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The map label for this gene is nuoD

Identifier: 158317833

GI number: 158317833

Start: 7415429

End: 7416802

Strand: Reverse

Name: nuoD

Synonym: Franean1_6091

Alternate gene names: 158317833

Gene position: 7416802-7415429 (Counterclockwise)

Preceding gene: 158317834

Following gene: 158317832

Centisome position: 82.57

GC content: 69.14

Gene sequence:

>1374_bases
ATGAGCACGCACACCGAGACGCCCGTCGACGGTTCGGCCGAGACCATCACCGGCGCGCAGCCCTACGAGGCCGGGTTCAC
CGAGTCCTCCGCCGGCCGCGTCTACACCGTGACGGGCGGTGACTGGGAGCAGGTCCTCGGCGTCGGCGAGGACGACGGTG
AGCGGATCACCGTCAACATGGGCCCGCAGCACCCGTCCACCCACGGCGTGCTGCGGCTGGTGCTGGAGATCGAGGGCGAG
ACGGTTACCGAGACCCGCCTGGTCATCGGCTACCTGCACACCGGGATCGAGAAGAGCTGCGAGTACCGCACCTGGACGCA
GGCGGTCACGTTCCTCACCCGCGCCGACTACCTCTCGCCGCTGTACAACGAGGCGGCGTACTGCCTGTCGGTGGAGAAGC
TGCTCGGCATCACCGGCGAGGTGCCGGAGCGGGCGACCGTCATCCGGGTGCTCGTCATGGAGCTGCAGCGGATCGCCTCG
CACCTGGTGTGGCTGGCGACCGGAGGCATGGAGCTCGGCGCCACCACCGGCATGATCTTCGGGTTCCGTGAGCGGGAGAA
GATCCTCGACCTGCTCGAGACGATCACCGGCCTGCGGATGAACCACGCCTACATCCGCCCCGGCGGCCTGGCCCAGGACA
TCCCGGACGAGGTGATCCCGGAGATCCGCGCGTTCCTCGACTACATGCCCAAGCGCATCCGCGAGTACCACGCGCTGCTG
ACCGGCCAGCCCATCTGGAAGGCGCGGATGGTCGACGTCAACTTCCTCGACGCCGCCGCCTGCCTCGCGCTGGGGACGAC
CGGCCCGGTGCTGCGCGCCGCCGGTCTGCCCTGGGACCTGCGCAAGACCATGCCGTACTGCGGCTACGAGACCTACGAGT
TCGACGTCCCGACCGCGCTCGAGGGCGACTCCTACGCCCGGTACCTGGTGCGGATCGAGGAGATGGGCGAGTCCCTCAAG
ATCATCGAGCAGTGCCTGGACCGGCTGCGCCCCGGCCCGGTCATGGTCGCCGACAAGAAGATCGCCTGGCCGTCGCAGCT
GGCCATCGGCTCGGATGGCATGGGCAACTCGCTCGAGTACATCCGCAAGATCATGGGGACCTCGATGGAGGCCCTGATCC
ACCACTTCAAGCTCGTCACCGAGGGCTTCCGGGTGCCCGCCGGCCAGGTGTACACGCAGATCGAGTCGCCGCGCGGCGAG
CTCGGCTACCACGTCGTCAGCGACGGCGGCACCAGGCCGTTCCGCGTCCACGTGCGGGACCCAAGCTTCGTGAACCTGCA
GGCCGTGCCCGCGCTGACGGAGGGCGGGCAGGTGGCCGACGTGATCGTCGGCGTCGCCTCCGTCGACCCGGTGCTCGGGG
GAGTTGATCGCTGA

Upstream 100 bases:

>100_bases
TACTCGTGACCGGGCACTGTCCGGCCGGCACCCGGGCGCGGGCCACCACGGGGTCACGCGTGACCGCCAGGCATCCCCGA
GCCGACTTCCGAGGTTCGCT

Downstream 100 bases:

>100_bases
TGCCACTGACCGAACAGACCCGCGCCGCGGCCCGCGAGATCATCGCGCGCTACCCCGAGGGACGTTCCCGCTCGGCGCTG
CTGCCGATGCTGCACCTGGT

Product: NADH dehydrogenase subunit D

Products: NA

Alternate protein names: NADH dehydrogenase I subunit D; NDH-1 subunit D

Number of amino acids: Translated: 457; Mature: 456

Protein sequence:

>457_residues
MSTHTETPVDGSAETITGAQPYEAGFTESSAGRVYTVTGGDWEQVLGVGEDDGERITVNMGPQHPSTHGVLRLVLEIEGE
TVTETRLVIGYLHTGIEKSCEYRTWTQAVTFLTRADYLSPLYNEAAYCLSVEKLLGITGEVPERATVIRVLVMELQRIAS
HLVWLATGGMELGATTGMIFGFREREKILDLLETITGLRMNHAYIRPGGLAQDIPDEVIPEIRAFLDYMPKRIREYHALL
TGQPIWKARMVDVNFLDAAACLALGTTGPVLRAAGLPWDLRKTMPYCGYETYEFDVPTALEGDSYARYLVRIEEMGESLK
IIEQCLDRLRPGPVMVADKKIAWPSQLAIGSDGMGNSLEYIRKIMGTSMEALIHHFKLVTEGFRVPAGQVYTQIESPRGE
LGYHVVSDGGTRPFRVHVRDPSFVNLQAVPALTEGGQVADVIVGVASVDPVLGGVDR

Sequences:

>Translated_457_residues
MSTHTETPVDGSAETITGAQPYEAGFTESSAGRVYTVTGGDWEQVLGVGEDDGERITVNMGPQHPSTHGVLRLVLEIEGE
TVTETRLVIGYLHTGIEKSCEYRTWTQAVTFLTRADYLSPLYNEAAYCLSVEKLLGITGEVPERATVIRVLVMELQRIAS
HLVWLATGGMELGATTGMIFGFREREKILDLLETITGLRMNHAYIRPGGLAQDIPDEVIPEIRAFLDYMPKRIREYHALL
TGQPIWKARMVDVNFLDAAACLALGTTGPVLRAAGLPWDLRKTMPYCGYETYEFDVPTALEGDSYARYLVRIEEMGESLK
IIEQCLDRLRPGPVMVADKKIAWPSQLAIGSDGMGNSLEYIRKIMGTSMEALIHHFKLVTEGFRVPAGQVYTQIESPRGE
LGYHVVSDGGTRPFRVHVRDPSFVNLQAVPALTEGGQVADVIVGVASVDPVLGGVDR
>Mature_456_residues
STHTETPVDGSAETITGAQPYEAGFTESSAGRVYTVTGGDWEQVLGVGEDDGERITVNMGPQHPSTHGVLRLVLEIEGET
VTETRLVIGYLHTGIEKSCEYRTWTQAVTFLTRADYLSPLYNEAAYCLSVEKLLGITGEVPERATVIRVLVMELQRIASH
LVWLATGGMELGATTGMIFGFREREKILDLLETITGLRMNHAYIRPGGLAQDIPDEVIPEIRAFLDYMPKRIREYHALLT
GQPIWKARMVDVNFLDAAACLALGTTGPVLRAAGLPWDLRKTMPYCGYETYEFDVPTALEGDSYARYLVRIEEMGESLKI
IEQCLDRLRPGPVMVADKKIAWPSQLAIGSDGMGNSLEYIRKIMGTSMEALIHHFKLVTEGFRVPAGQVYTQIESPRGEL
GYHVVSDGGTRPFRVHVRDPSFVNLQAVPALTEGGQVADVIVGVASVDPVLGGVDR

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translo

COG id: COG0649

COG function: function code C; NADH:ubiquinone oxidoreductase 49 kD subunit 7

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein; Cytoplasmic side

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I 49 kDa subunit family

Homologues:

Organism=Homo sapiens, GI4758786, Length=404, Percent_Identity=45.049504950495, Blast_Score=349, Evalue=4e-96,
Organism=Homo sapiens, GI260898743, Length=406, Percent_Identity=43.8423645320197, Blast_Score=340, Evalue=2e-93,
Organism=Escherichia coli, GI145693162, Length=410, Percent_Identity=40.2439024390244, Blast_Score=296, Evalue=1e-81,
Organism=Escherichia coli, GI1789076, Length=407, Percent_Identity=27.027027027027, Blast_Score=139, Evalue=3e-34,
Organism=Escherichia coli, GI1788832, Length=419, Percent_Identity=25.5369928400955, Blast_Score=118, Evalue=9e-28,
Organism=Caenorhabditis elegans, GI17568379, Length=408, Percent_Identity=42.4019607843137, Blast_Score=343, Evalue=1e-94,
Organism=Caenorhabditis elegans, GI17555284, Length=408, Percent_Identity=41.9117647058824, Blast_Score=340, Evalue=1e-93,
Organism=Drosophila melanogaster, GI24638644, Length=416, Percent_Identity=43.0288461538462, Blast_Score=355, Evalue=5e-98,
Organism=Drosophila melanogaster, GI221459469, Length=400, Percent_Identity=42.5, Blast_Score=342, Evalue=4e-94,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NUOD_FRASN (A8LC98)

Other databases:

- EMBL:   CP000820
- RefSeq:   YP_001510341.1
- ProteinModelPortal:   A8LC98
- SMR:   A8LC98
- GeneID:   5674412
- GenomeReviews:   CP000820_GR
- KEGG:   fre:Franean1_6091
- HOGENOM:   HBG459705
- OMA:   MADVITI
- ProtClustDB:   PRK06075
- BioCyc:   FSP1855:FRANEAN1_6091-MONOMER
- GO:   GO:0006810
- HAMAP:   MF_01358
- InterPro:   IPR010219
- InterPro:   IPR001135
- InterPro:   IPR022885
- TIGRFAMs:   TIGR01962

Pfam domain/function: PF00346 Complex1_49kDa

EC number: =1.6.99.5

Molecular weight: Translated: 50259; Mature: 50128

Theoretical pI: Translated: 4.84; Mature: 4.84

Prosite motif: PS00535 COMPLEX1_49K

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTHTETPVDGSAETITGAQPYEAGFTESSAGRVYTVTGGDWEQVLGVGEDDGERITVNM
CCCCCCCCCCCCCCEECCCCCCCCCCCCCCCCEEEEEECCCHHHHCCCCCCCCCEEEEEE
GPQHPSTHGVLRLVLEIEGETVTETRLVIGYLHTGIEKSCEYRTWTQAVTFLTRADYLSP
CCCCCCCHHEEEEEEEECCCEEEHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHH
LYNEAAYCLSVEKLLGITGEVPERATVIRVLVMELQRIASHLVWLATGGMELGATTGMIF
HHHHHHHHEEHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHEEHEECCEECCCCCCCEE
GFREREKILDLLETITGLRMNHAYIRPGGLAQDIPDEVIPEIRAFLDYMPKRIREYHALL
CHHHHHHHHHHHHHHHCCCCCCEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
TGQPIWKARMVDVNFLDAAACLALGTTGPVLRAAGLPWDLRKTMPYCGYETYEFDVPTAL
CCCCCCEEEEEECCHHHHHHHHHHCCCCHHHHHCCCCHHHHHCCCCCCCEEEEECCCCCC
EGDSYARYLVRIEEMGESLKIIEQCLDRLRPGPVMVADKKIAWPSQLAIGSDGMGNSLEY
CCCHHHHHHHHHHHHCHHHHHHHHHHHHCCCCCEEEECCCCCCCCCEECCCCCCCCHHHH
IRKIMGTSMEALIHHFKLVTEGFRVPAGQVYTQIESPRGELGYHVVSDGGTRPFRVHVRD
HHHHHCCCHHHHHHHHHHHHHCCCCCCHHHHHEECCCCCCCCEEEEECCCCCCEEEEECC
PSFVNLQAVPALTEGGQVADVIVGVASVDPVLGGVDR
CCEEEEEECCCCCCCCCHHHHHHHHHHHCHHHCCCCC
>Mature Secondary Structure 
STHTETPVDGSAETITGAQPYEAGFTESSAGRVYTVTGGDWEQVLGVGEDDGERITVNM
CCCCCCCCCCCCCEECCCCCCCCCCCCCCCCEEEEEECCCHHHHCCCCCCCCCEEEEEE
GPQHPSTHGVLRLVLEIEGETVTETRLVIGYLHTGIEKSCEYRTWTQAVTFLTRADYLSP
CCCCCCCHHEEEEEEEECCCEEEHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHH
LYNEAAYCLSVEKLLGITGEVPERATVIRVLVMELQRIASHLVWLATGGMELGATTGMIF
HHHHHHHHEEHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHEEHEECCEECCCCCCCEE
GFREREKILDLLETITGLRMNHAYIRPGGLAQDIPDEVIPEIRAFLDYMPKRIREYHALL
CHHHHHHHHHHHHHHHCCCCCCEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
TGQPIWKARMVDVNFLDAAACLALGTTGPVLRAAGLPWDLRKTMPYCGYETYEFDVPTAL
CCCCCCEEEEEECCHHHHHHHHHHCCCCHHHHHCCCCHHHHHCCCCCCCEEEEECCCCCC
EGDSYARYLVRIEEMGESLKIIEQCLDRLRPGPVMVADKKIAWPSQLAIGSDGMGNSLEY
CCCHHHHHHHHHHHHCHHHHHHHHHHHHCCCCCEEEECCCCCCCCCEECCCCCCCCHHHH
IRKIMGTSMEALIHHFKLVTEGFRVPAGQVYTQIESPRGELGYHVVSDGGTRPFRVHVRD
HHHHHCCCHHHHHHHHHHHHHCCCCCCHHHHHEECCCCCCCCEEEEECCCCCCEEEEECC
PSFVNLQAVPALTEGGQVADVIVGVASVDPVLGGVDR
CCEEEEEECCCCCCCCCHHHHHHHHHHHCHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA