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The map label for this gene is mcl1 [H]

Identifier: 158316307

GI number: 158316307

Start: 5410246

End: 5411211

Strand: Reverse

Name: mcl1 [H]

Synonym: Franean1_4534

Alternate gene names: 158316307

Gene position: 5411211-5410246 (Counterclockwise)

Preceding gene: 158316308

Following gene: 158316306

Centisome position: 60.24

GC content: 65.22

Gene sequence:

>966_bases
GTGTCTGCTCATGCTCGGTCCGCTCGTGCTCGCCGGTCGTGTCTGGCTGTTCCGGCTTCGAACGTGAAGATGTTGGGGAA
GGCGCAGGGTCTTCCTGCCGACCAGATCTTCTGTGATCTGGAGGACTCGGTTGCCCCGGGGGCGAAGGAGTCGGCGCGGG
GGAACGTCGTGTCGGTGTTGAACGAGGGTGACTGGGCGGGTAAGACCCGGGTTGTGCGGGTCAATGACCTGACGACGAAG
TGGACCTATCGTGATGTCGTGACGGTGGTCGAGGGTGCGGGGGCGAACCTGGACTGTGTGATGCTGCCGAAGGTGCAGAC
CGCCGCGCAGGTGCAGTGGCTGGATCTGTTGCTGACGCAGATCGAGGAGGTGATGGGTTTCGAGGTCGGGCGGATCGGTA
TCGAGGCGCAGATCGAGAACGCGCTGGGTCTGTCGAACGTGAAGGAGATCGCGTTCGCCAGCCCGCGGATCGAGACGATC
ATCTTTGGTCCGGCGGATTTCATGGCGTCGATGAACATGCCGTCGCTGGTGGTGGGTGCGCTGAACCCGGATTATCCGGG
GGACCCGTTCCACTATGTGCTGTTCAAGATTTTGGAGGCGGCGCGGGCGCGGGGGGTGCAGGCGATCGACGGGCCGTTCC
TGCAGATCCGGGATGTGGAGGCGTTCCGTGGGGTGGCGAAGAAGTCCGCGGCGTTGGGTTATGACGGTAAGTGGGTGCTG
CATCCGGGGCAGATCGATGCCGCGAACGAGGTGTACGCCCCCCGGCAGGAGGATTACGACCACGCTGAGCTGATCCTGGA
CGCCTATGCCTGGCACACCTCGGACGAGGGTGGGCTGCGGGGCGCGGTGATGCTCGGGGACGAGATGATCGACGAGGCGA
GCCGGAAGATGGCCGAGGTGATCGCGGGCAAGGGGCGTGCCGCGGGTATGGCGCGTACCGCGGCCTTCGAGCCGCCGGCC
GGCTGA

Upstream 100 bases:

>100_bases
TGACTGGTTGCCGGTGACGGTCGGGGGATCGCAGAGACTGCGCGCTGTGAATCACCGGGTTCGTTACCGCCACTGGTTTA
CAGTCGAATCGGGAGTATTT

Downstream 100 bases:

>100_bases
ACCCCGGTCTGGCTGTTTCTCCGTCGAGACCTCAAGGACACAGGAGCCGTTATGGGCAGGATCGCGCAGACCGATGGGCT
GACCGAGGTGCAGTCCGACA

Product: Citryl-CoA lyase

Products: NA

Alternate protein names: (3S)-malyl-CoA/beta-methylmalyl-CoA lyase; L-malyl-CoA/beta-methylmalyl-CoA lyase [H]

Number of amino acids: Translated: 321; Mature: 320

Protein sequence:

>321_residues
MSAHARSARARRSCLAVPASNVKMLGKAQGLPADQIFCDLEDSVAPGAKESARGNVVSVLNEGDWAGKTRVVRVNDLTTK
WTYRDVVTVVEGAGANLDCVMLPKVQTAAQVQWLDLLLTQIEEVMGFEVGRIGIEAQIENALGLSNVKEIAFASPRIETI
IFGPADFMASMNMPSLVVGALNPDYPGDPFHYVLFKILEAARARGVQAIDGPFLQIRDVEAFRGVAKKSAALGYDGKWVL
HPGQIDAANEVYAPRQEDYDHAELILDAYAWHTSDEGGLRGAVMLGDEMIDEASRKMAEVIAGKGRAAGMARTAAFEPPA
G

Sequences:

>Translated_321_residues
MSAHARSARARRSCLAVPASNVKMLGKAQGLPADQIFCDLEDSVAPGAKESARGNVVSVLNEGDWAGKTRVVRVNDLTTK
WTYRDVVTVVEGAGANLDCVMLPKVQTAAQVQWLDLLLTQIEEVMGFEVGRIGIEAQIENALGLSNVKEIAFASPRIETI
IFGPADFMASMNMPSLVVGALNPDYPGDPFHYVLFKILEAARARGVQAIDGPFLQIRDVEAFRGVAKKSAALGYDGKWVL
HPGQIDAANEVYAPRQEDYDHAELILDAYAWHTSDEGGLRGAVMLGDEMIDEASRKMAEVIAGKGRAAGMARTAAFEPPA
G
>Mature_320_residues
SAHARSARARRSCLAVPASNVKMLGKAQGLPADQIFCDLEDSVAPGAKESARGNVVSVLNEGDWAGKTRVVRVNDLTTKW
TYRDVVTVVEGAGANLDCVMLPKVQTAAQVQWLDLLLTQIEEVMGFEVGRIGIEAQIENALGLSNVKEIAFASPRIETII
FGPADFMASMNMPSLVVGALNPDYPGDPFHYVLFKILEAARARGVQAIDGPFLQIRDVEAFRGVAKKSAALGYDGKWVLH
PGQIDAANEVYAPRQEDYDHAELILDAYAWHTSDEGGLRGAVMLGDEMIDEASRKMAEVIAGKGRAAGMARTAAFEPPAG

Specific function: Catalyzes the reversible condensation of glyoxylate and acetyl-CoA to L-malyl-CoA and the reversible condensation of glyoxylate and propionyl-CoA to beta-methylmalyl-CoA [H]

COG id: COG2301

COG function: function code G; Citrate lyase beta subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HpcH/HpaI aldolase family [H]

Homologues:

Organism=Homo sapiens, GI45545437, Length=303, Percent_Identity=29.042904290429, Blast_Score=107, Evalue=1e-23,
Organism=Escherichia coli, GI87081764, Length=260, Percent_Identity=35.3846153846154, Blast_Score=142, Evalue=4e-35,
Organism=Caenorhabditis elegans, GI17557458, Length=295, Percent_Identity=26.4406779661017, Blast_Score=78, Evalue=5e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005000
- InterPro:   IPR011206
- InterPro:   IPR015813 [H]

Pfam domain/function: PF03328 HpcH_HpaI [H]

EC number: =4.1.3.24 [H]

Molecular weight: Translated: 34511; Mature: 34380

Theoretical pI: Translated: 4.87; Mature: 4.87

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSAHARSARARRSCLAVPASNVKMLGKAQGLPADQIFCDLEDSVAPGAKESARGNVVSVL
CCCCHHHHHHHHHEEECCCCCCEEHHHCCCCCHHHEEECCCCCCCCCCCCCCCCCEEEEE
NEGDWAGKTRVVRVNDLTTKWTYRDVVTVVEGAGANLDCVMLPKVQTAAQVQWLDLLLTQ
ECCCCCCCEEEEEEECCCCEEEHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHHHHHH
IEEVMGFEVGRIGIEAQIENALGLSNVKEIAFASPRIETIIFGPADFMASMNMPSLVVGA
HHHHHCCCCCCEEEEEEHHHHCCCCHHHHHHHCCCCEEEEEECCHHHHHHCCCCEEEEEC
LNPDYPGDPFHYVLFKILEAARARGVQAIDGPFLQIRDVEAFRGVAKKSAALGYDGKWVL
CCCCCCCCHHHHHHHHHHHHHHHCCCEECCCCEEEEEECHHHHHHHHHHHHCCCCCEEEE
HPGQIDAANEVYAPRQEDYDHAELILDAYAWHTSDEGGLRGAVMLGDEMIDEASRKMAEV
ECCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCEEEEEECHHHHHHHHHHHHHH
IAGKGRAAGMARTAAFEPPAG
HHCCCCCCCCHHHCCCCCCCC
>Mature Secondary Structure 
SAHARSARARRSCLAVPASNVKMLGKAQGLPADQIFCDLEDSVAPGAKESARGNVVSVL
CCCHHHHHHHHHEEECCCCCCEEHHHCCCCCHHHEEECCCCCCCCCCCCCCCCCEEEEE
NEGDWAGKTRVVRVNDLTTKWTYRDVVTVVEGAGANLDCVMLPKVQTAAQVQWLDLLLTQ
ECCCCCCCEEEEEEECCCCEEEHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHHHHHH
IEEVMGFEVGRIGIEAQIENALGLSNVKEIAFASPRIETIIFGPADFMASMNMPSLVVGA
HHHHHCCCCCCEEEEEEHHHHCCCCHHHHHHHCCCCEEEEEECCHHHHHHCCCCEEEEEC
LNPDYPGDPFHYVLFKILEAARARGVQAIDGPFLQIRDVEAFRGVAKKSAALGYDGKWVL
CCCCCCCCHHHHHHHHHHHHHHHCCCEECCCCEEEEEECHHHHHHHHHHHHCCCCCEEEE
HPGQIDAANEVYAPRQEDYDHAELILDAYAWHTSDEGGLRGAVMLGDEMIDEASRKMAEV
ECCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCEEEEEECHHHHHHHHHHHHHH
IAGKGRAAGMARTAAFEPPAG
HHCCCCCCCCHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA