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The map label for this gene is ppiB [H]

Identifier: 158316890

GI number: 158316890

Start: 6150629

End: 6151489

Strand: Direct

Name: ppiB [H]

Synonym: Franean1_5134

Alternate gene names: 158316890

Gene position: 6150629-6151489 (Clockwise)

Preceding gene: 158316888

Following gene: 158316892

Centisome position: 68.48

GC content: 73.05

Gene sequence:

>861_bases
GTGTCGAGCACGAAGGAACGGCGGCAGCGCGAGATAGCCGCCGCGCGGGCGGCGCGCCAGGCGCAGCGCCGCCGCCAGGC
GTACCAGCGACGGCAACGCCGCCTGACGATCGTCGCGGCGGTGGCCGTGGTGGCCATCGTCGGCTCGGTGATCGCCGCGG
TCCTGCTCAGCGGCGGCGGGGACAACGACAATCTCAGCGCGACCGATCCCGCGGCCAACCCGTCGGCGTCGGCGGCACCG
GCGGTGCCGGCCGGGCAGACGAGCAAGGTCGGCGACTGCGTCTACACCTCGAGCGGCGAGTCGCCGTCCCGCCCGGTGGG
GCTCCCGACGGCCGCCGCCACGGTGAGCAAGGCCCCCGCCACCATGGTCATCACCACCGACCAGGGCACGATGACGGCCG
CGCTCGACGCGGACAAGGCTCCCTGCACGGTGAACGCGCTGCGCACGCTCGCCGAGGCGGGCTTCTACAACGACACCGCC
TGCCACCGGCAGACGGGTGGCGCCGACGCCGGCATCAACGTGCTGCAGTGCGGGGACCCGACCGGCAGCGGGACGGGCGG
CCCAGGCTTCGGCTACGCCAACGAGAACACCGAGGGCGTGAACTACAACCGGGGTGTCCTGGCCATGGCGCACAGCAGCC
AGCCGGACAGCAACGGCAGCCAGTTCTTCATCAACTACGCCGACCCGAGCCAGCAGGGCGCCGCGGCGCTCGCCGGCGGC
TACACCGTCTTCGGCCACATCACCGAGGGCCTCGACGTCCTGGACAAGCTGACGTCCCCGGGTGTCGAGGGCGGCGGGTC
GGACGGCGCGCCGGCCAGCAAGCCGCAGATCAAGTCGATCGAGATCACCCAGGGGCCCTGA

Upstream 100 bases:

>100_bases
GATTGCCGGCCGGGGCCGATCACCTGATGGACGGATGACTTGGTGACGACCTGATGACCATCCGGTAGTCACGCCGACGA
GGAGCGGGAGGCCGGCGAGG

Downstream 100 bases:

>100_bases
CCTCGTCCGCCCCATCGCCCCGCCGTCCCGTCCCGGACTGACCGCCCGGGACGGGGCGGCGGACAACCTGGACGGACGAG
GACCGGCGCGCTGGACGAGG

Product: cyclophilin type peptidyl-prolyl cis-trans isomerase

Products: NA

Alternate protein names: PPIase B; Rotamase B [H]

Number of amino acids: Translated: 286; Mature: 285

Protein sequence:

>286_residues
MSSTKERRQREIAAARAARQAQRRRQAYQRRQRRLTIVAAVAVVAIVGSVIAAVLLSGGGDNDNLSATDPAANPSASAAP
AVPAGQTSKVGDCVYTSSGESPSRPVGLPTAAATVSKAPATMVITTDQGTMTAALDADKAPCTVNALRTLAEAGFYNDTA
CHRQTGGADAGINVLQCGDPTGSGTGGPGFGYANENTEGVNYNRGVLAMAHSSQPDSNGSQFFINYADPSQQGAAALAGG
YTVFGHITEGLDVLDKLTSPGVEGGGSDGAPASKPQIKSIEITQGP

Sequences:

>Translated_286_residues
MSSTKERRQREIAAARAARQAQRRRQAYQRRQRRLTIVAAVAVVAIVGSVIAAVLLSGGGDNDNLSATDPAANPSASAAP
AVPAGQTSKVGDCVYTSSGESPSRPVGLPTAAATVSKAPATMVITTDQGTMTAALDADKAPCTVNALRTLAEAGFYNDTA
CHRQTGGADAGINVLQCGDPTGSGTGGPGFGYANENTEGVNYNRGVLAMAHSSQPDSNGSQFFINYADPSQQGAAALAGG
YTVFGHITEGLDVLDKLTSPGVEGGGSDGAPASKPQIKSIEITQGP
>Mature_285_residues
SSTKERRQREIAAARAARQAQRRRQAYQRRQRRLTIVAAVAVVAIVGSVIAAVLLSGGGDNDNLSATDPAANPSASAAPA
VPAGQTSKVGDCVYTSSGESPSRPVGLPTAAATVSKAPATMVITTDQGTMTAALDADKAPCTVNALRTLAEAGFYNDTAC
HRQTGGADAGINVLQCGDPTGSGTGGPGFGYANENTEGVNYNRGVLAMAHSSQPDSNGSQFFINYADPSQQGAAALAGGY
TVFGHITEGLDVLDKLTSPGVEGGGSDGAPASKPQIKSIEITQGP

Specific function: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides [H]

COG id: COG0652

COG function: function code O; Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family

Gene ontology:

Cell location: Periplasmic Protein [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PPIase cyclophilin-type domain [H]

Homologues:

Organism=Homo sapiens, GI19557636, Length=171, Percent_Identity=32.7485380116959, Blast_Score=80, Evalue=2e-15,
Organism=Homo sapiens, GI7706339, Length=146, Percent_Identity=33.5616438356164, Blast_Score=72, Evalue=4e-13,
Organism=Escherichia coli, GI1789763, Length=168, Percent_Identity=34.5238095238095, Blast_Score=81, Evalue=1e-16,
Organism=Escherichia coli, GI1786736, Length=171, Percent_Identity=30.9941520467836, Blast_Score=72, Evalue=5e-14,
Organism=Caenorhabditis elegans, GI71980594, Length=170, Percent_Identity=29.4117647058824, Blast_Score=71, Evalue=5e-13,
Organism=Caenorhabditis elegans, GI17539496, Length=137, Percent_Identity=35.7664233576642, Blast_Score=70, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI71980590, Length=147, Percent_Identity=31.2925170068027, Blast_Score=69, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI17506311, Length=164, Percent_Identity=31.0975609756098, Blast_Score=66, Evalue=2e-11,
Organism=Drosophila melanogaster, GI19922376, Length=152, Percent_Identity=32.8947368421053, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI17986117, Length=160, Percent_Identity=33.75, Blast_Score=75, Evalue=4e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015891
- InterPro:   IPR002130 [H]

Pfam domain/function: PF00160 Pro_isomerase [H]

EC number: =5.2.1.8 [H]

Molecular weight: Translated: 28949; Mature: 28818

Theoretical pI: Translated: 6.77; Mature: 6.77

Prosite motif: PS50072 CSA_PPIASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSTKERRQREIAAARAARQAQRRRQAYQRRQRRLTIVAAVAVVAIVGSVIAAVLLSGGG
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
DNDNLSATDPAANPSASAAPAVPAGQTSKVGDCVYTSSGESPSRPVGLPTAAATVSKAPA
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEECCCCCCCCCCCCCHHHHHHCCCCE
TMVITTDQGTMTAALDADKAPCTVNALRTLAEAGFYNDTACHRQTGGADAGINVLQCGDP
EEEEECCCCCEEEEECCCCCCCHHHHHHHHHHCCCCCCCHHHCCCCCCCCCCEEEEECCC
TGSGTGGPGFGYANENTEGVNYNRGVLAMAHSSQPDSNGSQFFINYADPSQQGAAALAGG
CCCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCEEEEEECCCCCCCCHHHHCC
YTVFGHITEGLDVLDKLTSPGVEGGGSDGAPASKPQIKSIEITQGP
EEEEHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCEEEEECCCC
>Mature Secondary Structure 
SSTKERRQREIAAARAARQAQRRRQAYQRRQRRLTIVAAVAVVAIVGSVIAAVLLSGGG
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
DNDNLSATDPAANPSASAAPAVPAGQTSKVGDCVYTSSGESPSRPVGLPTAAATVSKAPA
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEECCCCCCCCCCCCCHHHHHHCCCCE
TMVITTDQGTMTAALDADKAPCTVNALRTLAEAGFYNDTACHRQTGGADAGINVLQCGDP
EEEEECCCCCEEEEECCCCCCCHHHHHHHHHHCCCCCCCHHHCCCCCCCCCCEEEEECCC
TGSGTGGPGFGYANENTEGVNYNRGVLAMAHSSQPDSNGSQFFINYADPSQQGAAALAGG
CCCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCEEEEEECCCCCCCCHHHHCC
YTVFGHITEGLDVLDKLTSPGVEGGGSDGAPASKPQIKSIEITQGP
EEEEHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCEEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]