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The map label for this gene is gldA [H]

Identifier: 158317704

GI number: 158317704

Start: 7264559

End: 7265656

Strand: Direct

Name: gldA [H]

Synonym: Franean1_5962

Alternate gene names: 158317704

Gene position: 7264559-7265656 (Clockwise)

Preceding gene: 158317702

Following gene: 158317706

Centisome position: 80.88

GC content: 74.77

Gene sequence:

>1098_bases
ATGCTCGCCGTGTTCGGGTCGCCGGGTCGATACGTCCAGGGTCGGGATGCCACCGCCGCGCTCGGGCCGGAGATGGCCCG
CCTCGGCCTGACCGGCCCGGCGGTCATCGTGACGAGCGGGGCCCCGCTGCGCCTGCTCGAGGACACCTGGCGGACGAGCC
TGGACGGCGCGGGCATCCCCTACTCCGTGCACCTGTTCGGCGGCGAGTGCAGCGACCAGGAGATCGACCGGGTCGTCTCG
GCGGCGCGTGACCCGGAGGCGACGGTGATCGTCGGTGCCGGTGGCGGGAAGGTGCTCGACACCGCCCGCGCGGCGGCCGC
CGCGCTCGACCTGCCGGTGGTGACCTGCCCGACGACCGCGTCCAGCGACGCGCCGTGCAGCGCGTTGTCCGTCGTGTACT
CCCAGGACGGGACGTTCGAGCGGTACCTGTTCTACCCGCGCAACCCGGATCTGGTCCTGGTCGACACCACCGCGGTCGCC
GCGGCGCCGGCCCGCCTGCTGGTCGCCGGGATCGGCGACGCGCTCGCCACCTGGTACGAGGCCCGTACCGTCGGCGAGGC
CCGGCGGGCCAACCAGCTCGACGGCGCGCAGACGGCGACGGCCGGCGCGCTGGCCGAGTTGTGCCGACGCATCCTGTTCG
ACGACGCGGCGGCGGCGATCCGCGCGGTGCGCGCCGGCGCGGTGACACCGGCGCTGGAGCGGGTCGTCGAGGCGAACACG
CTGCTGTCGGGGCTGGGCTTCGAGTCGGGTGGGCTGGCCGTGGCGCACTCGGTGCACAACGGCCTGACCGTGGCCGCGGA
GACCCACCGGTATCTGCACGGCGAGAAGGTCGCGTTCGGGCTGATCGTCCAGCTCGTGGTCGAGGGACGGCCGGAGGAGG
AGCTGGCCGAGGTGCTCGCGTTCTGCGGCGGGGTGGGGCTGCCGCGCACACTCGCCCAGGTGGGGCTGGCGGATCCGCCG
ATCGAGCTGCTGCGCGGCATCGCCGTCCGGGCGCTCGCCGACGGGGAGACAGCCCACAACGAGCCCTTCGACCTCGACCC
GCCGATGATCGTCGACGCGATCCTGGCAGCCGACGCCGCCGGCCGGGCCAGCCGCTGA

Upstream 100 bases:

>100_bases
CCGGGCCTACCCAGCCGACGGCGTTTCGATCGCGCACCGGGGAGCGGACACGGAGCGGACATGCTGGCGCAGCCCGGCGG
AACCGCTACCGTAACCGTTC

Downstream 100 bases:

>100_bases
CCCGAGTGTCACCGCGGTGGCCGGCCCGCCGACGAGGGCCGTCACGTCCATGCGGCCGTAACGACGGCGCGGCCGTCACC
GCGTGGCGCGGGCCGTCGCG

Product: iron-containing alcohol dehydrogenase

Products: NA

Alternate protein names: GDH; GLDH [H]

Number of amino acids: Translated: 365; Mature: 365

Protein sequence:

>365_residues
MLAVFGSPGRYVQGRDATAALGPEMARLGLTGPAVIVTSGAPLRLLEDTWRTSLDGAGIPYSVHLFGGECSDQEIDRVVS
AARDPEATVIVGAGGGKVLDTARAAAAALDLPVVTCPTTASSDAPCSALSVVYSQDGTFERYLFYPRNPDLVLVDTTAVA
AAPARLLVAGIGDALATWYEARTVGEARRANQLDGAQTATAGALAELCRRILFDDAAAAIRAVRAGAVTPALERVVEANT
LLSGLGFESGGLAVAHSVHNGLTVAAETHRYLHGEKVAFGLIVQLVVEGRPEEELAEVLAFCGGVGLPRTLAQVGLADPP
IELLRGIAVRALADGETAHNEPFDLDPPMIVDAILAADAAGRASR

Sequences:

>Translated_365_residues
MLAVFGSPGRYVQGRDATAALGPEMARLGLTGPAVIVTSGAPLRLLEDTWRTSLDGAGIPYSVHLFGGECSDQEIDRVVS
AARDPEATVIVGAGGGKVLDTARAAAAALDLPVVTCPTTASSDAPCSALSVVYSQDGTFERYLFYPRNPDLVLVDTTAVA
AAPARLLVAGIGDALATWYEARTVGEARRANQLDGAQTATAGALAELCRRILFDDAAAAIRAVRAGAVTPALERVVEANT
LLSGLGFESGGLAVAHSVHNGLTVAAETHRYLHGEKVAFGLIVQLVVEGRPEEELAEVLAFCGGVGLPRTLAQVGLADPP
IELLRGIAVRALADGETAHNEPFDLDPPMIVDAILAADAAGRASR
>Mature_365_residues
MLAVFGSPGRYVQGRDATAALGPEMARLGLTGPAVIVTSGAPLRLLEDTWRTSLDGAGIPYSVHLFGGECSDQEIDRVVS
AARDPEATVIVGAGGGKVLDTARAAAAALDLPVVTCPTTASSDAPCSALSVVYSQDGTFERYLFYPRNPDLVLVDTTAVA
AAPARLLVAGIGDALATWYEARTVGEARRANQLDGAQTATAGALAELCRRILFDDAAAAIRAVRAGAVTPALERVVEANT
LLSGLGFESGGLAVAHSVHNGLTVAAETHRYLHGEKVAFGLIVQLVVEGRPEEELAEVLAFCGGVGLPRTLAQVGLADPP
IELLRGIAVRALADGETAHNEPFDLDPPMIVDAILAADAAGRASR

Specific function: Catalyzes the NAD-dependent oxidation of glycerol to dihydroxyacetone (glycerone). Allows microorganisms to utilize glycerol as a source of carbon under anaerobic conditions [H]

COG id: COG0371

COG function: function code C; Glycerol dehydrogenase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the iron-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Escherichia coli, GI87082352, Length=362, Percent_Identity=48.3425414364641, Blast_Score=317, Evalue=1e-87,
Organism=Escherichia coli, GI1786815, Length=298, Percent_Identity=32.8859060402685, Blast_Score=127, Evalue=1e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001670
- InterPro:   IPR018211
- InterPro:   IPR016205 [H]

Pfam domain/function: PF00465 Fe-ADH [H]

EC number: =1.1.1.6 [H]

Molecular weight: Translated: 37632; Mature: 37632

Theoretical pI: Translated: 4.54; Mature: 4.54

Prosite motif: PS00913 ADH_IRON_1 ; PS00687 ALDEHYDE_DEHYDR_GLU

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
0.8 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLAVFGSPGRYVQGRDATAALGPEMARLGLTGPAVIVTSGAPLRLLEDTWRTSLDGAGIP
CEEEECCCCCEECCCCCHHHHCCHHHHHCCCCCEEEEECCCCHHHHHHHHHCCCCCCCCC
YSVHLFGGECSDQEIDRVVSAARDPEATVIVGAGGGKVLDTARAAAAALDLPVVTCPTTA
EEEEEECCCCCHHHHHHHHHHCCCCCCEEEEECCCCCHHHHHHHHHHHHCCCEEECCCCC
SSDAPCSALSVVYSQDGTFERYLFYPRNPDLVLVDTTAVAAAPARLLVAGIGDALATWYE
CCCCCHHHHEEEECCCCCEEEEEEECCCCCEEEEECHHHHHCCHHHHHHHHHHHHHHHHH
ARTVGEARRANQLDGAQTATAGALAELCRRILFDDAAAAIRAVRAGAVTPALERVVEANT
HHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHH
LLSGLGFESGGLAVAHSVHNGLTVAAETHRYLHGEKVAFGLIVQLVVEGRPEEELAEVLA
HHHHCCCCCCCEEEEEECCCCEEEEEHHHHHHCCCHHHHHHHHHHHHCCCCHHHHHHHHH
FCGGVGLPRTLAQVGLADPPIELLRGIAVRALADGETAHNEPFDLDPPMIVDAILAADAA
HHCCCCCHHHHHHHCCCCCHHHHHHHHHHHHEECCCCCCCCCCCCCCHHHHHHHHHHCCC
GRASR
CCCCC
>Mature Secondary Structure
MLAVFGSPGRYVQGRDATAALGPEMARLGLTGPAVIVTSGAPLRLLEDTWRTSLDGAGIP
CEEEECCCCCEECCCCCHHHHCCHHHHHCCCCCEEEEECCCCHHHHHHHHHCCCCCCCCC
YSVHLFGGECSDQEIDRVVSAARDPEATVIVGAGGGKVLDTARAAAAALDLPVVTCPTTA
EEEEEECCCCCHHHHHHHHHHCCCCCCEEEEECCCCCHHHHHHHHHHHHCCCEEECCCCC
SSDAPCSALSVVYSQDGTFERYLFYPRNPDLVLVDTTAVAAAPARLLVAGIGDALATWYE
CCCCCHHHHEEEECCCCCEEEEEEECCCCCEEEEECHHHHHCCHHHHHHHHHHHHHHHHH
ARTVGEARRANQLDGAQTATAGALAELCRRILFDDAAAAIRAVRAGAVTPALERVVEANT
HHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHH
LLSGLGFESGGLAVAHSVHNGLTVAAETHRYLHGEKVAFGLIVQLVVEGRPEEELAEVLA
HHHHCCCCCCCEEEEEECCCCEEEEEHHHHHHCCCHHHHHHHHHHHHCCCCHHHHHHHHH
FCGGVGLPRTLAQVGLADPPIELLRGIAVRALADGETAHNEPFDLDPPMIVDAILAADAA
HHCCCCCHHHHHHHCCCCCHHHHHHHHHHHHEECCCCCCCCCCCCCCHHHHHHHHHHCCC
GRASR
CCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10360571; 12193646 [H]