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The map label for this gene is phhA [H]

Identifier: 158317197

GI number: 158317197

Start: 6586485

End: 6587375

Strand: Direct

Name: phhA [H]

Synonym: Franean1_5444

Alternate gene names: 158317197

Gene position: 6586485-6587375 (Clockwise)

Preceding gene: 158317194

Following gene: 158317198

Centisome position: 73.33

GC content: 68.8

Gene sequence:

>891_bases
GTGTTCGAGGAAGCGCAGTATTTCGCCCCTGTCGTCGAAAAGGCGGACGGACAGGTCGAGGTCCGCCTGGCCAGGTCACA
TCCGGGTGCGGCCGACCGCGAGTACCAGGCCCGGCGCAATCAGATCGCCGAGCTCGCCCTGCGGTGGCGACCAGGACAGC
CCGTTCCACGGGTGGCGTACACCGAGGCCGAGCATGCGGTCTGGCGGCTGGTCACCGGTAAGCTGGCGTTGGCCTACCGC
GGGTGCGCCTGCGCCGAGTTCCTGCGCGGCGCGGCGCGGATGGGCCTGCCCACCGACCGGATCCCGCAGCTGGACGAGGT
GAGCGGACCGCTGAGCGAGCTGACCGGTTTCCGTTACGTGCCCGCGGCCGGGCTCGTCGGGCTGCGGGAGTTCTACGGCT
CGCTCGCCGACGGCGTCTTCCACGCCACCCAGTACCTGCGGCACCACACGGTTCCCTTCTACACGCCGGAACCGGACATC
ATCCACGAGGTCGTCGGGCACGCGAACGCGCTCGCCAGCGATCGGTTCGCCGCGTTGTACCGGGCGGCCGGTGAGGCGGC
CCGCCGCGCCGAGTCGGCCGACACGCTTCAGTTCATCTCCAAGGTCTTCTGGTTCACGCTGGAATTCGGCACGGTCTACG
AGGACGGCGAGCTCAAGGCCTACGGCGCCGGAATCCTTTCCTCGTACGGAGAAATGGCGGAGTTCCGCTCCGTGAACGTC
CGCCCGCTGGACGTCGCAATCATGGGGACCACCGACTACGACATCACCAGATACCAGCCGGTGCTGTACGCGGCCGATTC
CTTCGGCCAGGTCGAGGATGTCGTCGGCGGCTTCTTCGCCGGCTGCGACGACACGTCGATCGCGGGGCTTCGCGCGGCCG
CGGTCGACTGA

Upstream 100 bases:

>100_bases
TCGCCGCCGTGGCCAGGCCTACCACCGTGCGGTGTGGTTGCGACCCCGCGGAGCCGGTGGTGTCCTGAGTTGAGGGTCTG
CCCCGGCGGAGGAGGTGGCC

Downstream 100 bases:

>100_bases
CCGGCCCATCACGCCACGAGCGGACTCGCACCGGCCCTACTATCGGGCCCGTGCGAATTCAGGTCCTCGGACCGGTCGAG
GTGCTCCTGGGCGGCGCGCC

Product: phenylalanine 4-monooxygenase

Products: NA

Alternate protein names: PAH; Phe-4-monooxygenase [H]

Number of amino acids: Translated: 296; Mature: 296

Protein sequence:

>296_residues
MFEEAQYFAPVVEKADGQVEVRLARSHPGAADREYQARRNQIAELALRWRPGQPVPRVAYTEAEHAVWRLVTGKLALAYR
GCACAEFLRGAARMGLPTDRIPQLDEVSGPLSELTGFRYVPAAGLVGLREFYGSLADGVFHATQYLRHHTVPFYTPEPDI
IHEVVGHANALASDRFAALYRAAGEAARRAESADTLQFISKVFWFTLEFGTVYEDGELKAYGAGILSSYGEMAEFRSVNV
RPLDVAIMGTTDYDITRYQPVLYAADSFGQVEDVVGGFFAGCDDTSIAGLRAAAVD

Sequences:

>Translated_296_residues
MFEEAQYFAPVVEKADGQVEVRLARSHPGAADREYQARRNQIAELALRWRPGQPVPRVAYTEAEHAVWRLVTGKLALAYR
GCACAEFLRGAARMGLPTDRIPQLDEVSGPLSELTGFRYVPAAGLVGLREFYGSLADGVFHATQYLRHHTVPFYTPEPDI
IHEVVGHANALASDRFAALYRAAGEAARRAESADTLQFISKVFWFTLEFGTVYEDGELKAYGAGILSSYGEMAEFRSVNV
RPLDVAIMGTTDYDITRYQPVLYAADSFGQVEDVVGGFFAGCDDTSIAGLRAAAVD
>Mature_296_residues
MFEEAQYFAPVVEKADGQVEVRLARSHPGAADREYQARRNQIAELALRWRPGQPVPRVAYTEAEHAVWRLVTGKLALAYR
GCACAEFLRGAARMGLPTDRIPQLDEVSGPLSELTGFRYVPAAGLVGLREFYGSLADGVFHATQYLRHHTVPFYTPEPDI
IHEVVGHANALASDRFAALYRAAGEAARRAESADTLQFISKVFWFTLEFGTVYEDGELKAYGAGILSSYGEMAEFRSVNV
RPLDVAIMGTTDYDITRYQPVLYAADSFGQVEDVVGGFFAGCDDTSIAGLRAAAVD

Specific function: Unknown

COG id: COG3186

COG function: function code E; Phenylalanine-4-hydroxylase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the biopterin-dependent aromatic amino acid hydroxylase family [H]

Homologues:

Organism=Homo sapiens, GI4557819, Length=264, Percent_Identity=40.9090909090909, Blast_Score=199, Evalue=2e-51,
Organism=Homo sapiens, GI88900503, Length=258, Percent_Identity=41.4728682170543, Blast_Score=192, Evalue=3e-49,
Organism=Homo sapiens, GI88900505, Length=258, Percent_Identity=41.4728682170543, Blast_Score=191, Evalue=5e-49,
Organism=Homo sapiens, GI88900501, Length=258, Percent_Identity=41.4728682170543, Blast_Score=191, Evalue=5e-49,
Organism=Homo sapiens, GI4759248, Length=262, Percent_Identity=38.9312977099237, Blast_Score=187, Evalue=1e-47,
Organism=Homo sapiens, GI31795563, Length=262, Percent_Identity=37.7862595419847, Blast_Score=180, Evalue=2e-45,
Organism=Caenorhabditis elegans, GI17531391, Length=264, Percent_Identity=40.9090909090909, Blast_Score=199, Evalue=1e-51,
Organism=Caenorhabditis elegans, GI71980736, Length=248, Percent_Identity=38.7096774193548, Blast_Score=172, Evalue=2e-43,
Organism=Caenorhabditis elegans, GI115533973, Length=223, Percent_Identity=39.9103139013453, Blast_Score=163, Evalue=1e-40,
Organism=Caenorhabditis elegans, GI115532103, Length=227, Percent_Identity=39.647577092511, Blast_Score=162, Evalue=2e-40,
Organism=Caenorhabditis elegans, GI71980731, Length=182, Percent_Identity=37.3626373626374, Blast_Score=123, Evalue=1e-28,
Organism=Drosophila melanogaster, GI62472054, Length=262, Percent_Identity=40.4580152671756, Blast_Score=200, Evalue=1e-51,
Organism=Drosophila melanogaster, GI24660393, Length=262, Percent_Identity=40.4580152671756, Blast_Score=200, Evalue=1e-51,
Organism=Drosophila melanogaster, GI17136776, Length=260, Percent_Identity=40.3846153846154, Blast_Score=186, Evalue=2e-47,
Organism=Drosophila melanogaster, GI17136774, Length=260, Percent_Identity=40.3846153846154, Blast_Score=186, Evalue=2e-47,
Organism=Drosophila melanogaster, GI24654994, Length=263, Percent_Identity=36.5019011406844, Blast_Score=162, Evalue=2e-40,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001273
- InterPro:   IPR018301
- InterPro:   IPR019774
- InterPro:   IPR005960 [H]

Pfam domain/function: PF00351 Biopterin_H [H]

EC number: =1.14.16.1 [H]

Molecular weight: Translated: 32499; Mature: 32499

Theoretical pI: Translated: 4.95; Mature: 4.95

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFEEAQYFAPVVEKADGQVEVRLARSHPGAADREYQARRNQIAELALRWRPGQPVPRVAY
CCCCHHHHHHHHHCCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCEEH
TEAEHAVWRLVTGKLALAYRGCACAEFLRGAARMGLPTDRIPQLDEVSGPLSELTGFRYV
HHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCCCCCHHHCCCCHHHHCCCEEC
PAAGLVGLREFYGSLADGVFHATQYLRHHTVPFYTPEPDIIHEVVGHANALASDRFAALY
CHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
RAAGEAARRAESADTLQFISKVFWFTLEFGTVYEDGELKAYGAGILSSYGEMAEFRSVNV
HHHHHHHHHHCCHHHHHHHHHHHHHHEECCCEEECCCEEEHHHHHHHHHHHHHHHHCCCC
RPLDVAIMGTTDYDITRYQPVLYAADSFGQVEDVVGGFFAGCDDTSIAGLRAAAVD
CEEEEEEEECCCCCCHHCCEEEEECCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MFEEAQYFAPVVEKADGQVEVRLARSHPGAADREYQARRNQIAELALRWRPGQPVPRVAY
CCCCHHHHHHHHHCCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCEEH
TEAEHAVWRLVTGKLALAYRGCACAEFLRGAARMGLPTDRIPQLDEVSGPLSELTGFRYV
HHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCCCCCHHHCCCCHHHHCCCEEC
PAAGLVGLREFYGSLADGVFHATQYLRHHTVPFYTPEPDIIHEVVGHANALASDRFAALY
CHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
RAAGEAARRAESADTLQFISKVFWFTLEFGTVYEDGELKAYGAGILSSYGEMAEFRSVNV
HHHHHHHHHHCCHHHHHHHHHHHHHHEECCCEEECCCEEEHHHHHHHHHHHHHHHHCCCC
RPLDVAIMGTTDYDITRYQPVLYAADSFGQVEDVVGGFFAGCDDTSIAGLRAAAVD
CEEEEEEEECCCCCCHHCCEEEEECCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10952301 [H]