Click here to switch to the map view.

The map label for this gene is lpd [H]

Identifier: 158317228

GI number: 158317228

Start: 6620149

End: 6621549

Strand: Reverse

Name: lpd [H]

Synonym: Franean1_5475

Alternate gene names: 158317228

Gene position: 6621549-6620149 (Counterclockwise)

Preceding gene: 158317229

Following gene: 158317222

Centisome position: 73.72

GC content: 67.52

Gene sequence:

>1401_bases
ATGGCAGCGCACTTTGATCTCGTCGTCCTAGGCGGAGGTCCTGGCGGCTACGTCGCGGCGATCCGGGCGGCCCAGCTCGG
GCTGTCGGTCGCGGTCGTCGAGGAGAAGTACTGGGGCGGCGTTTGCCTGAACGTCGGGTGCATCCCCTCGAAGGCGTTGC
TGCGCAACGCCGAGCTCGCGCACCTGTTCGCCCACGAGGCGAAGACCTTCGGTATCTCCGGCGAGGTGAGCTTCGACTTC
GGCGCCGCCTTCGACCGCAGCCGCCAGGTCGCCGAGGGGCGCGTCAAGGGCGTGCACTTCCTGATGAAGAAGAACAAGAT
CACCGAGTTCACCGGCCGCGGTACCTTCCGTGACCCGAACACCCTGGACGTCGCGCTCTCCGCCGGCGGCACCGACCAGG
TGAGCTTCGACCACGCGATCATCGCGACGGGTTCCCGGGTCCGGCTGCTGCCCGGCGTCGAGCTCTCCGACAACATCGTC
ACCTACGAGACGCAGATCCTCACCCGCGAGCTGCCGCGGTCGATGGCGATCGTCGGCGCCGGGGCGATCGGCATGGAGTT
CGCCTACGTCCTGCGCAACTACGGCGTGGACGTCACGATCATCGAGTTCCTCGACCGCGCGCTGCCGAACGAGGACGCCG
ACGTCTCCAAGGAGATCGTCCGCCAGTACAAGAAGCTCGGCGTGCCGATCCTGACCTCGACCAAGGTCGAGACGGTGACG
GACAACGGCTCCTCGGTGACCGTCGAGTACACCGGCAAGGACGGCGCCCGGGGCTCGCTCGAGGTGGACAAGGTCCTCAT
GTCCATCGGGTTCGCGCCCAACGTCGAGGGCTTCGGCCTGGAGAACACCGGCGTGGCGCTCACCGACCGCGGCGCGATCG
CGATCGACGACCACATGCGCACCAACGTCGAGCACATCTACGCCATCGGCGACGTGACGGCGAAGCTCATGCTGGCGCAT
GTCGCCGAGGCTCAGGGCGTCGTCGCGTCCGAGACCATTGCCGGTGCGGAGACGGTGATGCTCGGTGACTACCGGATGAT
GCCGCGGGCCACCTTCTGTCAGCCCCAGGTCGCCAGCTTCGGTCTCACCGAGGCACAGGCACGGGAGGAGGGCCACGACA
TCAAGGTGGCGAAGTTCCCGTTCACCGCGAACGGCAAGGCCCACGGCCTGGGCGACCCGAACGGCTTCGTCAAGCTGATC
TCCGACACGAAGTACGGCGAGCTGCTCGGCGGCCACCTGATCGGCCCGGACGTCTCCGAGCTGCTGCCCGAGCTGACGCT
GGCCCAGAAATGGGACCTCACCGCGCTCGAGCTCGCCCGCAACGTGCACACCCACCCGACGCTGAGCGAGGCGTTGCAGG
AGGCGATCCACGGCCTCGCCGGCCACATGATCAACCTCTGA

Upstream 100 bases:

>100_bases
CCCACCTGTGGGCGAGGCGGAATGACGCTGGCAGCATGCGTGGTTGAAGTCTCCGCACCGCGCCGCGAATCGGCGTCCTG
ACTGATCGTAGGGTGGACCT

Downstream 100 bases:

>100_bases
CGGGCCGGCGATGAGGATCAACCTGACCAGCGTCCTGGTCGACGACCAGGACAAGGCGCTGCGCTTCTATATCGTCCACC
AGCACTGACTGCAGCCAGCT

Product: dihydrolipoamide dehydrogenase

Products: NA

Alternate protein names: Dihydrolipoamide dehydrogenase; E3 component of alpha keto acid dehydrogenase complexes [H]

Number of amino acids: Translated: 466; Mature: 465

Protein sequence:

>466_residues
MAAHFDLVVLGGGPGGYVAAIRAAQLGLSVAVVEEKYWGGVCLNVGCIPSKALLRNAELAHLFAHEAKTFGISGEVSFDF
GAAFDRSRQVAEGRVKGVHFLMKKNKITEFTGRGTFRDPNTLDVALSAGGTDQVSFDHAIIATGSRVRLLPGVELSDNIV
TYETQILTRELPRSMAIVGAGAIGMEFAYVLRNYGVDVTIIEFLDRALPNEDADVSKEIVRQYKKLGVPILTSTKVETVT
DNGSSVTVEYTGKDGARGSLEVDKVLMSIGFAPNVEGFGLENTGVALTDRGAIAIDDHMRTNVEHIYAIGDVTAKLMLAH
VAEAQGVVASETIAGAETVMLGDYRMMPRATFCQPQVASFGLTEAQAREEGHDIKVAKFPFTANGKAHGLGDPNGFVKLI
SDTKYGELLGGHLIGPDVSELLPELTLAQKWDLTALELARNVHTHPTLSEALQEAIHGLAGHMINL

Sequences:

>Translated_466_residues
MAAHFDLVVLGGGPGGYVAAIRAAQLGLSVAVVEEKYWGGVCLNVGCIPSKALLRNAELAHLFAHEAKTFGISGEVSFDF
GAAFDRSRQVAEGRVKGVHFLMKKNKITEFTGRGTFRDPNTLDVALSAGGTDQVSFDHAIIATGSRVRLLPGVELSDNIV
TYETQILTRELPRSMAIVGAGAIGMEFAYVLRNYGVDVTIIEFLDRALPNEDADVSKEIVRQYKKLGVPILTSTKVETVT
DNGSSVTVEYTGKDGARGSLEVDKVLMSIGFAPNVEGFGLENTGVALTDRGAIAIDDHMRTNVEHIYAIGDVTAKLMLAH
VAEAQGVVASETIAGAETVMLGDYRMMPRATFCQPQVASFGLTEAQAREEGHDIKVAKFPFTANGKAHGLGDPNGFVKLI
SDTKYGELLGGHLIGPDVSELLPELTLAQKWDLTALELARNVHTHPTLSEALQEAIHGLAGHMINL
>Mature_465_residues
AAHFDLVVLGGGPGGYVAAIRAAQLGLSVAVVEEKYWGGVCLNVGCIPSKALLRNAELAHLFAHEAKTFGISGEVSFDFG
AAFDRSRQVAEGRVKGVHFLMKKNKITEFTGRGTFRDPNTLDVALSAGGTDQVSFDHAIIATGSRVRLLPGVELSDNIVT
YETQILTRELPRSMAIVGAGAIGMEFAYVLRNYGVDVTIIEFLDRALPNEDADVSKEIVRQYKKLGVPILTSTKVETVTD
NGSSVTVEYTGKDGARGSLEVDKVLMSIGFAPNVEGFGLENTGVALTDRGAIAIDDHMRTNVEHIYAIGDVTAKLMLAHV
AEAQGVVASETIAGAETVMLGDYRMMPRATFCQPQVASFGLTEAQAREEGHDIKVAKFPFTANGKAHGLGDPNGFVKLIS
DTKYGELLGGHLIGPDVSELLPELTLAQKWDLTALELARNVHTHPTLSEALQEAIHGLAGHMINL

Specific function: Lipoamide dehydrogenase is a component of the alpha- ketoacid dehydrogenase complexes [H]

COG id: COG1249

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family [H]

Homologues:

Organism=Homo sapiens, GI91199540, Length=460, Percent_Identity=37.1739130434783, Blast_Score=288, Evalue=9e-78,
Organism=Homo sapiens, GI50301238, Length=466, Percent_Identity=29.3991416309013, Blast_Score=151, Evalue=1e-36,
Organism=Homo sapiens, GI22035672, Length=463, Percent_Identity=28.9416846652268, Blast_Score=129, Evalue=4e-30,
Organism=Homo sapiens, GI33519430, Length=459, Percent_Identity=26.3616557734205, Blast_Score=114, Evalue=2e-25,
Organism=Homo sapiens, GI33519428, Length=459, Percent_Identity=26.3616557734205, Blast_Score=114, Evalue=2e-25,
Organism=Homo sapiens, GI33519426, Length=459, Percent_Identity=26.3616557734205, Blast_Score=114, Evalue=2e-25,
Organism=Homo sapiens, GI148277071, Length=461, Percent_Identity=26.6811279826464, Blast_Score=114, Evalue=2e-25,
Organism=Homo sapiens, GI148277065, Length=461, Percent_Identity=26.6811279826464, Blast_Score=114, Evalue=2e-25,
Organism=Homo sapiens, GI291045266, Length=459, Percent_Identity=24.1830065359477, Blast_Score=98, Evalue=1e-20,
Organism=Homo sapiens, GI291045268, Length=455, Percent_Identity=22.4175824175824, Blast_Score=80, Evalue=5e-15,
Organism=Escherichia coli, GI1786307, Length=466, Percent_Identity=36.2660944206009, Blast_Score=258, Evalue=7e-70,
Organism=Escherichia coli, GI87081717, Length=455, Percent_Identity=29.2307692307692, Blast_Score=187, Evalue=1e-48,
Organism=Escherichia coli, GI1789915, Length=456, Percent_Identity=30.4824561403509, Blast_Score=154, Evalue=9e-39,
Organism=Escherichia coli, GI87082354, Length=463, Percent_Identity=26.7818574514039, Blast_Score=142, Evalue=6e-35,
Organism=Caenorhabditis elegans, GI32565766, Length=465, Percent_Identity=39.7849462365591, Blast_Score=331, Evalue=4e-91,
Organism=Caenorhabditis elegans, GI17557007, Length=484, Percent_Identity=27.6859504132231, Blast_Score=134, Evalue=1e-31,
Organism=Caenorhabditis elegans, GI71983429, Length=456, Percent_Identity=28.0701754385965, Blast_Score=114, Evalue=1e-25,
Organism=Caenorhabditis elegans, GI71983419, Length=456, Percent_Identity=28.0701754385965, Blast_Score=113, Evalue=2e-25,
Organism=Caenorhabditis elegans, GI71982272, Length=478, Percent_Identity=24.2677824267782, Blast_Score=91, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI17559934, Length=235, Percent_Identity=31.063829787234, Blast_Score=80, Evalue=3e-15,
Organism=Saccharomyces cerevisiae, GI6321091, Length=464, Percent_Identity=38.7931034482759, Blast_Score=296, Evalue=7e-81,
Organism=Saccharomyces cerevisiae, GI6325240, Length=476, Percent_Identity=27.9411764705882, Blast_Score=172, Evalue=1e-43,
Organism=Saccharomyces cerevisiae, GI6325166, Length=466, Percent_Identity=29.1845493562232, Blast_Score=160, Evalue=6e-40,
Organism=Drosophila melanogaster, GI21358499, Length=457, Percent_Identity=41.1378555798687, Blast_Score=324, Evalue=7e-89,
Organism=Drosophila melanogaster, GI17737741, Length=482, Percent_Identity=29.045643153527, Blast_Score=128, Evalue=1e-29,
Organism=Drosophila melanogaster, GI24640549, Length=477, Percent_Identity=28.0922431865828, Blast_Score=125, Evalue=5e-29,
Organism=Drosophila melanogaster, GI24640553, Length=482, Percent_Identity=28.8381742738589, Blast_Score=125, Evalue=5e-29,
Organism=Drosophila melanogaster, GI24640551, Length=478, Percent_Identity=28.4518828451883, Blast_Score=125, Evalue=5e-29,

Paralogues:

None

Copy number: 380 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1880 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 6,000 Molecules/Cell In: Glucose minimal

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016156
- InterPro:   IPR013027
- InterPro:   IPR006258
- InterPro:   IPR004099
- InterPro:   IPR012999
- InterPro:   IPR001327 [H]

Pfam domain/function: PF00070 Pyr_redox; PF07992 Pyr_redox_2; PF02852 Pyr_redox_dim [H]

EC number: =1.8.1.4 [H]

Molecular weight: Translated: 49796; Mature: 49665

Theoretical pI: Translated: 5.43; Mature: 5.43

Prosite motif: PS00076 PYRIDINE_REDOX_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAAHFDLVVLGGGPGGYVAAIRAAQLGLSVAVVEEKYWGGVCLNVGCIPSKALLRNAELA
CCCEEEEEEEECCCCCHHHHHHHHHHCCEEEEEEECCCCCEEEEECCCCCHHHHHCCHHH
HLFAHEAKTFGISGEVSFDFGAAFDRSRQVAEGRVKGVHFLMKKNKITEFTGRGTFRDPN
HHHHHHHHHCCCCCEEEECCCCHHHHHHHHHHCHHHHEEEEEECCCCEEECCCCCCCCCC
TLDVALSAGGTDQVSFDHAIIATGSRVRLLPGVELSDNIVTYETQILTRELPRSMAIVGA
CEEEEEECCCCCCEECCEEEEECCCEEEEECCCCCCCCEEEEHHHHHHHHCCCCEEEEEC
GAIGMEFAYVLRNYGVDVTIIEFLDRALPNEDADVSKEIVRQYKKLGVPILTSTKVETVT
CHHHHHHHHHHHHCCCCEEHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCEEECCEEEEEE
DNGSSVTVEYTGKDGARGSLEVDKVLMSIGFAPNVEGFGLENTGVALTDRGAIAIDDHMR
CCCCEEEEEECCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCEEEECCCCEEECCHHH
TNVEHIYAIGDVTAKLMLAHVAEAQGVVASETIAGAETVMLGDYRMMPRATFCQPQVASF
CCCEEEEEEHHHHHHHHHHHHHHHCCCEEHHHCCCCCEEEECCEEECCCCCCCCCHHHHC
GLTEAQAREEGHDIKVAKFPFTANGKAHGLGDPNGFVKLISDTKYGELLGGHLIGPDVSE
CCCHHHHHHCCCCEEEEECCEECCCCCCCCCCCCCEEEEECCCCHHHHHCCCCCCCCHHH
LLPELTLAQKWDLTALELARNVHTHPTLSEALQEAIHGLAGHMINL
HHHHHHHHCCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
AAHFDLVVLGGGPGGYVAAIRAAQLGLSVAVVEEKYWGGVCLNVGCIPSKALLRNAELA
CCEEEEEEEECCCCCHHHHHHHHHHCCEEEEEEECCCCCEEEEECCCCCHHHHHCCHHH
HLFAHEAKTFGISGEVSFDFGAAFDRSRQVAEGRVKGVHFLMKKNKITEFTGRGTFRDPN
HHHHHHHHHCCCCCEEEECCCCHHHHHHHHHHCHHHHEEEEEECCCCEEECCCCCCCCCC
TLDVALSAGGTDQVSFDHAIIATGSRVRLLPGVELSDNIVTYETQILTRELPRSMAIVGA
CEEEEEECCCCCCEECCEEEEECCCEEEEECCCCCCCCEEEEHHHHHHHHCCCCEEEEEC
GAIGMEFAYVLRNYGVDVTIIEFLDRALPNEDADVSKEIVRQYKKLGVPILTSTKVETVT
CHHHHHHHHHHHHCCCCEEHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCEEECCEEEEEE
DNGSSVTVEYTGKDGARGSLEVDKVLMSIGFAPNVEGFGLENTGVALTDRGAIAIDDHMR
CCCCEEEEEECCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCEEEECCCCEEECCHHH
TNVEHIYAIGDVTAKLMLAHVAEAQGVVASETIAGAETVMLGDYRMMPRATFCQPQVASF
CCCEEEEEEHHHHHHHHHHHHHHHCCCEEHHHCCCCCEEEECCEEECCCCCCCCCHHHHC
GLTEAQAREEGHDIKVAKFPFTANGKAHGLGDPNGFVKLISDTKYGELLGGHLIGPDVSE
CCCHHHHHHCCCCEEEEECCEECCCCCCCCCCCCCEEEEECCCCHHHHHCCCCCCCCHHH
LLPELTLAQKWDLTALELARNVHTHPTLSEALQEAIHGLAGHMINL
HHHHHHHHCCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]