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The map label for this gene is atzB [H]

Identifier: 158317423

GI number: 158317423

Start: 6887281

End: 6888702

Strand: Direct

Name: atzB [H]

Synonym: Franean1_5674

Alternate gene names: 158317423

Gene position: 6887281-6888702 (Clockwise)

Preceding gene: 158317421

Following gene: 158317424

Centisome position: 76.68

GC content: 69.97

Gene sequence:

>1422_bases
GTGATTGGCGCGGAGCTTGTCGCCACGGTCGATGCCGACCGCCGAGAGATCCCAGGCGGCTGGGTAGCAATCACCGACGG
CCTCGTCAGCTCCCTCGGCGGCCCGGCGGAGACACCCCCGACCGCGACCCGGACCCTGCGTGCCGACGGCTGTCTCATAA
CGCCGGGCCTGGTGAACACACATCATCACATCTACCAGAACCTCACCCGTTCCTTCGCTCCGGCACTCGGCGGCACCCTT
TTCACCTGGCTGACCACGCTCTATCCACTCTGGTCACGGCTGGACGAGGAGGCCGTCCACACCTCGGCCTACGTGGGCCT
GACCGAACTGGCGCTCGGCGGCTGCACGACATCAACAGACCACCTCTACGTGCACCCGCGCGGTGGCGGCGATCTCATCT
CCGCCGAGATCGCGGCAGCCCGGACCCTGGGCATGCGGTTCCACCCGACCCGCGGCTCGATGTCGCTTTCGGTCAAGGAC
GGCGGGCTCCCTCCTGACTCTGTCGTCCAGGACGCGGATGAGATCCTCGCCGACTCCGCCCGGCTTGTGGCCCAGCATCA
CGACCCGTCCCACGGCGCGATGGTGCGGATCGCCCTGGCCCCCTGTTCGCCGTTCTCCGTCAGTCCGGAACTCATGCGGG
CCACCGCGGAACTGGCCGAGTCCTTGGACGTCCGGCTACACACGCATCTCGCCGAGGACCCCGAGGAGGACGACTACTGC
CTGGCGGTGTTCGGACGGCGTCCGATCGACCAGTTCGCGGAGGTTGGCTGGGGCGGCGACCGGGCGTGGGTCGCGCACTG
CATCTGCCCCAATGACGAGGAGGTCGAGCAGCTCGGCAGGTGGGGCACAGGGGTGGCCCACTGCCCGAGCAGCAACATGA
TTCTCGGCGGCGGCCTCGCGCCCGTGGCCGAGCTCCGCTCGGCCGGCGCCCCGGTCGGCCTGGGCTGCGACGGGTCGTCA
TCCGCCGACTCCGCCTCGCTGTGGTTGGAGGCTCGTACCGCCATGCTGTTGGGCCGGCTGCGACACGGCGCCGCGGCGAT
GTCCGCCCGGGACGCGCTGGAGATCGCCACCCGGGGCGGCGCAGGCTGTCTCGGCAGGACCGGTGAGATCGGTGAGCTCT
CCGTCGGGTCTGTCGGCGACCTCGTCGTCTGGCCGTTGGACGGGGTCGCGTACGCGGGAGCGCTCTCCGATCCGATCGAC
GCCTGGCTGCGTTGCGGGCCCACAGCGGCCCGGCACACGATCGTGGCCGGCAGGCTGGTGGTGGAGAACGGAGTGCCGGT
CCATCCTGATCTCGACGAGATGCTCGTCCGGCACCGCCGGACCGCCGGCGGCATCCAGGCGGCGTTCGACGATGCGGGCA
TCGATCCGACCGTTCCCATCAATACCGGCGGCAGCAGCGTCGGGGCGGCAAAATCACTTTGA

Upstream 100 bases:

>100_bases
GACCAGCAGCCCAGGCGGCCCAGCCAGGCCAAGCGGCACGGCCGCGGCTGGCGACGCACCGGCGGGGCAACGCCCGGATC
ATCTTCCTGTCGATCTCCTG

Downstream 100 bases:

>100_bases
GCATTCTGGCCCATAGAAGGCAGTTCGACGCCCCAACACCGAAATCTCCGCCCGTTGAGATCGACCCGGGTGCTCCGCAC
CTGACCGCGGAACCTCATAT

Product: amidohydrolase

Products: NA

Alternate protein names: Hydroxyatrazine hydrolase [H]

Number of amino acids: Translated: 473; Mature: 473

Protein sequence:

>473_residues
MIGAELVATVDADRREIPGGWVAITDGLVSSLGGPAETPPTATRTLRADGCLITPGLVNTHHHIYQNLTRSFAPALGGTL
FTWLTTLYPLWSRLDEEAVHTSAYVGLTELALGGCTTSTDHLYVHPRGGGDLISAEIAAARTLGMRFHPTRGSMSLSVKD
GGLPPDSVVQDADEILADSARLVAQHHDPSHGAMVRIALAPCSPFSVSPELMRATAELAESLDVRLHTHLAEDPEEDDYC
LAVFGRRPIDQFAEVGWGGDRAWVAHCICPNDEEVEQLGRWGTGVAHCPSSNMILGGGLAPVAELRSAGAPVGLGCDGSS
SADSASLWLEARTAMLLGRLRHGAAAMSARDALEIATRGGAGCLGRTGEIGELSVGSVGDLVVWPLDGVAYAGALSDPID
AWLRCGPTAARHTIVAGRLVVENGVPVHPDLDEMLVRHRRTAGGIQAAFDDAGIDPTVPINTGGSSVGAAKSL

Sequences:

>Translated_473_residues
MIGAELVATVDADRREIPGGWVAITDGLVSSLGGPAETPPTATRTLRADGCLITPGLVNTHHHIYQNLTRSFAPALGGTL
FTWLTTLYPLWSRLDEEAVHTSAYVGLTELALGGCTTSTDHLYVHPRGGGDLISAEIAAARTLGMRFHPTRGSMSLSVKD
GGLPPDSVVQDADEILADSARLVAQHHDPSHGAMVRIALAPCSPFSVSPELMRATAELAESLDVRLHTHLAEDPEEDDYC
LAVFGRRPIDQFAEVGWGGDRAWVAHCICPNDEEVEQLGRWGTGVAHCPSSNMILGGGLAPVAELRSAGAPVGLGCDGSS
SADSASLWLEARTAMLLGRLRHGAAAMSARDALEIATRGGAGCLGRTGEIGELSVGSVGDLVVWPLDGVAYAGALSDPID
AWLRCGPTAARHTIVAGRLVVENGVPVHPDLDEMLVRHRRTAGGIQAAFDDAGIDPTVPINTGGSSVGAAKSL
>Mature_473_residues
MIGAELVATVDADRREIPGGWVAITDGLVSSLGGPAETPPTATRTLRADGCLITPGLVNTHHHIYQNLTRSFAPALGGTL
FTWLTTLYPLWSRLDEEAVHTSAYVGLTELALGGCTTSTDHLYVHPRGGGDLISAEIAAARTLGMRFHPTRGSMSLSVKD
GGLPPDSVVQDADEILADSARLVAQHHDPSHGAMVRIALAPCSPFSVSPELMRATAELAESLDVRLHTHLAEDPEEDDYC
LAVFGRRPIDQFAEVGWGGDRAWVAHCICPNDEEVEQLGRWGTGVAHCPSSNMILGGGLAPVAELRSAGAPVGLGCDGSS
SADSASLWLEARTAMLLGRLRHGAAAMSARDALEIATRGGAGCLGRTGEIGELSVGSVGDLVVWPLDGVAYAGALSDPID
AWLRCGPTAARHTIVAGRLVVENGVPVHPDLDEMLVRHRRTAGGIQAAFDDAGIDPTVPINTGGSSVGAAKSL

Specific function: Catalyzes the deamination reaction of hydroxyatrazine to N-isopropylammelide (dihydroxy-isopropyl-atrazine). The enzyme is also capable of catalyzing some dechlorinating reactions [H]

COG id: COG0402

COG function: function code FR; Cytosine deaminase and related metal-dependent hydrolases

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATZ/TRZ family [H]

Homologues:

Organism=Homo sapiens, GI4758426, Length=341, Percent_Identity=23.7536656891496, Blast_Score=84, Evalue=4e-16,
Organism=Escherichia coli, GI1789249, Length=430, Percent_Identity=28.1395348837209, Blast_Score=117, Evalue=2e-27,
Organism=Escherichia coli, GI87082177, Length=438, Percent_Identity=21.689497716895, Blast_Score=66, Evalue=5e-12,
Organism=Saccharomyces cerevisiae, GI6319963, Length=345, Percent_Identity=26.0869565217391, Blast_Score=96, Evalue=2e-20,
Organism=Drosophila melanogaster, GI24643849, Length=399, Percent_Identity=25.31328320802, Blast_Score=87, Evalue=2e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006680
- InterPro:   IPR011059 [H]

Pfam domain/function: PF01979 Amidohydro_1 [H]

EC number: =3.5.99.3 [H]

Molecular weight: Translated: 49337; Mature: 49337

Theoretical pI: Translated: 4.89; Mature: 4.89

Prosite motif: PS00606 B_KETOACYL_SYNTHASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIGAELVATVDADRREIPGGWVAITDGLVSSLGGPAETPPTATRTLRADGCLITPGLVNT
CCCCCEEEEECCCHHHCCCCEEEEHHHHHHHCCCCCCCCCCCCEEEECCCCEECCCCCCH
HHHIYQNLTRSFAPALGGTLFTWLTTLYPLWSRLDEEAVHTSAYVGLTELALGGCTTSTD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
HLYVHPRGGGDLISAEIAAARTLGMRFHPTRGSMSLSVKDGGLPPDSVVQDADEILADSA
EEEEEECCCCCCHHHHHHHHHHHCCEEECCCCCEEEEEECCCCCHHHHHHHHHHHHHHHH
RLVAQHHDPSHGAMVRIALAPCSPFSVSPELMRATAELAESLDVRLHTHLAEDPEEDDYC
HHHHHCCCCCCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHEEEHHCCCCCCCCEE
LAVFGRRPIDQFAEVGWGGDRAWVAHCICPNDEEVEQLGRWGTGVAHCPSSNMILGGGLA
EEEECCCCHHHHHHCCCCCCCEEEEEEECCCHHHHHHHHCCCCCEEECCCCCEEEECCCH
PVAELRSAGAPVGLGCDGSSSADSASLWLEARTAMLLGRLRHGAAAMSARDALEIATRGG
HHHHHHHCCCCEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
AGCLGRTGEIGELSVGSVGDLVVWPLDGVAYAGALSDPIDAWLRCGPTAARHTIVAGRLV
CCCCCCCCCCCCCCCCCCCCEEEECCCCHHHCCCCCCHHHHHHHCCCHHHHHEEEECEEE
VENGVPVHPDLDEMLVRHRRTAGGIQAAFDDAGIDPTVPINTGGSSVGAAKSL
EECCCCCCCCHHHHHHHHHHCCCCCEEHHCCCCCCCCEEECCCCCCCCCCCCC
>Mature Secondary Structure
MIGAELVATVDADRREIPGGWVAITDGLVSSLGGPAETPPTATRTLRADGCLITPGLVNT
CCCCCEEEEECCCHHHCCCCEEEEHHHHHHHCCCCCCCCCCCCEEEECCCCEECCCCCCH
HHHIYQNLTRSFAPALGGTLFTWLTTLYPLWSRLDEEAVHTSAYVGLTELALGGCTTSTD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
HLYVHPRGGGDLISAEIAAARTLGMRFHPTRGSMSLSVKDGGLPPDSVVQDADEILADSA
EEEEEECCCCCCHHHHHHHHHHHCCEEECCCCCEEEEEECCCCCHHHHHHHHHHHHHHHH
RLVAQHHDPSHGAMVRIALAPCSPFSVSPELMRATAELAESLDVRLHTHLAEDPEEDDYC
HHHHHCCCCCCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHEEEHHCCCCCCCCEE
LAVFGRRPIDQFAEVGWGGDRAWVAHCICPNDEEVEQLGRWGTGVAHCPSSNMILGGGLA
EEEECCCCHHHHHHCCCCCCCEEEEEEECCCHHHHHHHHCCCCCEEECCCCCEEEECCCH
PVAELRSAGAPVGLGCDGSSSADSASLWLEARTAMLLGRLRHGAAAMSARDALEIATRGG
HHHHHHHCCCCEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
AGCLGRTGEIGELSVGSVGDLVVWPLDGVAYAGALSDPIDAWLRCGPTAARHTIVAGRLV
CCCCCCCCCCCCCCCCCCCCEEEECCCCHHHCCCCCCHHHHHHHCCCHHHHHEEEECEEE
VENGVPVHPDLDEMLVRHRRTAGGIQAAFDDAGIDPTVPINTGGSSVGAAKSL
EECCCCCCCCHHHHHHHHHHCCCCCEEHHCCCCCCCCEEECCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9055410 [H]