| Definition | Frankia sp. EAN1pec chromosome, complete genome. |
|---|---|
| Accession | NC_009921 |
| Length | 8,982,042 |
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The map label for this gene is yxbG [H]
Identifier: 158316472
GI number: 158316472
Start: 5622819
End: 5623523
Strand: Reverse
Name: yxbG [H]
Synonym: Franean1_4707
Alternate gene names: 158316472
Gene position: 5623523-5622819 (Counterclockwise)
Preceding gene: 158316473
Following gene: 158316471
Centisome position: 62.61
GC content: 67.09
Gene sequence:
>705_bases ATGGGGTTTTCCATCTGCGAGCACCTTGCTCGGCGCGGGGACCGCGTGGCGGTGCTCGACGTGAACGGGGACGCGGCGCA GCAGGCGGTCAAGAAGCTGCGGGGACGTGGCGCGCAGGCCATGGCGTGTGCCGTGGATGTCTCCGATCGAGCGGCGGTCG AAGATGCGCTGGCCCAGGTGCGCGGCGAACTCGGACCCATCGAGATCATGGTGACCTCCGCGGCGATCGCACCGTTTGAT CCCTTCACCGAGATTTCCCTTGACTCGTGGGAGCGTGTCCTTGCCGTTAATCTCACCGGCACGTTCCACTGCCTGCAGGC GGCCATCCCCGACATGGTCGCGGCCGGCTGGGGCCGCATCGTCACGATCACGTCGTCGGCTGCCCAGATCATGACCTCTA ACCACGCGCACTACGTCGCGTCGAAGGGCGGCGTGGTCGCGTTGACGAGAGCGGTGTCCTTCGAATATGCGCGGCAGGGG ATCACGGTGAACACCATTGCGCCCCACATCATCGACACCCCGATGCTCCGCCAGGCCCGCGCGGAGCTCGGGGATCCGAC GGGCGACGGAGGTGCCAGCCACATCCCCGTCGGCCGGCTGGGCACAGGCGACGACATCGCCGCTGCCTGTCTGTACCTGT GCTCTGAGGAGGCCAGCTACATCACGGGGCAGCTGTTCGGTGTCAATGGCGGTGCCGTCGCGTGA
Upstream 100 bases:
>100_bases GTTCCAAGAGTGCCGTTCTAAGAGTGCCGAATTCTCCAAGTGCAAGGAAGCGGTGGTGTACGTGGGCCGAGTGGCAGTCG TGACAGGGAGCGCATCGGGG
Downstream 100 bases:
>100_bases CAGCTCCGGTGGCGCAGCTGCGGCTACGGTCTCGAGCCGTCTCGGGCCCTGAACAGCTCGCCGATCGAGGAGTGTAGATG TTGAAACCAGTACAACCTGC
Product: short-chain dehydrogenase/reductase SDR
Products: (3R)-hydroxyacyl-[acyl-carrier-protein]; NADP; NADPH; Proton; beta-ketoacyl-ACP [C]
Alternate protein names: NA
Number of amino acids: Translated: 234; Mature: 233
Protein sequence:
>234_residues MGFSICEHLARRGDRVAVLDVNGDAAQQAVKKLRGRGAQAMACAVDVSDRAAVEDALAQVRGELGPIEIMVTSAAIAPFD PFTEISLDSWERVLAVNLTGTFHCLQAAIPDMVAAGWGRIVTITSSAAQIMTSNHAHYVASKGGVVALTRAVSFEYARQG ITVNTIAPHIIDTPMLRQARAELGDPTGDGGASHIPVGRLGTGDDIAAACLYLCSEEASYITGQLFGVNGGAVA
Sequences:
>Translated_234_residues MGFSICEHLARRGDRVAVLDVNGDAAQQAVKKLRGRGAQAMACAVDVSDRAAVEDALAQVRGELGPIEIMVTSAAIAPFD PFTEISLDSWERVLAVNLTGTFHCLQAAIPDMVAAGWGRIVTITSSAAQIMTSNHAHYVASKGGVVALTRAVSFEYARQG ITVNTIAPHIIDTPMLRQARAELGDPTGDGGASHIPVGRLGTGDDIAAACLYLCSEEASYITGQLFGVNGGAVA >Mature_233_residues GFSICEHLARRGDRVAVLDVNGDAAQQAVKKLRGRGAQAMACAVDVSDRAAVEDALAQVRGELGPIEIMVTSAAIAPFDP FTEISLDSWERVLAVNLTGTFHCLQAAIPDMVAAGWGRIVTITSSAAQIMTSNHAHYVASKGGVVALTRAVSFEYARQGI TVNTIAPHIIDTPMLRQARAELGDPTGDGGASHIPVGRLGTGDDIAAACLYLCSEEASYITGQLFGVNGGAVA
Specific function: Fatty acid biosynthesis pathway; first reduction step. [C]
COG id: NA
COG function: NA
Gene ontology:
Cell location: Cytoplasm [C]
Metaboloic importance: Essential [C]
Operon status: Not Known
Operon components: None
Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]
Homologues:
Organism=Homo sapiens, GI15277342, Length=240, Percent_Identity=34.1666666666667, Blast_Score=118, Evalue=5e-27, Organism=Homo sapiens, GI32483357, Length=232, Percent_Identity=30.1724137931034, Blast_Score=102, Evalue=3e-22, Organism=Homo sapiens, GI40254992, Length=231, Percent_Identity=29.8701298701299, Blast_Score=100, Evalue=1e-21, Organism=Homo sapiens, GI7705925, Length=189, Percent_Identity=30.6878306878307, Blast_Score=96, Evalue=3e-20, Organism=Homo sapiens, GI66933014, Length=226, Percent_Identity=25.2212389380531, Blast_Score=95, Evalue=5e-20, Organism=Homo sapiens, GI10190704, Length=236, Percent_Identity=30.5084745762712, Blast_Score=88, Evalue=7e-18, Organism=Homo sapiens, GI19923817, Length=237, Percent_Identity=25.7383966244726, Blast_Score=87, Evalue=1e-17, Organism=Homo sapiens, GI59889578, Length=224, Percent_Identity=29.4642857142857, Blast_Score=82, Evalue=4e-16, Organism=Homo sapiens, GI5031737, Length=231, Percent_Identity=27.2727272727273, Blast_Score=80, Evalue=1e-15, Organism=Homo sapiens, GI4758504, Length=243, Percent_Identity=29.2181069958848, Blast_Score=79, Evalue=3e-15, Organism=Homo sapiens, GI126723750, Length=235, Percent_Identity=26.8085106382979, Blast_Score=79, Evalue=4e-15, Organism=Homo sapiens, GI4503817, Length=169, Percent_Identity=28.4023668639053, Blast_Score=74, Evalue=1e-13, Organism=Homo sapiens, GI4503301, Length=217, Percent_Identity=28.110599078341, Blast_Score=74, Evalue=1e-13, Organism=Homo sapiens, GI4504505, Length=173, Percent_Identity=30.635838150289, Blast_Score=72, Evalue=3e-13, Organism=Homo sapiens, GI142976729, Length=182, Percent_Identity=23.6263736263736, Blast_Score=70, Evalue=2e-12, Organism=Homo sapiens, GI25282469, Length=145, Percent_Identity=30.3448275862069, Blast_Score=70, Evalue=2e-12, Organism=Homo sapiens, GI40807363, Length=174, Percent_Identity=27.0114942528736, Blast_Score=69, Evalue=5e-12, Organism=Escherichia coli, GI1787335, Length=231, Percent_Identity=33.7662337662338, Blast_Score=134, Evalue=4e-33, Organism=Escherichia coli, GI1790717, Length=232, Percent_Identity=31.4655172413793, Blast_Score=123, Evalue=9e-30, Organism=Escherichia coli, GI87082100, Length=237, Percent_Identity=30.379746835443, Blast_Score=112, Evalue=2e-26, Organism=Escherichia coli, GI1787905, Length=233, Percent_Identity=33.4763948497854, Blast_Score=112, Evalue=2e-26, Organism=Escherichia coli, GI1788459, Length=209, Percent_Identity=32.5358851674641, Blast_Score=105, Evalue=3e-24, Organism=Escherichia coli, GI1789057, Length=245, Percent_Identity=30.2040816326531, Blast_Score=101, Evalue=5e-23, Organism=Escherichia coli, GI2367175, Length=234, Percent_Identity=32.4786324786325, Blast_Score=95, Evalue=4e-21, Organism=Escherichia coli, GI1789208, Length=208, Percent_Identity=27.8846153846154, Blast_Score=87, Evalue=1e-18, Organism=Escherichia coli, GI1786812, Length=194, Percent_Identity=29.3814432989691, Blast_Score=79, Evalue=3e-16, Organism=Escherichia coli, GI1789378, Length=226, Percent_Identity=28.7610619469027, Blast_Score=76, Evalue=2e-15, Organism=Escherichia coli, GI87082160, Length=231, Percent_Identity=24.2424242424242, Blast_Score=74, Evalue=6e-15, Organism=Escherichia coli, GI2367365, Length=206, Percent_Identity=28.6407766990291, Blast_Score=70, Evalue=8e-14, Organism=Caenorhabditis elegans, GI25147288, Length=234, Percent_Identity=31.6239316239316, Blast_Score=107, Evalue=6e-24, Organism=Caenorhabditis elegans, GI17555706, Length=232, Percent_Identity=31.4655172413793, Blast_Score=103, Evalue=6e-23, Organism=Caenorhabditis elegans, GI17560676, Length=232, Percent_Identity=27.1551724137931, Blast_Score=99, Evalue=1e-21, Organism=Caenorhabditis elegans, GI17561402, Length=246, Percent_Identity=30.0813008130081, Blast_Score=97, Evalue=9e-21, Organism=Caenorhabditis elegans, GI115534694, Length=233, Percent_Identity=30.4721030042918, Blast_Score=82, Evalue=3e-16, Organism=Caenorhabditis elegans, GI17567345, Length=173, Percent_Identity=28.3236994219653, Blast_Score=79, Evalue=3e-15, Organism=Caenorhabditis elegans, GI71994600, Length=189, Percent_Identity=29.6296296296296, Blast_Score=77, Evalue=9e-15, Organism=Caenorhabditis elegans, GI17564282, Length=173, Percent_Identity=25.4335260115607, Blast_Score=72, Evalue=2e-13, Organism=Caenorhabditis elegans, GI193203115, Length=171, Percent_Identity=25.7309941520468, Blast_Score=72, Evalue=3e-13, Organism=Caenorhabditis elegans, GI193203117, Length=171, Percent_Identity=25.7309941520468, Blast_Score=71, Evalue=4e-13, Organism=Caenorhabditis elegans, GI71994604, Length=229, Percent_Identity=23.5807860262009, Blast_Score=71, Evalue=5e-13, Organism=Caenorhabditis elegans, GI17508895, Length=179, Percent_Identity=24.5810055865922, Blast_Score=71, Evalue=5e-13, Organism=Caenorhabditis elegans, GI17538182, Length=243, Percent_Identity=26.3374485596708, Blast_Score=69, Evalue=2e-12, Organism=Caenorhabditis elegans, GI17568967, Length=179, Percent_Identity=27.9329608938547, Blast_Score=69, Evalue=2e-12, Organism=Caenorhabditis elegans, GI17562910, Length=247, Percent_Identity=24.6963562753036, Blast_Score=69, Evalue=2e-12, Organism=Caenorhabditis elegans, GI17561272, Length=233, Percent_Identity=27.4678111587983, Blast_Score=68, Evalue=4e-12, Organism=Caenorhabditis elegans, GI17508651, Length=244, Percent_Identity=26.2295081967213, Blast_Score=66, Evalue=2e-11, Organism=Caenorhabditis elegans, GI17559104, Length=242, Percent_Identity=23.5537190082645, Blast_Score=64, Evalue=5e-11, Organism=Saccharomyces cerevisiae, GI6324126, Length=237, Percent_Identity=27.4261603375527, Blast_Score=82, Evalue=9e-17, Organism=Saccharomyces cerevisiae, GI6322861, Length=168, Percent_Identity=29.1666666666667, Blast_Score=68, Evalue=1e-12, Organism=Drosophila melanogaster, GI24639444, Length=235, Percent_Identity=33.6170212765957, Blast_Score=110, Evalue=1e-24, Organism=Drosophila melanogaster, GI21355319, Length=235, Percent_Identity=27.6595744680851, Blast_Score=90, Evalue=1e-18, Organism=Drosophila melanogaster, GI23397609, Length=234, Percent_Identity=28.2051282051282, Blast_Score=84, Evalue=7e-17, Organism=Drosophila melanogaster, GI24640492, Length=184, Percent_Identity=27.1739130434783, Blast_Score=84, Evalue=7e-17, Organism=Drosophila melanogaster, GI21357041, Length=228, Percent_Identity=27.1929824561404, Blast_Score=79, Evalue=3e-15, Organism=Drosophila melanogaster, GI18859837, Length=169, Percent_Identity=31.3609467455621, Blast_Score=76, Evalue=2e-14, Organism=Drosophila melanogaster, GI24644339, Length=190, Percent_Identity=28.9473684210526, Blast_Score=75, Evalue=4e-14, Organism=Drosophila melanogaster, GI281364892, Length=194, Percent_Identity=27.8350515463918, Blast_Score=75, Evalue=5e-14, Organism=Drosophila melanogaster, GI24581726, Length=180, Percent_Identity=25.5555555555556, Blast_Score=74, Evalue=1e-13, Organism=Drosophila melanogaster, GI28571526, Length=236, Percent_Identity=25, Blast_Score=73, Evalue=2e-13, Organism=Drosophila melanogaster, GI24643142, Length=188, Percent_Identity=26.5957446808511, Blast_Score=73, Evalue=2e-13, Organism=Drosophila melanogaster, GI17737361, Length=188, Percent_Identity=29.2553191489362, Blast_Score=70, Evalue=1e-12, Organism=Drosophila melanogaster, GI21355631, Length=156, Percent_Identity=28.2051282051282, Blast_Score=69, Evalue=2e-12, Organism=Drosophila melanogaster, GI21356301, Length=132, Percent_Identity=28.7878787878788, Blast_Score=67, Evalue=1e-11,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR002198 - InterPro: IPR002347 - InterPro: IPR016040 - InterPro: IPR020904 [H]
Pfam domain/function: PF00106 adh_short [H]
EC number: 1.1.1.100 [C]
Molecular weight: Translated: 24347; Mature: 24216
Theoretical pI: Translated: 5.24; Mature: 5.24
Prosite motif: PS00061 ADH_SHORT
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
2.1 %Cys (Translated Protein) 2.6 %Met (Translated Protein) 4.7 %Cys+Met (Translated Protein) 2.1 %Cys (Mature Protein) 2.1 %Met (Mature Protein) 4.3 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MGFSICEHLARRGDRVAVLDVNGDAAQQAVKKLRGRGAQAMACAVDVSDRAAVEDALAQV CCHHHHHHHHHCCCEEEEEECCCHHHHHHHHHHHCCCCCEEEEEEECCCHHHHHHHHHHH RGELGPIEIMVTSAAIAPFDPFTEISLDSWERVLAVNLTGTFHCLQAAIPDMVAAGWGRI HCCCCCEEEEEEECCCCCCCCCCCCCCCCCCEEEEEECCHHHHHHHHHHHHHHHCCCCEE VTITSSAAQIMTSNHAHYVASKGGVVALTRAVSFEYARQGITVNTIAPHIIDTPMLRQAR EEEECHHHHHHHCCCCEEEECCCCEEEEHHHHHHHHHHCCCEEECCCCHHHCCHHHHHHH AELGDPTGDGGASHIPVGRLGTGDDIAAACLYLCSEEASYITGQLFGVNGGAVA HHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCEEEEEEEECCCCCCC >Mature Secondary Structure GFSICEHLARRGDRVAVLDVNGDAAQQAVKKLRGRGAQAMACAVDVSDRAAVEDALAQV CHHHHHHHHHCCCEEEEEECCCHHHHHHHHHHHCCCCCEEEEEEECCCHHHHHHHHHHH RGELGPIEIMVTSAAIAPFDPFTEISLDSWERVLAVNLTGTFHCLQAAIPDMVAAGWGRI HCCCCCEEEEEEECCCCCCCCCCCCCCCCCCEEEEEECCHHHHHHHHHHHHHHHCCCCEE VTITSSAAQIMTSNHAHYVASKGGVVALTRAVSFEYARQGITVNTIAPHIIDTPMLRQAR EEEECHHHHHHHCCCCEEEECCCCEEEEHHHHHHHHHHCCCEEECCCCHHHCCHHHHHHH AELGDPTGDGGASHIPVGRLGTGDDIAAACLYLCSEEASYITGQLFGVNGGAVA HHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCEEEEEEEECCCCCCC
PDB accession: NA
Resolution: NA
Structure class: Alpha Beta
Cofactors: NADPH [C]
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: Oxoacyl-[acyl-carrier-protein]; NADPH; D-3-hydroxy-acyl-ACP; NADP [C]
Specific reaction: Oxoacyl-[acyl-carrier-protein] + NADPH = (3R)-hydroxyacyl-[acyl-carrier-protein] + NADP+ D-3-hydroxy-acyl-ACP + NADP = NADPH + Proton + beta-ketoacyl-ACP [C]
General reaction: Redox reaction [C]
Inhibitor: NA
Structure determination priority: 10.0
TargetDB status: NA
Availability: NA
References: 7584049; 9384377 [H]