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The map label for this gene is cobA [H]

Identifier: 158317540

GI number: 158317540

Start: 7038167

End: 7038982

Strand: Reverse

Name: cobA [H]

Synonym: Franean1_5796

Alternate gene names: 158317540

Gene position: 7038982-7038167 (Counterclockwise)

Preceding gene: 158317541

Following gene: 158317536

Centisome position: 78.37

GC content: 74.75

Gene sequence:

>816_bases
GTGGCCGTGGACGCGCAGGCGGGATGGGTAGCGCTTGTCGGAGGCGGGCCGGGCCGGGGTGATCTGATCACGCTGCGCGG
CCTGCGCCTGCTGCGGCGCGCCGACGTGGTCGTCGTCGACCGCCTCGCCCCCCGTGAGCTGCTGGACGAGCTGCGGCCGG
ACGTCGAGATCGTCGACGCCGGCAAGGCACCGCACGGCCACAACCTCACCCAGGACGAGATCAACGCCCTCATCGTGGAA
CGGGCGCTGCGTGGCCTCGGGGTCGTCCGTCTCAAGGGCGGCGACCCGTTCGTCTTCGGCCGGGGCGGTGAGGAGGCGCT
GGCCTGCACCGCCGCCGGCGTGCCGTGCGAGGTGGTGCCCGGGGTGACCAGCGCGGTAGCCGTGCCCGCGATGGCCGGGA
TCCCGGTCACCCACCGCGGCATCACCCAGGACGTGGCGATCGTCAGCGGCCACCTCGACCCGTCCCACCCCGGTTCGACG
GCGGACTGGGACGCGCTCGCGACCGGTCCCGGCACCGTGGTCGTGCTCATGGGGGTCGCGGCGCTGCCCCGGATCAGCGC
TGAGCTGATCAAACGCGGGCGGTCACCGCGGACCCCGACCGCGGTGATCCACGCCGGTGGCACGGAGCACGAACGGCTGG
TGACCGGCCCGCTGGGCGAGATCACCCGGCTGGCGCTGGCGGCGGACGTCTCCTCGCCGGCCGTGATCGTCATCGGCGAG
GTCGTCGCCCTGCGCGACCAGCTCGCCGTGGGTCGCATCCCGGATCGCGCGGACGACGGCCCTGCCCGGGACGACGGCCC
CGGTCAGGTGGGGTGA

Upstream 100 bases:

>100_bases
CCCGGTCCGCAACGTGACGCGGCGCGACGCCCTGTGGGGCAACGCGGCGCGGGGCGACACGAGGTGGGGCGACACGAGGT
GGGGCGACGCGAGGTGGGGA

Downstream 100 bases:

>100_bases
GCAGGGCTCACTCGAACCGGATCTCGGTCAGGCGGGCGGCCTCCTCGCGGCTGATCCCGCGCGCGAACGTCCAGCCCTCC
CGGGCCAGCGACCCATCCTG

Product: uroporphyrin-III C-methyltransferase

Products: NA

Alternate protein names: Urogen III methylase; SUMT; Uroporphyrinogen III methylase; UROM [H]

Number of amino acids: Translated: 271; Mature: 270

Protein sequence:

>271_residues
MAVDAQAGWVALVGGGPGRGDLITLRGLRLLRRADVVVVDRLAPRELLDELRPDVEIVDAGKAPHGHNLTQDEINALIVE
RALRGLGVVRLKGGDPFVFGRGGEEALACTAAGVPCEVVPGVTSAVAVPAMAGIPVTHRGITQDVAIVSGHLDPSHPGST
ADWDALATGPGTVVVLMGVAALPRISAELIKRGRSPRTPTAVIHAGGTEHERLVTGPLGEITRLALAADVSSPAVIVIGE
VVALRDQLAVGRIPDRADDGPARDDGPGQVG

Sequences:

>Translated_271_residues
MAVDAQAGWVALVGGGPGRGDLITLRGLRLLRRADVVVVDRLAPRELLDELRPDVEIVDAGKAPHGHNLTQDEINALIVE
RALRGLGVVRLKGGDPFVFGRGGEEALACTAAGVPCEVVPGVTSAVAVPAMAGIPVTHRGITQDVAIVSGHLDPSHPGST
ADWDALATGPGTVVVLMGVAALPRISAELIKRGRSPRTPTAVIHAGGTEHERLVTGPLGEITRLALAADVSSPAVIVIGE
VVALRDQLAVGRIPDRADDGPARDDGPGQVG
>Mature_270_residues
AVDAQAGWVALVGGGPGRGDLITLRGLRLLRRADVVVVDRLAPRELLDELRPDVEIVDAGKAPHGHNLTQDEINALIVER
ALRGLGVVRLKGGDPFVFGRGGEEALACTAAGVPCEVVPGVTSAVAVPAMAGIPVTHRGITQDVAIVSGHLDPSHPGSTA
DWDALATGPGTVVVLMGVAALPRISAELIKRGRSPRTPTAVIHAGGTEHERLVTGPLGEITRLALAADVSSPAVIVIGEV
VALRDQLAVGRIPDRADDGPARDDGPGQVG

Specific function: Catalyzes both methylations at C-2 and C-7 of uroporphyrinogen III leading to precorrin-1 and precorrin-2; their oxidative esterification gives respectively factor I octamethyl ester and sirohydrochlorin [H]

COG id: COG0007

COG function: function code H; Uroporphyrinogen-III methylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the precorrin methyltransferase family [H]

Homologues:

Organism=Escherichia coli, GI1789768, Length=241, Percent_Identity=42.7385892116183, Blast_Score=189, Evalue=2e-49,
Organism=Saccharomyces cerevisiae, GI6322922, Length=243, Percent_Identity=32.0987654320988, Blast_Score=110, Evalue=3e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000878
- InterPro:   IPR014777
- InterPro:   IPR014776
- InterPro:   IPR006366
- InterPro:   IPR003043 [H]

Pfam domain/function: PF00590 TP_methylase [H]

EC number: =2.1.1.107 [H]

Molecular weight: Translated: 27776; Mature: 27645

Theoretical pI: Translated: 5.60; Mature: 5.60

Prosite motif: PS00178 AA_TRNA_LIGASE_I

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
0.7 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAVDAQAGWVALVGGGPGRGDLITLRGLRLLRRADVVVVDRLAPRELLDELRPDVEIVDA
CCCCCCCCEEEEECCCCCCCCEEEHHHHHHHHHCCEEEEECCCHHHHHHHHCCCEEEEEC
GKAPHGHNLTQDEINALIVERALRGLGVVRLKGGDPFVFGRGGEEALACTAAGVPCEVVP
CCCCCCCCCCHHHHHHHHHHHHHHHCCEEEECCCCEEEEECCCCCEEEEEECCCCEEECC
GVTSAVAVPAMAGIPVTHRGITQDVAIVSGHLDPSHPGSTADWDALATGPGTVVVLMGVA
CCHHHHHHHHHCCCCCCCCCCCCCEEEEECCCCCCCCCCCCCCCEEECCCCCEEEEHHHH
ALPRISAELIKRGRSPRTPTAVIHAGGTEHERLVTGPLGEITRLALAADVSSPAVIVIGE
HHHHHHHHHHHCCCCCCCCEEEEECCCCCCCEEEECCHHHHHHHHHHHCCCCCEEEEEHH
VVALRDQLAVGRIPDRADDGPARDDGPGQVG
HHHHHHHHHHCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
AVDAQAGWVALVGGGPGRGDLITLRGLRLLRRADVVVVDRLAPRELLDELRPDVEIVDA
CCCCCCCEEEEECCCCCCCCEEEHHHHHHHHHCCEEEEECCCHHHHHHHHCCCEEEEEC
GKAPHGHNLTQDEINALIVERALRGLGVVRLKGGDPFVFGRGGEEALACTAAGVPCEVVP
CCCCCCCCCCHHHHHHHHHHHHHHHCCEEEECCCCEEEEECCCCCEEEEEECCCCEEECC
GVTSAVAVPAMAGIPVTHRGITQDVAIVSGHLDPSHPGSTADWDALATGPGTVVVLMGVA
CCHHHHHHHHHCCCCCCCCCCCCCEEEEECCCCCCCCCCCCCCCEEECCCCCEEEEHHHH
ALPRISAELIKRGRSPRTPTAVIHAGGTEHERLVTGPLGEITRLALAADVSSPAVIVIGE
HHHHHHHHHHHCCCCCCCCEEEEECCCCCCCEEEECCHHHHHHHHHHHCCCCCEEEEEHH
VVALRDQLAVGRIPDRADDGPARDDGPGQVG
HHHHHHHHHHCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1906874 [H]