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The map label for this gene is CYP127A1 [H]

Identifier: 158316266

GI number: 158316266

Start: 5357824

End: 5359089

Strand: Reverse

Name: CYP127A1 [H]

Synonym: Franean1_4491

Alternate gene names: 158316266

Gene position: 5359089-5357824 (Counterclockwise)

Preceding gene: 158316267

Following gene: 158316265

Centisome position: 59.66

GC content: 66.9

Gene sequence:

>1266_bases
ATGTCCGTTGACGACACCGAGGCGTCCGCGCCCACGACCCAGCGCGGGTACGCCACGGCCCCCACGCTCGCGGGGTTCTC
GCACGCGGCGAACGAGCGTCTCAATGCCGACCCGTGGGGCGAGCTCGACCGGCTCCGCGACGAGTCGCCGACATTCCGTA
GCGACATGCCGAATCCTCTCGTCCCCGGCGCGTCGCTGTGGTATCTCCTCGACTACGAGAGCGTCTACACCGCGCTGCGT
GACTGGGAGACCTTCTCCAACGTGGGATCGGCGCACCCGTTCTCCGACAGCGACCCGTACAGCATGATCCCCGGCGAGCT
GGACCCGCCGGACCACACCAAGTTCCGGCGGCCGCTGAACGCCCACTTCTCGCCCGGCGCGATCCGCGCGCTCGAGCCGG
ATATCCGCCGGACGGCCGTTGAGCTCATCGAGTCGTTCAAGGATTCCGGCCAGTGCGACTTCGTCACCGACTTCGCGCTG
CACTTTCCTACCCGGGTCTTCGAGCGGATGTTCGGCGTCCCGCTCGAGGATCACGACCAGCTCACCGCGTGGGTGCATAC
CTTCGGCCAGCAGATGGCGACACAGACCGCGATCGACAAGGCCGTCGCCGCCGAGCAGGAGGTGCTGGCCTACCTGGGGA
AGAAGCTGGACGAGCGCGAGCAGTCCCCCAGGGAGGACCTGCTCGGCGCGATCGCCTTCATGGAAGTCGACGGCGCCCGG
ATCAGTCGCAAGGAGCAGGTGGCGGTCGCCTACCTGATGTTCCAGGCGGGTATGGACACGGTGGCGAGCCAGCTGGGCTG
GTCCTTCCGCCACCTCGCCGAGAACGAGGTCGACCGGCAGGCGATCCTCGCCGACCCGAAGCTGATTCCCTCGACGGTGG
AGGAGCTCCTGCGCTCCTACGACATCCTCTCGCACACCATGATCGTCGCCAAGGATGTCGAGTTCAACGGCTGCCCGATG
AAGAAAGGCGACCGGGTGGTCACCATGATCTCGGCGGCGAACCGGGACCCGAACGAGTTCCCGGACCCGGACACCTTCGA
CGTCTCCCGCAAGCCGAACCGGCACATGGCCTTCGGGGTGGGGCCGCACCGCTGCATCGGTGCGCACCTGGCCCGGATCG
AGCTGAACATCGCGCTGGAGGAGTGGCACCAGCGGATCCCGAATTACAAGGTGGCCGAGGGCGCCGAGTTCGGCCAGTCC
ATGAAATGGGCGGTCACCTCGATGGAATCGCTCCCGCTCGAATGGGATGTCGAGGCGGTGAACTGA

Upstream 100 bases:

>100_bases
TATCTGCGTCATACTTGCGATACTCTATCCGTGAATAGTAGATCCATGGATATTTGCTGACGCGACTACTGTTAACCGCG
GCGGCAGATGGGGAGTTCTG

Downstream 100 bases:

>100_bases
TGCGGATCGTGGCGGAACGGGAGATGTGCAGCGGTCACACCCGGTGCGCGGCGGTGCTTCCGGGGGTTTTCGCGCTCGAT
GACGACGGCTACCTGAACAT

Product: cytochrome P450

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 421; Mature: 420

Protein sequence:

>421_residues
MSVDDTEASAPTTQRGYATAPTLAGFSHAANERLNADPWGELDRLRDESPTFRSDMPNPLVPGASLWYLLDYESVYTALR
DWETFSNVGSAHPFSDSDPYSMIPGELDPPDHTKFRRPLNAHFSPGAIRALEPDIRRTAVELIESFKDSGQCDFVTDFAL
HFPTRVFERMFGVPLEDHDQLTAWVHTFGQQMATQTAIDKAVAAEQEVLAYLGKKLDEREQSPREDLLGAIAFMEVDGAR
ISRKEQVAVAYLMFQAGMDTVASQLGWSFRHLAENEVDRQAILADPKLIPSTVEELLRSYDILSHTMIVAKDVEFNGCPM
KKGDRVVTMISAANRDPNEFPDPDTFDVSRKPNRHMAFGVGPHRCIGAHLARIELNIALEEWHQRIPNYKVAEGAEFGQS
MKWAVTSMESLPLEWDVEAVN

Sequences:

>Translated_421_residues
MSVDDTEASAPTTQRGYATAPTLAGFSHAANERLNADPWGELDRLRDESPTFRSDMPNPLVPGASLWYLLDYESVYTALR
DWETFSNVGSAHPFSDSDPYSMIPGELDPPDHTKFRRPLNAHFSPGAIRALEPDIRRTAVELIESFKDSGQCDFVTDFAL
HFPTRVFERMFGVPLEDHDQLTAWVHTFGQQMATQTAIDKAVAAEQEVLAYLGKKLDEREQSPREDLLGAIAFMEVDGAR
ISRKEQVAVAYLMFQAGMDTVASQLGWSFRHLAENEVDRQAILADPKLIPSTVEELLRSYDILSHTMIVAKDVEFNGCPM
KKGDRVVTMISAANRDPNEFPDPDTFDVSRKPNRHMAFGVGPHRCIGAHLARIELNIALEEWHQRIPNYKVAEGAEFGQS
MKWAVTSMESLPLEWDVEAVN
>Mature_420_residues
SVDDTEASAPTTQRGYATAPTLAGFSHAANERLNADPWGELDRLRDESPTFRSDMPNPLVPGASLWYLLDYESVYTALRD
WETFSNVGSAHPFSDSDPYSMIPGELDPPDHTKFRRPLNAHFSPGAIRALEPDIRRTAVELIESFKDSGQCDFVTDFALH
FPTRVFERMFGVPLEDHDQLTAWVHTFGQQMATQTAIDKAVAAEQEVLAYLGKKLDEREQSPREDLLGAIAFMEVDGARI
SRKEQVAVAYLMFQAGMDTVASQLGWSFRHLAENEVDRQAILADPKLIPSTVEELLRSYDILSHTMIVAKDVEFNGCPMK
KGDRVVTMISAANRDPNEFPDPDTFDVSRKPNRHMAFGVGPHRCIGAHLARIELNIALEEWHQRIPNYKVAEGAEFGQSM
KWAVTSMESLPLEWDVEAVN

Specific function: Cytochromes P450 are a group of heme-thiolate monooxygenases. They oxidize a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics [H]

COG id: COG2124

COG function: function code Q; Cytochrome P450

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cytochrome P450 family [H]

Homologues:

Organism=Caenorhabditis elegans, GI17531287, Length=184, Percent_Identity=27.7173913043478, Blast_Score=74, Evalue=1e-13,
Organism=Drosophila melanogaster, GI21357631, Length=374, Percent_Identity=22.4598930481283, Blast_Score=67, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001128
- InterPro:   IPR002397 [H]

Pfam domain/function: PF00067 p450 [H]

EC number: NA

Molecular weight: Translated: 47227; Mature: 47096

Theoretical pI: Translated: 4.61; Mature: 4.61

Prosite motif: PS00086 CYTOCHROME_P450

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSVDDTEASAPTTQRGYATAPTLAGFSHAANERLNADPWGELDRLRDESPTFRSDMPNPL
CCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCHHHHHHCCCCCCHHHCCCCCC
VPGASLWYLLDYESVYTALRDWETFSNVGSAHPFSDSDPYSMIPGELDPPDHTKFRRPLN
CCCCCEEEEECHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCHHHCCCCC
AHFSPGAIRALEPDIRRTAVELIESFKDSGQCDFVTDFALHFPTRVFERMFGVPLEDHDQ
CCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCHH
LTAWVHTFGQQMATQTAIDKAVAAEQEVLAYLGKKLDEREQSPREDLLGAIAFMEVDGAR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHEECCCH
ISRKEQVAVAYLMFQAGMDTVASQLGWSFRHLAENEVDRQAILADPKLIPSTVEELLRSY
HCHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHH
DILSHTMIVAKDVEFNGCPMKKGDRVVTMISAANRDPNEFPDPDTFDVSRKPNRHMAFGV
HHHHHHEEEEECCCCCCCCCCCCCEEEEEEECCCCCCCCCCCCCCCCCCCCCCCCEEECC
GPHRCIGAHLARIELNIALEEWHQRIPNYKVAEGAEFGQSMKWAVTSMESLPLEWDVEAV
CHHHHHHHHEEEEEEEEHHHHHHHHCCCCCCCCCHHHCCCHHHHHHHHHHCCCEEECEEC
N
C
>Mature Secondary Structure 
SVDDTEASAPTTQRGYATAPTLAGFSHAANERLNADPWGELDRLRDESPTFRSDMPNPL
CCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCHHHHHHCCCCCCHHHCCCCCC
VPGASLWYLLDYESVYTALRDWETFSNVGSAHPFSDSDPYSMIPGELDPPDHTKFRRPLN
CCCCCEEEEECHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCHHHCCCCC
AHFSPGAIRALEPDIRRTAVELIESFKDSGQCDFVTDFALHFPTRVFERMFGVPLEDHDQ
CCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCHH
LTAWVHTFGQQMATQTAIDKAVAAEQEVLAYLGKKLDEREQSPREDLLGAIAFMEVDGAR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHEECCCH
ISRKEQVAVAYLMFQAGMDTVASQLGWSFRHLAENEVDRQAILADPKLIPSTVEELLRSY
HCHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHH
DILSHTMIVAKDVEFNGCPMKKGDRVVTMISAANRDPNEFPDPDTFDVSRKPNRHMAFGV
HHHHHHEEEEECCCCCCCCCCCCCEEEEEEECCCCCCCCCCCCCCCCCCCCCCCCEEECC
GPHRCIGAHLARIELNIALEEWHQRIPNYKVAEGAEFGQSMKWAVTSMESLPLEWDVEAV
CHHHHHHHHEEEEEEEEHHHHHHHHCCCCCCCCCHHHCCCHHHHHHHHHHCCCEEECEEC
N
C

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8796346; 9163424 [H]