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The map label for this gene is upp [H]

Identifier: 158317664

GI number: 158317664

Start: 7192326

End: 7192949

Strand: Direct

Name: upp [H]

Synonym: Franean1_5922

Alternate gene names: 158317664

Gene position: 7192326-7192949 (Clockwise)

Preceding gene: 158317662

Following gene: 158317666

Centisome position: 80.07

GC content: 74.04

Gene sequence:

>624_bases
GTGCAGGTTCAGGTCGTCGATCATCCGCTGGCAGCGACCGCGCTCACCGTCCTGCGGGACGAGCGCACGGCACGCGCCGC
CTTCCGCGCCGCCCTGCACGACCTGTCGACGATGCTCGTCTACGAGGCGACCCGCGAGCTGCCGACGATGCCCGTCTCGG
TGACGACGCCGCTGGCGACCACCGCCGGGGTGGTGCTCGCGGCCGAGCCGGTGGTCGTGCCCGTGCTGCGGGCCGGTCTC
GGCATGCTGCCGGCCGCGCTCACCCTGATGCCGGACGCGCGGTCGGCGTTCATCGGCCTCTCCCGCGACGAGACGACCTT
CGAGCCCCGGGTCTACCTCGAGTCGGTGCCGGCGGACCTGGCGGGGCGGCCGGTGTTCCTGCTCGACCCGATGCTGGCGA
CCGGCGGCTCCGCGCTGCACGCACTGCGGCTGCTCACCGCCCGGGGCGCGACCGGCATCGTCGTGGTCTCCGTCGTCGCC
GCGCCAGAGGGGGTCGCCGCGCTGGAGGGCAGCGGCCTGGACATCAGCGTGGTCACCGCCGTGGTGGACGAGAAGCTGAA
CGACACCGCCTACATCGTTCCGGGGCTCGGCGACGCCGGCGACCGGATCTACGGCGCCGTCTAG

Upstream 100 bases:

>100_bases
CCCGGCGCGGGACGGTCGGGTCCGGCGGGAGCCGTTGTCATACCTTGCATCATCGCCCATGCGCAGTGTGGGTTCTCGAG
TGTCCCGGTAGGAGCCAACC

Downstream 100 bases:

>100_bases
CGCGCCGCCCGCCGACCCGCGTGTGCGTCGGGACCGCTCCGCGCGTGTCACCGGGGAGATCGGCACGCTCCCGCAGCACG
CCCTTCTCCCCGCTGTCCGC

Product: uracil phosphoribosyltransferase

Products: NA

Alternate protein names: UMP pyrophosphorylase; UPRTase [H]

Number of amino acids: Translated: 207; Mature: 207

Protein sequence:

>207_residues
MQVQVVDHPLAATALTVLRDERTARAAFRAALHDLSTMLVYEATRELPTMPVSVTTPLATTAGVVLAAEPVVVPVLRAGL
GMLPAALTLMPDARSAFIGLSRDETTFEPRVYLESVPADLAGRPVFLLDPMLATGGSALHALRLLTARGATGIVVVSVVA
APEGVAALEGSGLDISVVTAVVDEKLNDTAYIVPGLGDAGDRIYGAV

Sequences:

>Translated_207_residues
MQVQVVDHPLAATALTVLRDERTARAAFRAALHDLSTMLVYEATRELPTMPVSVTTPLATTAGVVLAAEPVVVPVLRAGL
GMLPAALTLMPDARSAFIGLSRDETTFEPRVYLESVPADLAGRPVFLLDPMLATGGSALHALRLLTARGATGIVVVSVVA
APEGVAALEGSGLDISVVTAVVDEKLNDTAYIVPGLGDAGDRIYGAV
>Mature_207_residues
MQVQVVDHPLAATALTVLRDERTARAAFRAALHDLSTMLVYEATRELPTMPVSVTTPLATTAGVVLAAEPVVVPVLRAGL
GMLPAALTLMPDARSAFIGLSRDETTFEPRVYLESVPADLAGRPVFLLDPMLATGGSALHALRLLTARGATGIVVVSVVA
APEGVAALEGSGLDISVVTAVVDEKLNDTAYIVPGLGDAGDRIYGAV

Specific function: Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate [H]

COG id: COG0035

COG function: function code F; Uracil phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UPRTase family [H]

Homologues:

Organism=Homo sapiens, GI301129207, Length=194, Percent_Identity=30.9278350515464, Blast_Score=91, Evalue=6e-19,
Organism=Homo sapiens, GI57863312, Length=194, Percent_Identity=30.9278350515464, Blast_Score=91, Evalue=7e-19,
Organism=Homo sapiens, GI21450816, Length=170, Percent_Identity=27.0588235294118, Blast_Score=69, Evalue=4e-12,
Organism=Escherichia coli, GI87082118, Length=208, Percent_Identity=39.4230769230769, Blast_Score=158, Evalue=2e-40,
Organism=Caenorhabditis elegans, GI17539892, Length=200, Percent_Identity=26.5, Blast_Score=84, Evalue=4e-17,
Organism=Caenorhabditis elegans, GI17539894, Length=200, Percent_Identity=26.5, Blast_Score=84, Evalue=5e-17,
Organism=Saccharomyces cerevisiae, GI6321920, Length=192, Percent_Identity=34.375, Blast_Score=113, Evalue=3e-26,
Organism=Drosophila melanogaster, GI45550449, Length=194, Percent_Identity=28.3505154639175, Blast_Score=81, Evalue=4e-16,
Organism=Drosophila melanogaster, GI28573516, Length=194, Percent_Identity=28.3505154639175, Blast_Score=78, Evalue=4e-15,
Organism=Drosophila melanogaster, GI28573514, Length=194, Percent_Identity=28.3505154639175, Blast_Score=78, Evalue=4e-15,
Organism=Drosophila melanogaster, GI28573512, Length=194, Percent_Identity=28.3505154639175, Blast_Score=78, Evalue=4e-15,

Paralogues:

None

Copy number: 2580 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000836
- InterPro:   IPR005765 [H]

Pfam domain/function: PF00156 Pribosyltran [H]

EC number: =2.4.2.9 [H]

Molecular weight: Translated: 21391; Mature: 21391

Theoretical pI: Translated: 4.54; Mature: 4.54

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQVQVVDHPLAATALTVLRDERTARAAFRAALHDLSTMLVYEATRELPTMPVSVTTPLAT
CEEEEECCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCHH
TAGVVLAAEPVVVPVLRAGLGMLPAALTLMPDARSAFIGLSRDETTFEPRVYLESVPADL
HCCEEEECCCHHHHHHHHCHHHHHHHHEECCCCHHHEEECCCCCCCCCCEEEEECCCCCC
AGRPVFLLDPMLATGGSALHALRLLTARGATGIVVVSVVAAPEGVAALEGSGLDISVVTA
CCCCEEEECCHHHCCCHHHHHHHHHHHCCCCCEEEEEEEECCCCCEEECCCCCCHHHHHH
VVDEKLNDTAYIVPGLGDAGDRIYGAV
HHHHCCCCCEEEECCCCCCCCEEECCC
>Mature Secondary Structure
MQVQVVDHPLAATALTVLRDERTARAAFRAALHDLSTMLVYEATRELPTMPVSVTTPLAT
CEEEEECCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCHH
TAGVVLAAEPVVVPVLRAGLGMLPAALTLMPDARSAFIGLSRDETTFEPRVYLESVPADL
HCCEEEECCCHHHHHHHHCHHHHHHHHEECCCCHHHEEECCCCCCCCCCEEEEECCCCCC
AGRPVFLLDPMLATGGSALHALRLLTARGATGIVVVSVVAAPEGVAALEGSGLDISVVTA
CCCCEEEECCHHHCCCHHHHHHHHHHHCCCCCEEEEEEEECCCCCEEECCCCCCHHHHHH
VVDEKLNDTAYIVPGLGDAGDRIYGAV
HHHHCCCCCEEEECCCCCCCCEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 14602910 [H]