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The map label for this gene is galK [H]

Identifier: 158316447

GI number: 158316447

Start: 5592512

End: 5593786

Strand: Reverse

Name: galK [H]

Synonym: Franean1_4682

Alternate gene names: 158316447

Gene position: 5593786-5592512 (Counterclockwise)

Preceding gene: 158316448

Following gene: 158316446

Centisome position: 62.28

GC content: 75.45

Gene sequence:

>1275_bases
ATGAGCCAGCGTGGTGAGGTTTCCGCGACGGCCGGGGGCGTCGGCGCAACCCCCGCCCCGGGCAGCCCGGGCACCCCGGG
CGCGGCGGAGCGGGCCGTCGCGGCTTTCGTCCGGTGCCACGGGGCCCGGCCGGCCTACCTGGTCCGCTCGCCTGGTCGGG
TGAATCTGATCGGCGAGCACACCGACTACAACGGTGGCCTCTGCCTGCCGGTGGCGATCGACCTCGAGCTGTGTCTCGCG
TTCTCCCCGTCCCCGCGCGCGACTGCGGGCCACGGGTTTGTCGAGGTGCTTTCCGAGCATCGCGCGGCACCGGCCCGGAT
CGACCTGCCGCCGCCTCCGCCGCCTGAGCCCGGGTCACCGGGCCGGGCCGGGGCCGCGCAATCCGGATGGGCCGGGTACG
TCGAAGGTGTCGTCGTGATGGCGGCGTCGGTCGCCGGCGCCGCCGCGTCGCGAGGCTGGTACGGGACGCTGGCCAGCGAC
CTGCCGCTCGGCGCGGGGCTGTCGTCGTCGGCCGCGCTGGAGCTTGCCGTGGCCCGGGCCTGCGCGGTGGTGTGGAAGAC
CGGCTGGGATCCGATCGAGGCGGCCCGGCTCGCCCAGCGGGCCGAGAACGGCTGGGTGGGCGCCGCCACCGGCCTGCTTG
ACCAGATCGCCTGCGCCGCGGCGACGGCCGGCCACGCTCTGGAGATCGACTTTCGTGATCTGACGGTGACCGCGGTCGCC
GTCCCGGATTCGGTCGTCGTCGCGGTCGTGGACACCGGCACCCGCCGGGAGCTGGTCACCAGCGCCTACGCCCAGCGCCG
GGCCGAATGTGAGCGGGCGGCGGCCGGGTTGGGCGTCGCGAGCCTGCGCGACCTCGGCGACCGGTTGCCCGCCGACGCGG
CCCGCCGGCTCGACCCGGTGGCGTTGCGCCGGGCGCGCCACATCGTCACCGAGAACACGCGGGTACGGGAGCTCGCCGAC
GCACTGCGCCGCGTGGACCTGCCGCGGGCCGGCACCGTGCTCCTCGACGGCCACCGGTCGATCCGGGATGACTTCGAGGT
GTCCGGTCCCGAACTGGAAGCTGCGGTCGAGGCCTGCCTGAACGCTCCCGGCTGCCACGGTGCGCGGATGACCGGCGGCG
GTTTCGCCGGCTGCGTCGTCGCCCTGGTCGACGCGGACTCGGCGGCTGCCTTCGCCGCGGCGGTGGTCGGTGCCTACCGC
GCGAGAACTGGGAACGAGGCGGTGGTCCATCTGTGCGCGCCGGTCGACGGCACCTCGCTGGTGGACGCGCCCTGA

Upstream 100 bases:

>100_bases
GCTACGAGATGCTGGCCGGCGCGCAGCGCGACATCACCCCGGAGCAAGCCGCGGCGATGCTGCGGGCCCACGTCCCGGCC
GCCGGACCGGACCGGGTCCG

Downstream 100 bases:

>100_bases
TGACGGGTCAGCCGGCCTGCGCGGCGGACACCATCGACAGCCCCACAGACGGGGGGCAACGGATGAGAAGGACTCATGAA
CGCCAACCCGATCCTGCCCG

Product: galactokinase

Products: NA

Alternate protein names: Galactose kinase [H]

Number of amino acids: Translated: 424; Mature: 423

Protein sequence:

>424_residues
MSQRGEVSATAGGVGATPAPGSPGTPGAAERAVAAFVRCHGARPAYLVRSPGRVNLIGEHTDYNGGLCLPVAIDLELCLA
FSPSPRATAGHGFVEVLSEHRAAPARIDLPPPPPPEPGSPGRAGAAQSGWAGYVEGVVVMAASVAGAAASRGWYGTLASD
LPLGAGLSSSAALELAVARACAVVWKTGWDPIEAARLAQRAENGWVGAATGLLDQIACAAATAGHALEIDFRDLTVTAVA
VPDSVVVAVVDTGTRRELVTSAYAQRRAECERAAAGLGVASLRDLGDRLPADAARRLDPVALRRARHIVTENTRVRELAD
ALRRVDLPRAGTVLLDGHRSIRDDFEVSGPELEAAVEACLNAPGCHGARMTGGGFAGCVVALVDADSAAAFAAAVVGAYR
ARTGNEAVVHLCAPVDGTSLVDAP

Sequences:

>Translated_424_residues
MSQRGEVSATAGGVGATPAPGSPGTPGAAERAVAAFVRCHGARPAYLVRSPGRVNLIGEHTDYNGGLCLPVAIDLELCLA
FSPSPRATAGHGFVEVLSEHRAAPARIDLPPPPPPEPGSPGRAGAAQSGWAGYVEGVVVMAASVAGAAASRGWYGTLASD
LPLGAGLSSSAALELAVARACAVVWKTGWDPIEAARLAQRAENGWVGAATGLLDQIACAAATAGHALEIDFRDLTVTAVA
VPDSVVVAVVDTGTRRELVTSAYAQRRAECERAAAGLGVASLRDLGDRLPADAARRLDPVALRRARHIVTENTRVRELAD
ALRRVDLPRAGTVLLDGHRSIRDDFEVSGPELEAAVEACLNAPGCHGARMTGGGFAGCVVALVDADSAAAFAAAVVGAYR
ARTGNEAVVHLCAPVDGTSLVDAP
>Mature_423_residues
SQRGEVSATAGGVGATPAPGSPGTPGAAERAVAAFVRCHGARPAYLVRSPGRVNLIGEHTDYNGGLCLPVAIDLELCLAF
SPSPRATAGHGFVEVLSEHRAAPARIDLPPPPPPEPGSPGRAGAAQSGWAGYVEGVVVMAASVAGAAASRGWYGTLASDL
PLGAGLSSSAALELAVARACAVVWKTGWDPIEAARLAQRAENGWVGAATGLLDQIACAAATAGHALEIDFRDLTVTAVAV
PDSVVVAVVDTGTRRELVTSAYAQRRAECERAAAGLGVASLRDLGDRLPADAARRLDPVALRRARHIVTENTRVRELADA
LRRVDLPRAGTVLLDGHRSIRDDFEVSGPELEAAVEACLNAPGCHGARMTGGGFAGCVVALVDADSAAAFAAAVVGAYRA
RTGNEAVVHLCAPVDGTSLVDAP

Specific function: Galactose metabolism; first step. [C]

COG id: COG0153

COG function: function code G; Galactokinase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GHMP kinase family. GalK subfamily [H]

Homologues:

Organism=Homo sapiens, GI4503895, Length=394, Percent_Identity=38.8324873096447, Blast_Score=228, Evalue=7e-60,
Organism=Escherichia coli, GI1786972, Length=389, Percent_Identity=36.2467866323907, Blast_Score=233, Evalue=2e-62,
Organism=Caenorhabditis elegans, GI71989053, Length=417, Percent_Identity=26.378896882494, Blast_Score=95, Evalue=6e-20,
Organism=Saccharomyces cerevisiae, GI6319494, Length=273, Percent_Identity=30.7692307692308, Blast_Score=83, Evalue=1e-16,
Organism=Saccharomyces cerevisiae, GI6320212, Length=267, Percent_Identity=29.2134831460674, Blast_Score=78, Evalue=3e-15,
Organism=Drosophila melanogaster, GI24661292, Length=425, Percent_Identity=26.3529411764706, Blast_Score=98, Evalue=8e-21,
Organism=Drosophila melanogaster, GI21355577, Length=425, Percent_Identity=26.3529411764706, Blast_Score=98, Evalue=8e-21,
Organism=Drosophila melanogaster, GI24661285, Length=425, Percent_Identity=26.3529411764706, Blast_Score=98, Evalue=8e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000705
- InterPro:   IPR022963
- InterPro:   IPR019741
- InterPro:   IPR019539
- InterPro:   IPR006204
- InterPro:   IPR013750
- InterPro:   IPR006203
- InterPro:   IPR006206
- InterPro:   IPR020568
- InterPro:   IPR014721 [H]

Pfam domain/function: PF10509 GalKase_gal_bdg; PF08544 GHMP_kinases_C; PF00288 GHMP_kinases_N [H]

EC number: =2.7.1.6 [H]

Molecular weight: Translated: 43115; Mature: 42984

Theoretical pI: Translated: 6.05; Mature: 6.05

Prosite motif: PS00106 GALACTOKINASE ; PS00627 GHMP_KINASES_ATP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.4 %Cys     (Translated Protein)
0.7 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
2.4 %Cys     (Mature Protein)
0.5 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSQRGEVSATAGGVGATPAPGSPGTPGAAERAVAAFVRCHGARPAYLVRSPGRVNLIGEH
CCCCCCCEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCEEEEECCCEEEEEECC
TDYNGGLCLPVAIDLELCLAFSPSPRATAGHGFVEVLSEHRAAPARIDLPPPPPPEPGSP
CCCCCCEEEEEEEEEEEEEEECCCCCCCCCHHHHHHHHHHCCCCCEECCCCCCCCCCCCC
GRAGAAQSGWAGYVEGVVVMAASVAGAAASRGWYGTLASDLPLGAGLSSSAALELAVARA
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHCCCCCCCCCCCHHHHHHHHHHH
CAVVWKTGWDPIEAARLAQRAENGWVGAATGLLDQIACAAATAGHALEIDFRDLTVTAVA
HHHHHHCCCCHHHHHHHHHHHCCCCEEHHHHHHHHHHHHHHCCCCEEEEEECCEEEEEEE
VPDSVVVAVVDTGTRRELVTSAYAQRRAECERAAAGLGVASLRDLGDRLPADAARRLDPV
CCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCHHHHHCCCHH
ALRRARHIVTENTRVRELADALRRVDLPRAGTVLLDGHRSIRDDFEVSGPELEAAVEACL
HHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCEEEECCCHHHCCCCCCCCCHHHHHHHHHH
NAPGCHGARMTGGGFAGCVVALVDADSAAAFAAAVVGAYRARTGNEAVVHLCAPVDGTSL
CCCCCCCCEECCCCHHEEEEEEECCCCHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCC
VDAP
CCCC
>Mature Secondary Structure 
SQRGEVSATAGGVGATPAPGSPGTPGAAERAVAAFVRCHGARPAYLVRSPGRVNLIGEH
CCCCCCEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCEEEEECCCEEEEEECC
TDYNGGLCLPVAIDLELCLAFSPSPRATAGHGFVEVLSEHRAAPARIDLPPPPPPEPGSP
CCCCCCEEEEEEEEEEEEEEECCCCCCCCCHHHHHHHHHHCCCCCEECCCCCCCCCCCCC
GRAGAAQSGWAGYVEGVVVMAASVAGAAASRGWYGTLASDLPLGAGLSSSAALELAVARA
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHCCCCCCCCCCCHHHHHHHHHHH
CAVVWKTGWDPIEAARLAQRAENGWVGAATGLLDQIACAAATAGHALEIDFRDLTVTAVA
HHHHHHCCCCHHHHHHHHHHHCCCCEEHHHHHHHHHHHHHHCCCCEEEEEECCEEEEEEE
VPDSVVVAVVDTGTRRELVTSAYAQRRAECERAAAGLGVASLRDLGDRLPADAARRLDPV
CCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCHHHHHCCCHH
ALRRARHIVTENTRVRELADALRRVDLPRAGTVLLDGHRSIRDDFEVSGPELEAAVEACL
HHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCEEEECCCHHHCCCCCCCCCHHHHHHHHHH
NAPGCHGARMTGGGFAGCVVALVDADSAAAFAAAVVGAYRARTGNEAVVHLCAPVDGTSL
CCCCCCCCEECCCCHHEEEEEEECCCCHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCC
VDAP
CCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA