Click here to switch to the map view.

The map label for this gene is ureC

Identifier: 158317443

GI number: 158317443

Start: 6913101

End: 6914828

Strand: Direct

Name: ureC

Synonym: Franean1_5695

Alternate gene names: 158317443

Gene position: 6913101-6914828 (Clockwise)

Preceding gene: 158317442

Following gene: 158317444

Centisome position: 76.97

GC content: 72.4

Gene sequence:

>1728_bases
GTGAGTGAGCTGGAGCGGTCCCGGTACGCCACCCTGTACGGGCCGACGGTGGGCGACCGGATCCGCCTCGCGGACACCGA
CCTGTTCATCGAGGTCACCGACGACCTCAGCCGCGGCCCGGGCGGCACGGCCACCGGCGACGAGGCGGTGTTCGGCGGCG
GCAAGGTCATCCGCGAGTCGATGGGCCAGGCCCGCGCCACCCGCGCGCAGGGCGCACCCGACCTGGTGATCACCGGTGCG
GTCGTGCTCGACCACTGGGGAGTCGTCAAGGCCGACGTCGGCATCCGGGACGGACGGATCAGCGCGCTGGGCAAGGCCGG
CAACCCCGACACCATGGACGGCGTCCACCCGGATCTGGTGATCGGCCCCGGCACCGAGATCATCGCGGGCAACGGGAAGA
TCCTCACCGCGGGCGCGGTCGACACCCACGTCCACTTCATCTGCCCGCAGCAGGTTCCCGAGGCCCTCGGCACGGGCGTC
ACCACGCTCATCGGCGGCGGCACCGGGCCGGCGGAGGGCACCAAGGCGACGACCGTCACCGCGTCGCCGTGGAACCTGCA
CCGGATGATGTCCGCGATGGACGGCTGGCCGGTCAACGTCGCCCTGCTCGGCAAGGGCAACACGGTCAGCGAGGACGCGA
TGTGGGAACAGCTGCGCGCCGGCGCGGCCGGCTTCAAGCTGCACGAGGACTGGGGCACCACCCCGGCGGCCATCGACGCC
TGCCTGCGCGTCGCCGACGCCTCGGGGGTACAGGTGGCACTGCACTCCGACACCCTCAACGAGGCCGGGTTCGTCGAGGA
CACCCTCGCCGCGATCGCCGGCCGGGCGATCCACGCCTACCACACGGAGGGTGCCGGCGGCGGGCACGCGCCGGACATCA
TCACCGTCGCCTCGTTCGCGAACATCCTGCCGTCGTCGACGAACCCCACCCGGCCGCACACGGTCAACACCCTCGACGAG
CACCTCGACATGCTGATGGTCTGCCATCATCTGAACCCGTCGGTGCCCGAGGACCTGGCGTTCGCGGAGAGCCGCATCCG
GCCGTCCACGATCGCGGCCGAGGACATCCTGCACGACCTGGGCGCGATCTCGATGATCGGCTCGGACTCGCAGGCGATGG
GCCGCGTCGGCGAGGTCGTCACGCGGACCTGGCAGACCGCGCACGTCATGAAACGCCGCCGCGGCGCACTGCCCGGCGAC
ACGGTCGCCGACAACAACCGGGCCCGGCGCTACGTCGCCAAGTACACGATCTGCCCGGCGGTGGCGCACGGCCTGGACGC
CGAGATCGGGTCGGTGGAGGCCGGGAAGTTGGCCGACCTGGTGCTCTATGAGCCGGCCTTCTTCGGGGTGCGGCCGTCGC
TGGTCCTCAAGGGCGGTTTCATCGCGTGGGCGGCGATGGGCGACGCGAACGCCTCGATCCCGACCCCGCAGCCGGTGCTG
CCGCGGCCCATGTTCGGCGCCGCCCCCGGCCCGGCCGCGGCGAGTTCGCTGATGTTCGTCGCGCCCGCGGCGCTGCAGGA
CGGCCTCGACGAGCGGCTGGGCCTGGCGAAGCCGATGGTCGCCACGGCGGACGTCCGCCGGCGGGGCAAGGCGGACCTGC
CGGAGAACACCGCGACGCCGGACATCCGCGTCGACCCGGACACCTTCACCGTGCGCATCGACGGCGAGGCGGTGGAGGCG
GCTCCGGCCGCCGAGCTGCCCATGGCCCAGCGGTATTTCCTCTTCTGA

Upstream 100 bases:

>100_bases
GAGCTGGTCGCCCTGGCAGGCGCCCGGGTCGTCCCGGGGCTGCGCCCGGAGTGGGCCGGCCCGCTCGACGGTGGCCGCGG
TGACCGTAAGGGGAGCGGCA

Downstream 100 bases:

>100_bases
TCCTGCCTCTCGTCCAGGGCCGGCGGCGCCCGCCGGGGATGGCGCGCGGCCGGGTTTTCGGACCTCCGGGGGCTTGACCC
ACGGCCGCCGCCGTGCCCGC

Product: urease subunit alpha

Products: NA

Alternate protein names: Urea amidohydrolase subunit alpha

Number of amino acids: Translated: 575; Mature: 574

Protein sequence:

>575_residues
MSELERSRYATLYGPTVGDRIRLADTDLFIEVTDDLSRGPGGTATGDEAVFGGGKVIRESMGQARATRAQGAPDLVITGA
VVLDHWGVVKADVGIRDGRISALGKAGNPDTMDGVHPDLVIGPGTEIIAGNGKILTAGAVDTHVHFICPQQVPEALGTGV
TTLIGGGTGPAEGTKATTVTASPWNLHRMMSAMDGWPVNVALLGKGNTVSEDAMWEQLRAGAAGFKLHEDWGTTPAAIDA
CLRVADASGVQVALHSDTLNEAGFVEDTLAAIAGRAIHAYHTEGAGGGHAPDIITVASFANILPSSTNPTRPHTVNTLDE
HLDMLMVCHHLNPSVPEDLAFAESRIRPSTIAAEDILHDLGAISMIGSDSQAMGRVGEVVTRTWQTAHVMKRRRGALPGD
TVADNNRARRYVAKYTICPAVAHGLDAEIGSVEAGKLADLVLYEPAFFGVRPSLVLKGGFIAWAAMGDANASIPTPQPVL
PRPMFGAAPGPAAASSLMFVAPAALQDGLDERLGLAKPMVATADVRRRGKADLPENTATPDIRVDPDTFTVRIDGEAVEA
APAAELPMAQRYFLF

Sequences:

>Translated_575_residues
MSELERSRYATLYGPTVGDRIRLADTDLFIEVTDDLSRGPGGTATGDEAVFGGGKVIRESMGQARATRAQGAPDLVITGA
VVLDHWGVVKADVGIRDGRISALGKAGNPDTMDGVHPDLVIGPGTEIIAGNGKILTAGAVDTHVHFICPQQVPEALGTGV
TTLIGGGTGPAEGTKATTVTASPWNLHRMMSAMDGWPVNVALLGKGNTVSEDAMWEQLRAGAAGFKLHEDWGTTPAAIDA
CLRVADASGVQVALHSDTLNEAGFVEDTLAAIAGRAIHAYHTEGAGGGHAPDIITVASFANILPSSTNPTRPHTVNTLDE
HLDMLMVCHHLNPSVPEDLAFAESRIRPSTIAAEDILHDLGAISMIGSDSQAMGRVGEVVTRTWQTAHVMKRRRGALPGD
TVADNNRARRYVAKYTICPAVAHGLDAEIGSVEAGKLADLVLYEPAFFGVRPSLVLKGGFIAWAAMGDANASIPTPQPVL
PRPMFGAAPGPAAASSLMFVAPAALQDGLDERLGLAKPMVATADVRRRGKADLPENTATPDIRVDPDTFTVRIDGEAVEA
APAAELPMAQRYFLF
>Mature_574_residues
SELERSRYATLYGPTVGDRIRLADTDLFIEVTDDLSRGPGGTATGDEAVFGGGKVIRESMGQARATRAQGAPDLVITGAV
VLDHWGVVKADVGIRDGRISALGKAGNPDTMDGVHPDLVIGPGTEIIAGNGKILTAGAVDTHVHFICPQQVPEALGTGVT
TLIGGGTGPAEGTKATTVTASPWNLHRMMSAMDGWPVNVALLGKGNTVSEDAMWEQLRAGAAGFKLHEDWGTTPAAIDAC
LRVADASGVQVALHSDTLNEAGFVEDTLAAIAGRAIHAYHTEGAGGGHAPDIITVASFANILPSSTNPTRPHTVNTLDEH
LDMLMVCHHLNPSVPEDLAFAESRIRPSTIAAEDILHDLGAISMIGSDSQAMGRVGEVVTRTWQTAHVMKRRRGALPGDT
VADNNRARRYVAKYTICPAVAHGLDAEIGSVEAGKLADLVLYEPAFFGVRPSLVLKGGFIAWAAMGDANASIPTPQPVLP
RPMFGAAPGPAAASSLMFVAPAALQDGLDERLGLAKPMVATADVRRRGKADLPENTATPDIRVDPDTFTVRIDGEAVEAA
PAAELPMAQRYFLF

Specific function: Unknown

COG id: COG0804

COG function: function code E; Urea amidohydrolase (urease) alpha subunit

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 urease domain

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): URE1_FRASN (A8L7B0)

Other databases:

- EMBL:   CP000820
- RefSeq:   YP_001509951.1
- ProteinModelPortal:   A8L7B0
- SMR:   A8L7B0
- GeneID:   5674021
- GenomeReviews:   CP000820_GR
- KEGG:   fre:Franean1_5695
- HOGENOM:   HBG357507
- OMA:   GSWHIST
- ProtClustDB:   PRK13206
- BioCyc:   FSP1855:FRANEAN1_5695-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_01953
- InterPro:   IPR006680
- InterPro:   IPR011059
- InterPro:   IPR011612
- InterPro:   IPR005848
- InterPro:   IPR017951
- InterPro:   IPR017950
- PRINTS:   PR01752
- TIGRFAMs:   TIGR01792

Pfam domain/function: PF01979 Amidohydro_1; PF00449 Urease_alpha; SSF51338 Metalo_hydrolase

EC number: =3.5.1.5

Molecular weight: Translated: 60165; Mature: 60034

Theoretical pI: Translated: 5.12; Mature: 5.12

Prosite motif: PS01120 UREASE_1; PS00145 UREASE_2; PS51368 UREASE_3

Important sites: ACT_SITE 329-329 BINDING 228-228

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSELERSRYATLYGPTVGDRIRLADTDLFIEVTDDLSRGPGGTATGDEAVFGGGKVIRES
CCCHHHHCEEEEECCCCCCEEEEECCEEEEEECCCCCCCCCCCCCCCCEEECCHHHHHHH
MGQARATRAQGAPDLVITGAVVLDHWGVVKADVGIRDGRISALGKAGNPDTMDGVHPDLV
HHHHHHHHCCCCCCEEEEEEHEECCCCEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCEE
IGPGTEIIAGNGKILTAGAVDTHVHFICPQQVPEALGTGVTTLIGGGTGPAEGTKATTVT
ECCCCEEEECCCEEEEECCCCCEEEEECHHHHHHHHCCCCEEEECCCCCCCCCCEEEEEE
ASPWNLHRMMSAMDGWPVNVALLGKGNTVSEDAMWEQLRAGAAGFKLHEDWGTTPAAIDA
CCCHHHHHHHHHHCCCCEEEEEEECCCCCCHHHHHHHHHCCCCCCEEECCCCCCHHHHHH
CLRVADASGVQVALHSDTLNEAGFVEDTLAAIAGRAIHAYHTEGAGGGHAPDIITVASFA
HHHHCCCCCCEEEEECCCCCCCCCHHHHHHHHHCCEEEEEECCCCCCCCCCHHHHHHHHH
NILPSSTNPTRPHTVNTLDEHLDMLMVCHHLNPSVPEDLAFAESRIRPSTIAAEDILHDL
HHCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCHHHHHHHHHHHH
GAISMIGSDSQAMGRVGEVVTRTWQTAHVMKRRRGALPGDTVADNNRARRYVAKYTICPA
HHEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHH
VAHGLDAEIGSVEAGKLADLVLYEPAFFGVRPSLVLKGGFIAWAAMGDANASIPTPQPVL
HHCCCCCCCCCCCCCCCEEEEEECCHHHCCCCCEEEECCEEEEEEECCCCCCCCCCCCCC
PRPMFGAAPGPAAASSLMFVAPAALQDGLDERLGLAKPMVATADVRRRGKADLPENTATP
CCCCCCCCCCCHHHCCCCEEECHHHHCCHHHHHCCCCCCHHHHHHHHCCCCCCCCCCCCC
DIRVDPDTFTVRIDGEAVEAAPAAELPMAQRYFLF
CEEECCCEEEEEECCCCCCCCCCCCCCCCHHHCCC
>Mature Secondary Structure 
SELERSRYATLYGPTVGDRIRLADTDLFIEVTDDLSRGPGGTATGDEAVFGGGKVIRES
CCHHHHCEEEEECCCCCCEEEEECCEEEEEECCCCCCCCCCCCCCCCEEECCHHHHHHH
MGQARATRAQGAPDLVITGAVVLDHWGVVKADVGIRDGRISALGKAGNPDTMDGVHPDLV
HHHHHHHHCCCCCCEEEEEEHEECCCCEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCEE
IGPGTEIIAGNGKILTAGAVDTHVHFICPQQVPEALGTGVTTLIGGGTGPAEGTKATTVT
ECCCCEEEECCCEEEEECCCCCEEEEECHHHHHHHHCCCCEEEECCCCCCCCCCEEEEEE
ASPWNLHRMMSAMDGWPVNVALLGKGNTVSEDAMWEQLRAGAAGFKLHEDWGTTPAAIDA
CCCHHHHHHHHHHCCCCEEEEEEECCCCCCHHHHHHHHHCCCCCCEEECCCCCCHHHHHH
CLRVADASGVQVALHSDTLNEAGFVEDTLAAIAGRAIHAYHTEGAGGGHAPDIITVASFA
HHHHCCCCCCEEEEECCCCCCCCCHHHHHHHHHCCEEEEEECCCCCCCCCCHHHHHHHHH
NILPSSTNPTRPHTVNTLDEHLDMLMVCHHLNPSVPEDLAFAESRIRPSTIAAEDILHDL
HHCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCHHHHHHHHHHHH
GAISMIGSDSQAMGRVGEVVTRTWQTAHVMKRRRGALPGDTVADNNRARRYVAKYTICPA
HHEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHH
VAHGLDAEIGSVEAGKLADLVLYEPAFFGVRPSLVLKGGFIAWAAMGDANASIPTPQPVL
HHCCCCCCCCCCCCCCCEEEEEECCHHHCCCCCEEEECCEEEEEEECCCCCCCCCCCCCC
PRPMFGAAPGPAAASSLMFVAPAALQDGLDERLGLAKPMVATADVRRRGKADLPENTATP
CCCCCCCCCCCHHHCCCCEEECHHHHCCHHHHHCCCCCCHHHHHHHHCCCCCCCCCCCCC
DIRVDPDTFTVRIDGEAVEAAPAAELPMAQRYFLF
CEEECCCEEEEEECCCCCCCCCCCCCCCCHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA