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The map label for this gene is drrB [H]

Identifier: 158316754

GI number: 158316754

Start: 5989715

End: 5990527

Strand: Reverse

Name: drrB [H]

Synonym: Franean1_4992

Alternate gene names: 158316754

Gene position: 5990527-5989715 (Counterclockwise)

Preceding gene: 158316755

Following gene: 158316752

Centisome position: 66.69

GC content: 67.65

Gene sequence:

>813_bases
ATGACCACTCTCGACCTGACACCCGTCGCGCGTCGGAGCCGGCTGACCTGGGAGCTCCTCGACGCCTGGGTGATGTGCCG
GCGCAACCTGATGAAGACCTGGCGGGTGCCCGAGCTGCTGGTCTTCGCGACCATCCAGCCTGTGATGTTCGTCCTGCTGT
TCAGCTACGTGTTCGGGGGCGCGATCGACGTCGGCCCGGATCTCGACTACGTCGACTTCCTGATGCCCGGCGTCTTCGTG
CAGACAGTGATCTTCGGCGCGATGATGACCGGGATCGGTCTCGCCAACGACAAGGAGGAGGGGCTGATCGACCGCTTCCG
GTCGCTGCCGATGAGCCGCTCGGCCCTGCTGACCGGGCGGACACTCGCCGACCTGGTCCGTAACGCCTTCATCATCCTGA
TCATGCTGTTGGTCGGCCTGGCGGTCGGCTTCCGCTTCGGTGACACCACGGTTCCGGCCATCCTGGCGGGATTCGGCGTG
ATGCTGATCTTCTCCTACGCCTTCTCCTGGGTGTCGGCGGTGATCGGCATGTCGGTCCGCAGCACGGAGGCGGCACAGTC
CGGCGGGATGATCTGGGTCTTCCCGCTCGTCTTCGCCAGCTCCGCCTTCGCCCGGGTCGACACGATGCCGGGCTGGCTGC
AGGCGTTCGCCGACCACCAGCCGGTCACCGTCACGGTGGATGCCGTGCGCGCCCTGTTCCTCGGCGGCCCGGTGGCTGAC
GACCTGCTGCTCTCACTCGCCTGGTGCGGCGGGATCCTGCTGCTGTTCGGGCCGCTGGCCGTCCGGGCCTTCCGGAGGGA
CGCCGCAGGCTGA

Upstream 100 bases:

>100_bases
CGCGCGGCCCGGCGGGTGCGACCGGCCCCGGCGGGCCGGGCGGTGACGACGGGCCTCCCGGCCCGCGTACCGGCGGCGAC
GAGCGGGATCTGGTGAAGGC

Downstream 100 bases:

>100_bases
CGAGGCCGCGAGATCAGGCCGCTCGGATCACGGCAGGGCCGATCGTGGCGGGCCGCGGCCTCAGGTGCGTCCCTCGGTGT
CCTGGGCGTTGCCCAGGGTG

Product: ABC-2 type transporter

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 270; Mature: 269

Protein sequence:

>270_residues
MTTLDLTPVARRSRLTWELLDAWVMCRRNLMKTWRVPELLVFATIQPVMFVLLFSYVFGGAIDVGPDLDYVDFLMPGVFV
QTVIFGAMMTGIGLANDKEEGLIDRFRSLPMSRSALLTGRTLADLVRNAFIILIMLLVGLAVGFRFGDTTVPAILAGFGV
MLIFSYAFSWVSAVIGMSVRSTEAAQSGGMIWVFPLVFASSAFARVDTMPGWLQAFADHQPVTVTVDAVRALFLGGPVAD
DLLLSLAWCGGILLLFGPLAVRAFRRDAAG

Sequences:

>Translated_270_residues
MTTLDLTPVARRSRLTWELLDAWVMCRRNLMKTWRVPELLVFATIQPVMFVLLFSYVFGGAIDVGPDLDYVDFLMPGVFV
QTVIFGAMMTGIGLANDKEEGLIDRFRSLPMSRSALLTGRTLADLVRNAFIILIMLLVGLAVGFRFGDTTVPAILAGFGV
MLIFSYAFSWVSAVIGMSVRSTEAAQSGGMIWVFPLVFASSAFARVDTMPGWLQAFADHQPVTVTVDAVRALFLGGPVAD
DLLLSLAWCGGILLLFGPLAVRAFRRDAAG
>Mature_269_residues
TTLDLTPVARRSRLTWELLDAWVMCRRNLMKTWRVPELLVFATIQPVMFVLLFSYVFGGAIDVGPDLDYVDFLMPGVFVQ
TVIFGAMMTGIGLANDKEEGLIDRFRSLPMSRSALLTGRTLADLVRNAFIILIMLLVGLAVGFRFGDTTVPAILAGFGVM
LIFSYAFSWVSAVIGMSVRSTEAAQSGGMIWVFPLVFASSAFARVDTMPGWLQAFADHQPVTVTVDAVRALFLGGPVADD
LLLSLAWCGGILLLFGPLAVRAFRRDAAG

Specific function: Part of the ABC transporter complex drrAB involved in daunorubicin and doxorubicin resistance. Probably responsible for the translocation of the substrate across the membrane [H]

COG id: COG0842

COG function: function code V; ABC-type multidrug transport system, permease component

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ABC transmembrane type-2 domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000412
- InterPro:   IPR013525 [H]

Pfam domain/function: PF01061 ABC2_membrane [H]

EC number: NA

Molecular weight: Translated: 29454; Mature: 29323

Theoretical pI: Translated: 5.94; Mature: 5.94

Prosite motif: PS51012 ABC_TM2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
4.8 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
4.5 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
TTLDLTPVARRSRLTWELLDAWVMCRRNLMKTWRVPELLVFATIQPVMFVLLFSYVFGG
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCC
AIDVGPDLDYVDFLMPGVFVQTVIFGAMMTGIGLANDKEEGLIDRFRSLPMSRSALLTGR
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCCHHHHHHHH
TLADLVRNAFIILIMLLVGLAVGFRFGDTTVPAILAGFGVMLIFSYAFSWVSAVIGMSVR
HHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHH
STEAAQSGGMIWVFPLVFASSAFARVDTMPGWLQAFADHQPVTVTVDAVRALFLGGPVAD
HHHHHHCCCEEEEHHHHHHHHHHHHHHCCHHHHHHHCCCCCEEEEHHHHHHHHHCCCHHH
DLLLSLAWCGGILLLFGPLAVRAFRRDAAG
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 1924314 [H]