase [H]

Number of amino acids: Translated: 570; Mature: 570

Protein sequence:

>570_residues
MHAVAVVTPGPQARGSGSDPAPSQVSRPGEVWLVGAGPGDPGLLTVRGRELLATADVVVTDRLAAAVLLDVARPDARVIH
VGKSPTTSRSQDEVNALLVEHARAGARVVRLKGGDPFLLGRGGEEAEACAAAGVSCTVVPGVTSAIAVPAYAGIPVTHRG
VAQDLAIISGHLPPGHPESTVDWAALGASRATIVVLMGVARLVDIVDALLAGGRPPGTPAAVIERGTTPAQRVLRTTLDA
LVVDAVAFGLRSPAVLVVGEVAARRDAAVPIPPVVEADADHGERVPDGYGTGDTRVPDGQGISDGRGVSGGQGGRASSGR
PGVAGDAPLAGIRVLVPRTRARQGLLARRLRELGGEAVETVVSRLVPTGDATPLREALPGADGLVLADSDEVAAVVSLLR
GAGTDVRALAGLTLVAASASAAAALDALGLACARSSAEVQVAHTVVTEVPVPGLRVVICGAAPPPVGIRTLRRVRLLADA
PAEADPRIAEELRHGDVDAVALASSTAARCLVELYGPLPDSVLVAAMGRRTAQACEAVGLRVDAIPSEPGIYPLAAAVAD
LVAGRRAPTA

Sequences:

>Translated_570_residues
MHAVAVVTPGPQARGSGSDPAPSQVSRPGEVWLVGAGPGDPGLLTVRGRELLATADVVVTDRLAAAVLLDVARPDARVIH
VGKSPTTSRSQDEVNALLVEHARAGARVVRLKGGDPFLLGRGGEEAEACAAAGVSCTVVPGVTSAIAVPAYAGIPVTHRG
VAQDLAIISGHLPPGHPESTVDWAALGASRATIVVLMGVARLVDIVDALLAGGRPPGTPAAVIERGTTPAQRVLRTTLDA
LVVDAVAFGLRSPAVLVVGEVAARRDAAVPIPPVVEADADHGERVPDGYGTGDTRVPDGQGISDGRGVSGGQGGRASSGR
PGVAGDAPLAGIRVLVPRTRARQGLLARRLRELGGEAVETVVSRLVPTGDATPLREALPGADGLVLADSDEVAAVVSLLR
GAGTDVRALAGLTLVAASASAAAALDALGLACARSSAEVQVAHTVVTEVPVPGLRVVICGAAPPPVGIRTLRRVRLLADA
PAEADPRIAEELRHGDVDAVALASSTAARCLVELYGPLPDSVLVAAMGRRTAQACEAVGLRVDAIPSEPGIYPLAAAVAD
LVAGRRAPTA
>Mature_570_residues
MHAVAVVTPGPQARGSGSDPAPSQVSRPGEVWLVGAGPGDPGLLTVRGRELLATADVVVTDRLAAAVLLDVARPDARVIH
VGKSPTTSRSQDEVNALLVEHARAGARVVRLKGGDPFLLGRGGEEAEACAAAGVSCTVVPGVTSAIAVPAYAGIPVTHRG
VAQDLAIISGHLPPGHPESTVDWAALGASRATIVVLMGVARLVDIVDALLAGGRPPGTPAAVIERGTTPAQRVLRTTLDA
LVVDAVAFGLRSPAVLVVGEVAARRDAAVPIPPVVEADADHGERVPDGYGTGDTRVPDGQGISDGRGVSGGQGGRASSGR
PGVAGDAPLAGIRVLVPRTRARQGLLARRLRELGGEAVETVVSRLVPTGDATPLREALPGADGLVLADSDEVAAVVSLLR
GAGTDVRALAGLTLVAASASAAAALDALGLACARSSAEVQVAHTVVTEVPVPGLRVVICGAAPPPVGIRTLRRVRLLADA
PAEADPRIAEELRHGDVDAVALASSTAARCLVELYGPLPDSVLVAAMGRRTAQACEAVGLRVDAIPSEPGIYPLAAAVAD
LVAGRRAPTA

Specific function: Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into si

COG id: COG0007

COG function: function code H; Uroporphyrinogen-III methylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the precorrin methyltransferase family [H]

Homologues:

Organism=Escherichia coli, GI1789768, Length=239, Percent_Identity=44.7698744769874, Blast_Score=197, Evalue=1e-51,
Organism=Saccharomyces cerevisiae, GI6322922, Length=245, Percent_Identity=35.9183673469388, Blast_Score=127, Evalue=6e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000878
- InterPro:   IPR014777
- InterPro:   IPR014776
- InterPro:   IPR006366
- InterPro:   IPR016040
- InterPro:   IPR019478
- InterPro:   IPR006367
- InterPro:   IPR003043 [H]

Pfam domain/function: PF10414 CysG_dimeriser; PF00590 TP_methylase [H]

EC number: =2.1.1.107; =1.3.1.76; =4.99.1.4 [H]

Molecular weight: Translated: 57265; Mature: 57265

Theoretical pI: Translated: 6.26; Mature: 6.26

Prosite motif: PS00839 SUMT_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
0.5 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
0.5 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHAVAVVTPGPQARGSGSDPAPSQVSRPGEVWLVGAGPGDPGLLTVRGRELLATADVVVT
CCEEEEECCCCCCCCCCCCCCCHHCCCCCCEEEEECCCCCCCEEEECCCEEEEHHHHHHH
DRLAAAVLLDVARPDARVIHVGKSPTTSRSQDEVNALLVEHARAGARVVRLKGGDPFLLG
HHHHHHHHHHHCCCCCEEEEECCCCCCCCCHHHHHHHHHHHHCCCCEEEEEECCCEEEEE
RGGEEAEACAAAGVSCTVVPGVTSAIAVPAYAGIPVTHRGVAQDLAIISGHLPPGHPEST
CCCCHHHHHHHCCCEEEECCCCHHHHHCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCC
VDWAALGASRATIVVLMGVARLVDIVDALLAGGRPPGTPAAVIERGTTPAQRVLRTTLDA
CHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHCCCCCHHHHHHHHHHHH
LVVDAVAFGLRSPAVLVVGEVAARRDAAVPIPPVVEADADHGERVPDGYGTGDTRVPDGQ
HHHHHHHHHCCCCCEEEEECHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
GISDGRGVSGGQGGRASSGRPGVAGDAPLAGIRVLVPRTRARQGLLARRLRELGGEAVET
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEECCHHHHHHHHHHHHHHHCCHHHHH
VVSRLVPTGDATPLREALPGADGLVLADSDEVAAVVSLLRGAGTDVRALAGLTLVAASAS
HHHHHCCCCCCCHHHHHCCCCCCEEEECCHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCH
AAAALDALGLACARSSAEVQVAHTVVTEVPVPGLRVVICGAAPPPVGIRTLRRVRLLADA
HHHHHHHHHHHHHCCCCCEEEEEHHHHHCCCCCEEEEEECCCCCCHHHHHHHHHHHHHCC
PAEADPRIAEELRHGDVDAVALASSTAARCLVELYGPLPDSVLVAAMGRRTAQACEAVGL
CCCCCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCC
RVDAIPSEPGIYPLAAAVADLVAGRRAPTA
EEECCCCCCCCHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MHAVAVVTPGPQARGSGSDPAPSQVSRPGEVWLVGAGPGDPGLLTVRGRELLATADVVVT
CCEEEEECCCCCCCCCCCCCCCHHCCCCCCEEEEECCCCCCCEEEECCCEEEEHHHHHHH
DRLAAAVLLDVARPDARVIHVGKSPTTSRSQDEVNALLVEHARAGARVVRLKGGDPFLLG
HHHHHHHHHHHCCCCCEEEEECCCCCCCCCHHHHHHHHHHHHCCCCEEEEEECCCEEEEE
RGGEEAEACAAAGVSCTVVPGVTSAIAVPAYAGIPVTHRGVAQDLAIISGHLPPGHPEST
CCCCHHHHHHHCCCEEEECCCCHHHHHCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCC
VDWAALGASRATIVVLMGVARLVDIVDALLAGGRPPGTPAAVIERGTTPAQRVLRTTLDA
CHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHCCCCCHHHHHHHHHHHH
LVVDAVAFGLRSPAVLVVGEVAARRDAAVPIPPVVEADADHGERVPDGYGTGDTRVPDGQ
HHHHHHHHHCCCCCEEEEECHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
GISDGRGVSGGQGGRASSGRPGVAGDAPLAGIRVLVPRTRARQGLLARRLRELGGEAVET
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEECCHHHHHHHHHHHHHHHCCHHHHH
VVSRLVPTGDATPLREALPGADGLVLADSDEVAAVVSLLRGAGTDVRALAGLTLVAASAS
HHHHHCCCCCCCHHHHHCCCCCCEEEECCHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCH
AAAALDALGLACARSSAEVQVAHTVVTEVPVPGLRVVICGAAPPPVGIRTLRRVRLLADA
HHHHHHHHHHHHHCCCCCEEEEEHHHHHCCCCCEEEEEECCCCCCHHHHHHHHHHHHHCC
PAEADPRIAEELRHGDVDAVALASSTAARCLVELYGPLPDSVLVAAMGRRTAQACEAVGL
CCCCCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCC
RVDAIPSEPGIYPLAAAVADLVAGRRAPTA
EEECCCCCCCCHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA